2
Dr. Hari Singh Gour Vishwavidylaya, Sagar
M.Sc. Semester III Industrial Chemistry
2010-2011
Course structure and Distribution of Marks
Theory examination will consist of the following Scheme
Paper / Subject / Credits / Marks / MMICH-C-321 / Industrial Polymer-I / 04 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-322 / Industrial Chemicals / 04 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-323 / Chemistry of Natural Products / 04 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-324 / Applied Electrochemistry – I / 03 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-325 / Analytical Chemistry – I / 03 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-326 / Medicinal Chemistry – I / 03 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-327 / Laboratory Course I : Common to all / 04 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-3284
3285,
3286 / Laboratory Course II : Elective wise / 02 / Quiz I,II,III,
Mid Sem I,II and
End Semester / 5,5,5
12,13
60
Chairman, Board of Studies in Chemistry
Dr. Hari Singh Gour Vishwavidylaya, Sagar (M.P.) - 470003
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – C – 321: PAPER – I: INDUSTRIAL POLYMERS-I
Types of polymerization: classification, chain growth reactions (radical, ionic and Ziegler-Natta Polymerization) and step growth reactions (poly addition, reversible and irreversible polycondensation.
Polymer Solution: Polymer Solubility and its thermodynamics, Composition of dissolved polymer chains, fractionation of polymers by solubility.
Commercial polymers-: Polyenes; Preparation, properties and uses of poly-thene, polypropene, polyvinylchloride, polystyrene and polybutene. Effect of stereochemistry on the structure and properties of polymers.
Polymer Rheology and Morphology: Introduction stress and strain, ideal elastic solid, Newtonian and non- Newtonian fluid. Apparent viscosity, the power, low molecular hole concept, Wessenberg effects,Rheological properties of fluid, melt fracture and irregular, time dependent flow, viscoelastic behavior, mechanical model of a viscoelastic material relaxation enhancement under constant stress. Hysteresis, creep and relaxation of typical plastics.
X- ray diffraction: Structural studies of polymer crystal structure, ESCA to study surface and bonding in polymers.
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH–C- 322: PAPER II: INDUSTRIAL CHEMICALS
Petrochemicals: Chemicals from paraffin’s, olefins, acetylenes and aromatics. Chemicals from natural gas,
Greases-: Structure, mechanical properties of greases in general. Types of greases, preparation, properties and uses of sodium, calcium, lithium aluminum and lead base greases. Greases- : Mixed based Lubricating greases.
Lubrication oils-: Methods of Preparation- production, properties and uses of refrigeration oils, cutting oils, transformer oils and gear oil.
Additives for lubrication oils and greases (antioxidant; passivators, pour point depressants, detergents, adhesives and emulsifiers.
Industrial organic synthesis: Introduction, raw materials and basic processes. Petroleum products as raw materials in industrial synthesis. Synthesis of methanol, ethanol, acetaldehyde, glycol, glycerol, acetone 1,3 butadiene.
Corrosion-: Corrosion testing, corrosion by water and steam, atmospheric corrosion, corrosion by soil, oxidizing acids, reducing acid, CO2, H2S, chlorine and salts.
Corrosion current and corrosion potential, corrosion measurement methods: Weight loss method, electrochemical approach, corrosion rate at short time intervals.
Corrosion studies on specific metals in different mediums (acid / neutral / alkaline environment): C-steel, Fe-Steel, Copper, Aluminum...
Corrosion Hazards and its industrial implications.
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – C- 323: PAPER III: Chemistry of Natural Products
Terpenoids and Carotenoids : Classification, nomenclature, occurrence, isolation, general methods of structure determination, isoprene rule.
Structure determination, stereochemistry, biosynthesis and synthesis of the following representative molecules; citral, a-Terpeniols, Menthol, Zingiberene, Santonin, Phytol and b-carotene
Perfumes: Introduction and synthesis of some important synthetic chemicals used in perfume industry- coumarin, ionone etc.
Porphyrins : Structure and synthesis of Haemoglobin and Chlorophyll
Alkaloids : Definition, nomenclature and physiological action, occurrence, isolation,general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic rings, role of alkaloids in plants. Structure, seterochemistry.
Synthesis and biosynthesis of the following: Nicotine, Quinine and Morphine.
Steroids : Occurrence, nomenclature, basic skeleton, Diel hydrocarbon and stereochemistry. Isolation, structure determination and synthesis of Cholesterol, Bile acids, Testosterone, sterone, Progesterone. Biosynthesis of steroids.
Prostaglandins : Occurrence, Classification, nomenclatur, biogenesis and physiological effects,
Pyrthroids and Rotenones ; Synthesis and Reacation of Pyrthroids and Rotenones
Plant Pigments
Occurrence, nomenclature, general methods of isolation, Synthesis and structure determinaton, of Quercetin, Myrcetin, Quercetin-3-glucoside. Butein, Cyanidin-3,5-diglucoide, Hirustidin, change of colours in cyandin with pH Variation. Biosynthesis of flavanoids:Acetate pathway and Shikimic acid pathway.
M. Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – C - 324 : PAPER IV A : Elective : APPLIED ELECTROCHEMISTRY
Ion-solvent Interaction:
Ion-solvent Interaction, structure of liquids, dissociation theory of Ion-solvent Interaction, Solvation and hydration of ions.
Electrokinetic phenomenon : Electrokinetic effects, the electrical double layer and its structure, Stern theory of the double layer, Electro-osmosis, streaming potential, influence of ions on electrokinetic phenomenon.
Solid State electrochemistry: Fuel cells and solid state batteries, Introductory ideas of semi-conductor electrochemistry.
Newer Polarographic techniques: General treatment and applications of the following techniques: (a). Oscilographic polarography; (b). AC polarography ; (c). Pulse polarography, NPP and DPP
Polarographic study of Metal Complexes: Effect of ligand on polarographic waves, determination of stability constants of complexes (in reversible diffusion- controlled systems) by Lingane’s method, Deford and Hume’s method, Schaap and McMasters method. Determination of metal ions (by masking) in multicomponent systems.
Environmentally oriented electrochemistry : The environmental situation, the electrochemical advantages. The solar-hydrogen solution. The CO2 fixing, Photo-electrochemical reduction of CO2. Electrochemical removal of wastes: (i) Waste water (ii) Sulphur dioxide (iii) Removal of metals (iv) Destruction of nitrates.
Electrochemical treatment of low level nuclear wastes. Bactericidal effects.
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – E – 325 PAPER IV : Elective : Analytical Chemistry
Classification and sample preparations :
Classification of Analytical methods – classical and instrumental. Types of instrumental analysis. Volumetric analysis glassware calibration, Samples and sample preparation - Introductory idea of sampling, dissolution and decomposition. Gravimetric techniques. Reagents in analysis and their application.
Errors and Evaluation :
Definition of terms in meanand median. Precision- standard deviation, relative standards deviation. Accuracy – absolute error, relative error,. Types of error in experimental data determinate (systematic), Intermediate (or random) and gross. Sources of errors and the effects upon the analytical results. Methods for reporting analytical data. Statisticalevaluation of data – indeterminate errors. The uses of standard statistical packages.
Food analysis :
Moisture, ash, crude protein, fat, crude fiber,carbohydrates, calcium, potassium, sodium and phosphate. Food adultraton-commen adlutrants in food, contamination of food stuffs. Microscopic examination of foods for adulterants. Pesticide analysis in food products. Extraction and purification of sample. HPLC. Gas chromatography for organophosphates. Thin layer chromatography for indentification of chlorinated pesticides in food products.
Analysis of Water Pollutants :
Origin of waste water, types water pollutants and their effects, sources of water pollution, domestic, induatrial, agricultural and radio active wastes as source of pollution. Objectives of analysis parameters for the analysis – color, turbidity, total solid, conductivity, acidity, alkalinity, hardness, chloride, sulphates, fluoride, silica, phosphates and differenr forms of nitrogen. Heavey metal pollution, public health significance of Cd, Cr, Cu, Pb, Mn, Zn and As. General survey of the instrumental techniques for the analysis of heavy metals in aqueous system. Measurement of DO, BOD and COD. Pesticide as water pollutants and analysis. Water pollution law and standards.
Analysis of Soil, Fuel, Body fluids and Drugs:
a. Analysis of soil, moisture, pH, total nitrogen phosphourus, lime, magnesis, manganese. Sulphur ans alkali salts.
b. Fuel analysis, solid liquid and gas. Ultimate and approximate analysis, heating values, grading of coals, liquid fuels – flash point, aniline point, octane number and Carbon residue. Gaseous fuel products. Gas and water gas – calorific value.
c. Clinical chemistry, Composition of blood, collection and preservation of sample, clinical anal;ysis, serum electrolytes, blood glucose, blood urea nitrogen, immuno asay, principle of radi immunoassay, RIA and applications. The blood gas analysis, trace elements in the body.
d. Drug analysis. Narcotic and dangerous drugs. Classification of drugs. Screeningby gas and thin layer chromatography and spectrphotometric measurements.
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – E - 326 PAPER IV C: Elective : MEDICINAL CHEMISTRY - I
Drug therapy of allergies, general idea about drug acid in ophthalmic d isorders;
Principal of toxicology and treatment of poisoning: cyanide, salicylic acid, organ phosphorous compounds
Anticonvulsants and antiepileptic drugs- Classification, pharmacology, mode of action and adverse effects of drugs used in convulsive and epileptic disorders. Drug used in depression, mania and CNS degenerative disorders.
Diuretic and ant diuretic drugs, drug used in therapy of migraine, CNS stimulant, hallucinogens.
Composition and functions of blood R.B.C. W.B.C., Haemoglobin, platelets and plasma Leukemia , blood coagulation factor and its mechanism.
General description, collection preservation, physical chemical and microscopic examinations of stool, sputum and semen.
Pharamacokinetics and Pharmacodynamics : Introduction, uses of pharmacokinetic and pharmacodynamics in drug development, drug receptor. Theories, effect of drugs and drug doses.
Antineoplastic Agents : Introduction, cancer chemotherapy, special problems, role alkylating agents and antimetabolites in treatment of cancer. Mention of carcinolytic antibiotics and mitotic inhibitors
Synthesis of merchlorethamine, cyclophosphamide, melphalan, uracil, mustard and 6-mercaptopurine. Recent development in cancer chemotherapy.
M. Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – C - 327 : Laboratory Course I (Compulsory to all)
Four days in a Week 04 Credits
The M.Sc. Sem III Industrial Chemistry practical examination comprises of two parts. Each part will be of 100 marks each and separate examinations will be conducted.
First part (Lab course I) shall consist of experiments of general nature and the Second part (Lab course II) shall consist of combined experiments from elective papers viz., electrochemistry, analytical chemistry and Medicinal Chemistry. Student will have to perform 2/3rd of the total list of experiments opting his special elective paper.
Lab course
SECTION I :Non-Instrumental Quantitative analysis and polymer synthesis:Gravimetric / Volumetric methods
i. Analysis of Alloys, Brass, Bronze, Solder, Ni-Coin, Cupro-Ni, etc.
ii. Estimation of organic chlorine.
iii. Analysis of Steel samples
iv. Analysis of Cement
v. Estimation of heavy metals by complex – titrimetric methods.
vi. Polymer synthesis : Phenol/Urea formaldehyde, Nylon 66, polysterene
vii. Rock phosphate/surfactant/lubricating oil samples
viii. Soli Analysis : Moisture, Cl,SO4,CO3,Fe, SiO2 etc
SECTION II : Chromatography Paper and thin layer chromatographic seperation of:
a. Chromatographic separation and determination of Rf values of Ni, Mn, Fe, Cu, Co, Zn, Mg, Cd individually and in mixtures.
b. Separation of glucose, fructose, sucrose by chromatography.
c. Separation of amino acids by chromatography.
M.Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – E : 3284 : Elective : Laboratory Course II Electrochemistry
02 Credits (Two days a week jointly with other elective)
1. Condutometry: Study of relationship between ionic conductance and viscosity, measurement of conductivities of electrolytes in mixed solvents.
II pH-metry: Titrations of polyprotic systems and Zwitter ions.
III Potentiometry: Acid-Base titrations in aqueous and non-aqueous media.
IV. Polarography: Determination of
(i). Vitamin C in fruit juices. (ii)Zn, Cd, Pb, Cu in samples of drinking water.
(iii). Heavy metals in wood samples.
IV Amperometry: Amperometric titration of
(i)Thiourea Vs Silver nitrate. (ii)Vitamin C Vs Ferric nitrate.
Note: Common for both (III) and (IV) semester Laboratory work.
V. Statistical treatment of data: Suitable experiments may be designed for statistical treatment of data: Standard deviation, correlation coefficient, regression line, F-test, Q-test.
M.Sc. Industrial Chemistry
ICH-E-3285 Semester – III : Laboratory Course II : Elective : Analytical Chemistry
02 Credits (Two days a week jointly with other elective)
Gravimetric / Volumetric methods/ chromatographic methods
a. Water analysis : Estimation of acidity/ alkalinity in water carbonates / Hydroxides/ Bi-carbonates in combination – preferably by conductometric measurements
b. Determination of DO (COD/BOD) preferably by DO meter..
c. Estimation of chloride / sulphate / fluoride in water samples-by ion selective methods
d. Estimation of Ca/ Mg in water sample by titrimetry / flame photometric analysis.
e. Analysis of ores : Pyrolusite, hematite, dolomite etc.
f. Separation and identification of organo - phosphorous pesticides in leaves/soil and vegetables using chromatography / spectrophotometry
g. Separation and identification of barbiturates from drug samples chromatography / spectrophotometry
SECTION II : pH-potentiometry :
a. Fabrication of ion-selective electrodes ( for Co, Ni, Cu, Zn, Pd, Cd ions) and record the electrode response and sensitivity.
b. Estimation of heavy metal toxicity using ion-selective electrodes: Pb, Cd, Hg etc.
M. Sc. INDUSTRIAL CHEMISTRY
SEMESTER - III
ICH – C 3286 : Laboratory Course-II :Elective wise: Medicinal
02 Credits (Two days a week jointly with other elective)
Combinatorial Chemistry
Spectral Interpretation of Simple Inorganic and Organic compounds (Preferably simpler drugs / drug precursors) (UV, IR, NMR and Mass ) , Making use of PC Model and Dragon computational software
Dr. Hari Singh Gour Vishwavidylaya, Sagar
M.Sc. Semester IV Industrial Chemistry
2010-2011
Course structure and Distribution of Marks
Theory examination will consist of the following Scheme
Paper / Subject / Credits / Marks / MMICH-C-421 / Industrial Polymer-II / 04 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-422 / Advanced Analytical Techniques / 04 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-423 / Drug Designing / 04 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-424 / Applied Electrochemistry – II / 03 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-425 / Environmental and Green Chemistry / 03 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-E-426 / Medicinal Chemistry – II / 03 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-427 / Laboratory Course I Common to all / 04 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
ICH-C-4284,
4285,
4286 / Laboratory Course II Elective Wise / 02 / Quiz I,II,III, Mid Sem I,II and
End Semester / 5,5,5
12,13
60
Chairman, Board of Studies in Chemistry