(A)Annotation of Upregulated Genes

Table S1

Functional annotation (using DAVID) of differentially expressed genes (cut-off ≥1.5 fold change)identified by microarray analysis in NaF exposed cells.

(A)Annotation of upregulated genes

GO term / Count / Gene symbol
GO category -Biological process
Response to wounding (response to stress/ response to stimulus) / 10 / ANXA8, ANXA8L2, APOL1, CCL2, C1R, PLAU, PLAUR, SAA1, SAA2, C3
Homeostasis / 6 / ANXA8, ANXA8L2, PLAU, PLAUR, SAA1, SAA2
Inflammatory response / 6 / APOL2, CCL2, C1R, SAA1, SAA2, C3
Regulation of cell proliferation / 6 / EBI3, CCL2, IFITM1, PLAU, RARRES3, RPS15A
Neurological system process / 3 / DHRS3, EML2, PRR4
GO category -Molecular function
Calcium ion binding / 5 / ANXA8, ANXA8L1, ANXA8L2, C1R, FBLN1
Metal ion binding / 7 / ANXA8, ANXA8L1, ANXA8L2, C1R, FBLN1, SLC12A8, ZNF836
Peptidase activity / 3 / C1R, EML2, PLAU
GO category –Cellular component
Extracellular region / 12 / EBI3, APOL1, APOL2, CCL2, C1R, FBLN1, PLAU, PLAUR, PRR4, SAA1, SAA2, C3
Protein-lipid complex / 3 / APOL1, SAA1, SAA2

(B)Annotation of downregulated genes

GO term / Count / Gene symbol
GO category -Biological process
Cell cycle process / 154 / BARD1, BLM, CTCFL, CD2AP, CDC5L, CHEK1, DBF4, E2F3, E2F7, E2F8, EID1, FBXO5, FANCI, GSPT1, HAUS1, HAUS2, HAUS3, KHDRBS1, MAD2L1, NDC80, NAE1, NEK2, NEK4, NSL1, OIP5, PAPD5, PDS5A, PDS5B, PBK, PCNP, RABGAP1, RAD1, RAD21, RINT1, RAD51C, RAD54B, RAN, RBM7, SEH1L, SUGT1, SH3BP4, TAF2, TARDBP, TTK, WEE1, WTAP, ZW10, ZWILCH, APP, APBB2, ANAPC13, ANAPC1, ANAPC4, ANLN, ANXA1, AURKAPS1, BOD1, BCAT1, BUB1B, BUB3, CAMK2D, CDK1, CDC23, CDC27, CDC7, CDC73, CCAR1, CDCA2, CGRRF1, CEP55, CCDC99,CUL2, CUL4A, CUL4B, CUL5, CCNA2, CCNE2, CCNG1, CDK6, CLASP2, CKAP5, DSCC1, DLGAP5, EML4, ESCO2, EIF4G2, ERCC6L, FMN2, GMNN, HELLS, HMGA2, RBBP4, ID4, ITGB1, KIF11, KIF15, KIF23, KNTC1, MND1, MCM6, MCM8, MAPK1, MSH2, MSH6, MYH10, NEDD1, NCOR1, NOLC1, NUSAP1, NPM1, TOP2B, NUP43, PAFAH1B1, PBRM1, POLA1, PDCD6IP, PSMC2, PSMC6, PSMD1, PSMD10, PSMD12, PSMD14, PSMD5, PSMA3, PPP1CB, PPP1CC, PPM1D, PPP3CA, PPP3CB, PPP6C, PTP4A1, RB1, RNF2, SPAST, SPIN1, ZAK, STAG1, STAG2, SMC1A, SMC2, SMC3, SMC4, SUV39H2, THBS1, TLK1, TACC1, TP53BP2, USP9X, UBE2D1, UBE2E1, UHRF2, VCPIP1, ZNF655, ZMYND11
Protein localization / 151 / AKAP12, ARF6, ARL6IP1, ATG3, BCAP29, CD24, COX18, CSE1L, CLPX, DERL1, FGFR1OP, GDI2, GLI3, G3BP2, GRPEL2, MORC3, NAPG, NSF, NDC80, NMD3, NOP58, RABGEF1, RAB10, RAB11A, RAB14, RAB18, RAB1A, RAB21, RAB23, RAB2A, RAB3GAP2, RAB5A, RAB7L1, RAB8B, RINT1, RANBP6, RAN, SDAD1, SEC23IP, SEC24A, SEC24B, SEC24D, SEC31A, SEC62, SEC63, SEH1L, SEC23A, USO1, VTA1, YIPF5, ZW10, AP1G1, AP1S2, AP3B1, AP3M1, AP4E1, AFTPH, APPBP1, ALS2, ARCN1, CANX, CAV1, CDC42, CEP57, CHMP2B, C4ORF16, CLTC, COPB1, CCDC99, COG5, EPS15, EXOC2, EXOC5, EXOC8, XPO1, GOSR1, GOPC, HSPA9, HSP90B1, HOOK3, IPO5, IPO7, IPO8, KPNA1, KPNA3, KPNA4, LIN7C, MAPK1IP1L, MYO6, NEDD4, NUP107, NUP133, NUP153, NUP155, NUP160, NUP205, NUP35, NUP37, NUP43, NUP50, NUP54, NUP98, NUPL1, PEX13, PEX3, PHAX, PDCD6IP, PRKCI, PTPRK, RDX, SCFD1, SCAMP1, SHROOM3, SRP72, SSR1, SSR3, STAM, STAM2, SLC15A4, SNX14, SNX18, SNX2, SNX7, SNX4, SNX9, SERP1, SDCBP, STX6, STX7, TRNT1, TNKS2, TLK1, TRAK2, TRAM1, TRAM2, TMED2, TMED10, TMEM48, TAP2, TNPO1, YWHAB, YWHAG, VPS26A, VPS37A, VTI1B, VAMP7
Proteolysis / 133 / ADAM9, ATG12, ATG3, BARD1, BTBD10, CD2AP, CD46, CD55, CLPX, DCUN1D1, EDEM3, FBXW2, FBXL17, FBKL3, FBXO11, FBXO28, FBXO3, FBXO33, FBXO38, FBXO45, FBXO5, KIAA0368, MAD2L1, NSF, NAE1, OSGEPL1, PCNP, RABGEF1, RAD23B, SUGT1, SMURF2, SUMO1, SENP6, WSB1, YME1L1, ANAPC13, ANAPC4, APH1B, ARIH1, BUB1B, BUB3, CAPN7, CDC23, CDC27, CRBN, CUL2, CUL4A, CUL4B, CUL5, CAND1, CTL, DLD, DPP8, ENC1, HSP90B1, IDE, ITCH, KLHL13, KLHL15, KLHL9, MBTPS2, METAP2, MAP3K1, NRD1, NEDD4, NLN, PEG10, PM20D2, PIGK, KCMF1, PJA2, PREPL, PSMC2, PSMC6, PSMD10, PSMD12, PSMD14, PSMD5, PSMD1, PSMA3, RNF111, RNF138, RNF139, RNF2, RNF20, SPCS3, SOCS5, TRIP12, TRHDE, TBL1XR1, TRIM33, UBR1, UBE3A, USP1, USP14, USP33, USP38, USP32, USP46, USP42, USP48, USP7, USP8, USP9X, UBE2V2, UBE2J1, UBE2B, UBE2D1, UBE2D3, UBE2E1, UBE2H, UBE2K, UBE2N, UBE2Q2, UBA2, UBA5, UBA6, UHRF2, VCPIP1, ZMPSTE24
RNA processing / 110 / C1D, CDC5L, DDX1, DDX20, DDX46, DDX5, DDX15, DDX9, DIS3, GRSF1, GAR1, HEATR1, KHDRBS1, KIAA1429, KRR1, LSM5, NOP58, PAPD4, PRPF18, PRPF38B, PRPF40A, RBM17, RBM25, RBMS1, RNGTT, SLU7, SMAD1, SMAD2, SNW1, TARBP1, TARDBP, THCO1, THCO2, TRUB1, UPF3B, UTP15, UTP18, WTR12, WTR3, WTR36, WTAP, YTHDC1, APP, AQR, BCAS2, CCAR1, CPSF2, CSTF2T, CSTF2, CSTF3, ERI1, GEMIN5, HNRNPA0, HNRNPA3, HNRNPC, HNRPDL, HNRNPH1, HNRNPH3, HNRNPK, HNRNPM, HNRNPR, HNRNPU, INTS6, INTS7, LIN28B, MRPL13, NCBP1, NUFIP1, NOLC1, NUDT21, PPIL3, PPWD1, PHAX, PNN, PLRG1, PAPOLA, PAPOLG, POLR2B, PTBP2, PPP4R2, RPP40, STRAP, SNRNP48, SNRPD1, SNRPB2, SF3B1, SMC1A, SKIV2L2, SYNCRIP, TRIT1, TRMT11, TRMT61B, TRNT1, TFB2M, TRA2A, TRA2B, ZCCHC8, ZRANB2
Cytoskeleton organization / 80 / ARF6, ATP2C1, AGFG1, CAP2, FBXO5, FGFR1OP, FHDC1, HAUS1, HAUS2, HAUS3, LMO7, LIMA1, NDC80, NEK2, RANBP9, RND3, SEH1L, TTK, WASF1, WASL, ZW10, ABL2, ABLIM1, ANLN, ANTXR1, AURKAPS1, BUB1B, CALD1, CNN3, CAPZA1, CAPZA2, CAV1, CDC42, CCDC99, CKAP5, DOCK7, DLC1, DIAPH3, DLG1, DAAM1, EPS8, EPB41L2, EPB41L3, FERMT2, NPM1, ROCK1, RRAS2, FMN2, FMNL2, HOOK3, ITGB1, KIF11, KIF23, LPIN1, MAP1B, MYH10, NRAS, NUSAP1, PAK2, PALLD, PARVA, PCLO, PLS3, PAFAH1B2, SHROOM3, PPP3CA, SPAST, SMC1A, SMC3, SVIL, SDCBP, SYNM, SS18, TUBGCP3, TUBGCP4, UBE2B, KRAS, RALA
Chromosome organization including histone modification / 76 / AEBP2, ASF1A, ARID1B, ARID2, BMI1, BLM, CTCFL, CTR9, MAD2L1, NDC80, NEK2, PDS5B, PHF16, PHF17, RAD51C, RCOR1, SATB2, SEH1L, SMARCA1, SMARCA2, SMARCA5, SMARCAD1, UTP3, XRCC5, ZW10, ATXN7, BUB3, CDC23, CDC73, CHD1, CCDC99, DSCC1, DLGAP5, EYA3, EYA4, HELLS, HMGA2, HMGB1, HAT1, HDAC2, HDAC9, KDM3A, MORF4L2, MSH2, MSH6, NCOR1, NR3C1, NUSAP1, NAP1L1, PBRM1, PTGES3, RB1, RNF2, RNF20, SIRT1, SMC1A, SMC2, SMC3, SMC4, SUPT16H, SUV420H1, SUZ12, TOP2A, TLK1, TADA1, TBL1XR1, TRRAP, UBE2E1, UBE2N, CBX1, NPM1, CBX3, PRKDC, SUV39H2, UBE2B, GSPT1
Regulation of cell cycle / 49 / BLM, FBXO5, MAD2L1, NAE1, NEK2, RAD1, RINT1, TTK, ZW10, APP, APBB2, ANLN, BUB1B, BUB3, CAMK2D, CDC23, CDC7, CCNA2, CCNE2, CCNG1, CDK6, DLGAP5, DLG1, XPO1, GMNN, GTF2H1, HDAC2, ID2, ITGB1, KNTC1, MSH2, NUSAP1, PGGT1B, PTPRK, RB1, ZAK, SMC1A, TRRAP, TP53BP2, UHRF2, ETS1, ZNF655, ZWILCH, CDC42, NPM1, PTEN, PPP1CB, PTPN11
DNA repair / 45 / ASF1A, BARD1, BLM, FANCI, PMS1, RAD1, RAD21, RAD23, RAD51, RAD54, BOLA2. SUMO1, XRCC5, ANKRD17, CUL4A, CUL4B, EXCO2, ERCC8, EYA3, EYA4, GTF2H1, GTF2H2, MBD4, MORF4L2, MSH2, MSH6, POLA1, POLE2, RFC3, SIRT1, SMC1A, CMC6, SUPT16H, TOP2A, TOPBP1, USP1, UBE2V2, REV1, HMGB1, TDG, PRKDC, UBE2B, UBE2N
Negative regulation of apoptosis / 38 / API5, BAG4, BNIP2, BNIP3L, BARD1, SON, SOX4, TAF9B, XRCC5, ADNP, APBB2, ANXA1, FOXO1, GCLC, GLO1, HSPA9, HSP90B1/MIR3652, HELLS, ITSN1, MAP3K7, MSH2, MCL1, NRAS, PRDX3, PRNP, PRKCI, SGMS1, TMX1, THBS1, TGFBR1, KRAS, HSPD1, HMGB1, HIPK2, NPM1, PTEN, ROCK1, MINPP1
Bone development / 9 / NAB1,SATB2,SMAD1,SMAD5, SOX9,SP1,WWTR1,CBFB,TWSG1
Regulation of osteoblast differentiation / 5 / SMAD5, BMPR2, BMPR1A, CDK6,TWSG1
GO category -Molecular function
Purine nucleotide binding / 288 / MTRR, ARF6, ARL1, ARL13B, ARL5A, ARL8B, ACTR2, ACTR3, ABCB10, ABCD3, ATAD1, ATAD2, ATP13A3, ATP2B1, ATP2C1, ATP6V1A, ATP8B5P, ATP10D, ATP11A, ATP11C, BTAF1, BLM, CLK1, CLPX, DDX18, DDX18, DDX20, DDX21, DDX3X, DDX42, DDX46, DDX5, DDX50, DDX6, DHX15, DHX29, DHX33, DHX36, DHX9, FASTKD1, FASTKD2, FASTKD3, GFM1, GFM2, GSPT1, GCH1, GTPBP8, G3BP1, GUF1, GRPEL2, HBS1L, MDN1, MORC3, MORC4, NSF, NKIRAS1, NEK2, NEK4, NEK7, PAN3, PAPD4, PDS5B, PBK, PMS1, RAB10, RAB11A, RAB14, RAB18, RAB1A, RAB21, RAB23, RAB28, RAB2A, RAB5A, RAB7L1, RAB8B, RAD51C, RAD54B, RAN, RAP1A, RAP1B, RAP2A, RAP2C, RIOK1 ,RIOK2 ,RIOK3, RNGTT, ARHGAP5, RND3, RHOBTB3, SCYL2, SMG1, SNRK, SWAP70, SMARCA1, SMARCA2, SMARCA5, SMARCAD1, TTK, WEE1, XRCC5, YME1L1, YTHDC2, ASCC3, ACSL1, ACSL3, ACSL4, ACADM, ACOX1, ADSS, AGPS, ANKRD17, RARS, NARS, DARS, ATL2, ATL3, AURKAPS1, BMPR2, BUB3, CAMK2D, CASK, CSNK1A1, CSNK1G1, CSNK1G3, CDC42, CDC7, CCT5, CCT6A, CHD1, C10orf88, CDK6, CDK8, CMPK1, DOCK7, DOCK9, DLD, DDR2, DYRK1A, DYRK2, DNM1L, DYNC1LI2, EFTUD1, ETNK1, EIF5, ERCC6L, FIGNL1, GCLC, EPRS, GNA13, GNAI1, GNAI3, GNAQ, GNL2, HSPH1, HSPD1, HSPA14, HSPA4, HSPA9, HSPA13, MIR3652, HELLS, HNRNPA3, HIPK1, HIPK2, IDE, IARS2, KIF11, KIF15, KIF1B, KIF23, KIF4B/KIF4A, KIF5B, KIF5C, KIF2A, LARS, ME1, MET, MARS2, MCM4, MCM6, MCM8, MCM9, MTIF2, MFN1, MAPK1IP1L, MAP3K1, MAP3K2, MAP3K7, MAP4K3, MAP4K4, MSH2, MSH6, MYO1B, MYOVI, MYOX, MYH10, NRAS, NAV2, NIN, NOLC1, OXSR1, PAK2, PANK3, PIK3C2A, PIK3C3, PIK3R4, PRPS2, PAICS, PAPOLA, PAPOLG, PSMC2, PSMC6, PRKCA, PRKCI, PRKD3, PKN2, PRKAA1, PRKAR1A, PRKAR2A, RHOT1, RRAS2, RFC3, RP2, RFK, RRM1, RPS6KB1, RPS6KA3, RUNX1, SLFN11, STK17A, STK17B, MST4, SGK1, ABCB1, EIF4A2 , PRKDC, SACS, SPAST, SPATA5L1, ZAK, SMC1A, SMC2, SMC3, SMC4, SMC6, SUCLA2, SKIV2L2, TRIT1, TRNT1, TXNRD1, TARS, TOPBP1, TOP2A, TOP2B, TLK1, TGFBR1, TGFBR2, TAP2, WARS2, UBE2J1, UBE2B, UBE2D1, UBE2D3, UBE2E1, UBE2H, UBE2K, UBE2N, UBE2Q2, UBA2, UBA6, KRAS, ABL2, RALA, YES1
Transcription regulator activity / 150 / AEBP2, AFF1, AFF4, ARID1B,ARID5B, ATAD2, BTAF1, BACH1, CTBP2, C1D, CTCFL, CNOT7, COPS2, DDX20, DDX5, DEK, E2F3, E2F5, E2F7, E2F8, EID1, GLI3, WDR11, KHDRBS1, KLF10, KLF3,MKL2, MEIS2, NKRF, NAB1, PRDM2, PAWR, RAN, RYBP, SATB2, SERTAD2, SIX4, SMAD1, SMAD2, SMAD5, SNW1, SOX4, SOX9, SUB1, SMARCA1, SMARCA2, SMARCA5, SP1, SP4, TAF4, TAF9B, TARDBP, TAF1A, TBPL1, TEAD1, THOC1, TIAL1, TSC22D2, WWTR1, YAF2, YY1, YAP1, ATF1, ADNP, BNC1, CREB1, CREM, CBFB, CAND1, CUX1, DR1, ELL2, ELP4, FUBP3, FOXJ3, FOXO1, FOXO3, FOXP1, GTF2A2, GTF2H1, GTF2H2, GTF3C3, HSF2, HDAC2, HDAC9, HOXA9, HIPK2, HIF1A, ID2, ID4, LRRFIP1, MED1, MED13, MED14, MED21, MED23, MED7, MYEF2, MYNN, NFE2L2, NCOR1, NCOA4, NR2C1, NR2C2, NR3C2, NFYB, NFXL1, NPM1, PDE8A, PLRG1, PCGF6, PBX3, PURA, PURB, RREB1, RBPJ, RB1, RNF2, RNF20, RUNX1, STAT1, BCLAF1, CBX3, SIRT1, SUPT16H, TRIP4, TCEA1, TCEB1, TCERG1, TCF12, TFAM, TFB2M, TADA1, TBL1XR1, TRRAP, TRIM24, YWHAB, ETS1, MYBL1, VEZF1, RNF140, RNF217, RNF238, RNF281, RNF36, RNF367, RNF639, RNF711, ZFPM2, ZRANB2
ATPase activity / 61 / ATP5L, ABCB10, ABCD3, ATAD2, ATP13A3, ATP2B1, ATP2C1, ATP6V1D, ATP6V1C1, ATP6V1A, ATP1B1, ATP1B3, ATP10D, ATP11A, ATP11C, BLM, DDX1, DDX18, DDX20, DDX21, DDX3X, DDX42, DDX46, DDX5, DDX50, DDX6, DDX15, DDX29, DDX33, DDX36, DDX9, G3BP1, MDN1, NAPG, RAD51C, RAD54C, RHOBTB3, SMARCA1, SMARCA2, SMARCA5, XRCC5, ASCC3, CRBN, CHD1, C10orf88, ERCC8, GTF2H1, GTF2H2 , HSPD1, IDE, KIF1B, MSH2, MSH6, MYH10, PSMC2, PSMC6, RFC3, SPAST, SKIV2L2, TOP2A, TAP2
Ligase activity, forming carbon-nitrogen bonds / 34 / ATG3, BARD1, FBXW2, FBXL3, FBXO11, FBXO30, HECTD1, LMO7, ADSS, ANAPC4, ARIH1, ASNSD1, CDC23, ERCC8, GCLC, ITCH, MIB1, MAP3K1, NEDD4, PAICS, RNF2, RNF20, TRIP12, UBR1, UBE3A, UBE2V2, UBE2J1, UBE2B, UBE2D1, UBE2D3, UBE2E1, UBE2H, UBE2K, UBE2N, UBE2Q, UHRF2, UBE4A
GO category –Cellular component
Intracellular non-membrane-Bounded organelle / 350 / AKAP11, AKAP12, ARL8B, ACTR2, ACTR3, ARID1B, BACH1/GRIK1-AS2, BLM, C1D, CAP2, CD2AP, CDC14B, CDC42EP3, CDC5L, COPS2, CTTNBP2NL, CLPX, DDX20, DDX21, DDX5, DDX50, DHX33, DHX9, DIS3, DNAJB9, DNAJC21, FBXO5, FRMD6, FGFR1OP, FANCI, GAR1, GLI3, HAUS1, HAUS2, HAUS3, HEATR1, IQGAP1, KIAA0368, KRR1, LIMA1, MAD2L1, MKI67IP, MINA, MEIS2, NDC80, NKRF, NEK2, NEK4, NMD3, NOP58, NSL1, OIP5, PDS5A, PDS5B, PDLIM5, RABGAP1, RAD21, RANBP9, RAN, RRN3, SDAD1, SEC62, SEH1L, SUGT1, SH3D19, SMEK1, SMEK2, SNW1, SOX9, SUB1, SMARCA5, SMARCAD1, SP1, MIR1257 / TAF4, TARDBP, TAF1A, TTK, TWISTNB, UAP1, UTP15, UTP18, UTP3, VAPA, WASF1, WDR12, WDR3, WDR43, WDR44, WDR75, WWTR1, WTAP, WASL, XRCC5, ZW10, ZWILCH, ABLIM1, ADNP, APP, APPBP2, ALS2, ANLN, ANXA1, RARS, ATXN7, AURKAPS1, BIRC2, BOD1, BCAS2, BRIX1, BRIX2, BRIX5, BAZ1A, BUB1B, BUB3, CREB1, CASK, CALD1, CAMSAP1, CNN3, CASC5, CAPZA1, CAPZA2, CDC27, CENPQ, CEP170, CEP192, CEP55, CEP57, CEP68, CSPP1, CCT5, CLIC4, CBX1, CHD1, CSTF2T, CFL2, CCDC6, CCDC99, COIL, CLASP2, CKAP5, DOCK4, DSCC1, DSP, DLGAP5, DLG1, DCTN4, DYNC1LI2, EML4, ENC1, ENAH, EPS8, EPB41L2, EPB41L3, EIF3E, ERCC6L, ERI1, XPO1, FAM82A1, FAM82B, FERMT2, FOXP1, FMN2, FNBP1L, FMR1, FXR1, GPHN, GNL2, HSPA9, HELLS, HNRNPA3, HNRNPH1, HNRNPK, HNRNPM, HMGA2, HMGB1, HDAC2, HIPK1, HIPK2, HOMER1, HOOK3, ZMYM6, RBBP4, HIF1A, IPO5, INTS6, KLHL7, KIF11, KIF15, KIF1B, KIF23, KIF4B, KIF5B, KIF5C, KIF2A, KNTC1, LMNB1, LRRFIP1, LRP12, ME1, MTDH, MBD4, MAP1B, MCM4, MRPL1, MRPL13, MRPL15, MRPL3, MRPL50, MRPL10, MRPS35, MAPK1IP1L, MAP3K1, MORF4L2, MSH6, MYEF2, MYOF, MYO1B, MYO6, MYO10, MYH10, MARCKS, NEDD1, NEDD4, NAV2, NIN, NUFIP1, NUFIP2, NCOR1, NR2C2, NR3C1, NOLC1, NUSAP1, NOL11, NOL8, NOM1, NUP107, NUP133, NUP160, NUP37, NUP43, NUP98, NUDT21, PAK2, PALLD, PARVA, PCLO, PNN, PKP2, PAFAH1B2, PSD3,PAPOLA, PBRM1, PCGF5, POLA1, PJA2, PRIM1, PGRMC1, PDCD6IP, PTGES3, PSMD10, PSMA3, PRMT3, PTP4A1, PRKRIR, PURA, PURB, RDX, RBPJ, RFC3, RB1, RAI14, RPP40, RSL24D1, RPL22L1, RPS6KB1, RNF2, RNF20, STK17B, SHROOM3, STAT1, ESF1, ROCK1, ZNF532, SIRT1, SPAST, SPIN1, SERP1, STAG1, STAG2, SMC1A, SMC2, SMC3, SMC4, SMC6, SKIV2L2, SVIL, SUV39H2, SUV420H1, SUZ12, SDCBP, SYNM, SS18, TNKS2, TANC1, TRIP4, TOP1, TOP2A, TOP2B, TOPBP1, TFAM, TFB2M, TBL1XR1, TACC1, TRIM24, TUBGCP3, TUBGCP4, TWF1, UBE2B, MYBL1, VCL, WAPAL, ZFR, ZBTB11, ZBTB33, ZNF106, ZNF146, ZNF238, ZNF655
Membrane enclosed lumen / 289 / OXCT1, ARID1B, BACH1 / GRIK1-AS2, BLM, CTBP2, C1D, CNOT7, CD2AP, CDC14B, CDC5L, COPS4, CLPX, CTR9, DBF4, DDX20, DDX21, DDX3X, DDX42, DDX46, DDX5, DDX50, DDX33, DDX9, DIS3, DNAJB11, DNAJB9, E2F3, E2F5, E2F7, E2F8, EDEM3, FBXO5, FANCI, GAR1, GLI3, GRPEL2, HEATR1, IQGAP1, KRR1, MKI67IP, MORC3, MINA, MEIS2, NKRF, NEK2, NEK4, NMD3, NARG2, NOP58, OGT, OIP5, PHF16, PHF17, PRPF18, PRPF40, RAD23B, RAN, RYBP, RBM25, RBM27, RNGTT, RRN3, SATB2, SDAD1, SH3D19, SLU7, SMAD1, SMAD2, SMAD5, SUMO1, SNW1, SON, SOX9, SUB1, SMARCA2, SMARCA5, SMARCAD1, SP1, TAF2, TAF4, TAF9B, TARDBP, TAF1A, TBPL1, TEAD1, THOC1, TWISTNB, UAP1, UTP15, UTP18, UTP3, WDR12, WDR3, WDR43, WDR75, WEE1, WAC, WWTR1, WTAP, WASL, XRCC5, YTHDC1, YY1, YAP1, ACAT1, ATF1, ADNP, ACADM, APBB2, ANAPC4, ANKRD28, RARS, ATXN7, BCAS2, BRIX1, BRIX2, BRIX5, BUB3, CREB1, CREM, CDC23, CDC27, CDC7, CDC73, CLN5, CCT5, CFL2, COIL, CCNA2, CCNE2, CDK8, CYCS, DSCC1, DLAT, DLD, DYRK1A, ENC1, ELL2, ELP4, EIF3E, ERCC8, ERI1, XPO1, XPOT, FAR1, FOXO1, FOXP1, FMR1, FXR1, GEMIN5, GMNN, GTF2A2, GTF2H1, GTF2H2 / GTF2H2B / GTF2H2C / GTF2H2D, GTF3C3, GLS, GNL2, HSPD1, HSPA9, HSP90B1 / MIR3652, HNRNPA3, HNRNPH1, HNRNPK / MIR7-1, HNRNPM, HNRNPR, HMGB1, HDAC2, HDAC9, HOXA9, HIPK1, HIPK2, RBBP4, HIF1A, IPO5, IDE, INTS6, INTS7, IARS2, KPNA1, KLHL7, KIF23, KIF4A/KIF4B, LMNB1, LRP12, ME1, MATR3, MED1, MED13, MED14, MED21, MED23, MED7, MTDH, MARS2, MBD4, MUT, MCM10, MCM4, MCM6, MCM8, MRPL15, MRPL13, MRPL3, MRPS35, MAPK1, MORF4L2, MYEF2, MCL1, MYO6, NLN, NAV2, NCBP1, NUFIP1, NCOR1, NR2C2, NR3C1, NFYB, NOLC1, NUSAP1, NOL11, NOL8, NOM1, NUP153, NUP50, NUP54, NUP98, NUDT21, PHAX, PNN, PLRG1, PAPOLA, POLA1, POLE2, POLR2B, PBX3, PRIM1, PGRMC1, PSME4, PPP1CB, PPP1CC, PRKRIR, PDHX, PDH1, RREB1, RBPJ, RFC3, RCN2, RB1, RBBP5, RPP40, RSL24D1, RPS6KA3, RNF2, RNF20, STAT1, SIRT1, SNRPD1, SF3B1, SMC3, SKIV2L2, SUPT16H, SUZ12, SYNCRIP, THBS1, TRIP4, TOP1, TOP2A, TOP2B, TOPBP1, TCEA1, TCEB3, TCF12, TFAM, TFB2M, TADA1, TBL1XR1, TRRAP, TAP2, WARS2, YWHAB, USP1, UBE2D1, UBE2E1, MYBL1, ZFR, ZBTB11, ZBTB33, ZNF106, ZNF146, ZNF326, ZNF655, ZMYM2, CBX1
Chromosome / 88 / BLM, FANCI, MAD2L1, MKI67IP, NDC80, NEK2, NSL1, OIP5, PDS5A, PDS5B, RAD21, RAN, SEH1L, SUGT1, SMARCA5, XRCC5, ZW10, ZWILCH, BIRC2, BOD1, BAZ1A, BUB1B, BUB3B, CREB1, CASC5, CENPQ, CBX1, CHD1, CCDC99, CLASP2, DSCC1, EIF3E, ERCC6L, XPO1, HELLS, HMGA2, HMGB1, HDAC2, RBBP4, KNTC1, MBD4, MSH6, NEDD4, NUFIP1, NUP107, NUP133, NUP160, NUP37, NUP43, NUP98, PAFAH1B2, PBRM1, POLA1, PRIM1, PTGES3, PURA, PURB, RFC3, RB1, RNF2,RNF20, STAG1, STAG2, SMC1A, SMC2, SMC3, SMC4, SMC6, SUPT16H, SUV39H2, SUV420H1, SUZ12, TNKS2, TOP1, TOP2A, TOP2B, TOPBP1, TRIM24, UBE2B, WAPAL, ZNF238
Microtubule cytoskeleton / 84 / AKAP11, ARL8B, DHX9, FBXO5, FGFR1OP, HAUS1, HAUS2, HAUS3, KIAA0368, MAD2L1, NEK2, RABGAP1, RANBP9, SMEK1, SMEK2, TTK, VAPA, WDR44, ZW10, APP, APPBP2, ALS2, AURKAPS1, BOD1, BUB1B, CAMSAP1, CDC27, CEP170, CEP192, CEP55, CEP57, CEP68, CSPP1, CBX1, CCDC99, CLASP2, CKAP5, DLGAP5, DCTN4, DYNC1LI2, EML4, FAM82A1, FAM82B, HIPK1, HIPK2, HOOK3, KIF11, KIF15, KIF1B, KIF23, KIF4B, KIF5B, KIF5C, KIF2A, KNTC1, MAP1B, MYOF, MYH10, MARCKS, NEDD1, NIN, NCOR1, NUSAP1, NUDT21, PAFAH1B2, PCGF5, PDCD6IP, PTP4A1, RB1, SHROOM3, ROCK1, SPAST, SPIN1, SMC3, SS18, TNKS2, TOP2A, TOP2BP1, TBL1XR1, TACC1, TUBGCP3, TUBGCP4
Organelle envelope / 80 / ATP5L, ABCB10, AGFG1, BNIP2, BNIP3L, COX11, COX18, CSE1L, CLPX, GRPEL2, LEMD3, MAD2L1, MRS2, RAN, SEH1L, SMAD1, SUMO1, UBXN4, WASF1, WTAP, ACAT1, ACSL1, ACSL3, ACSL4, CRLS1, CSDE1, CYCS, DNM1L, XPO1, XPOT, GJA1, GPD2, HSPD1, HIPK2, IPO5, IPO7, IPO8, KPNA1, KPNA3, KPNA4, LBR, LMNB1 , MATR3, MTDH, MFN1, MCL1, MYOF, MYO6, MTMR6, NLN, NUP107, NUP133, NUP153, NUP155, NUP160, NUP205, NUP35, NUP37, NUP43, NUP50, NUP54, NUP98, NUPL1, PAFAH1B2, POLA1, PPP1CC, RHOT1, RTN4, SCRN1, SIRT1, SLC25A24, SLC25A32, SLC25A46, SYNJ2BP, TNKS2, TMEM38B, TMEM48, TNPO1
Endoplasmic reticulum part / 40 / HMGCR, ARL6IP1, DNAJB11, EDEM3, SACM1L, SEC24A, SEC24B, SEC24D, STT3B, VAPA, VMA21, ALG6, ALG8, ASPH, CEPT1, CYP1B1, DLG1, DPM1, HSP90B1, JPH1, KTN1, MAGT1, PIGK, PIGX, PIGY, RCN2, RTN4, SERINC1, SPTLC1, SPCS3, SSR1, SSR3, SLC9, SOAT1, TMX1, TRAM1, TRAM2, TMEM38B, TAP2, VAMP7
Coated vesicle / 28 / KIAA0368, RAB14, RAB5A, SCYL2, SEC24A, SEC24B, SEC24D, SEC31A, SH3BP4, SEC23A, VMA21, YIPF5, AP1G1, AP1S2, AP4E2, AFTPH, ARCN1, CLINT1, CLTC, COPB1, HSPD1, MYO6, PICALM, PIK3C2A, PCLO, SCAMP1, SYPL1, STX6