Kevin M. Chan, M.D.
Associate Professor of Internal Medicine
Division of Pulmonary & Critical Care Medicine
University of Michigan, Health System
Kevin M. Chan M.D.
Associate Professor of Internal Medicine
Division of Pulmonary & Critical Care Medicine
University of Michigan, Health System
1500 E. Medical Center Drive, 3916 Taubman Center
Ann Arbor, MI 48109-5360
Phone: 734-936-5201; Fax: 734-936-5048
Education and Training 3
Certification and Licensure 3
Academic, Administrative, and Clinical Appointments 3
Research Interests 4
Grants 5
Honors and Awards 7
Memberships in Professional Societies 7
Editorial Positions, Boards, and Peer-Review Service 8
Teaching 8
Committee, Organizational, and Volunteer Service 11
Visiting Professorships, Seminars, and Extramural Invited Presentations 13
Bibliography 18
Kevin M. Chan M.D.
Associate Professor of Internal Medicine
Division of Pulmonary & Critical Care Medicine
University of Michigan, Health System
1500 E. Medical Center Drive, 3916 Taubman Center
Ann Arbor, MI 48109-5360
Phone: 734-936-5201; Fax: 734-936-5048
Education and Training
09/1979-05/1983 Albion College, Albion, Michigan, B.A. Summa Cum Laude, Major: Chemistry
08/1983-06/1987 Wayne State University School of Medicine, M.D. Detroit, Michigan
07/1987-06/1990 Residency, Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois, Internal Medicine
07/1990-06/1993 Fellowship, University of California Los Angeles Center for the Health Sciences, Los Angeles, California, Pulmonary & Critical Care Medicine
Certification and Licensure
06/1990 – 07/1999 Medical Licensure (036-080084), Illinois
09/1990 – 11/2020 Diplomat Internal Medicine (Recertification, November 2000, 2010)
05/1991 – 02/2001 Medical Licensure (G71262), California
11/1992 – 12/2022 Diplomat in Pulmonary Medicine (Recertification, November 2000, 2010)
11/1993 – 11/2013 Diplomat in Critical Care Medicine (Recertification, November 2003)
03/1997 – 01/2013 Medical Licensure (4301069535), Michigan
09/2002 – 08/2013 DEA Licensure (BC2297530)
Academic, Administrative, and Clinical Appointments
ACADEMIC APPOINTMENTS
07/1993 – 06/1997 Assistant Professor of Clinical Medicine University of Southern California, Los Angeles, California
07/1997 – 09/2005 Senior Staff Physician, Henry Ford Hospital, Detroit, Michigan
09/2005 - 09/2009 Assistant Professor of Medicine University of Michigan, Ann Arbor, Michigan
09/2009 - Associate Professor of Medicine University of Michigan, Ann
Arbor, Michigan
ACADEMIC ADMINISTRATIVE APPOINTMENTS
07/1991 – 06/1993 Tuberculosis Clinic Physician Imperial Height Health Clinic, Inglewood Health District, Los Angeles County Department of Health Services, Los Angeles, California
07/1993 – 06/1997 Associate Medical Director University of Southern California, Lung Transplant Program
06/1995 – 06/1997 Associate Director, Lung Volume Reduction Surgery, University of Southern California
07/1996 – 06/1997 Medical Faculty Assembly Alternate, University of Southern California
09/2005 - Medical Director Lung Transplantation, University of Michigan Health Services
03/2011 – 10/2011 Medical Director, Inpatient Medical ICU Step Down/Lung Transplant Service, University of Michigan Health Services
11/2011- Fellowship Program Director, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan School of Medicine
CLINICAL/HOSPITAL APPOINTMENTS
07/1997 – 09/2005 Medical Director, Lung Transplantation, Henry Ford Hospital
10/1998 – 09/2005 Medical Director, Oakland Community College Respiratory Therapy Program
01/1998 – 03/2002 Associate Medical Director, Pulmonary Rehabilitation Program, Henry Ford Hospital
12/2000 – 12/2004 Director, Pulmonary Hypertension Program, Henry Ford Hospital
03/2002 – 09/2005 Medical Director, F2 General Practice Unit, Henry Ford Hospital
07/2008 – 10/2011 Ambulatory Care Unit (ACU) Medical Director, Pulmonary and Critical Care Medicine, University of Michigan Health Services
12/2010- 10/2011 MiChart Physician Champion, Pulmonary and Critical Care Medicine, University of Michigan Health Services
Research Interests
· Lung transplant outcomes
· Infection in the immunocompromised host
· Predictors of outcomes in end stage lung disease
· Pulmonary Hypertension
· Interstitial lung diseases associated with connective tissue disease
Grants
CURRENT RESEARCH FUNDING
Alnylam Pharmaceuticals
ALN-RSV-01-106: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safty and Antiviral Activity of Aerosolized ALn-RXV01 Plus Standard of Care in Lung Transplant Patients Infected with Respiratory Syncytial Virus (RSV) Principal Investigator: Kevin M. Chan, M.D.
Funding: 12/05/08 – 02/04/2011 ($90,280 full amount)
Broncus Technologies, Inc. EASE Study
EASE Study, “A randomized double-blind study to evaluate the safety and effectiveness of the exhale drug – Eluting Stent in homogeneous emphysema subjects with severe hyperinflation. Principle Investigator: Steven E. Gay M.D., M.S., Co-Investigator: Kevin M. Chan, M.D. (3%)
Funding: 09/1/2007 – 08/31/2013 ($606,308 full amount)
Gilead Sciences
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multi-Center, Parallel-Group, Event-Driven Study to Evaluate the Efficacy and Safety of Ambrisentan in Subjects with Early Idiopathic Pulmonary Fibrosis. The goal of this study is to determine if ambrisentan is effective in delaying disease progression and death in subjects with IPF.
Principal Investigator: Kevin M. Chan, M.D.
Funding: 12/16/09 – 07/31/2011 ($156,624 full amount)
Gilead Sciences
ARTEMIS-PH: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Mutli-Center, Parallel-Group Study to Evaluate the Efficacy and Safety of Ambrisentan in Subjects with Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension The goal of this study is to compare the changes in 6 minute walk distance after initiating ambrisentan or placebo treatment in subjects with pulmonary hypertension associated with idiopathic pulmonary fibrosis.
Principal Investigator: Kevin M. Chan, M.D.
Funding: 10/1/09-9/30/11 ($116,526 full amount)
Medpace (Alnylam)
A Multicenter, Multinational, Randomized, DoubleBlind, Placebo-Controlled study to evaluate the efficacy and safety of aerosolised ALN-RSV01 plus standard of care in Lung transplant patients infected with Respiratory syncytial Virus (RSV) Phase 2B
Principal Investigator: Kevin M. Chan, M.D.
Funding: 2/1/10-5/31/13 ($116,325 full amount)
PREVIOUS GRANTS
Lung Rx, Inc.
A single-dose, dose-escalation study exploring the safety, pharmacokinetics and pharmacodynamic effects of inhaled treprostinil using the Nebu-Tec OPTINEB inhalaiton device in patients with pulmonary hypertension associated with idiopathic pulmonary fibrosis. Principle Investigator: Valerie McLaughlin, M.D., Co-Investigator: Kevin M. Chan, M.D. (1%)
Funding: 7/1/2008 – 6/30/2009 ($90,227 full amount)
Centers for Disease Control and Prevention
Organ Transplant Infection Prevention and Detection Project 1.0: Cohort Study of Transplant Recipients at “Ultra-High” Risk for Invasive Fungal Infections.
Principle Investigator: Carol Kauffman, M.D., Co-investigator: Kevin M. Chan, M.D.
(0%) Funding: 01/2005-01/2010
XDX Expression Diagnostics, Inc.
Lung Allograft Refection Gene Expression Observational Study (LARGO)
Principle Investigator: Kevin M. Chan, M.D. (4%)
Funding: 2/1/2008 – 6/30/2009 ($119,679 full amount)
NHLBI P50 HL60289
SCCOR in Acute Lung Injury
Program Director, Theodore Standiford, M.D.
Principle Investigator: Galen B. Toews, M.D.
Co-Investigator: Kevin M. Chan, M.D. (5%)
Funding: 07/2006-06/2009 ($2,799,527 full amount, $934,246 Clinical Core A amount)
NIH/NHLBI U01 HL077150-01A1
Prospective Investigation of Pulmonary Embolism Diagnosis-III (PIOPED-III)
Principle Investigator: John G. Weg, MD
Program Director: Paul D. Stein, MD
Co-Investigator: Kevin M. Chan, M.D. (5%)
Funding: 08/01/05-05/31/09 ($254,605 annual direct costs)
Co-investigator, Henry Ford Hospital Site: A randomized, double blind, placebo controlled, parallel group trial assessing the rate of decline of lung function with tiotropium 18 mcg inhaltaiton capsule once daily in patients with chronic obstructive pulmonary disease (COPD). Henry Ford Hospital, January 2003 – September 2005. Principle Investigator: Michael Eichenhorn, M.D.
Principle investigator: A phase 3 multicenter, randomized, double blind, comparative study of the efficacy and safety of tigecycline vs levofloxicin to treat subjects hospitalized with community acquired pneumonia. Henry Ford Hospital, October 2003-July 2005.
Principle investigator: Phase III Study of the Safety and Efficacy of Interferon gamma-1b in Patients with Idiopathic Pulmonary Fibrosis. Henry Ford Hospital, November 2004-September 2005.
Duke University VAL 038
A Phase III, Randomized, Double-blind Comparison of Oral Valganciclovir and Placebo for prevention of CMV Disease After Lung Transplantation.
Principle Investigator: Kevin M. Chan, M.D. (10%)
Funding: 04/2006-04/2008 ($117,873, full amount)
CoTherix Inc.
An Open Lavel Pilot Study to Assess the Safety and Efficacy of Inhaled Iloprost in Adults with Pulmonary Hypertension Secondary to Interstitial Lung Disease in Systemic Sclerosis. Principle Investigator: James Seibold, M.D., Co-Investigator: Kevin M. Chan, M.D. (3%)
Funding: 9/1/2006 – 4/30/2008 ($123,715 full amount)
Honors and Awards
1982 Albion College Fellow, Omicron Delta Kappa, Mortar Board
1983 Phi Beta Kappa, Phi Lambda Upsilon
1985 Completed 1985 academic year with “honors” and recommended for
National Dean’s List
1986 Clinical honors and letters of commendation in internal medicine and psychiatry clerkships
1991 Nominated as “Physician of the Year”, UCLA Medical Center
1999 Chief Medical Resident’s Teacher Appreciation Award, Henry Ford Hospital
2004 The CHEST Foundation, Governors Community Service Award, $5,000 level for “You Have the Power To Donate Life” in conjunction with the Donate Life Coalition of Michigan
2006 Donate Life Coalition of Michigan, 2006 Visionary Award
2007 Named to “Best Doctors in America”, 2007-2009, 2010-2012
2008 Scleroderma Foundation of Michigan, 2008 Spirit of Leadership Award
2009 University of Michigan Pulmonary Fellows Class of 2009, Outstanding Faculty
Award
Memberships in Professional Societies
1990 American Thoracic Society
1995 – 1996 Trudeau Society, Program Chair, Los Angeles County Chapter
1996 American College of Chest Physicians, Fellow
1996 – 1997 Trudeau Society, Treasurer, Los Angeles County Chapter
1997 International Society of Heart and Lung Transplantation
1997 American College of Physicians, Fellow
1997 – 1997 20th Southern California Pulmonary Research Conference, Co-Chairman
1998 – 2006 Michigan Thoracic Society, Past President (2006-2008), President (2004 – 2006), Vice President (2002-2004), Secretary (2000-2002), Councilor at large (1998-2000)
2000 Pulmonary Hypertension Association
2002 – 2002 Michigan Thoracic Society Scientific Session 2002, Program Chairman
2004 - 2006 American Lung Association of Michigan, Board Member
Editorial Positions, Boards, and Peer-Review Service
Peer Review Service
1998 - Journal of Heart and Lung Transplantation
1999 - 2003 Critical Care Medicine
2001 Hepatology
2001 – 2002 Liver Transplantation
2006 - 2011 American Journal of Respiratory and Critical Care Medicine
2007 - 2011 Journal of Hospital Medicine
2008 - 2011 Respiration
2008 - 2009 Clinical Transplantation
2009 - CHEST
2009 - 2011 Lung
Continuing Medical Education Reviewer
2008 – 2011 Advances in Pulmonary Hypertension
2009 - 2011 PAH Preceptorship Program: A Collaborative Approach for Clinicians on
Front Line
2010- 2011 PAH 20 City Educational Tour
Teaching
05/1993 “New modes of mechanical ventilation in ARDS.” Presented at UCLA Internal
Medicine Grand Rounds, Los Angeles, CA
11/1998 “Novel Approaches to Therapy for ALI and ARDS”, Henry Ford Hospital,
Internal Medicine Grand Rounds, MI
03/2001 “Approach to Interstitial Lung Disease.” Presented to Internal Medicine
Residents, Henry Ford Hospital, Detroit, MI
03/2005 “Respiratory Failure in Lung Transplant Recipients.” Invited speaker at the
University of Michigan Division of Pulmonary and Critical Care Medicine
Clinical Conference, Ann Arbor, MI
03/2006 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
04/2006 “Indications for Lung Transplantation” Presented to University of Michigan
Nursing, University of Michigan Transplant Center Nursing Education,
Ann Arbor, MI
04/2006 “Improving Outcomes in Hospitalized Patients with CAP.” Presented at the
University of Michigan Division of Pulmonary and Critical Care Medicine
Clinical Conference, Ann Arbor, MI
05/2006 “Selection of Patients with IPAH for Lung Transplantation.” Presented to
University of Michigan Scleroderma, Lung Transplantation and Pulmonary
Hypertension Staff, Ann Arbor, MI
08/2006 “Michigan Lung Transplantation: 15 Years of Success.” Presented at University
of Michigan Internal Medicine Grand Rounds, Ann Arbor, MI
10/2006 “Lung Transplant Update” Presented to University of Michigan Division of
Pulmonary and Critical Care Medicine Fellows, Ann Arbor, MI
01/2007 “COPD: What is it?” Presented to Medical Assistants, University of Michigan
Brighton Health Center, Brighton, MI
02/2007 “Journal Club: Salmeterol and fluticasone propionate and survival in COPD”.
Discussion with Urvashi Bhan, M.D., University of Michigan Division of
Pulmonary and Critical Care Medicine Fellows, Ann Arbor, MI
03/2007 “Ambulatory Medicine Morning Report: Obstructive Sleep Apnea”. Internal
Medicine Residents, University of Michigan Department of Internal Medicine,
Ann Arbor, MI
03/2007 “Dyspnea in the Elderly” Presented at the University of Michigan Division of
Pulmonary and Critical Care Medicine Clinical Conference, Ann Arbor, MI
03/2007 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
06/2007 “Finances in Academic Medicine” University of Michigan Internal Medicine Resident Conference, Ann Arbor, MI
07/2007 “Practical Aspects of Patient Management; Lung Transplantation” Invited Speaker, Pulmonary Hypertension Preceptorship, University of Michigan Cardiovascular Center, Ann Arbor, MI
08/2007 “Non-Research Based Practice Settings” University of Michigan House Officer Retreat, Invited Participant, University of Michigan, Ann Arbor, MI
08/2007 “Diagnostic Dilemma: Dyspnea with Airway Obstruction”, Pulmonary Clinical Conference, University of Michigan, Ann Arbor, MI
09/2007 “Inhaled Corticosteroids and Risk of Lung Cancer”, Pulmonary/CCM Fellow Journal Club, University of Michigan, Ann Arbor, MI
09/2007 “Practical Aspects of Patient Management; Lung Transplantation” Invited Speaker, Pulmonary Hypertension Preceptorship, University of Michigan Cardiovascular Center, Ann Arbor, MI
10/2007 “Interesting Case Conference”, Pulmonary/CCM Fellows Conference, University of Michigan, Ann Arbor, MI
06/2008 "Morbidity and Mortality Case Presentation" Participant and discussant, University of Michigan Internal Medicine Grand Rounds, Ann Arbor, MI
08/2008 “Lung Transplantation”, Pulmonary Core Research Lecture Series, University of Michigan, Ann Arbor, MI
09/2008 “The Decisions We Make: Holding Patients’ Lives In Our Hands”, Invited Speaker, Schwartz Rounds, University of Michigan, Ann Arbor, MI
11/2008 “Pre-operative pulmonary evaluation of solid organ transplant recipients" Presented to University of Michigan Nursing, University of Michigan Transplant Center Nursing Education, Ann Arbor, MI
02/2009 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
03/2009 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
10/2009 Transplant Center Customer Service "Going the Extra Mile". Storyboard participant, University of Michigan Quality Improvement Fair, Ann Arbor, MI
01/2010 “The Big Picture: The Role of the Pulmonary Function Laboratory in the care of the Pulmonary Patient" Presentation to Pulmonary Function Laboratory Staff, Ann Arbor, MI
02/2010 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
03/2010 "Understanding Lung Transplantation: Updated information for the Waitlist Candidate and Recipient.", Presentation to the University of Michigan Lung Transplant Support Group, Ann Arbor, MI
04/2010 “Clinical Fellowship Training Summary at the University of Michigan”.
Presentation to Pulmonary and Critical Care Fellowship Applicants, Ann Arbor,
MI
04/2010 "Pulmonary PFT Potpourri", Pulmonary CCM Fellows Clinical Conference, University of Michigan, Ann Arbor, MI
04/2010 “Didactic Instruction on Question and Writing Practice”. Participant, APCCMPD 6th Annual Conference and Workshop for Pulmonary and Critical Care Fellowship Training Directors, Ft. Lauderdale, Florida
05/2010 "Lung Transplantation: Management and Complications". Pulmonary and Critical Care Medicine Fellows Core Clinical Conference, University of Michigan, Ann Arbor, MI
07/2010 "Lung Transplantation 101". Pulmonary and Critical Care Medicine Fellows Orientation Conference, University of Michigan, Ann Arbor, MI
10/2010 "Breath of Fresh Air: Improving Patient Inhaler Education." Storyboard participant, University of Michigan Quality Improvement Fair, Ann Arbor, MI
10/2010 "Cardiopulmonary Exercise Testing: Indications and Interpretation." Discussant, Pulmonary and Critical Care Medicine Fellows Conference, University of Michigan, Ann Arbor, MI
01/2011 "Approach to the Patient with Dyspnea". Invited speaker at the University Health Service CME Conference, Ann Arbor, MI
01/2011 "Lung Transplantation" Invited speaker to Quest for Breath IPF Support Group, Ann Arbor, MI
01/2011 "Morning Report" Invited discussant at University of Michigan Internal Medicine Morning Report, Ann Arbor, MI
02/2011 “Clinical Case Discussion: 44 yo with SLE and dyspnea”. Pulmonary and Critical Care Medicine Clinical Case Conference, University of Michigan, Ann Arbor, MI
03/2011 “ 5th Annual University of Michigan Lung Transplant Retreat”, Organizer and presenter, Ann Arbor, MI