Table S1. Rgg-associated changes in transcript levels during post-exponential growth (2-fold or greater)
SPy no.a / Gene / Description / wt mean (sem)b / rgg mean (sem) / Fold change rgg-/wt c2088 / - / putative cationic amino acid transporter protein / 0.04 (0.02) / 2.17 (0.16) / 58
165 / nga / nicotine adenine dinucleotide glycohydrolase precursor / 0.08 ( < 0.01) / 4.23 (< 0.01) / 53
2081 / hutI / imidazolonepropionase (imidazolone-5-propionate hydrolase) / 0.06 (0.01) / 3.03 (0.26) / 51
2087 / - / hypothetical protein / 0.07 (< 0.01) / 3.23 (0.34) / 47
1542 / - / putative Xaa-His dipeptidase / 0.22 (< 0.01) / 10.64 (0.59) / 47
2083 / - / formiminotransferase cyclodeaminase / 0.05 (< 0.01) / 2.54 (0.25) / 47
1544 / arcB / ornithine transcarbamylase / 0.28 (0.03) / 12.95 (1.57) / 47
1541 / arcC / carbamate kinase / 0.23 (0.08) / 9.74 (0.71) / 43
1543 / - / hypothetical protein / 0.23 (0.01) / 9.84 (1.30) / 43
166 / - / hypothetical protein / 0.26 (< 0.01) / 8.24 (1.33) / 32
1059 / - / putative phosphotransferase system (PTS), enzyme II, component C / 0.12 (0.03) / 3.61 (0.35) / 30
167 / slo / streptolysin O precursor / 0.20 (0.02) / 5.46 (0.18) / 28
2084 / - / putative serine cycle enzyme / 0.08 (0.02) / 2.16 (0.23) / 28
1436 / mf-3 / putative deoxyribonuclease / 0.27 (0.04) / 7.42 (0.13) / 27
2085 / fhs.2 / putative formate-tetrahydrofolate ligase / 0.12 (< 0.01) / 3.15 (0.36) / 27
1060 / - / putative phosphotransferase system (PTS), enzyme II component D / 0.10 (0.02) / 2.49 (0.05) / 26
1437 / - / hypothetical protein / 0.12 (< 0.01) / 2.97 (0.41) / 25
2089 / hutH / putative histidine ammonia-lyase / 0.17 (0.03) / 3.37 (0.24) / 20
2082 / hutU / putative urocanate hydratase / 0.18 (0.07) / 3.44 (0.22) / 20
1546 / - / hypothetical protein / 0.63 (0.04) / 12.38 (0.46) / 20
1547 / arcA / arginine deiminase / 0.66 (0.04) / 10.87 (0.97) / 17
1058 / - / putative phosphotransferase system (PTS), enzyme II component B / 0.29 (< 0.01) / 3.92 (0.10) / 14
1983 / scl / collagen-like surface protein / 0.07 (0.05) / 0.95 (0.13) / 13
1111 / - / putative zinc-containing alcohol dehydrogenase / 0.19 (0.02) / 1.82 (0.04) / 10
254 / - / sugar transport system (permease) / 0.15 (0.03) / 1.34 (0.22) / 9
428 / - / hypothetical protein / 0.22 (0.01) / 1.83 (0.04) / 9
2066 / - / putative dipeptidase / 0.66 (0.06) / 5.43 (0.30) / 8
258 / - / putative glucose kinase / 0.24 (0.03) / 1.92 (0.17) / 8
1057 / - / hypothetical protein / 0.63 (0.02) / 4.71 (0.02) / 8
1698 / yitS / hypothetical protein / 0.62 (0.06) / 4.34 (0.01) / 7
255 / - / probable sugar transport protein (permease) / 0.16 (0.01) / 1.08 (0.06) / 7
1596 / - / putative transcriptional regulator / 0.04 (< 0.01) / 0.22 (< 0.01) / 6
1563 / - / hypothetical protein / 0.42 (0.04) / 2.54 (0.16) / 6
1339 / - / hypothetical protein / 0.12 (0.02) / 0.73 (0.08) / 6
2090 / hutG / putative formiminoglutamate hydrolase / 0.56 (< 0.01) / 3.34 (0.58) / 6
1949 / - / hypothetical protein / 0.12 (0.01) / 0.70 (0.18) / 6
256 / - / hypothetical protein / 0.32 (0.02) / 1.89 (0.07) / 6
44 / adhA / putative alcohol dehydrogenase I / 1.24 (0.04) / 6.75 (0.17) / 5
252 / - / putative sugar transporter sugar binding lipoprotein / 0.44 (0.10) / 2.38 (0.02) / 5
1979 / ska / streptokinase A precursor / 0.44 (0.06) / 2.37 (1.03) / 5
136 / - / hypothetical protein / 0.14 (< 0.01) / 0.72 (0.02) / 5
2043 / mf / mitogenic factor / 1.26 (0.04) / 6.45 (0.55) / 5
1549 / ahrC.2 / putative arginine repressor / 0.47 (< 0.01) / 2.38 (0.32) / 5
2010 / scpA / C5A peptidase precursor / 0.65 (0.01) / 3.19 (0.30) / 5
257 / nanH / putative acylneuraminate lyase / 0.37 (0.07) / 1.78 (0.15) / 5
1680 / - / putative transcriptional regulatory protein / 0.15 (0.04) / 0.69 (0.02) / 5
251 / - / putative N-acetylmannosamine-6-P epimerase / 0.27 (0.07) / 1.24 (0.14) / 5
1562 / - / hypothetical protein / 0.46 (0.03) / 2.11 (0.11) / 5
1564 / - / hypothetical protein / 0.48 (0.01) / 2.11 (< 0.01) / 4
2009 / - / hypothetical protein / 0.66 (0.14) / 2.92 (0.03) / 4
1681 / - / putative NADH peroxidase / 0.15 (< 0.01) / 0.64 (0.11) / 4
1586 / - / putative beta-galactosidase / 0.49 (< 0.01) / 1.96 (0.13) / 4
1592 / - / hypothetical protein / 0.17 (0.01) / 0.66 (0.06) / 4
1565 / - / hypothetical protein / 0.57 (0.02) / 2.23 (0.22) / 4
1589 / - / hypothetical protein / 0.15 (0.02) / 0.58 (0.15) / 4
1566 / - / hypothetical protein / 0.26 (< 0.01) / 1.00 (0.11) / 4
741 / - / hypothetical protein / 1.81 (0.28) / 6.89 (0.50) / 4
1708 / lacA.1 / putative galactose-6-phosphate isomerase / 0.12 (0.02) / 0.43 (0.16) / 4
1947 / - / putative transaldolase / 0.08 (< 0.01) / 0.28 (0.04) / 4
2019 / mga / M protein trans-acting positive regulator / 0.02 (< 0.01) / 0.07 (0.02) / 4
742 / - / hypothetical protein / 1.83 (0.14) / 6.52 (0.08) / 4
631 / agaV / putative PTS dependent N-acetyl-galactosamine-IIB component / 0.07 (< 0.01) / 0.26 (0.02) / 4
739 / sagB / streptolysin S associated ORF / 1.19 (0.03) / 6.51 (0.40) / 4
2091 / - / putative regulatory protein / 0.16 (0.01) / 0.56 (0.07) / 3
1950 / - / hypothetical protein / 0.19 (0.02) / 0.64 (0.02) / 3
2173 / yoxJ / hypothetical protein / 1.28 (0.24) / 4.29 (0.03) / 3
1588 / - / putative two-component sensor histidine kinase / 0.36 (< 0.01) / 1.20 (0.02) / 3
416 / prtS / putative cell envelope proteinase / 0.11 (0.02) / 0.37 (0.05) / 3
1190 / citX / hypothetical protein / 0.08 (< 0.01) / 0.27 (0.04) / 3
844 / - / hypothetical protein / 1.84 (0.41) / 6.04 (0.76) / 3
740 / sagC / streptolysin S associated ORF / 2.08 (0.34) / 6.80 (0.29) / 3
1683 / glpO / putative alpha-glycerophosphate oxidase / 0.16 (< 0.01) / 0.52 (0.11) / 3
1678 / - / putative transaldolase / 0.21 (0.01) / 0.66 (< 0.01) / 3
1113 / - / putative acid phosphatase (class B) / 1.73 (0.38) / 5.49 (0.43) / 3
151 / ntpC / putative V-type Na+ -ATPase subunit C / 0.17 (0.03) / 0.54 (0.03) / 3
179 / araD / putative L-ribulose 5-phosphate 4-epimerase / 0.02 (< 0.01) / 0.05 (0.02) / 3
746 / - / putative ABC-2 type transport system permease protein / 1.50 (0.23) / 4.66 (0.02) / 3
843 / - / hypothetical protein / 1.30 (0.13) / 3.96 (0.23) / 3
1587 / - / putative two-component sensor response regulator / 0.58 (0.04) / 1.77 (0.10) / 3
1599 / - / putative beta-glucosidase / 0.26 (< 0.01) / 0.79 (0.15) / 3
414 / lctO / putative lactate oxidase / 0.08 (0.02) / 0.25 (0.07) / 3
1567 / - / hypothetical protein / 0.24 (0.02) / 0.74 (0.02) / 3
157 / ntpD / putative V-type Na+ -ATPase subunit D / 0.22 (0.04) / 0.66 (0.03) / 3
1189 / citF / putative citrate lyase, alpha subunit / 0.12 (0.03) / 0.36 (0.05) / 3
155 / ntpB / putative V-type Na+ -ATPase subunit B / 0.44 (0.03) / 1.31 (0.04) / 3
1191 / oadA / putative oxaloacetate decarboxylase alpha chain / 0.18 (0.02) / 0.54 (0.16) / 3
738 / sagA / streptolysin S associated protein / 1.80 (0.28) / 5.25 (0.54) / 3
154 / ntpA / putative V-type Na+ -ATPase alpha subunit / 0.31 (0.02) / 0.90 (0.02) / 3
743 / - / hypothetical protein / 2.10 (0.41) / 6.07 (0.64) / 3
2060 / - / hypothetical protein / 0.83 (0.04) / 2.37 (0.31) / 3
1593 / - / putative sugar-binding transport protein / 0.13 (0.01) / 0.37 (< 0.01) / 3
1067 / gabD / putative succinic semialdehyde dehydrogenase / 0.94 (< 0.01) / 2.68 (0.15) / 3
2000 / dppA / surface lipoprotein / 1.78 (0.22) / 5.07 (0.59) / 3
148 / ntpI / V-type Na+ -ATPase subunit I / 0.14 (< 0.01) / 0.39 (0.02) / 3
1548 / - / hypothetical protein / 0.92 (0.14) / 2.58 (0.25) / 3
2006 / - / hypothetical protein / 0.42 (0.01) / 1.16 (0.06) / 3
1054 / scl / putative collagen-like protein / 1.70 (0.22) / 4.71 (0.78) / 3
1794 / - / putative ABC transporter (permease) / 0.38 (< 0.01) / 1.01 (< 0.01) / 3
1324 / - / putative PTS system enzyme II / 0.31 (0.06) / 0.84 (0.08) / 3
1791 / - / putative ABC transporter (ATP-binding protein) / 0.30 (0.04) / 0.80 (0.12) / 3
150 / ntpE / putative V-type Na+ -ATPase subunit E / 0.28 (0.02) / 0.74 (0.04) / 3
1591 / - / hypothetical protein / 0.15 (0.06) / 0.39 (0.03) / 3
747 / - / hypothetical protein / 1.89 (0.22) / 5.00 (0.13) / 3
149 / ntpK / V-type Na+ -ATPase subunit K / 0.28 (0.01) / 0.73 (0.02) / 3
1602 / - / putative transcription regulator / 0.25 (0.01) / 0.66 (0.04) / 3
1233 / coaA / putative pantothenate kinase / 0.47 (0.06) / 1.23 (0.19) / 3
744 / - / putative ABC transporter (ATP-binding protein) / 2.23 (0.30) / 5.80 (0.32) / 3
1731 / - / hypothetical protein / 1.49 (0.17) / 3.86 (0.05) / 3
1795 / - / putative ABC transporter (periplasmic binding protein) / 0.34 (0.03) / 0.88 (0.03) / 3
1730 / hit / putative cell-cycle regulation histidine triad (HIT) protein / 1.74 (0.24) / 4.47 (0.33) / 3
1186 / citD / putative citrate lyase, gamma subunit / 0.17 (0.01) / 0.44 (0.04) / 3
2172 / - / hypothetical protein / 1.57 (0.12) / 3.96 (0.39) / 3
1046 / - / hypothetical protein / 0.72 (0.04) / 1.80 (0.18) / 3
1595 / - / putative sugar-binding transport protein / 0.21 (0.03) / 0.53 (0.02) / 3
147 / - / hypothetical protein / 0.18 (0.02) / 0.46 (0.10) / 2
170 / - / hypothetical protein / 0.23 (0.13) / 0.57 (0.10) / 2
2007 / lmb / putative laminin adhesion / 0.28 (0.02) / 0.67 (0.06) / 2
469 / - / putative 42 kDa protein / 2.56 (0.60) / 6.26 (0.29) / 2
745 / sagH / ABC transporter (ATP-binding protein) - streptolysin S associated ORF / 2.35 (0.35) / 5.73 (0.49) / 2
1742 / serS / putative seryl-tRNA synthetase / 1.85 (0.04) / 4.51 (0.89) / 2
944 / - / hypothetical protein / 0.70 (0.05) / 1.70 (0.03) / 2
1796 / - / hypothetical protein / 0.23 (0.02) / 0.55 (0.03) / 2
1263 / - / hypothetical protein / 3.55 (0.18) / 8.56 (0.55) / 2
1710 / - / putative PTS system, galactitol-specific IIB component / 0.19 (0.02) / 0.45 (0.05) / 2
1219 / - / putative trimethylamine dehydrogenase / 0.98 (0.09) / 2.32 (0.30) / 2
1952 / - / hypothetical protein / 0.16 (< 0.01) / 0.38 (0.02) / 2
1049 / - / hypothetical protein / 0.88 (0.06) / 2.05 (0.09) / 2
2135 / - / putative replication protein / 0.09 (0.01) / 0.22 (< 0.01) / 2
1991 / trpG / anthranilate synthase component II / 1.09 (0.07) / 2.48 (0.21) / 2
2002 / dppC / transmembrane transport protein / 0.61 (0.03) / 1.38 (0.13) / 2
569 / ftsY / putative signal recognition particle (docking protein) / 1.37 (0.42) / 3.11 (0.16) / 2
1684 / glpK / putative glycerol kinase / 0.12 (< 0.01) / 0.27 (< 0.01) / 2
1325 / - / putative transcriptional antiterminator (BglG family) / 0.24 (0.06) / 0.54 (0.09) / 2
1220 / - / hypothetical protein / 1.10 (0.04) / 2.48 (0.13) / 2
1638 / atoD.1 / putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit / 0.43 (0.07) / 0.97 (0.09) / 2
1600 / - / putative hyaluronidase / 0.35 (0.05) / 0.77 (0.04) / 2
1260 / - / hypothetical protein / 2.88 (0.44) / 6.43 (0.19) / 2
1833 / mutY / putative A G-specific adenine glycosylase / 0.6 (0.05) / 1.33 (0.09) / 2
- / hypothetical protein / 0.11 (0.03) / 0.24 (0.07) / 2
1641 / - / hypothetical protein / 0.45 (0.02) / 0.97 (0.09) / 2
1815 / scrA / putative sucrose-specific PTS permease, enzyme II / 0.43 (0.07) / 0.92 (0.29) / 2
1188 / citE / putative citrate lyase, beta subunit / 0.19 (0.05) / 0.41 (0.03) / 2
177 / - / putative hexulose-6-phosphate synthase / 0.03 (< 0.01) / 0.06 (0.02) / 2
142 / - / butyrate-acetoacetate CoA-transferase, beta subunit / 0.06 (0.01) / 0.13 (0.04) / 2
1561 / - / hypothetical protein / 0.32 (0.03) / 0.68 (0.04) / 2
2132 / - / hypothetical protein / 0.03 (< 0.01) / 0.05 (0.02) / 2
437 / - / hypothetical protein / 0.01 (< 0.01) / 0.02 (< 0.01) / 2
169 / - / hypothetical protein / 0.06 (0.03) / 0.14 (0.01) / 2
1432 / pyrD / putative dihydroorotate dehydrogenase / 0.49 (< 0.01) / 1.05 (< 0.01) / 2
1790 / - / putative ABC transporter (ATP-binding protein) / 0.47 (0.04) / 0.99 (0.02) / 2
1160 / - / hypothetical protein / 2.20 (0.08) / 4.65 (0.14) / 2
1793 / - / putative ABC transporter (ATP-binding protein) / 0.36 (< 0.01) / 0.76 (0.06) / 2
1159 / hlyIII / putative hemolysin III / 2.41 (0.45) / 5.01 (0.71) / 2
1574 / - / putative transposase - IS1548 / 0.07 (< 0.01) / 0.15 (0.03) / 2
1788 / ybaF / hypothetical protein / 1.22 (0.08) / 2.51 (0.22) / 2
1048 / - / hypothetical protein / 1.24 (0.10) / 2.56 (0.07) / 2
1783 / - / hypothetical protein / 0.77 (0.02) / 1.58 (0.19) / 2
121 / - / putative deoxyguanosine kinase deoxyadenosine kinase(I) subunit / 1.66 (0.19) / 3.39 (0.17) / 2
1218 / - / hypothetical protein / 2.22 (0.16) / 4.53 (0.50) / 2
45 / - / hypothetical protein / 0.32 (< 0.01) / 0.65 (0.05) / 2
1972 / pulA / putative pullulanase / 0.89 (0.07) / 1.81 (0.15) / 2
720 / - / hypothetical protein / 1.36 (0.17) / 2.76 (0.33) / 2
1557 / msrA / putative peptide methionine sulfoxide reductase / 0.09 (0.02) / 0.18 (0.04) / 2
1094 / - / hypothetical protein / 1.61 (0.15) / 3.24 (0.20) / 2
2001 / dppB / transmembrane transport protein / 0.81 (0.05) / 1.62 (0.21) / 2
2144 / - / hypothetical protein / 0.21 (0.02) / 0.10 (0.03) / -2
454 / mtsB / ABC transporter (ATP-binding protein) / 6.39 (0.92) / 3.18 (0.24) / -2
1405 / - / hypothetical protein / 0.21 (0.03) / 0.10 (0.01) / -2
235 / - / putative dUTPase, phage associated / 2.54 (0.25) / 1.26 (0.03) / -2
870 / fms / putative polypeptide deformylase / 1.85 (0.16) / 0.91 (0.07) / -2
237 / - / hypothetical protein / 1.68 (0.07) / 0.83 (0.03) / -2
315 / - / hypothetical protein / 2.04 (0.28) / 1.00 (0.23) / -2
1918 / lacF / putative PTS system, lactose-specific component IIA / 1.52 (0.23) / 0.74 (0.01) / -2
1844 / - / putative exodeoxyribonuclease V (alpha subunit) / 1.53 (0.31) / 0.75 (< 0.01) / -2
1935 / - / hypothetical protein / 0.54 (0.05) / 0.26 (< 0.01) / -2
1425 / - / hypothetical protein / 4.74 (0.94) / 2.28 (0.02) / -2
599 / - / putative transcription regulator / 2.06 (0.20) / 0.98 (0.07) / -2
784 / rmlD / putative dTDP-4-keto-L-rhamnose reductase / 4.21 (0.50) / 2.00 (0.38) / -2
723 / - / putative transposase / 1.57 (0.08) / 0.75 (0.05) / -2
1395 / - / putative transcription factor / 1.10 (0.13) / 0.52 (0.13) / -2
2186 / - / hypothetical protein / 3.37 (0.32) / 1.59 (0.17) / -2
1131 / - / hypothetical protein / 0.40 (0.08) / 0.19 (0.01) / -2
1208 / - / hypothetical protein / 3.85 (0.58) / 1.81 (1.13) / -2
1864 / dnaQ / putative DNA polymerase III epsilon subunit / 1.82 (0.06) / 0.85 (0.05) / -2
1804 / acpS / putative holo-(acyl carrier protein) synthase / 3.23 (0.51) / 1.51 (0.11) / -2
570 / - / putative drug resistance protein / 2.26 (0.17) / 1.06 (0.12) / -2
1995 / flaR / topology modulator / 2.21 (0.18) / 1.03 (0.11) / -2
1888 / rpmB / 50S ribosomal protein L28 / 10.99 (3.47) / 5.08 (0.63) / -2
191 / - / hypothetical protein / 0.43 (0.03) / 0.20 (0.03) / -2
2140 / - / hypothetical protein / 0.03 (< 0.01) / 0.01 (< 0.01) / -2
456 / mtsC / ABC transporter (permease protein) / 4.53 (0.71) / 2.05 (0.01) / -2
1895 / rpoE / putative DNA-directed RNA polymerase (delta subunit) / 7.94 (2.60) / 3.57 (0.30) / -2
1206 / - / putative ABC transporter (ATP-binding protein) / 3.43 (0.42 ) / 1.54 (0.18) / -2
987 / - / conserved hypothetical protein - phage 370.2 protein / 0.09 (0.03) / 0.04 (< 0.01) / -2
1927 / - / hypothetical protein / 0.98 (0.23) / 0.44 (0.03) / -2
552 / - / hypothetical protein / 0.41 (< 0.01) / 0.18 (0.02) / -2
1392 / - / putative oxalate:formate antiporter / 0.55 (0.07) / 0.24 (0.03) / -2
- / hypothetical protein / 0.64 (0.06) / 0.28 (0.05) / -2
1356 / - / putative acetyl transferase / 9.09 (1.88) / 3.93 (0.30) / -2
1921 / lacC.2 / putative tagatose 6-phosphate kinase / 1.46 (0.22) / 0.63 (0.17) / -2
1956 / - / hypothetical protein / 1.20 (0.03) / 0.05 (< 0.01) / -2
1355 / ytoI / hypothetical protein / 7.96 (1.87) / 3.41 (0.02) / -2
1658 / - / putative amino acid ABC transproter (permease protein) / 5.49 (0.92) / 2.35 (0.05) / -2
737 / epf / putative extracellular matrix binding protein / 0.04 (0.02) / 0.02 (< 0.01) / -2
1298 / malA / putative maltodextrose utilization protein / 0.04 (< 0.01) / 0.02 (< 0.01) / -2
1398 / - / putative 16S pseudouridylate synthetase / 1.91 (0.29) / 0.80 (0.10) / -2
1374 / nrdH / putative glutaredoxin / 5.65 (1.12) / 2.37 (0.28) / -2
1926 / - / hypothetical protein / 1.21 (0.27) / 0.51 (0.05) / -2
903 / - / putative ABC transporter (binding protein) / 4.95 (0.68) / 2.04 (0.12) / -2
1024 / - / hypothetical protein / 1.94 (0.17) / 0.80 (0.09) / -2
1697 / - / hypothetical protein / 2.31 (0.28) / 0.95 (0.05) / -2
1275 / - / putative amino acid ABC transporter (ATP-binding protein) / 4.22 (0.66) / 1.73 (< 0.01) / -2
145 / - / hypothetical protein / 2.60 (0.79) / 1.06 (0.19) / -2
1657 / - / putative amino acid ABC transport system (ATP-binding protein) / 3.63 (0.71) / 1.47 (0.12) / -2
1211 / - / hypothetical protein / 4.29 (1.03) / 1.72 (0.06) / -2
1759 / dnaJ / heat-shock (chaperone) protein / 3.01 (0.69) / 1.21 (0.45) / -3
722 / - / hypothetical protein / 1.61 (0.04) / 0.64 (0.03) / -3
230 / - / putative ABC transporter (ATP-binding protein) / 0.90 (0.05) / 0.36 (< 0.01) / -3
1273 / cfa / CAMP factor / 2.29 (0.15) / 0.91 (0.05) / -3
902 / amiC / putative amidase / 3.68 (0.43) / 1.46 (0.28) / -3
940 / - / hypothetical protein / 0.73 (0.27) / 0.28 (0.09) / -3
1118 / radC / putative DNA repair protein / 0.36 (0.06) / 0.14 (0.01) / -3
163 / - / putative ABC transporter (lipoprotein) / 4.92 (0.94) / 1.85 (0.05) / -3
1272 / - / putative cation efflux system protein / 3.78 (0.79) / 1.40 (0.10) / -3
1139 / - / putative 4-oxalocrotonate tautomerase / 2.24 (0.22) / 0.82 (0.12) / -3
971 / - / putative terminase, small subunit - phage associated / 0.26 (0.02) / 0.09 (< 0.01) / -3
28 / purN / Phosphoribosylglycinamide formyltransferase / 0.62 (< 0.01) / 0.23 (0.04) / -3
1367 / - / hypothetical protein / 1.80 (0.12) / 0.66 (0.12) / -3
2041 / - / hypothetical protein / 0.26 (0.01) / 0.10 (0.01) / -3
986 / - / hypothetical protein / 0.06 (0.02) / 0.02 (< 0.01) / -3
2176 / - / hypothetical protein / 0.31 (0.02) / 0.11 (0.02) / -3
977 / - / hypothetical protein / 0.18 (< 0.01) / 0.06 (< 0.01) / -3
370 / - / hypothetical protein / 2.41 (0.01) / 0.86 (0.19) / -3
1914 / salB, clyM / putative salivaricin A modification enzyme; amino acid dehydration / 0.29 (0.02) / 0.10 (< 0.01) / -3
912 / bdrA8 / hypothetical protein / 3.00 (1.00) / 1.05 (0.16) / -3
946 / - / putative P1-type antirepressor - phage associated / 0.21 (0.12) / 0.07 (0.02) / -3
24 / purC / putative phosphoribosylaminoimidazole - succinocarboxamide synthase (SAICAR synthetase) / 0.80 (0.03) / 0.27 (0.02) / -3
1093 / - / putative D,D-carboxypeptidase, penicillin-binding protein / 1.35 (0.17) / 0.46 (0.02) / -3
317 / - / hypothetical protein / 4.06 (0.44) / 1.38 (0.03) / -3
996 / - / hypothetical protein / 0.47 (0.06) / 0.16 (< 0.01) / -3
238 / - / hypothetical protein / 1.88 (0.03) / 0.63 (0.03) / -3
371 / - / putative rRNA methylase / 2.89 (0.42) / 0.92 (0.05) / -3
1404 / - / hypothetical protein / 0.10 (0.02) / 0.03 (< 0.01) / -3
1912 / salX / putative salivaricin A ABC transporter (ATP-binding protein) / 0.25 (0.05) / 0.08 (0.02) / -3
1277 / - / hypothetical protein / 5.67 (1.78) / 1.71 (0.05) / -3
1276 / - / putative amino acid ABC transporter (permease protein) / 5.12 (1.32) / 1.53 (0.10) / -3
1994 / pai1 / pai1 protein (theoretical repressor) / 1.58 (0.03) / 0.47 (0.03) / -3
1315 / - / hypothetical protein / 5.37 (1.42) / 1.56 (0.17) / -3
999 / - / hypothetical protein / 1.30 (0.25) / 0.38 (0.03) / -3
1274 / - / putative amino acid ABC transporter, periplasmic amino acid-binding protein / 5.10 (1.43) / 1.45 (0.03) / -4
1427 / - / putative transcriptional regulator / 6.66 (0.95) / 1.87 (0.04) / -4
835 / carB / putative carbamoylphosphate synthetase / 5.88 (1.52) / 1.63 (0.19) / -4
1366 / - / hypothetical protein / 1.03 (0.07) / 0.28 (< 0.01) / -4
1316 / - / putative ABC transporter (ATP-binding protein) / 4.75 (0.19) / 1.29 (0.43) / -4
833 / carA / putative carbamoyl phosphate synthetase small subunit / 6.18 (1.67) / 1.67 (0.02) / -4
832 / pyrB / aspartate carbamoyltransferase catalytic chain / 7.69 (1.94) / 2.02 (0.30) / -4
916 / - / hypothetical protein / 1.35 (0.07) / 0.35 (0.02) / -4
1923 / lacA.2 / galactosidase acetyltransferase / 1.83 (0.16) / 0.47 (< 0.01) / -4
1399 / nagB / putative N-acetylglucosamine-6-phosphate isomerase / 1.24 (0.08) / 0.32 (0.02) / -4
1135 / - / putative GMP reductase / 1.05 (0.07) / 0.27 (< 0.01) / -4
608 / ppc / putative phosphoenolpyruvate carboxylase / 2.95 (0.37) / 0.75 (0.17) / -4
972 / - / putative terminase, large subunit - phage associated / 0.20 (0.03) / 0.05 (0.01) / -4
1922 / lacB.2 / putative galactose-6-phosphate isomerase (B subunit) / 1.48 (0.19) / 0.37 (0.03) / -4
994 / - / putative minor tail protein - phage associated / 0.68 (0.04) / 0.17 (0.05) / -4
830 / pyrR / pyrimidine operon attenuation protein / uracil phosphoribosyltransferase / 5.50 (0.96) / 1.33 (0.32) / -4
1163 / smf / putative DNA processing protein (Smf family) / 0.35 (< 0.01) / 0.08 (< 0.01) / -4
982 / - / putative structural protein - phage associated / 0.42 (0.16) / 0.09 (< 0.01) / -4
981 / - / hypothetical protein / 1.02 (0.12) / 0.23 (0.01) / -4
831 / pyrP / putative uracil permease / 6.68 (1.78) / 1.49 (0.34) / -4
901 / pyrE / putative orotate phosphoribosyltransferase / 4.11 (0.45) / 0.91 (0.04) / -5
228 / - / hypothetical protein / 1.87 (< 0.01) / 0.41 (0.06) / -5
707 / - / putative holin, phage associated / 1.02 (0.03) / 0.22 (0.04) / -5
998 / - / hypothetical protein / 0.55 (0.04) / 0.11 (0.05) / -5
917 / - / hypothetical protein / 0.93 (0.02) / 0.18 (0.06) / -5
1736 / - / hypothetical protein / 3.57 (0.71) / 0.69 (0.06) / -5
1507 / - / putative amino acid ABC transporter (permease protein) / 2.69 (0.43) / 0.51 (0.04) / -5
1414 / kup / putative cation (K+) transport protein / 1.41 (< 0.01) / 0.26 (0.05) / -5
324 / - / putative sodium dicarboxylate symporter / 2.35 (0.71) / 0.43 (0.04) / -6
1506 / - / putative amino acid ABC transporter (ATP-binding protein) / 2.29 (0.17) / 0.41 (0.07) / -6
943 / - / hypothetical protein / 0.99 (0.12) / 0.17 (< 0.01) / -6
706 / - / hypothetical protein / 0.97 (< 0.01) / 0.17 (< 0.01) / -6
1340 / - / hypothetical protein / 2.00 (0.38) / 0.33 (< 0.01) / -6
900 / pyrF / putative orotidine-5 -decarboxylase PyrF / 3.60 (0.51) / 0.57 (0.13) / -6
1618 / cysM / putative O-acetylserine lyase / 6.19 (0.98) / 0.93 (< 0.01) / -7
1205 / - / putative antimicrobial resistance factor / 2.84 (0.04) / 0.42 (0.02) / -7
993 / - / hypothetical protein / 0.70 (0.06) / 0.10 (< 0.01) / -7
227 / - / hypothetical protein / 1.27 (0.20) / 0.18 (0.04) / -7
991 / - / putative structural protein - phage associated / 0.56 (0.12) / 0.08 (< 0.01) / -7
1357 / graB / protein GRAB (protein G-related alpha 2M-binding protein) / 7.69 (1.64) / 0.99 (0.20) / -8
995 / - / hypothetical protein / 0.29 (< 0.01) / 0.04 (0.02) / -8
323 / braB / putative branched-chain amino acid transport protein / 3.01 (0.78) / 0.31 (< 0.01) / -10
216 / - / putative regulatory protein - RofA related / 3.86 (0.43) / 0.37 (< 0.01) / -10
2040 / - / SpeB maturation protein / 1.41 (0.27) / 0.10 (0.01) / -14
2037 / - / peptidylprolyl isomerase / 7.13 (1.07) / 0.50 (0.02) / -14
1270 / - / putative amino acid symporter / 2.20 (0.21) / 0.14 (0.01) / -16
1137 / - / putative purine permease / 1.96 (0.08) / 0.12 (< 0.01) / -16
1136 / xpt / putative xanthine phosphoribosyltransferase / 2.93 (0.10) / 0.17 (< 0.01) / -17
2039 / speB / pyrogenic exotoxin B / 6.07 (0.94) / 0.17 (0.02) / -35
1856 / norA / putative antibiotic resistance protein NorA / 4.52 (0.25) / 0.08 (< 0.01) / -57
a SPy numbers are based on the SF370 S. pyogenes genome annotation (9).
b The results are the mean and (standard error of the mean) from two independent experiments.
c Positive and negative numbers indicate the transcript is more or less abundant, respectively in the rgg mutant strain.
Table S2. Rgg-associated changes in transcripts levels during exponential growth (2-fold or greater)
SPy no.a / Gene / Description / wt mean(sem)b / rgg
mean (sem) / Fold Change rgg-/wtc
1983 / sclA / collagen-like surface protein / 0.03 (0.02) / 1.84 (1.23) / 59
2191 / - / hypothetical protein / 0.24 (0.02) / 4.45 (0.12) / 18
170 / - / hypothetical protein / 0.28 (0.01) / 4.47 (4.14) / 16
1060 / - / putative phosphotransferase system (PTS), enzyme II component D / 0.22 (0.04) / 3.27 (0.53) / 15
165 / nga / nicotine adenine dinucleotide glycohydrolase precursor / 0.07 (0.04) / 0.98 (0.23) / 14
843 / - / hypothetical protein / 0.37 (0.02) / 4.65 (0.33) / 13
1057 / - / hypothetical protein / 0.76 (0.04) / 9.55 (1.57) / 13
937 / int3 / putative integrase - phage associated / 0.12 (0.02) / 1.36 (0.38) / 11
2083 / - / putative formiminotransferase cyclodeaminase / 0.08 (0.02) / 0.82 (0.22) / 11
1059 / - / putative phosphotransferase system (PTS), enzyme II, component C / 0.52 (0.09) / 5.40 (1.15) / 10
1562 / - / hypothetical protein / 0.39 (0.05) / 3.78 (0.26) / 10
1563 / - / hypothetical protein / 0.58 (0.02) / 5.10 (0.43) / 9
2081 / hutI / putative imidazolonepropionase / 0.10 (0.09) / 0.89 (0.11) / 9
1058 / - / putative phosphotransferase system (PTS), enzyme II component B / 0.85 (0.15) / 7.06 (1.23) / 8
305 / - / hypothetical protein / 0.72 (0.13) / 5.53 (0.19) / 8
844 / - / hypothetical protein / 0.66 (0.07) / 4.77 (0.05) / 7
1567 / - / hypothetical protein / 0.31 (< 0.01) / 2.23 (0.45) / 7
166 / - / hypothetical protein / 0.35 (0.02) / 2.43 (0.94) / 7
2010 / scpA / C5A peptidase precursor / 0.42 (0.04) / 2.90 (1.36) / 7
1566 / - / hypothetical protein / 0.36 (0.03) / 2.44 (0.22) / 7
1202 / - / putative transcription regulator, GntR family / 0.64 (0.06) / 4.26 (0.62) / 7
1565 / - / hypothetical protein / 0.69 (0.07) / 4.49 (0.35) / 7
1391 / - / putative methyltransferase / 0.40 (0.04) / 2.57 (0.58) / 6
2087 / - / hypothetical protein / 0.17 (< 0.01) / 1.08 (0.22) / 6
307 / - / hypothetical protein / 1.02 (0.12) / 6.26 (0.05) / 6
306 / - / hypothetical protein / 0.76 (0.10) / 4.65 (0.04) / 6
1046 / - / hypothetical protein / 0.24 (0.02) / 1.46 (0.04) / 6
1436 / mf-3 / deoxyribonuclease / 2.89 (0.52) / 17.05 (1.28) / 6
469 / - / putative 42 kDa protein / 1.11 (0.28) / 6.43 (1.46) / 6
1629 / priA / putative primosomal replication factor Y / 0.50 (0.03) / 2.75 (0.23) / 5
123 / - / putative heat shock protein HSP33 / 1.64 (< 0.01) / 8.85 (0.56) / 5
1437 / - / hypothetical protein / 0.56 (< 0.01) / 2.95 (0.03) / 5
831 / pyrP / putative uracil permease / 1.88 (0.51) / 9.87 (1.92) / 5
733 / - / hypothetical protein / 1.10 (0.02) / 5.52 (0.20) / 5
870 / fms / putative polypeptide deformylase / 0.26 (0.01) / 1.29 (0.10) / 5
2084 / - / putative serine cycle enzyme / 0.18 (< 0.01) / 0.91 (0.21) / 5
392 / upp / putative uracil phosphoribosyltransferase / 1.26 (0.20) / 6.27 (0.15) / 5
726 / - / hypothetical protein / 1.46 (0.39) / 7.15 (0.72) / 5
1564 / - / hypothetical protein / 0.88 (0.21) / 4.25 (0.09) / 5
833 / carA / putative carbamoyl phosphate synthetase small subunit / 1.87 (057) / 8.96 (1.67) / 5
846 / - / hypothetical protein / 0.31 (0.05) / 1.47 (0.15) / 5
1233 / coaA / putative pantothenate kinase / 0.18 (< 0.01) / 0.86 (0.11) / 5
1507 / - / putative amino acid ABC transporter (permease protein) / 0.24 (< 0.01) / 1.11 (0.29) / 5
1114 / - / hypothetical protein / 0.37 (< 0.01) / 1.65 (0.14) / 4
1203 / - / hypothetical protein / 0.25 (0.02) / 1.09 (0.10) / 4
2009 / - / hypothetical protein / 0.49 (0.11) / 2.17 (1.22) / 4
1979 / ska / streptokinase A precursor / 0.68 (0.10) / 2.90 (0.89) / 4
2066 / - / putative dipeptidase / 2.10 (0.30) / 8.91 (1.08) / 4
2085 / fhs.2 / putative formate-tetrahydrofolate ligase / 0.28 (0.11) / 1.17 (0.40) / 4
246 / rnpA / putative ribonuclease P protein component / 1.52 (0.41) / 6.31 (0.05) / 4
426 / nrdI / putative ribonucleotide reductase / 0.45 (< 0.01) / 1.87 (0.27) / 4
732 / - / hypothetical protein / 0.63 (0.06) / 2.59 (< 0.01) / 4
167 / slo / streptolysin O precursor / 0.30 (< 0.01) / 1.19 (0.51) / 4
393 / - / hypothetical protein / 1.65 (0.20) / 6.35 (0.24) / 4
830 / pyrR / putative pyrimidine regulatory protein / 2.37 (0.70) / 9.08 (1.57) / 4
1220 / - / hypothetical protein / 0.65 (0.11) / 2.42 (0.27) / 4
2082 / hutU / putative urocanate hydratase / 0.36 (0.10) / 1.34 (0.38) / 4
1047 / - / hypothetical protein / 0.42 (0.01) / 1.55 (0.18) / 4
540 / - / hypothetical protein / 0.33 (0.08) / 1.22 (0.19) / 4
308 / - / hypothetical protein / 1.40 (0.13) / 5.07 (< 0.01) / 4
832 / pyrB / putative aspartate transcarbamoylase / 3.45 (0.88) / 12.43 (2.41) / 4
1276 / - / putative amino acid ABC transporter (permease protein) / 1.56 (0.33) / 5.57 (2.40) / 4
1085 / srtF / ABC transporter (ATP-binding) - lantibiotic associated / 0.01 (< 0.01) / 0.04 (< 0.01) / 4
1254 / - / hypothetical protein / 0.49 (0.07) / 1.72 (0.14) / 4
1422 / recR / putative recombination protein / 0.92 (0.12) / 3.19 (0.47) / 3
1036 / - / hypothetical protein / 1.36 (0.04) / 4.69 (0.15) / 3
2088 / - / putative cationic amino acid transporter protein / 0.16 (< 0.01) / 0.55 (0.12) / 3
1506 / - / putative amino acid ABC transporter (ATP-binding protein) / 0.21 (0.03) / 0.73 (0.22) / 3
1201 / ylxM / putative DNA-binding protein / 1.67 (0.31) / 5.63 (0.65) / 3
1068 / uvrC / excinuclease ABC (subunit C) / 1.78 (0.13) / 5.88 (0.29) / 3
168 / - / hypothetical protein / 0.01 (< 0.01) / 0.04 (< 0.01) / 3
84 / - / hypothetical protein / 0.90 (0.23) / 2.91 (0.19) / 3
258 / - / putative glucose kinase / 0.29 (0.05) / 0.95 (0.16) / 3
1049 / - / hypothetical protein / 0.37 (0.05) / 1.20 (0.02) / 3
2042 / rgg / transcription regulator / 1.22 (0.13) / 3.86 (0.37) / 3
510 / yfhN / putative sugar transferase / 0.31 (0.13) / 0.97 (0.05) / 3
1071 / thdF / putative thiophene degradation protein F / 0.55 (0.05) / 1.76 (0.14) / 3
1741 / - / hypothetical protein / 0.67 (0.04) / 2.11 (0.16) / 3
1140 / tdk2 / putative thymidine kinase / 1.32 (0.36) / 4.17 (0.31) / 3
1067 / gabD / putative succinic semialdehyde dehydrogenase / 1.46 (0.11) / 4.54 (0.41) / 3
122 / - / possible transcriptional regulator / 2.81 (0.21) / 8.69 (0.03) / 3
1152 / gyrA / DNA gyrase A subunit / 3.20 (0.08) / 9.87 (0.74) / 3
847 / - / putative 16S rRNA processing protein / 0.62 (0.10) / 1.89 (< 0.01) / 3
1277 / - / hypothetical protein / 1.67 (0.11) / 5.08 (2.30) / 3
21 / - / hypothetical protein / 1.10 (0.18) / 3.34 (0.04) / 3
835 / carB / putative carbamoylphosphate synthetase / 2.66 (0.31) / 8.00 (1.59) / 3
247 / - / hypothetical protein / 2.07 (0.71) / 6.24 (0.12) / 3
729 / yueI / hypothetical protein / 0.34 (0.01) / 1.01 (0.01) / 3
1699 / - / putative transcription regulator / 0.20 (0.03) / 0.61 (0.06) / 3
338 / - / hypothetical protein / 1.41 (0.28) / 4.16 (0.22) / 3
1505 / phr / putative deoxyribodipyrimidine photolyase / 0.38 (< 0.01) / 1.11 (0.02) / 3
1432 / pyrD / putative dihydroorotate dehydrogenase / 0.33 (0.03) / 0.96 (0.06) / 3
745 / sagH / ABC transporter (ATP-binding protein) - streptolysin S associated ORF / 3.60 (0.27) / 10.38 (0.79) / 3
425 / nrdF.1 / putative ribonucleotide reductase 2 / 0.40 (0.04) / 1.14 (0.20) / 3
1561 / - / hypothetical protein / 0.47 (0.03) / 1.35 (0.02) / 3
1904 / hsdR / putative type I site-specific deoxyribonuclease / 1.45 (0.14) / 4.11 (0.13) / 3
1125 / - / putative GTP pyrophosphokinase / 2.76 (0.80) / 7.76 (1.02) / 3
2162 / cadD / putative cadmium resistance protein / 0.38 (0.02) / 1.05 (0.13) / 3
1094 / - / hypothetical protein / 1.40 (0.05) / 3.90 (0.21) / 3
600 / - / hypothetical protein / 0.87 (0.21) / 2.42 (0.28) / 3
169 / - / hypothetical protein / 0.09 (0.08) / 0.26 (0.07) / 3
1508 / - / hypothetical protein / 1.92 (0.06) / 5.31 (0.43) / 3
1297 / - / putative transcription regulator (LacI family) / 0.04 (0.01) / 0.12 (0.02) / 3
329 / gidB / putative glucose-inhibited division protein / 0.41 (< 0.01) / 1.10 (0.10) / 3
743 / - / hypothetical protein / 3.86 (0.43) / 10.49 (0.91) / 3
808 / - / hypothetical protein / 3.19 (0.54) / 8.59 (1.23) / 3
738 / sagA / streptolysin S associated protein / 5.52 (0.72) / 14.85 (0.41) / 3
466 / msrA.2 / putative peptide methionine sulfoxide reductase / 0.87 (0.03) / 2.33 (< 0.01) / 3
568 / - / hypothetical protein / 2.47 (0.12) / 6.63 (0.30) / 3
44 / adhA / putative alcohol dehydrogenase I / 5.42 (0.24) / 14.54 (1.42) / 3
472 / - / hypothetical protein / 1.19 (0.31) / 3.17 (0.10) / 3
685 / - / hypothetical protein / 0.02 (< 0.01) / 0.06 (< 0.01) / 3
742 / - / hypothetical protein / 3.98 (0.20) / 10.58 (0.97) / 3
567 / - / hypothetical protein / 1.92 (0.23) / 5.10 (0.08) / 3
1498 / fps / putative geranyltranstransferase (farnesyl diphosphate synthase) / 2.77 (0.18) / 7.34 (0.36) / 3
746 / - / putative ABC transporter (ATP-binding protein) / 2.42 (0.10) / 6.40 (0.24) / 3
744 / - / putative ABC transporter (ATP-binding protein) / 4.07 (0.03) / 10.76 (0.58) / 3
741 / - / hypothetical protein / 4.70 (0.49) / 12.31 (0.56) / 3
1219 / - / putative trimethylamine dehydrogenase / 0.74 (0.02) / 1.94 (0.25) / 3
2196 / pgsA / phosphatidylglycerophosphate synthase / 0.95 (0.13) / 2.48 (0.05) / 3
1218 / - / hypothetical protein / 1.41 (0.06) / 3.67 (0.52) / 3
1275 / - / putative amino acid ABC transporter (ATP-binding protein) / 1.69 (0.14) / 4.37 (1.70) / 3
2197 / - / hypothetical protein / 1.17 (0.05) / 3.02 (0.16) / 3
108 / ythI / hypothetical protein / 1.15 (0.03) / 2.98 (0.14) / 3
1048 / - / hypothetical protein / 0.71 (0.05) / 1.84 (0.18) / 3
1213 / fhs.1 / putative formate-tetrahydrofolate ligase / 1.02 (0.11) / 2.62 (0.32) / 3
508 / - / hypothetical protein / 0.90 (0.07) / 2.32 (0.43) / 3
117 / - / hypothetical protein / 1.00 (0.26) / 2.56 (0.15) / 3
2163 / cadC / putative cadmium efflux system accessory / 0.15 (0.05) / 0.38 (0.03) / 3
2060 / - / hypothetical protein / 3.14 (1.05) / 7.98 (0.58) / 3
1502 / folD / putative bifunctional methylenetetrahydrofolate dehydrogenase methenyltetrahydrofolate cyclohydrolase / 0.30 (0.01) / 0.74 (0.04) / 3
739 / sagB / streptolysin S associated ORF / 5.56 (0.57) / 13.92 (1.36) / 3
1499 / xseB / exodeoxyribonuclease VII (small subunit) / 3.82 (0.13) / 9.54 (0.69) / 3
1061 / - / putative two-component sensor histidine kinase / 0.58 (0.06) / 1.44 (< 0.01) / 2
849 / trmD / putative tRNA (guanine-N1)-methyltransferase / 0.87 (0.09) / 2.17 (0.17) / 2
312 / - / hypothetical protein / 0.41 (0.10) / 1.01 (0.21) / 2
- / hypothetical protein / 1.26 (0.17) / 3.10 (0.28) / 2
294 / oppB / oligopeptidepermease / 3.13 (0.32) / 7.65 (2.56) / 2
1849 / pfl / putative pyruvate formate-lyase / 4.79 (0.62) / 11.65 (1.23) / 2
786 / rgpA / conserved hypothetical protein / 2.30 (0.36) / 5.59 (0.49) / 2
296 / oppD / oligopeptidepermease (ATP-binding protein) / 3.27 (0.34) / 7.92 (2.67) / 2
1815 / scrA / putative sucrose-specific PTS permease, enzyme II / 1.36 (0.24) / 3.30 (0.36) / 2
1124 / - / hypothetical protein / 0.41 (< 0.01) / 1.00 (0.10) / 2
121 / - / putative deoxyguanosine kinase deoxyadenosine kinase(I) subunit / 2.15 (0.52) / 5.18 (0.06) / 2
1500 / xseA / putative exodeoxyribonuclease VII (large subunit) / 2.68 (0.31) / 6.44 (0.40) / 2
414 / lctO / putative lactate oxidase / 0.24 (0.05) / 0.57 (0.20) / 2
309 / - / hypothetical protein / 0.60 (0.06) / 1.43 (0.08) / 2
203 / tgt / putative tRNA-guanine transglycosylase / 2.54 (0.19) / 5.98 (0.12) / 2
1421 / ddlA / putative D-ala,D-ala ligase / 0.78 (0.07) / 1.84 (0.13) / 2
1621 / - / putative two-component response regulator / 1.73 (0.09) / 4.06 (0.13) / 2
1530 / - / hypothetical protein / 2.57 (0.49) / 6.02 (0.39) / 2
1001 / - / hypothetical protein / 0.04 (0.03) / 0.09 (< 0.01) / 2
771 / - / hypothetical protein / 0.83 (0.05) / 1.93 (0.02) / 2
1695 / - / hypothetical protein / 0.83 (0.03) / 1.92 (0.28) / 2
1886 / asp / putative alkaline-shock protein / 7.10 (0.36) / 16.37 (0.41) / 2
809 / aroD / putative 3-dehydroquinate dehydratase / 4.28 (0.35) / 9.87 (1.08) / 2
1290 / - / hypothetical protein / 1.05 (0.22) / 2.41 (0.13) / 2
314 / - / hypothetical protein / 0.42 (0.03) / 0.97 (0.24) / 2
1588 / - / putative two-component sensor histidine kinase / 0.48 (0.02) / 1.10 (0.12) / 2
2135 / - / putative replication protein / 0.10 (< 0.01) / 0.22 (0.03) / 2
2144 / - / hypothetical protein / 0.07 (0.01) / 0.16 (< 0.01) / 2
1874 / - / putative glycoprotein endopeptidase / 3.69 (0.47) / 8.38 (< 0.01) / 2
2195 / - / ABC transporter (ATP-binding protein) / 1.16 (0.14) / 2.63 (0.17) / 2
798 / - / hypothetical protein / 1.16 (0.22) / 2.64 (0.28) / 2
1735 / - / hypothetical protein / 0.82 (0.14) / 1.86 (0.24) / 2
1653 / - / putative nicotinate phosphoribosyltransferase / 1.53 (0.01) / 3.46 (0.05) / 2
433 / - / hypothetical protein / 0.01 (< 0.01) / 0.03 (< 0.01) / 2
1734 / - / hypothetical protein / 1.13 (0.33) / 2.54 (0.40) / 2
1217 / - / putative glycine cleavage system H protein / 1.76 (0.09) / 3.97 (0.21) / 2
427 / nrdE.1 / ribonucleoside-diphosphate reductase, large chain / 0.62 (0.10) / 1.39 (0.06) / 2
1534 / yutD / hypothetical protein / 2.38 (0.01) / 5.33 (0.07) / 2
471 / phoH / phosphate starvation-induced protein / 1.03 (0.14) / 2.32 (0.05) / 2
533 / - / putative positive regulator / 0.66 (0.09) / 1.47 (< 0.01) / 2
2089 / hutH / putative histidine ammonia-lyase / 0.44 (0.11) / 0.99 (0.22) / 2
1126 / - / hypothetical protein / 1.95 (0.45) / 4.33 (0.41) / 2
793 / - / hypothetical protein / 2.07 (0.15) / 4.60 (0.05) / 2
770 / - / hypothetical protein / 1.07 (0.05) / 2.37 (0.08) / 2
1622 / - / putative two-component sensor histidine kinase / 1.12 (0.08) / 2.48 (0.11) / 2
366 / - / hypothetical protein / 3.24 (0.29) / 7.17 (0.03) / 2
1253 / - / hypothetical protein / 0.89 (0.08) / 1.97 (0.28) / 2
1875 / - / hypothetical protein / 7.18 (0.17) / 15.87 (0.67) / 2
467 / yozE / hypothetical protein / 0.82 (0.09) / 1.81 (0.04) / 2
617 / - / hypothetical protein / 4.18 (0.04) / 9.18 (0.35) / 2
295 / oppC / oligopeptidepermease / 4.1 (0.09) / 8.99 (3.24) / 2
1340 / - / hypothetical protein / 0.50 (0.02) / 1.09 (0.20) / 2
365 / - / hypothetical protein (possible integrase recombinase) / 4.30 (0.23) / 9.40 (0.69) / 2
810 / aroF / putative chorismate synthase / 3.72 (0.54) / 8.10 (0.19) / 2
1411 / - / hypothetical protein / 0.74 (0.09) / 1.61 (0.31) / 2
542 / - / putative nucleotide sugar dehydrogenase / 0.34 (0.04) / 0.73 (0.03) / 2
1399 / nagB / putative N-acetylglucosamine-6-phosphate isomerase / 3.13 (1.02) / 6.75 (2.69) / 2
1247 / - / putative myo-inositol-1(or 4)-monophosphatase / 2.61 (0.11) / 5.62 (0.17) / 2
796 / - / hypothetical protein / 3.06 (0.16) / 6.60 (0.27) / 2
259 / - / hypothetical protein / 0.74 (0.11) / 1.59 (0.08) / 2
364 / - / hypothetical protein / 5.05 (0.36) / 10.86 (0.56) / 2
1587 / - / putative two-component sensor response regulator / 0.62 (0.07) / 1.33 (0.08) / 2
1589 / - / hypothetical protein / 0.23 (< 0.01) / 0.50 (0.07) / 2
1497 / hlyA1 / putative hemolysin / 4.26 (0.48) / 9.10 (0.62) / 2
148 / ntpI / V-type Na+ -ATPase subunit I / 0.06 (< 0.01) / 0.13 (< 0.01) / 2
650 / aspC / putative aspartate aminotransferase / 2.09 (0.03) / 4.43 (0.51) / 2
1113 / - / putative acid phosphatase (class B) / 4.18 (1.07) / 8.86 (0.20) / 2
1210 / - / hypothetical protein / 0.59 (0.03) / 1.25 (0.11) / 2
797 / - / hypothetical protein / 3.06 (0.07) / 6.47 (0.54) / 2
740 / sagC / streptolysin S associated ORF / 6.40 (0.34) / 13.55 (1.42) / 2
1586 / - / putative beta-galactosidase / 0.50 (0.05) / 1.06 (0.10) / 2
872 / - / putative secreted 5 -nucleotidase / 0.46 (< 0.01) / 0.98 (0.36) / 2
1419 / - / hypothetical protein / 0.54 (0.04) / 1.14 (0.03) / 2
1535 / - / putative ribose transport operon repressor / 1.17 (0.08) / 2.44 (0.13) / 2
616 / murM / putative peptidoglycan branched peptide synthesis protein, serine alanine adding enzyme / 1.88 (0.02) / 3.90 (0.11) / 2
1062 / - / putative two-component response regulator / 0.81 (< 0.01) / 1.67 (0.15) / 2
1647 / - / hypothetical protein / 0.65 (0.12) / 1.35 (0.15) / 2
256 / - / hypothetical protein / 0.49 (0.02) / 1.01 (0.06) / 2
252 / - / putative sugar transporter sugar binding lipoprotein / 0.81 (0.02) / 1.67 (0.15) / 2
475 / dgk / putative diacylglycerol kinase / 2.80 (0.18) / 5.78 (0.18) / 2
1398 / - / putative 16S pseudouridylate synthetase / 2.85 (0.38) / 5.86 (2.13) / 2
37 / - / hypothetical protein / 0.77 (0.12) / 1.59 (0.23) / 2
1965 / uppS / putative undecaprenyl pyrophosphate synthetase / 3.50 (0.85) / 7.16 (0.56) / 2
1221 / dpfB / putative flavoprotein / 1.65 (0.31) / 3.37 (0.22) / 2
864 / - / hypothetical protein / 6.65 (0.73) / 13.59 (0.52) / 2
1066 / - / hypothetical protein / 0.02 (< 0.01) / 0.05 (0.01) / 2
337 / csrS / putative sensory transduction histidine kinase / 2.02 (0.08) / 4.09 (0.49) / 2
251 / - / putative N-acetylmannosamine-6-P epimerase / 0.36 (0.01) / 0.73 (0.08) / 2
1155 / - / hypothetical protein / 0.43 (0.02) / 0.88 (0.09) / 2
310 / - / hypothetical protein / 0.76 (0.05) / 1.53 (0.11) / 2
2151 / argS / putative arginyl-tRNA synthetase / 4.09 (< 0.01) / 8.22 (0.15) / 2
2136 / - / putative DNA primase - phage associated / 0.06 (0.02) / 0.11 (< 0.01) / 2
727 / gyrB / putative DNA gyrase, subunit B / 3.81 (0.18) / 7.65 (0.01) / 2
255 / - / probable sugar transport protein (permease) / 0.26 (0.03) / 0.52 (0.13) / 2
1063 / bitA / putative periplasmic-iron-binding protein / 0.13 (0.04) / 0.06 (0.04) / -2
2169 / - / hypothetical protein / 2.52 (0.06) / 1.26 (0.06) / -2
6 / - / putative GTP-binding protein / 12.35 (0.49) / 6.18 (0.27) / -2
910 / parC / putative DNA topoisomerase IV (subunit C) / 2.81 (0.23) / 1.41 (0.10) / -2
590 / - / putative protease / 4.03 (0.31) / 2.01 (0.11) / -2
1148 / - / putative ABC transporter (ATP-binding protein) / 3.46 (0.91) / 1.72 (0.13) / -2
276 / - / putative amino acid ABC transporter (ATP-binding protein) / 2.52 (0.30) / 1.25 (0.06) / -2
2202 / hasC / UDP-glucose pyrophosphorylase / 0.44 (0.04) / 0.22 (0.01) / -2
61 / - / 50S ribosomal protein L14 / 24.09 (2.94) / 11.90 (0.59) / -2
173 / leuS / putative leucyl-tRNA synthetase / 3.02 (0.17) / 1.49 (0.03) / -2
2133 / - / hypothetical protein / 0.11 (< 0.01) / 0.06 (0.02) / -2
749 / - / hypothetical protein / 4.03 (0.75) / 1.98 (0.37) / -2
1627 / sunL / putative RNA-binding Sun protein / 11.76 (0.29) / 5.79 (0.43) / -2
1689 / glyQ / putative glycyl-tRNA synthetase (alpha subunit) / 4.88 (1.03) / 2.40 (< 0.01) / -2
1170 / ddh / putative D-specific D-2-hydroxyacid dehydrogenase / 0.25 (0.03) / 0.12 (0.02) / -2
724 / rplS / 50S ribosomal protein L19 / 3.99 (0.32) / 1.96 (0.12) / -2
242 / - / putative histidine kinase, possibly involved in competence / 1.46 (0.08) / 0.71 (0.06) / -2
1106 / - / putative two-component response regulator / 0.95 (0.03) / 0.47 (0.07) / -2
817 / thiI / putative thiamine biosynthesis protein / 4.42 (0.14) / 2.17 (0.32) / -2
1513 / ileS / putative isoleucyl-tRNA synthetase / 3.57 (0.54) / 1.74 (< 0.01) / -2
- / hypothetical protein / 8.04 (0.63) / 3.93 (0.08) / -2
1940 / - / hypothetical protein / 0.74 (0.02) / 0.36 (0.03) / -2
- / hypothetical protein / 1.05 (0.27) / 0.51 (0.01) / -2
1683 / glpO / putative alpha-glycerophosphate oxidase / 1.51 (0.13) / 0.74 (0.23) / -2
64 / rpsN / 30S ribosomal protein S14 / 25.73 (3.16) / 12.51 (0.02) / -2
72 / rplO / 50S ribosomal protein L15 / 18.60 (1.47) / 9.04 (0.38) / -2
1927 / - / hypothetical protein / 1.74 (0.18) / 0.84 (0.08) / -2
1087 / srtG / conserved hypothetical protein - lantibiotics associated / 0.06 (0.04) / 0.03 (< 0.01) / -2
804 / infC / putative translation initiation factor 3 (IF3) / 25.78 (0.33) / 12.43 (0.55) / -2
2184 / yybT / hypothetical protein / 11.96 (1.67) / 5.75 (0.30) / -2
926 / recJ / putative single-strand DNA-specific exonuclease / 2.48 (< 0.01) / 1.19 (0.06) / -2
383 / fhuG / putative ferrichrome ABC transporter (permease) / 0.32 (0.07) / 0.15 (0.03) / -2
69 / rpsE / 30S ribosomal protein S5 / 14.62 (1.60) / 7.00 (0.19) / -2
1771 / gatA / putative glutamyl-tRNA gln amidotransferase subunit A / 9.27 (0.28) / 4.44 (0.70) / -2
639 / kgdA / putative 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase / 0.25 (0.04) / 0.12 (0.02) / -2
62 / rplX / 50S ribosomal protein L24 / 27.88 (2.20) / 13.34 (0.50) / -2
49 / rplC / 50S ribosomal protein L3 / 21.27 (3.36) / 10.15 (0.73) / -2
898 / cpsY / putative transcriptional regulator / 3.87 (0.78) / 1.85 (0.02) / -2
32 / purD / phosphoribosylamine-glycine ligase / 0.69 (0.03) / 0.33 (0.08) / -2
1604 / - / hypothetical protein / 2.49 (0.16) / 1.18 (0.26) / -2
1835 / trx / putative thioredoxin / 27.00 (0.40) / 12.83 (0.26) / -2
588 / - / hypothetical protein / 21.35 (0.10) / 10.07 (0.78) / -2
815 / - / hypothetical protein / 8.44 (0.33) / 3.97 (0.09) / -2
1710 / - / putative PTS system, enzyme IIB component / 1.61 (0.06) / 0.76 (0.04) / -2
1816 / scrB / putative sucrose-6-phosphate hydrolase / 4.34 (0.05) / 2.04 (0.13) / -2