2006-07 Annual Budget Report

Office of Health Sciences

Part 1A: Summary and Overview Spreadsheets

Current Balances, PBA Funding History, and Mandates and Service Improvements tables are interspersed in Part 2, sections 1-3 of this budget report. The Performance Indicators are in the separate accompanying Excel file.

Part 1B: Summary and Overview Narrative

Current Situation

Briefly, describe your unit's mission, goals, and objectives, and progress toward achieving them. There should be a direct link between this section and your Performance Indicators.

HEALTH SCIENCES ADMINISTRATION

The Office of Health Sciences (OHS) is an integral part of the greater University Medical Center. As such, its goals are closely aligned with those of the Medical Center. Four years ago Dr. Fred Sanfilippo, Sr. Vice President and Executive Dean for Health Sciences; Dean, College of Medicine; and CEO, OSU Medical Center, set the goal “to rank among the top quartile of academic medical centers by 2008 as measured by nationally accepted metrics”. [1] Achieving this goal depends in part on attracting world class research faculty, department chairs, and clinicians, which also aligns closely with the Academic Plan goal to build world class faculty. Toward this end, the Office of Health Sciences has supported the recruitment of several world renowned researchers, five new clinical department chairs and other key research and clinical faculty. On the horizon are two additional clinical chairs, a director for the School of Allied Medical Professions, and directors for the School of Biomedical Science and the Heart Center, all of which will be supported in part by the Office of Health Sciences.

We are committed to the Academic Plan goal to develop academic programs by way of strategic investment in interdisciplinary initiatives.[2] The Office of Health Sciences at the Medical Center has submitted or collaborated on seven proposals for the Provost’s Targeted Investments in Excellence (TIE) funding. While targeted to specific areas of study, they are comprehensive in approach and focus to include many areas of health sciences across colleges and departments.

The Academic Plan goals of building a world class faculty and building Ohio’s future will be advanced with the completion of the Biomedical Research Tower, scheduled to open December, 2006. Health Sciences’ marginal indirect cost recovery is a key component of the financing of this state-of-the-art research facility.

The Academic Plan goal to enhance and better serve the student body is demonstrated by Health Sciences support for the College of Medicine’s Physician Scientist (MD/PhD) program, the Integrated Biomedical Science Graduate Program (IBGP), and the office of scholarship. These align well with President Holbrook’s focus on funding of graduate programs.[3]

OHS also provides support for initiatives within the Health Sciences, such as the Library and Center for Knowledge Management, the Center for Biostatistics and the Institute for Behavioral Medicine Research. Goals and achievements of those and other Health Sciences units are described below.

COMPREHENSIVE CANCER CENTER

The mission of the OSU Comprehensive Cancer Center (OSUCCC), which includes the OSU James Cancer Hospital, is: 1) to reduce cancer incidence, morbidity and mortality by conducting research and expediting the transfer of results from scientific investigation to quality patient care; and, 2) to provide high quality health services in prevention, detection, diagnosis, treatment and rehabilitation, contribute to the education of health professionals, increase public awareness of cancer and promote public policy changes to improve prevention, detection and treatment of cancer.

There are more than 240 active members (i.e. faculty investigators) in the OSUCCC representing 13 OSU colleges as well as other institutions, including the Columbus Children’s Hospital and the Cincinnati Children’s Hospital Medical Center (CCHMC).

The primary goal of the OSUCCC in the coming years is to be a top 10 nationally ranked cancer center based on NCI funding. The short-term objectives to reach this goal are:

· To provide research infrastructure that enhances and facilitates the conduct of basic, clinical, translation and population-based cancer research;

· To provide an intellectual environment that stimulates multi-disciplinary, collaborative research efforts amongst investigators;

· To provide a clinical research infrastructure that assures the highest levels of safety and quality in the conduct of clinical/translational research;

· To continually educate faculty, staff, patients and community on the benefits of cancer research;

· To recruit high caliber basic, clinical and population cancer investigators;

· To expand efforts in pediatric oncology basic and clinical research through a partnership between the OSUCCC, the CCHMC and the Columbus Children’s Hospital.

During the past year, through leadership and the investment of time, space and dollars, several significant accomplishments within the OSUCCC have resulted - a select few include the following:

· The OSUCCC received a total of $19.2 million (over 5-year period) in continued core grant support funding from the National Cancer Institute (NCI) after earning an “outstanding” rating in the most recent site review;

· The ranking of the OSUCCC-James Cancer Hospital improved from 39th to 29th in the 2005 U.S. News and World Report’s annual rankings of “America’s Best Hospitals”;

· Cancer was designated as one of the six Signature Programs within the Medical Center (OSUMC);

· The OSUCCC entered into a collaborative agreement with Columbus Children’s Hospital and Cincinnati Children’s Hospital Medical Center to broaden the study of childhood cancer and hasten the transfer of findings to clinical care. A new Pediatric Oncology Program has now been established as part of the OSUCCC;

· The OSUCCC was 1 of only 9 institutions in the country to receive an NCI Phase II contract. Having this $3M/3 year contract, entitled “Early Therapeutics Development with Phase II Emphasis” (PI = Miguel Villalona, MD) coupled with the longstanding NCI Phase I grant (PI=Michael Grever, MD) for new cancer drug development, will further distinguish the OSUCCC as a national leader in translational/early-phase clinical research;

· The OSUCCC participated in the joint recruitment of 19 junior and senior faculty cancer investigators to OSU over the past year;

· The OSUCCC subsidized expenses for 14 shared resource (core) facilities at an annual cost exceeding $2.5M (including the University Proteomics facility and the Microarray and Nucleic Acid Shared Resource facilities), and provided capital and annual operating support for the development of 3 new shared resources (Small Animal Imaging, Biomedical Informatics, and Pharmacoanalytics);

· The OSUCCC provided more than $1M to support and facilitate the cancer research efforts of new and existing cancer investigators as well as collaborative projects across the University.

· Numerous OSUCCC members received awards and honors and were elected members of prestigious scientific organizations.

Overall, the OSUCCC has been and continues to strive to serve as a model for integrating the effort and expertise of scientists, physicians and administration from multiple entities (colleges, departments and outside institutions) toward similar goals. It is expected that continuing to support the growth and expansion of such a Center of Excellence can and will continue to generate dividends for the University (such as new funding, philanthropic support, recruiting ability, national reputation) to far exceed the investment.

HEALTH SCIENCES LIBRARY & CENTER FOR KNOWLEDGE MANAGEMENT (CKM)

The Center for Knowledge Management (CKM) was chartered during the academic year 2003-04, to integrate the design, deployment and support of resource-intensive, technology-based academic initiatives. This integration included personnel, services and infrastructure, digital repositories, data sets, mobile computing devices, computerized testing, and interactive multimedia to enable the center to provide information tailored to the needs of students, faculty and staff on the medical center campus and its surrounding health sciences colleges. Applying and sharing new knowledge, information assets, and technologies in this way is a collaborative process.

As stewards of knowledge services, the Prior Health Sciences Library is an ideal partner with the CKM as the staff work together to acquire and organize knowledge and educate the faculty, staff and students of the Health Sciences Center on the use of information.

Goals

· Enhance our service-oriented model, following CKM’s recent reorganization.

· Develop systematic surveys for customers to ensure the services are meeting customer requirements in quality and time commitment. Provide tracking mechanism to manage customers’ needs and expectations.

· Fully integrate expert services of Research Librarian in health sciences research community.

· Increase funding support for the Medical Heritage Center (i.e. endowments).

· Acquire additional funds to support the annual 9% increase in library acquisitions costs.

· Provide integrated knowledge and information services and programs.

Achievements of the Library and Center for Knowledge Management are detailed below under ‘Innovations and Efficiencies’.

CENTER for BIOSTATISTICS

Our mission is to provide a single, readily identifiable source of expertise with whom biomedical investigators from both within and outside The Ohio State University can collaborate in all aspects of study design, data management, and statistical analysis of clinical, epidemiological, public health, and laboratory research data. This expertise is both interactive and multidisciplinary. Academics and health professionals provide a dynamic environment for biostatistical applications in which methodological research is enhanced through the knowledge and expertise provided by the Center’s biostatisticians.

The Center for Biostatistics personnel consists of two directors, 12 senior consulting statisticians, four graduate students, and six support staff. Center statisticians are involved in grant preparation, data management, study design and statistical analysis. Collaborations between OSU researchers and Center staff have resulted in 27 funded grants generating approximately $35 million. The Center has recently collaborated on over 20 grant proposals in which decisions are pending. Through support from the Office of Health Sciences, Center staff help OSU researchers write grant proposals without charge. In addition to collaborating on grants, the Center has an earnings operation that bills for services at an hourly rate. A total of 63 projects generated over $467,000 in revenues in calendar year 2005, including over $100,000 from state and private industry. The Center is currently negotiating contracts with several firms, including Children’s Hospital of Cincinnati.

Annually, the Center offers a Summer Program in Applied Statistical Methods. The 2006 version features 21 courses in the application of statistical methodology & epidemiology to a wide range of biomedical and public health problems. Program faculty are internationally known for their technical expertise as well as their teaching ability. The program brings participants from all over the world to the OSU campus to study new approaches to the analysis of data from epidemiologic studies, as well as the analysis of biologic, clinical trials, epidemiology, and laboratory data. All courses are designed to provide valuable hands-on experience in the analysis and interpretation of real data. The 2005 Summer Program attracted more than 300 students and we anticipate a larger turnout in 2006. Included in these numbers are 30 students from the College of Medicine’s Integrated Biomedical Science Graduate Program.

OFFICE of GERIATRICS and GERONTOLOGY

The Office’s key responsibilities, functions and programs are broad-based and respond to a combination of Board of Regents mandates, College of Medicine needs, Health Sciences and University priorities, and state and community imperatives. In addition, all of the office’s initiatives directly address the vision outlined in the University’s academic plan, most specifically diversity, academic excellence, workforce readiness, outreach and engagement, and our land grant mission.

Key examples of our progress in academic plan areas include:

· Ohio State’s undergraduate medical education initiatives in aging, which are considered the models for other schools.

· The university’s graduate and professional Specialization in Aging, developed and administered by us, which includes close to 116 courses and involves faculty and students from 24 departments.

· Web-based programs that meet the needs of a diverse nontraditional student body and are fully subscribed.

NISONGER CENTER

Nisonger Center is a University Center for Excellence (UCE) in Mental Retardation and Developmental Disabilities. The federal Developmental Disabilities Act of 2001 sets our overriding goals. Special goals are set forth in contracts providing federal core funding for the UCE. Each of the 50 states has at least one UCE; Ohio has two (the other is at the University of Cincinnati).

As a UCE, our goals are

· To provide intensive interdisciplinary training in mental retardation to approximately 50 post-undergraduate students each year. Included are pediatricians, psychiatrists, dentists, psychologists, special educators, social workers, and others.

· To operate on site, community, and rural training clinics that provide needed, exemplary services to approximately 3,500 people with mental retardation or their family members.

· To consult with nonprofit federal, state, and community agencies- as well as Ohio public schools- on a wide range of public policy issues, technical assistance, and service needs.

· To develop and disseminate locally, statewide and nationally guides, handbooks, curriculum, and other special products aimed at meeting the needs of people with developmental disabilities and their families. Examples include consumer guides that explain medication effects for people with mild mental retardation; standard reference material on best medical, psychological, or educational practices; and state-of-the-art assessment techniques.

· To conduct original scientific and applied research such as NIH-funded medication studies, studies of curiosity and learning, and studies of organ transplantation and mental retardation.

Our priorities are to continue to expand our Next Chapter Book Clubs and our project on organ transplantation and mental retardation. Linda Jones, a former national board member of UNOS who served as CEO of Lifeline of Ohio for 11 years, directs this project.

Our research is having significant impact on a worldwide and interdisciplinary basis; our programs are successful; and we have more funding opportunities than time to pursue them. Steven Reiss is the program chairperson for the 2006 International Conference on Mental Health and Mental Retardation to be held in Boston. His ideas about sensitivity to anxiety have been cited in 679 articles that showed a new, early diagnostic feature of Panic Disorder, which affects 5 million Americans. Reiss’ work on mental retardation and on anxiety has been translated in more than 25 languages and he consistently obtains SSCI rates of more than 200.

Our NIH-funded Research Unit on Pediatric Psychopharmacology (RUPP) conducts mental retardation safety and efficacy studies for autism and ADHD medications. Work from the lead RUPP researcher, Dr. Michael Aman, has been translated into 20 languages. Aman consistently runs a Social Science Citation Index (SSCI) rate of more than 100, meaning his publication receives over 100 citations in a year among professionals in the field.

INSTITUTE for BEHAVIORAL MEDICINE RESEARCH (IBMR)