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Editorially Revised 3-22-06

University Curriculum Committee

Course Proposal Form

for Courses Numbered 0001 – 4999

(Faculty Senate Resolution #04–18, April 2004)

Note: Before completing this form, please read the accompanying instructions carefully.

1. Course Prefix and Number: CLSC 4492 2. Date: 01/29/2007

3. Requested Action (check only one box):

X / New Course
Revision of Active Course
Revision & Unbanking of a Banked Course
Renumbering of an Existing Course
from / # / to / #

4. Justification for new course or course revision or renumbering:

The use of molecular diagnostic assays is becoming increasingly common in many clinical laboratories. As the molecular basis of more diseases is elucidated, these technologies are likely to continue to be methods utilized in clinical laboratories of the future. Therefore, it is important for CLS students become familiar with the genetic alterations of specific diseases and disorders as well as the methods and procedures for performing common molecular diagnostic tests. Additionally, our accrediting body, the National Accrediting Agency for Clinical Laboratory Sciences, specifically requires molecular diagnostics curriculum content to include practical application experiences performing common methodologies.

5. Course description exactly as it should appear in the next catalog:

4492. Molecular Diagnostics in Clinical Laboratory Science II (1) (S) 1 lecture hour per week for 7 weeks and 3 lab hours per week for 7 weeks. P: CLSC 4491, consent of instructor. Specific genetic alterations found in various diseases and disorders along with experience performing selected testing methodologies used for molecular diagnostics in the clinical laboratory.

6. If this is a course revision, briefly describe the requested change:

Not applicable.

7. Undergraduate Catalog Page Number from current undergraduate catalog:

169, 341

8. The Writing Across the Curriculum Committee must approve Writing Intensive

(WI) credit for all courses prior to their consideration by the UCC. If WI credit is

requested, has this course been approved for Writing Intensive (WI) credit?

Not applicable.

Yes No

If Yes, will all sections be Writing Intensive (yes/no)?

Yes No

9. Any course requesting Foundations Curriculum credit must be
reviewed by Academic Standards Committee prior to their consideration by
the UCC. If FC credit has been approved by the ASC, then check the
appropriate box (check at most one), otherwise leave all boxes blank.

English (EN) / Science (SC)
Humanities (HU) / Social Science (SO)
Fine Arts (FA) / Mathematics (MA)
Health (HL) / Exercise (EX)

10. Course Credit:

Lecture Hours / 1 / Weekly / OR / 7 / Per Term / Credit Hours / 1/2 / s.h.
Lab / 3 / Weekly / OR / 21 / Per Term / Credit Hours / 1/2 / s.h.
Studio / Weekly / OR / Per Term / Credit Hours / s.h.
Practicum / Weekly / OR / Per Term / Credit Hours / s.h.
Internship / Weekly / OR / Per Term / Credit Hours / s.h.
Other (e.g., independent study) Please explain.
Total Credit Hours / 1 / s.h.
16

11. Anticipated yearly student enrollment:

12. Affected Degrees or Academic Programs:

Degree(s)/Course(s) / Current
Catalog Page / Changes in Degree Hours
B.S. in Clinical Laboratory Science / 169, 341 / None

13. Overlap or Duplication with Affected Units or Programs:

X / Not Applicable
Applicable (notification and responses from affected units are attached)

14. Approval by the Council for Teacher Education (required for courses affecting

teacher education programs):

X / Not Applicable
Applicable (CTE has given its approval.)

15. Statements of Support: Already existing course. Resource needs are not affected by requested revision, therefore, this section is not applicable.

x / Current staff is adequate
Additional staff is needed (describe needs in the box below):
x / Current facilities are adequate
Additional facilities are needed (describe needs in the box below):
x / Initial library resources are adequate
Initial resources are needed (in the box below, give a brief explanation and an estimate for the cost of acquisition of required initial resources):
x / Unit computer resources are adequate
Additional unit computer resources are needed (in the box below, give a brief explanation and an estimate for the cost of acquisition):
x / ITCS resources are not needed
The following ITCS resources are needed (put a check beside each need):
Mainframe computer system
Statistical services
Network connections
Computer lab for students
Remember to forward email approval from the director of ITCS to UCC.

16. Syllabus – please insert course syllabus below. You must include (a) the

name of the textbook chosen for the course, (b) the course objectives, (c) the

course content outline, and (d) the course assignments and grading plan.

NOTE: This will be a required course in the senior year of the B.S. in Clinical Laboratory Science beginning with the professional phase (junior year) entry class admitted in Fall 2007. Therefore, the first offering of CLSC 4492 will be in Spring 2009.

CLSC 4492 Molecular Diagnostics in Clinical Laboratory Science II (1 s.h.)

Text: Coleman and Tsongalis. Molecular Diagnostics For the Clinical Laboratorian. 2nd edition. Humana Press Inc., Totowa, New Jersey. 2006.

Course Goal: To provide students with more in-depth knowledge of specific genetic alterations found in various diseases and disorders such as infectious diseases, cancers, leukemias, in thrombosis risk and paternity testing, and in forensic medicine along with hands-on experience performing some basic molecular diagnostic tests used in clinical laboratories.

Overall Course Objective: By the end of this course, students should be able to describe common modes of genetic disease, specific genetic alterations in diseases and disorders, and describe and perform techniques that can be used to manipulate and/or detect genetic materials in order to diagnose disease. Specific emphasis will be placed on evaluation of methods that diagnose diseases that fall within CLS disciplines of Clinical Microbiology, Hematology and Chemistry as well as Pharmacogenetics and Cytogenetics.

General Objectives:

Upon completion of CLSC 4492, the student will be able to:

1.  Describe the basis of common genetic diseases.

2. List the major clinical/medical uses of molecular techniques/biotechnology in:

  1. Diagnostics including: Infectious diseases, Genetic diseases, Cancer.
  2. Therapeutics including: p harmaceuticals; endogenous agents (IL-2, Erythropoietin); Designer drugs; Replacement therapies (Factor VIII, Insulin); Gene therapy; Cancer therapies; Immunosuppressive therapies.
  3. Vaccines.
  4. Reseach tools

3.  Describe the molecular techniques used in the following areas of the clinical laboratory (including where appropriate: examples of techniques used and the diseases that can be diagnosed, interpretation, acceptable specimens, commercially available systems/principles, QC issues, and advantages and disadvantages/limitations):

Clinical Microbiology, Hematology, Immunohematology, Clinical Chemistry,

and Clinical Immunology.

4. Properly perform selected molecular diagnostic techniques in the laboratory.

Grading:

Your final course grade will be determined as follows:

Exams 50%

Lecture Quizzes and Professional Evaluation 15%

Lab Exercises & Simulated Practical 20%

Other assignments (Case Studies/Review/

Class Preparation & Participation/Study Questions) 15%

There will be two major exams and a comprehensive final exam. Exam questions will involve

recall, interpretation and evaluation of the stated objectives, handouts, study questions, reading

assignments, lecture, lab, and audiovisuals. The exam format will include multiple choice,

matching and short answer and discussion questions. Exam dates will be announced. A

simulated lab practical will be given in addition to the individual labs.

The grading scale for CLSC 4492 is as follows:

90 - 100 A

80 - 89 B

70 - 79 C

60 - 69 D

Below 60 F

Course Schedule

Date / Week /Lecture / Topic / Reading Assignment
#1 / Molecular Diagnosis: Microbiology/Infectious Diseases – Review of common molecular procedures & formats used to detect/identify microorganisms and antibiotic resistance mechanisms;
Molecular Testing for: Chlamydia trachomatis & Neisseria gonorrhoeae, HIV-1, Hepatitis C, and Papillomavirus / Chs. 34, 36, 37 & 35; Notes, Blackboard (BB)/ Handouts (HO)
#2 / Molecular Diagnosis: Micro/ID cont.
#3 / Exam #1
#4 / Overview of Molecular Genetics and Molecular Diagnosis of Endocrine Disorders, Cardiovascular Disease, Coagulation and Cystic Fibrosis / Chs. 22, 24, 25 & 26; BB/HO
#5 / Overview Mol. Genetics etc. cont.
#6 / Molecular Pathogenesis of Human Cancer; Molecular Diagnosis of Lymphomas / Chs. 30 &32; BB/HO
#7 / Molecular Genetic Abnormalities in Acute and Chronic Leukemias; Pharmacogenetics / Ch. 33 & 29; BB/HO
#8 / Exam #2
Week/Lab
#8-10/
Lab #1-3 / Nucleic Acid isolation and quantitation / Kit System Product insert and Handouts (HO)
#11-12/
Lab #4-5 / Restriction Digestion of Nucleic Acid (Digestion, electrophoresis and interpretation) / “
#13-14/
Lab #6-7 / PCR Amplification, electrophoresis and evaluation of product (s) / “
#14/Lab Test / Simulated Lab Practical