Homework #1

Due day 15/11/04 12:00

a) If there were a gene with 3 alleles Y1, Y2, Y3, how many different genotypes could exist?

b) If there were a gene with N alleles Y1, Y2 … Yn, how many different genotypes could exist?

c) Assuming Xlinked gene with 3 alleles, how many different genotypes could exist (male and female)?

d) Assuming Xlinked gene with N alleles, how many different genotypes could exist (male and female)?

e) Assuming two genes with 3 alleles each, how many different genotypes could exist?

f) Assuming two genes with N and M alleles, how many different genotypes could exist?

  1. For each pedigree, answer following questions:
  2. Could this trait be inherited as a simple autosomal recessive?
  3. Could this trait be inherited as a simple autosomal recessive?
  4. Could this trait be inherited as a simple autosomal dominant?
  5. Could this trait be inherited as a simple X-linked recessive?
  6. Could this trait be inherited as a simple X-linked dominant?
  7. Could this trait be inherited as a simple Y-linked trait?

Pedigree A / Pedigree B
Pedigree C / Pedigree D

Briefly explain your answer.

  1. For next pedigree determinate the inheritance mode (autosomal/xlinked, recessive/dominant) and write the genotypes in every possible place. If only one allele is known, put “_” instead of second allele. Assume, that none of the people that married into the family are carry the gene.

  1. Htfoot (h), obese (o), and waved (wa) are recessive genes found in mice. A trihybrid whose parents were unknown was testcrossed, producing the following progeny:

hotfoot, obese, waved361

hotfoot, obese 74

waved 66

obese 74

wild-type348

hotfoot, waved 57

obese, waved 11

hotfoot 9

TOTAL 1000

What is the order along the chromosome of any linked gene loci? How do you know?

Draw the chromosomes with their associated alleles as they existed in the trihybrid.

Determinate recombination values.

  1. The mother of a family of 10 children has blood type Rh+. She also has a very rare condition, elliptocytosis, with no adverse clinical effect, in which the red blood cells are oval rather than round. The father is Rh- and has normal red cells. Their children include 1 Rh+ child with normal blood cells, 4 Rh+ children with oval blood cells, and 5 Rh- children with normal blood cells.

These traits are determined by genes at two different autosomal loci. The allele for elliptocytosis (E) is dominant to the allele for normal cells (e). The allele for the Rh+ phenotype (h+) is dominant to that for Rh- (h-).

a) What are the genotypes of the parents?

b) What are the genotypes of each of the 3 phenotypic classes amongst their children?

c) Could the elliptocytosis and Rh loci be on the same chromosome? If so, estimate the map distance between them.

d) Suppose, for the sake of argument that the parents of the mother (maternal grandparents of the 10 children) were both homozygous at both loci. What would their genotypes have been? (In fact, since elliptocytosis is very rare, this scenario is unlikely.)

  1. In Drosophila, an X-linked recessive mutation, scalloped (sd) causes irregular wing margins. Diagram the F1 and F2 results if:
  1. A scalloped female is crossed with a normal male.
  1. A scalloped male is crossed with a normal (homozygous) female.
  1. Compare the results in a & b to those that would be observed if the scalloped gene were autosomal. Assume that the P1 individuals are homozygous.