MAPP Network Publications
2016
Brain white matter changes associated with urological chronic pelvic pain syndrome: Multi-site neuroimaging from a MAPP case-control study. Huang, Lejian; Kutch, Jason J.; Ellingson, Benjamin M.; Martucci, Katherine T.; Harris, Richard E.; Clauw, Daniel J.; Mackey, Sean; Mayer, Emeran A.; Schaeffer, Anthony J.; Apkarian, A. Vania; Farmer, Melissa A.; on behalf of the MAPP Research Network. Pain. Post Acceptance: August 26, 2016. doi: 10.1097/j.pain.0000000000000703. Research Paper: PDF Only.
Multisite, multimodal neuroimaging of chronic urological pelvic pain: methodology of the MAPP research network. Alger JR, Ellingson BM, Ashe-McNalley C, Woodworth DC, Labus JS, Farmer M, Huang L, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Deutsch G, Harris RE, Clauw DJ, Glover GH, Parrish TB, den Hollander J, Kusek JW, Mullins C, Mayer EA, and the MAPP Research Network Investigators. Neuroimage Clin. 2016 Jan 6;12:65-77. doi: 10.1016/j.nicl.2015.12.009. eCollection 2016. PMC4925887 ScienceDirect
Symptom variability and early symptom regression in the MAPP study, a prospective study of urologic chronic pelvic pain syndrome. Stephens-Shields AJ, Clemens JQ, Jemielita T, Farrar J, Sutcliffe S, Hou X, Landis JR; MAPP Research Network. J Urol. 2016 Apr 27. pii: S0022-5347(16)30310-X. doi: 10.1016/j.juro.2016.04.070. [Epub ahead of print] NIHMS782387 ScienceDirect
Pain and urinary symptoms should not be combined into a single score: psychometric findings from the MAPP research network. Griffith JW, Stephens-Shields AJ, Hou X, Naliboff B, Pontari M, Edwards TC, Williams DA, Clemens JQ, Afari N, Tu F, Lloyd R, Patrick DL, Mullins C, Kusek JW, Sutcliffe S, Hong BA, Lai HH, Krieger JN, Bradley CS, Kim J, Landis JR. J Urol. 2016 Apr;195(4 Part 1):949-54 PMC4867140 [Available on 2017-05-14]. ScienceDirect
Inflammation and symptom change in interstitial cystitis or bladder pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Schrepf A., O'Donnell MA, Luo Y, Bradley CS, Kreder KJ, Lutgendorf SK. Urology. 2016 Apr;90:56-61. PMC4892365 [Available on 2017-04-01]. ScienceDirect
Bladder distension increases blood flow in pain-related brain structures in subjects with Interstitial Cystitis. Deutsch G, Deshpande H, Froelich MA, Lai HH, Ness TJ. J Urol. 2016 Sep;196(3):902-10. doi: 10.1016/j.juro.2016.03.135. Epub 2016 Mar 24. PMC5014638 [Available on 2017-09-01]. ScienceDirect
Alterations in connectivity on functional magnetic resonance imaging with provocation of lower urinary tract symptoms: a MAPP research network feasibility study of urological chronic pelvic pain syndromes. Kleinhans NM, Yang CC, Strachan ED, Buchwald DS, Maravilla KR. J Urol. 2016 Mar;195(3):639-45 PMC5035686 [Available on 2017-03-01]. ScienceDirect
Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network cohort. Parker KS, Crowley JR, Stephens-Shields AJ, van Bokhoven A, Lucia MS, Lai HH, Andriole GL, Hooton TM, Mullins C, Henderson JP. EBioMedicine. doi:10.1016/j.ebiom.2016.03.040. EBioMedicine. 2016 May;7:167-74. doi: 10.1016/j.ebiom.2016.03.040. Epub 2016 Mar 31. PMC4909380 ScienceDirect
Assessment of the lower urinary tract microbiota during symptom flare in women with urologic chronic pelvic pain syndrome: a MAPP Network Study. Nickel JC, Stephens A, Landis JR, Mullins C, van Bokhoven A, Lucia MS, Ehrlich GD; MAPP Research Network. J Urol. 2016 Feb;195(2):356-62 PMC4770794 [Available on 2017-02-01] ScienceDirect
2015
Painful bladder filling and painful urgency are distinct characteristics in men and women with urological chronic pelvic pain syndromes: a MAPP research network study. Lai HH, Krieger JN, Pontari MA, Buchwald D, Hou X, Landis JR, for the MAPP Research Network. J Urol. 2015 Dec;194(6):1634-41. PMC4669971 ScienceDirect
Toll-like receptor 4 and comorbid pain in interstitial cystitis/bladder pain syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Schrepf A, Bradley CS, O'Donnell M, Luo Y, Harte SE, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Brain Behav Immun. 2015 Oct;49:66-74. PMC4567436 [Available on 2016-10-01] ScienceDirect
Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: a MAPP metwork neuroimaging study. Woodworth D, Mayer E, Leu K, Ashe-McNalley C, Naliboff BD, Labus JS, Tillisch K, Kutch JJ, Farmer MA, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Landis JR, Deutsch G, Harris RE, Clauw DJ, Mullins C, Ellingson BM; MAPP Research Network. PLoS One. 2015 Oct 13;10(10):e0140250. doi: 10.1371/journal.pone.0140250. eCollection 2015. PMC4604194 PLOS one
The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network. A resting-state study from the MAPP research network. Martucci KT, Shirer WR, Bagarinao E, Johnson KA, Farmer MA, Labus JS, Apkarian AV, Deutsch G, Harris RE, Mayer EA, Clauw DJ, Greicius MD, Mackey SC. Pain. 2015 Sep;156(9):1755-64 PMC4545714
Brain white matter abnormalities in female interstitial cystitis/bladder pain syndrome: a MAPP network neuroimaging study. Farmer MA, Huang L, Martuchi K, Yang CC, Maravilla KR, Harris RE, Clauw DJ, Mackey S, Ellingson BM, Mayer EA, Schaeffer AJ, Apkarian AV, MAPP Research Network. J Urol. 2015 Jul;194(1):118-26. PMC447546 ScienceDirect
Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. Sutcliffe S, Bradley C, Clemens JQ, James AS, Konkle KS, Kreder KJ, Lai HHH, Mackey SC, Ashe-McNalley CP, Rodriguez LV, Barrell E, Hou X, Robinson NA, Mullins C., Berry SH. Int Urogynecol J. 2015 Jul;26(7):1047-60. PMC4489981 Springer Link
Search for microorganisms in men with urologic chronic pelvic pain syndrome: a culture-independent analysis in the MAPP research network. Nickel JC, Stephens A, Landis JR, Chen J, Mullins C, vanBokhoven A, Lucia MS, Melton-Kreft R, Ehrlich GD, and the MAPP Research Network J Urol. 2015 July; 194(1):127-135. PMC4475477 ScienceDirect
Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. Kutch JJ, Yani MS, Asavasopon S, Kirages DJ, Rana M, Cosand L, Labus JS, Kilpatrick LA, Ashe-McNalley C, Farmer MA, Johnson KA, Ness TJ, Deutsch G, Harris RE, Apkarian AV, Clauw DJ, Mackey SC, Mullins C, Mayer EA. Neuroimage Clin. 2015 Jun 5;8:493-502. PMC4474411 ScienceDirect
Animal models of urologic chronic pelvic pain syndromes: findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Lai H, Gereau RW 4th, Luo Y, O'Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ. Urology. 2015 Jun;85(6):1454-65. PMC4479414 ScienceDirect
Widespread psychosocial difficulties in men and women with urologic chronic pelvic pain syndromes: case-control findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Naliboff BD, Stephens AJ, Afari N, Lai H, Krieger JN, Hong B, Lutgendorf S, Strachan E, Williams D, for the MAPP Research Network. Urology 2015 Jun;85(6):1319-27 PMC4479402 ScienceDirect
Comparison of baseline urological symptoms in men and women in the MAPP research cohort. Clemens JQ, Clauw DJ, Kreder K, Krieger JN, Kusek JW, Lai HH, Rodriguez L, Williams DA, Hou X, Stephens A, Landis JR, for the MAPP Research Network. J Urol. 2015 May;193(5):1554-58. PMC4454891 ScienceDirect
Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodriguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA, for the MAPP Research Network. J Urol. Apr 2015;193(4):1254-62 PMC4497586 ScienceDirect
Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: Findings from one site of the MAPP Research Network. Sutcliffe S, Colditz GA, Pakpahan R, Bradley CS, Goodman MS, Andriole GL, Lai HH. Neurourol Urodyn. 2015 Feb;34(2):188-95. PMC4032370 Wiley Online Library
Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. Kairys AE, Schmidt-Wilcke T, Puiu T, Ichesco E, Labus JS, Martucci K, Farmer MA, Ness TJ, Deutsch G, Mayer EA, Mackey S, Apkarian AV, Maravilla K, Clauw DJ, Harris RE. J Urol. 2015 Jan:193(1):131-7. PMC4435781 ScienceDirect
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MAPP Network Publications
2014
Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study. Bagarinao E, Johnson KA, Martucci KT, Ichesco E, Farmer MA, Labus J, Ness TJ, Harris R, Deutsch G, Apkarian AV, Mayer EA, Clauw DJ, Mackey S. Pain. 2014 Dec;155(12):2502-9 PMC4504202. ScienceDirect
Evaluation of urinary protein precipitation protocols for the multidisciplinary approach to the study of chronic pelvic pain research network. Jonscher KR, Osypuk AA, van Bokhoven A, Lucia MS. J Biomol Tech. 2014 Dec;25(4):118-26. PMC4211279
Urologic chronic pelvic pain syndrome symptom flares: characterization of the full spectrum of flares at two sites of the MAPP research network. Sutcliffe S, Colditz GA, Goodman MS, Pakpahan R, Vetter J, Ness TJ, Andriole GL, Lai HH. BJU Int. 2014 Dec;114(6):916-25. PMC4198521 Pubfacts
Asymptomatic bacteriuria escherichia coli are live biotherapeutics for UTI. Rudick CN, Taylor AK, Yaggie RE, Schaeffer AJ, Klumpp DJ. PLoS One. 2014 Nov 18;9(11):e109321 PMC4236008 PLOSone
Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff B, Labus JS, Jiang Z, Farmer MA, Apkarian AV, Mackey S, Martucci KT, Clauw DJ, Harris RE, Deutsch G, Ness TJ, Yang CC, Maravilla K, Mullins C, Mayer EA. J Urol. Vol. 192, 947-955, September 2014 PMC4432915 ScienceDirect
Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Schrepf A, O’Donnell M, Luo Y, Bradley CS, Kreder K, Lutgendorf S, and the MAPP Research Network. Pain. 2014 Sep; 155(9):1755-61. PMC4166494 ScienceDirect
The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodriguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Buchwald D, Andriole GL, Lucia MS, Landis JR, Clauw DJ, and the MAPP Research Network Study Group. BMC Urol. 2014 Aug 1;14:57. PMC4134515 BioMed Central
The MAPP research network: design, patient characterization and operations. Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, vanBokhoven A, Stucliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ, and the MAPP Research Network Study Group. BMC Urol. 2014 Aug 1;14:58. PMC4126395 BioMed Central
Urological symptoms in a subset of patients with urological chronic pelvic pain syndrome and a polysymptomatic, polysyndromic pattern of presentation. Lai HH, North CS, Andriole GL, Cupps L, Song D, Ness TJ, Hong BA. J Urol. 2014 Jun;191(6):1802-7. PMC4411959 ScienceDirect
2013
Protamine sulfate-induced bladder injury protects from distention induced bladder pain. Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RW 4th and Mysorekar IU. J Urol 189(1): 343-51, 2013. PMC3662487 ScienceDirect
2012
Central amygdala mGluR5 in the modulation of visceral pain. Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW 4th. J Neurosci 10;32(41):14217-26, 2012. PMC3494864 JNeurosci
The siderophore yersiniabactin binds copper to protext pathogens during infection. Chaturvedi KS, Hung CS, Crowley JR, Stapleton AE, Henderson JP. Nat Chem Biol 8(8):731-6, 2012. PMC3600419 Nature Chemical Biology
O-Antigen Modulates Infection-Induced Pain States. Rudick CN, Jiang M, Yaggie RE, Pavlov VI, Done J, Heckman CJ, Whitfield C, Schaeffer AJ, Klumpp DJ. PLoS One 7(8):e41273, 2012. PMC3416823 PLOSone
Polysymptomatic, Polysyndromic Presentation of Patients with Urological Chronic Pelvic Pain Syndrome. Lai HH, North CS, Andriole GL, Sayuk GS, Hong BA. J Urol 2012 Jun;187(6):2106-12. PMC3957225 ScienceDirect
2011
Yersinia High Pathogenicity Island genes modify the Escherichia coli primary metabolome independently of siderophore production. Lv H, Henderson JP. J Proteome Res. 2011 Dec 2;10(12):5547-54 PMC3626101 ACSPublications
Intravesical Dimethyl Sulfoxide Inhibits Acute andChronic Bladder Inflammation in Transgenic ExperimentalAutoimmune CystitisModels. Kim R, Liu W, Chen X, Kreder KJ, Luo Y. J Biomed Biotechnol 2011:937061, 2011 PMC2989383 Hindawi Publishing Corp
Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Lai HH, Qiu CS, Crock LW, Morales ME, Ness TJ, Gereau RW 4th. Pain 152(9):2117-24, 2011. PMC3157542
Development of an Integrated Metabolomic Profiling Approach for Infectious Diseases Research. Lv H, Hung CS, Chaturvedi KS, Hooton TM, Henderson JP. Analyst 136(22):4752-63, 2011. PMC3746514 Royal Society of Chemistry
2009
Evidence for overlap between urological and non-urological unexplained clinical conditions. Rodriguez MA, Afari N, Buchwald DS. J Urol. 2009 Nov; 182(5):2123-31. PMC2957306 ScienceDirect
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