Tab. 1Supp. Reduction of Percentage of Animals with Metastatic Lesions and Mean RLU Values

Tab. 1supp. Reduction of percentage of animals with metastatic lesions and mean RLU values in different organs of orthotopic PCa models treated with GemLip or Gemc

LN / duo / SP / lung / kidney / Sto / femur / luSp / liver
No. of animals**
GemLip / 7/9 / 1/9(3) / 3/9(3) / 9/9 / 6/9(3) / 4/9(2) / 1/9(5) / 4/9(3) / 5/9(2)
Gemc / 6/10(2) / 5/10 / 6/10 / 10/10 / 7/10(2) / 6/10 / 1/10(5) / 6/10(1) / 7/10
RLU§
GemLip / 90.250* / 153.169 / 11.168 / 13.519* / 2.855* / 3.828* / 1.809 / 21.261 / 5.131
Gemc / 299.088 / 15.632 / 18.107 / 17.508* / 2.740* / 16.568 / 1.976 / 15.210 / 9.147
range
GemLip / 1.604 - 417.515 / 153.169 / 3.282 - 19.055 / 1.717 - 41.234 / 1.532 - 7.240 / 3.030 - 4.452 / 1.809 / 1.751 - 55.586 / 1.734 - 14.321
Gemc / 10.933 - 1.047.601 / 1.917 - 41.870 / 1.571 - 42.742 / 2.967 - 47.958 / 1.757 - 5.849 / 1.772 - 73.660 / 1.976 / 1.676 - 40.210 / 1.619 - 44.934

No. of animals: Shows the number of metastatic animals in individual tissues which are underlined in gray when reduced number of metastatic animals ranged from 1 to 5 additionally metastases-free animals.

RLU: Reduced values per tissue were underlined in gray when reduction of mean RLU in individual tissues was greater than 50% compared to untreated animals. § Mean RLU values only from metastatic animals.

* significantly reduced metastatic burden after GemLip or Gemc treatment (see also Fig. 6).

Range: Shows range of RLU-values in individual tissues.

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