Supplementary Table 1a. Correlationsa between selectb serum inflammation markers among lung cancer controls

CRP / CCL2/MCP-1 / CCL13/MCP-4 / CCL19/MIP-3b / CXCL5/ENA-78 / CXCL6/GCP2 / CXCL10/IP-10 / Amylin / C-peptide / Insulin / Leptin / sTNFR-II
CRP
CCL2/MCP-1 / 0.10
CCL13/MCP-4 / 0.03 / 0.33
CCL19/MIP-3b / 0.27 / 0.15 / 0.13
CXCL5/ENA-78 / 0.22 / 0.24 / 0.13 / 0.06
CXCL6/GCP2 / 0.23 / 0.37 / 0.24 / 0.36 / 0.38
CXCL10/IP-10 / 0.24 / 0.12 / 0.16 / 0.40 / 0.06 / 0.26
Amylin / n/a / n/a / n/a / n/a / n/a / n/a / n/a
C-peptide / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a
Insulin / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a
Leptin / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a / n/a
sTNFR-II / 0.36 / 0.20 / 0.05 / 0.40 / 0.10 / 0.33 / 0.38 / n/a / n/a / n/a / n/a

a Excludes marker values below the lower limit of detection.

b Among those with statistically-significantly associations for highest vs. lowest marker category in continuous model of body mass index (per 5 kg/m2) after FDR

Supplementary Table 1b. Correlationsa between selectb serum inflammation markers among NHL controls

CRP / CCL2/MCP-1 / CCL13/MCP-4 / CCL19/MIP-3b / CXCL5/ENA-78 / CXCL6/GCP2 / CXCL10/IP-10 / Amylin / C-peptide / Insulin / Leptin / sTNFR-II
CRP
CCL2/MCP-1 / n/a
CCL13/MCP-4 / n/a / 0.47
CCL19/MIP-3b / n/a / 0.09 / 0.19
CXCL5/ENA-78 / n/a / 0.28 / 0.31 / 0.14
CXCL6/GCP2 / n/a / 0.20 / 0.31 / 0.32 / 0.45
CXCL10/IP-10 / n/a / 0.13 / 0.08 / 0.37 / 0.08 / 0.11
Amylin / n/a / 0.07 / -0.08 / -0.04 / -0.07 / 0.001 / 0.02
C-peptide / n/a / 0.15 / 0.05 / 0.13 / 0.04 / 0.14 / 0.09 / 0.75
Insulin / n/a / 0.09 / 0.11 / 0.15 / 0.03 / 0.13 / 0.04 / 0.73 / 0.77
Leptin / n/a / 0.11 / 0.11 / 0.15 / 0.21 / 0.18 / 0.22 / 0.17 / 0.42 / 0.37
sTNFR-II / n/a / 0.15 / 0.12 / 0.29 / 0.12 / 0.19 / 0.40 / 0.14 / 0.10 / 0.06 / 0.04

a Excludes marker values below the lower limit of detection.

b Among those with statistically-significantly associations for highest vs. lowest marker category in continuous model of body mass index (per 5 kg/m2) after FDR

Supplementary Table 1c. Correlationsa between selectb serum inflammation markers among ovarian cancer controls

CRP / CCL2/MCP-1 / CCL13/MCP-4 / CCL19/MIP-3b / CXCL5/ENA-78 / CXCL6/GCP2 / CXCL10/IP-10 / Amylin / C-peptide / Insulin / Leptin / sTNFR-II
CRP
CCL2/MCP-1 / 0.14
CCL13/MCP-4 / n/a / n/a
CCL19/MIP-3b / n/a / n/a / n/a
CXCL5/ENA-78 / n/a / n/a / n/a / n/a
CXCL6/GCP2 / n/a / n/a / n/a / n/a / n/a
CXCL10/IP-10 / 0.18 / 0.25 / n/a / n/a / n/a / n/a
Amylin / 0.20 / 0.14 / n/a / n/a / n/a / n/a / 0.13
C-peptide / 0.19 / 0.05 / n/a / n/a / n/a / n/a / 0.05 / 0.65
Insulin / 0.18 / 0.08 / n/a / n/a / n/a / n/a / 0.08 / 0.74 / 0.87
Leptin / 0.26 / 0.13 / n/a / n/a / n/a / n/a / 0.23 / 0.16 / 0.31 / 0.30
sTNFR-II / 0.22 / 0.11 / n/a / n/a / n/a / n/a / 0.56 / 0.12 / 0.17 / 0.14 / 0.30

a Excludes marker values below the lower limit of detection.

b Among those with statistically-significantly associations for highest vs. lowest marker category in continuous model of body mass index (per 5 kg/m2) after FDR

Supplementary Table 2.Odds ratios (ORs)a and 95% confidence intervals (CIs) forselectbcirculating inflammation markers and body mass index

Body mass index
Marker / <25.0 kg/m2 / 25.0-29.9 kg/m2 / ≥30.0 kg/m2
Acute phase proteins
CRPc / 1.00 (ref) / 2.69 (1.28-5.68) / 6.05 (2.19-16.73)
Chemokines
CCL2/MCP-1c / 1.00 (ref) / 0.97 (0.57-1.67) / 2.62 (1.31-5.23)
CCL13/MCP-4c / 1.00 (ref) / 1.72 (0.90-3.29) / 4.59 (1.98-10.66)
CCL19/MIP-3bc / 1.00 (ref) / 2.60 (1.33-5.07) / 11.52 (4.88-27.19)
CXCL5/ENA-78c / 1.00 (ref) / 0.97 (0.47-2.02) / 2.68 (1.16-6.19)
CXCL6/GCP2c / 1.00 (ref) / 1.14 (0.60-2.17) / 2.94 (1.26-6.87)
CXCL10/IP-10c / 1.00 (ref) / 1.13 (0.65-1.97) / 3.04 (1.41-6.56)
Peptide hormones
Amylinc / 1.00 (ref) / 1.31 (0.58-2.92) / 3.43 (1.40-8.40)
C-peptidec / 1.00 (ref) / 1.34 (0.66-2.71) / 8.51 (3.05-23.76)
Insulinc / 1.00 (ref) / 1.50 (0.72-3.16) / 17.72 (5.28-59.40)
Leptin c / 1.00 (ref) / 18.14 (5.90-55.80) / >1,000 (184.07->1,000)
Soluble receptors
sTNFR-IIc / 1.00 (ref) / 0.86 (0.45-1.63) / 2.05 (0.91-4.62)

a Estimated using logistic regression models. ORs represent the association between highest vs. lowest level of a specific inflammation marker in relation to body mass index. All models adjusted for age (continuous), sex, cigarette smoking status (never, former, current), case-control study of origin (lung, NHL, ovary), and physical activity level (<1, 1-2, ≥3 hours/week)

b Among those with statistically-significantly associations for highest vs. lowest marker category in continuous model of body mass index (per 5 kg/m2) after FDR correction for multiple comparisons

c 4th vs. 1st quartile or 3rd tertile vs. undetectable

Supplementary Table 3.Odds ratios (ORs)a and 95% confidence intervals (CIs) forselectbcirculating inflammation markers and body mass index (per 5-kg/m2) by case-control study

Nested case-control study
Lung / NHL / Ovary
Marker / OR (95% CI) / P-interaction*
Amylin / 1.66 (1.02-2.69) / 2.53 (1.26-5.09) / 0.33
C-peptide / 2.52 (1.47-4.31) / 3.56 (1.65-7.70) / 0.47
CCL19/MIP-3b / 2.51 (1.54-4.09) / 4.69 (2.54-8.68) / 0.12
CRP / 3.56 (1.80-7.03) / 1.68 (0.62-4.54) / 0.22
CXCL6/GCP2 / 1.50 (0.94-2.41) / 2.08 (1.24-3.47) / 0.36
CXCL5/ENA-78 / 1.48 (0.97-2.26) / 1.70 (1.10-2.65) / 0.66
Insulin / 4.10 (2.20-7.66) / 4.64 (2.12-10.13) / 0.81
CXCL10/IP-10 / 1.65 (1.06-2.57) / 2.07 (1.14-3.75) / 1.44 (0.72-2.87) / 0.72
Leptin / 79.51 (23.34-270.91) / 58.89 (11.70-296.42) / 0.77
CCL2/MCP-1 / 2.02 (1.20-3.41) / 1.72 (1.09-2.71) / 0.94 (0.58-1.52) / 0.08
CCL13/MCP-4 / 1.69 (1.04-2.75) / 1.75 (1.04-2.93) / 0.92
sTNFR-II / 1.83 (1.09-3.06) / 1.38 (0.76-2.51) / 1.59 (0.84-2.99) / 0.78

*Based on chi-squared test for heterogeneity

a Estimated using logistic regression models. ORs represent the association between highest vs. lowest level of a specific inflammation marker in relation to body mass index. All models adjusted for age (continuous), sex, cigarette smoking status (never, former, current), and physical activity level (<1, 1-2, ≥3 hours/week) and used study-specific weights

b Among those with statistically-significantly associations for highest vs. lowest marker category in continuous model of body mass index (per 5 kg/m2) after FDR correction for multiple comparisons