Liwu Li, Ph.D
Liwu Li
Virginia Polytechnic Institute and State University Email:
Department of Biological Sciences
149 Life Science 1 Building
Blacksburg, VA 24061
EDUCATION:
1991-1996 Ph.D. in Cell and Molecular Biology, The University of Michigan, Ann Arbor, MI. Thesis Advisor: Dr. John Langmore, “In vitro and in vivo Reconstitution and Stability of Vertebrate Chromosome Ends”
1986-1989 M.S. in Plant Molecular Biology, The Academy of Sciences of China, Beijing, China. Thesis Advisor: Dr. Kehui Tan, “Specific Protein Occurrence Related with Photoperiodic Flower Induction in the Cotyledons of Pharbitis nil CV. Violet”
1982-1986 B.S. in Biology, Hebei Normal University, China.
ACADEMIC EMPLOYMENT:
2009-present Professor, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
2005-2009 Associate Professor, Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA
02/2005-08/2005 Associate Professor, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC
2001-2005 Assistant Professor, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC
1999-2001 Instructor, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC
1996-1999 Post-Doctoral Research Associate, Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI. Research Advisor, Dr. Jack E. Dixon
ACADEMIC AFFILIATION AND PROFESSIONAL EXPERIENCE:
2008-present Adjunct member, Department of Medicine, Virginia Tech-Carilion School of Medicine, Roanoke, VA Liwu Li, Ph.D 2
2008-present Adjunct Faculty, Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA
2008- present Member, the Board of Directors, Inflammation Research Association
2007-present Director, Center for Inflammation, Virginia Polytechnic Institute and State University, Blacksburg, VA
2005-present Affiliated Faculty, Virginia Tech-Wake Forest School of Biomedical Engineering
2005-present Affiliated Faculty, Virginia College of Osteopathic Medicine
2005-present Adjunct Faculty, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC
2003-2005 Associate Director, Section of Molecular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC
2001-2005 Adjunct Member, The NCI Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC
2001-2005 Associate Member, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC
HONORS AND AWARDS:
2008 Elected to the Board of Directors, Inflammation Research Association
2008 GE HealthCare Poster Competition Award, Inflammation Research Association
2005 Nominated and confirmed as a regular member of NIH review panel
2005 Faculty Travel Award, American Association of Immunologists
2 004 Paper of the Week Award, Journal of Biological Chemistry
2002 Young Faculty Investigator award, International Cytokine Society
1998 Post-doctoral Fellowship Award, the National Institute of Health Cancer Research Training Grant
1996 Predoctoral Travel Award, the American Society for Cell Biology
1995 The Block Grant Award, Department of Biology, University of Michigan
1995 Research Partnership Award, Rackham Graduate School, University of Michigan Liwu Li, Ph.D 3
CURRENT RESEARCH GRANTS:
03/2005-02/2011 National Institute of Health, “Novel Regulation and Function of IRAK”
$2,112,000 (direct+indirect)
Liwu Li, Principle Investigator; 100%
12/2007-02/2013 National Institute of Health, “Inflammatory Regulation of Lipid Accumulation in Skeletal Muscle With Obesity”
$1,950,000 (direct+indirect)
Matthew Hulver, Principle Investigator;
Liwu Li, CO- Principle Investigator; 5% effort
Other CO-PIs: Madlyn Frisad
07/2010-06/2012 American Heart Association, “Novel Signaling Cross-talk between Nuclear Receptors and TLR pathways”
$150,000
Liwu Li, PI
07/2008-06/2010 National Institute of Health, “Angiotensin II Receptor Blockade and Adipose Tissue Inflammation in Obesity”
$429,000 (direct+indirect)
PI: Kevin Devy, Principle Investigator;
Liwu Li, CO- Principle Investigator; 5% effort
Other CO-PIs: Madlyn Frisad, Matthew Hulver
10/2005-09/2011 National Institute of Health, “Animal Model Research for Veterinarians”
$774,197 (direct+indirect)
X.J. Meng, Principle Investigator;
Liwu Li, CO- Principle Investigator; 5%
Other CO-PIs: Ansar Ahmed, Tom Inzana, Roger Avery, Stephan Boyle, Thomas Caruso, Willard Eyestone, Brad Fenwick, Robert Grange, Stephan Holiday, William Huckle, D. Perez, Chris Reilly, Beverly Rzigalinsky, Edward Smith, N. Sriranganathan, Yasuhiro Suzuki, Craig Thatcher.
COMPLETED RESEARCH GRANTS:
03/2002-02/2008 National Institute of Health, “Regulation of Signaling Events in
Septic Leukocytes”
$1,812,000 (direct+indirect)
Liwu Li, Principle Investigator; 100% Liwu Li, Ph.D 4
01/2006-12/2007 Peter Harvey Grant, Virginia College of Osteopathic Medicine, “Involvement of IRAK in Aging Process”
$65,000 direct cost
Liwu Li, Principle Investigator; 100%
07/2000-06/2002 American Lung Association, “Alterations in Innate Immunity”
$50,000 direct cost
Liwu Li, Principle Investigator; 100%
PENDING RESEARCH GRANTS:
02/2011-06/2015 National Institute of Health, “Regulation of ROS generation in macrophages”
$1,687,000
Liwu Li, Principle Investigator; 100%
02/2011-06/1013 National Institute of Health, “Regulation of inflammation and metabolism in mesangial cells”
$465,000
Liwu Li, Principle Investigator; 100%
02/2011-06/1013 National Institute of Health, “Cancer immunotherapy by targeting IRAK-M”
$465,000
Liwu Li, Principle Investigator; 100%
01/2011-12/2013 American Diabetes Association, “Molecular mechanism underlying metabolic entotoxenia”
$450,000
Liwu Li, PI
PUBLICATIONS:
Peer-reviewed Journals articles:
1) Li L. (1990) A method of protein purification from higher plants for the purposes of 2-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Chinese Bulletin of Botany 4:121-124.
2) Li L, Kehui T. (1990) Changes in the protein synthesis of isolated mitochondria from cotyledons of pharbitis nil caused by photoperiodic flower induction. Chinese Journal of Botany 2:130-134.
3) Li L, Kehui T. (1991) Specific protein occurrence related with photoperiodic flower induction in the cotyledons of pharbitis nil cv. violet. Science in China (Scientia Sinica),Series B 34:570-576.
Liwu Li, Ph.D 5
4) Li L, Ernsting B, Wishart M, Lohse D, Dixon J. (1997) A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. Journal of Biological Chemistry 272:29403-29406.
5) Li L, Lejnine S, Makarov V, Langmore J. (1998) Reconstitution of vertebrate telomeric ends. Nucleic Acids Research 26:2908-2916.
6) Li L, Dixon J. (2000) Form, function, and regulation of protein tyrosine phosphatases and their involvement in human diseases. Seminars in Immunology 12:75-84.
7) Li L*, Ljungman M, Dixon JE. (2000) The Human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53. Journal of Biological Chemistry 275:2410-2414.
8) Li L*, Coursat, S, Hu, J, McCall CE. (2000) Characterization of IRAK in normal and endotoxin tolerance cells. Journal of Biological Chemistry 275: 23340-23345.
9) Mueller L, Yoza B, Neuhaus K, Loeser K, Cousart S, Chang MC, Meredith JW, Li L, and McCall CE. (2001) Repression of Transcriptional Signals Without Alterations in Posttranscritpional Events Regulates Differential Production of IL-1 and sIL-1Ra in Sepsis Leukocytes. Shock. 16(6):430-7.
10) Learn C#, Boger S, Li L*, McCall CE. (2001) Phosphortidyl-inositol-3-phosphate kinase selectively controls IL-1 RA protein production in tolerant cells. Journal of Biological Chemistry 276: 20234-20239.
11) Moors M, Li L, Mizel S. (2001) Bacterial FliC protein activates macrophages via TLR-IRAK mediated pathway. Infection and Immunity 69: 4424-4429.
12) Hu J@, Jacinto R#, McCall CE, Li Li*. (2002) Regulation of interleukin 1 receptor associated kinases by LPS. Journal of Immunology 168: 3910-3914.
13) Jacinto R#, Hu J, Hartung T, McCall CE, Li L*. (2002) LPS and LTA-induced tolerance and cross-tolerance: Distinct alterations in IRAK. Journal of Immunology 168: 6136-6141.
14) Li, L, Jacinto R, Yoza, B, and McCall, C. (2003) Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes. Journal Endotoxin Research 9: 39-44.
Liwu Li, Ph.D 6
15) Bensen JT, Li L, Langefeld C, McCall C, Cousart C, Dryman B, Freedman BI and Bowden DB. (2003) Association of an IL1A 3’UTR polymorphism with end stage renal disease and IL1 expression. Kidney International 63: 1211-1219.
16) Li L*. (2004) Regulation of innate immunity signaling and its connection with human diseases. Current Drug targets-Inflammation & Allergy. 3: 81-86.
17) . Li T@, Hu J, and Li L*. (2004) Regulation of Tollip by lipopolysaccharide in THP-1 cells. Molecular Immunology 41 (1):85-92.
18) Zheng S, Augustsson-Bälter K, Chang B, Hedelin M, Li L, Adami H, Bensen J, Li G, Johnasson J, Turner A, Adams T, Meyers DA, Isaacs WB, Xu J and Grönberg H. (2004) Sequence variants of TLR4 are associated with prostate cancer risk: results from the CAPS1 study. Cancer Research 64: 2918-1922.
19) Huang YS@, Li T@, Sane D, Li L*. (2004) IRAK1 serves a novel regulator essential for IL-10 gene expression. Journal of Biological Chemistry 279:51697-51703.
20) Li T@, Hu J, Thomas J, and Li L*. (2005) Differential regulation of apoptosis by LPS and taxol in THP-1 cells. Molecular Immunology 42 (9) 987-1127.
21) Chan C, Li L, McCall C, Yoza B. (2005) Decreased hostone H3 phosphorylation and NFkB p65 binding to the IL-1b promoter in endotoxin adapted cells. Journal of Immunology 175:461-468.
22) Sun J#, Zheng S, Chang B, Li L, Li G, Liu W, Turner AR, Meyers DA, Isaacs EB, Xu J, Grönberg H. (2005) Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) are associated with prostate cancer risk. Journal of the National Cancer Institute 927:525-532.
23) Huang Y@, Misior A#, Li L*. (2005) Novel Role and Regulation of the Interleukin-1 Receptor associated Kinase (IRAK) Family Proteins. Cellular and Molecular Immunology 2(1): 36-39.
24) Sun J, Wiklund F, Hsu FC, Balter K, Zheng SL, Johansson JE, Chang B, Liu W, Li T, Turner AR, Li L, Li G, Adami HO, Isaacs WB, Xu J, Gronberg H. (2006) Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk. Cancer Epidemiology Biomarkers and Prevention 15(3):480-5.
25) Fasciano S@, Li L* (2006) Intervention of human innate immunity and inflammation by synthetic compounds and naturally occurring products. Current Medicinal Chemistry 12: 1389-1395.
Liwu Li, Ph.D 7
26) Gan L#, Li L* (2006) Regulations and roles of interleukin-1 receptor associated kinases in innate and adaptive immunity. Immunologic Research 35: 295-302.
27) Paulsen MT, Starks AM, Derheimer FA, Hanasoge S, Li L, Dixon JE, Ljungman M. (2006) The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers. Molecular Cancer 5:25.
28) Su J@, Richter K@, Gu Q, Zhang C, Li L*. (2007) Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. Molecular Immunology 44:900-905.
29) Larkoski S, Li L, Liu Y, Bowden D, Langfield C, Harrington D. (2007) The Association Between Variation in Innate Immunity Gene (IRAK1) and C-Reactive Protein in Caucasian Women in the Diabetes Heart Study.Experimental and Molecular Pathology 82(3):280-3.
30) Su J@, Xie Q@, Li L*. (2007) Differential regulation and role of Interleukin-1 Receptor Associated Kinase-M in innate immunity signaling. Cellular Signaling 19(7):1596-601.
31) Xie QF@, Wang J@, Gan L#, Li L*. (2007) Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth. Molecular Immunology 44(14):3453-61.
32) Nordone S, Ignacio GA, Su L, Sempowski GD, Golenbock DT, Li L and Dean GA. (2007) Toll-Like Receptor 4 does not reactivate virus production during chronic HIV-1 infection. AIDS Research and Human Retroviruses 23(11): 1387-1395.
33) Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang BL. (2007) Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS ONE 2(10):e1035.
34) Surace M#, Li L*. (2007) Gene-Specific Control of Inflammation by TLR-induced Chromatin Modifications. Cell Science Vol4, No2.
35) Ringwood L#, Li L*. (2008) The involvement of the interleukin-1 Receptor-Associated Kinases (IRAKs) in cellular signaling networks controlling inflammation. Cytokine 42: 1-7.
36) Wang D@, Fasciano S@, Gan Lu, Li L*. (2008) The Interleukin-1 Receptor Associated Kinase 1 contributes to the regulation of NFAT. Molecular Immunology 45:3902-3908.
Liwu Li, Ph.D 8
37) Su J@, Zhang T, Tyson J, Li L*. (2009) The Interleukin-1 Receptor-Associated Kinase M (IRAK-M) selectively inhibits the alternative, instead of the classical NFB pathway. Journal of Innate Immunity 1: 164-174.
38) Peairs A , Davis S, Radjavi A , Li L* , Ahmed A , Giri S , and Reilly C. (2009) Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells. Clinical and Experimental Immunology. 156: 542-551.
39) Glaros T#, Li L*. (2009) Inflammation, tissue damage and organ injury. Frontiers in Bioscience 14: 3988-3993.
40) Maitra U@, Baglin S#, Li L*. (2009) Inflammatory Signaling networks as Targets for Pharmacological Intervention of Chronic Diseases. Current Signal Transduction Therapy. 4: 103-110.
41) Maitra U@, Davis S, Reilly C, Li L*. (2009) Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. Journal of Immunology. 182: 5763-5769.
42) Piao W, Song C, Chen H, Quevedo Diaz M, Wahl LM, Fitzgerald K, Li L, and Medvedev A. (2009) Endotoxin tolerance dysregulates MyD88-dependent and TRIF-dependent signaling pathways and increases expression of negative regulators of TLR signaling. Journal of Leukocyte Biology 86(4):863-75.
43) Li L, Chen SF, Liu Y. (2009) MAP kinase phosphatase-1, a critical negative regulator of the innate immune response. Int J Clin Exp Med. 2: 48-67.
44) Maitra U@, Chang S, Singh N, Li L*. (2009) Molecular Mechanism Underlying the Suppression of Lipid Oxidation during Endotoxemia. Molecular Immunology. 47(2-3):420-5.
45) Maitra U@, Parks J, Li L*. (2009) An Innate Immunity Signaling Process Modulates Macrophage ABCA1 Expression through IRAK-1 mediated down-regulation of RAR α and NFATc2. Molecular and Cellular Biology. 29(22):5989-5997.
46) Maitra U@, Singh N, Gan L, Ringwood L, Li L*. (2009) Regulation of reactive oxygen species generation and oxidative damage by LPS. Journal of Biological Chemistry. 284(51):35403-11.
47) Gan L#, Li L*. (2010) Interleukin-1 Receptor-Associated Kinase-1 (IRAK-1) functionally associates with PKCepsilon and VASP in the regulation of macrophage migration. Molecular Immunology. 47(6):1278-82.
Liwu Li, Ph.D 9
48) Peairs A, Dai R, Gan L#, Shimp S, Rylander MN, Li L, Reilly C. (2010) Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cellular and Molecular Immunology. 7(2):123-32.
49) Frisard MI, McMillan RP, Marchand J, Wahlberg K, Wu Y, Voelker K, Heilbronn L, Haynie K, Muoio B, Li L, Hulver MW. (2010) Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab. 298(5):E988-98.
50) Vaughan T, L Li (2010) Molecular mechanism underlying the inflammatory complication of leptin in macrophages. Mol Immunol. 2010 Jul 7. [Epub ahead of print]
51) Chafin C, Muse S, Hontecillas R,Bassaganya-Riera J, Caudell D, Shmip S, Rylander MN, Zhang J, Li L, Reilly C (2010) PPAR g deletion enhances susceptibility to anti-GBM disease. Inflammation Research. Provisionally accepted.
52) Maitra U, Gan L, Chang S, Li L (2010) Low dose endotoxin induces inflammation by selectively removing nuclear receptors and activating C/EBP, without activating NFB. J Exp Med. Under review.