UNIVERSITY OF MACAU
FACULTY OF SCIENCE AND TECHNOLOGY
DEPARTMENT of ELECTRICAL AND ELECTRONICS ENGINEERING
Ref: FST/SEM/037/2010
“Nonlinear Optical Microscopic Techniques For Label-free Biological Imaging”
by
Dr. Tim C. Lei
Departments of Electrical Engineering, Bioengineering, Physiology and Medicine, University of Colorado Denver, USA
Date : 10/6/2010 (THURSDAY)
Time : 11:00AM – 12:30PM
Venue : HG01
Abstract
The advance in confocal fluorescence microscopy, together with the developments of inorganic fluorescence dyes and fluorescence proteins, has tremendously been enhancing our ability to investigate biological systems from the system tissue level all the way down to the sub-cellular level. However, the major drawback of fluorescence microscopic technique is it requires the use of exogenous fluorophores or fluorescence proteins. Therefore, recent developments of using nonlinear optical techniques, such as Second Harmonic Generation (SHG), Two-Photo AutoFluorescence (TPAF), and Coherent Anti-Stokes Raman Scattering (CARS), to apply to microscopic uses have gain tremendous excitements due to the chemical specificity of these techniques without the needs of any exogenous fluorophores and therefore having the potential of optical imaging in human for disease diagnostics. In this talk, I will introduces some of these nonlinear optical techniques and discuss how these techniques can be applied to biomedical systems.
Biography
Dr. Lei is currently an assistant professor in the Electrical Engineering Department at the University of Colorado Denver, USA. Dr. Lei is an expert in ultrafast laser science and nonlinear optical spectroscopy. During his doctoral study, he has used femtosecond optical pulses to generate extreme ultraviolet pulses to study molecular dynamics on metal surfaces, with the goals of elucidating noble metal catalytic reactions at the molecular level. Recently, he has switched his research interests to use optical techniques to solve biomedical problems, including to develop new disease diagnostic techniques and to use optical microscopic techniques to study disease pathogenesis. To order to enhance synergistic efforts between engineering and medicine, he also has adjunct appointments in the departments of Bioengineering, Physiology, and Medicine at the University of Colorado Denver. In addition, he is the laboratory director of the Colorado Advanced Photonics Technology (CAPT) Laboratory for the College of Engineering and Applied Sciences of the University.
ALL ARE WELCOME!