HARVARD COMMITTEE ON MICROBIOLOGICAL SAFETY

“Select Agent” Registration

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On October 25, 2001 as a consequence of the 9/11 terrorist attack, Congress passed and the President signed legislation affecting the possession of biological agents with Bioterrorism potential. These are called “Select Agents.” The legislation, called the USA Patriot Act, extends previous legislation that restricted the transport, but not the possession, of these agents. The new legislation restricts possession, use and transport.

“Select Agents” consist of 82 pathogens, toxins and DNA coding for their pathogenic factors. They are listed on the next page.

To comply with the Act’s requirements Harvard needs to know who is working with Select Agents including toxins, the DNA from these agents and nature of the studies contemplated.

Please help us by filling out this form.

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Agent /

Amount in Lab

/

Storage

/

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Laboratory’s Location

On the basis of this information we may register your lab with the Harvard Committee on Microbiological Safety and keep you informed of your responsibilities under the USA Patriot Act. If it is decided that your lab has to be registered we assign a COMS registration number for the study. Periodically we will write and ask for an update as to your uses of Select Agents.

Alphabetical List Of Updated Select Agents And Toxins

January 30, 2003

This list is based on one proved to the Biosafety Listserve by Kathryn Harris, Northwestern University and Benedictus J.M. Verduin, Wageningen University, The Netherlands, in December 2002.

Except for exclusions listed in the Appendix, the viruses, bacteria, fungi, toxins, genetic elements, recombinant nucleic acids, and recombinant organisms specified in this list are HHS, USDA or HHS/USDA overlap select agents and toxins.

1.  Abrin (HHS)

2.  African horse sickness virus (USDA, Animal)

3.  African swine fever virus (USDA, Animal)

4.  Akabane virus (USDA, Animal)

5.  Avian influenza virus (highly pathogenic) (USDA, Animal)

  1. Bacillus anthracis (Overlap)

7.  Bluetongue virus (exotic) (USDA, Animal)

  1. Botulinum neurotoxin producing species of Clostridium (Overlap)

9.  Botulinum neurotoxins (Overlap)

10.  Bovine spongiform encephalopathy agent (USDA, Animal)

  1. Brucella abortus (Overlap)
  2. Brucella melitensis (Overlap)
  3. Brucella suis (Overlap)
  4. Burkholderia mallei (formerly Pseudomonas mallei) (Overlap)
  5. Burkholderia pseudomallei (formerly Pseudomonas pseudomallei) (Overlap)

16.  Camel pox virus (USDA, Animal)

17.  Central European Tick-borne encephalitis virus (HHS)

18.  Cercopithecine herpesvirus 1 (Herpes B virus) (HHS)

19.  Classical swine fever virus (USDA, Animal)

20.  Clostridium perfringens epsilon toxin (Overlap)

21.  Coccidioides immitis (Overlap)

22.  Coccidioides posadasii (HHS)

23.  Conotoxins (HHS)

24.  Cowdria ruminantium (Heartwater) (USDA, Animal)

  1. Coxiella burnetii (Overlap)

26.  Crimean-Congo haemorrhagic fever virus (HHS)

27.  Diacetoxyscirpenol (HHS)

28.  Eastern Equine Encephalitis virus (Overlap)

29.  Ebola viruses (HHS)

30.  Far Eastern Tick-borne encephalitis (HHS)

31.  Flexal virus (HHS)

32.  Foot-and-mouse disease virus (USDA, Animal)

  1. Francisella tularensis (Overlap)

34.  Goat pox virus (USDA, Animal)

35.  Guanarito, virus (HHS)

36.  Hendra virus (Overlap)

37.  Japanese encephalitis virus (USDA, Animal)

38.  Junin virus (HHS)

39.  Kyasanur Forest disease (HHS)

40.  Lassa fever virus (HHS)

41.  Liberobacter africanus (USDA, Plant)

42.  Liberobacter asiaticus (USDA, Plant)

43.  Lumpy skin disease virus (USDA, Animal)

44.  Machupo virus (HHS)

45.  Malignant catarrhal fever virus (exotic) (USDA, Animal)

46.  Marburg virus (HHS)

47.  Menangle virus (USDA, Animal)

48.  Monkeypox virus (HHS)

49.  Mycoplasma capricolum/ M. F38/M. mycoides capri (contagious caprine pleuropneumonia) (USDA, Animal)

50.  Mycoplasma mycoides mycoides (contagious bovine pleuropneumonia) (USDA, Animal)

51.  Newcastle disease virus (VVND) (USDA, Animal)

52.  Nipah virus (Overlap)

53.  Omsk Hemorrhagic Fever (HHS)

54.  Peronosclerospora philippinensis (USDA, Plant)

55.  Peste des petits ruminants virus (USDA, Animal)

56.  Phakopsora pachyrhizi (USDA, Plant)

57.  Plum pox potyvirus (USDA, Plant)

58.  Ralstonia solanacearum, race 3, biovar 2 (USDA, Plant)

59.  Ricin (HHS)

  1. Rickettsia prowazekii (HHS)
  2. Rickettsia rickettsii (HHS)

62.  Rift Valley fever virus (Overlap)

63.  Rinderpest virus (USDA, Animal)

64.  Russian Spring and Summer encephalitis (HHS)

65.  Sabia virus (HHS)

66.  Saxitoxin (HHS)

67.  Sclerophthora rayssiae var. zeae (USDA, Plant)

68.  Sheep pox virus (USDA, Animal)

69.  Shiga-like ribosome inactivating proteins (HHS)

70.  Shigatoxin (Overlap)

71.  Staphylococcal enterotoxins (Overlap)

72.  Swine vesicular disease virus (USDA, Animal)

73.  Synchytrium endobioticum (USDA, Plant)

74.  T-2 toxin (Overlap)

75.  Tetrodotoxin (HHS)

76.  Variola major virus (Smallpox virus) (HHS)

77.  Variola minor virus (Alastrim) (HHS)

78.  Venezuelan Equine Encephalitis virus (Overlap)

79.  Vesicular stomatitis virus (exotic) (USDA, Animal)

80.  Xanthomonas oryzae pv. oryzicola (USDA, Plant)

81.  Xylella fastidiosa (citrus variegated chlorosis strain) (USDA, Plant)

82.  Yersinia pestis (HHS)

Genetic Elements, Recombinant Nucleic Acids, and Recombinant Organisms:

1.  Viruses, bacteria, fungi, and toxins listed that have been genetically modified.

2.  Select agent viral nucleic acids (synthetic or naturally derived, contiguous or fragmented, in host chromosomes or in expression vectors) that can encode infectious and/or replication competent forms of any of the select agent viruses.

3.  Nucleic acids (synthetic or naturally derived) that encode for the functional form(s) of any of the toxins listed if the nucleic acids:

(i) are in a vector or host chromosome;

(ii) can be expressed in vivo or in vitro; or

(iii) are in a vector or host chromosome and can be expressed in vivo or in vitro.

APPENDIX

Exclusions:

1.  Any select agent or toxin that is in its naturally occurring environment provided it has not been intentionally introduced, cultivated, collected, or otherwise extracted from its natural source.

2.  Non-viable select agent organisms or nonfunctional toxins.

3.  Fixed tissues that bear or contain select agents or toxins.

4.  Genetic elements or sub-units of agents or toxins, if the genetic elements or sub-units are not capable of causing disease.

5.  The vaccine strain of Junin virus (Candid #1).

6.  The vaccine strain of Rift Valley fever virus (MP-12).

7.  Venezuelan Equine encephalitis virus vaccine strain TC-83.

8.  The following toxins (in the purified form or in combinations of pure and impure forms) if the aggregate amount under the control of a principal investigator does not, at any time, exceed the amount specified:

·  100 mg of Abrin

·  0.5 mg of Botulinum neurotoxins

·  100 mg of Clostridium perfringens epsilon toxin

·  100 mg of Conotoxins

·  1,000 mg of Diacetoxyscirpenol

·  100 mg of Ricin

·  100 mg of Saxitoxin

·  100 mg of Shigatoxin

·  100 mg of Shiga-like ribosome inactivating proteins

·  5 mg of Staphylococcal enterotoxins

·  100 mg of Tetrodotoxin

·  1,000 mg of T-2 toxin

Thank you for your help.