University Curriculum Committee s1

6

Editorially Revised 3-22-06

University Curriculum Committee

Course Proposal Form

for Courses Numbered 0001 – 4999

(Faculty Senate Resolution #04–18, April 2004)

Note: Before completing this form, please read the accompanying instructions carefully.

1. Course Prefix and Number: CLSC 3420, 3421 2. Date: 01/29/2007

3. Requested Action (check only one box):

4. Justification for new course or course revision or renumbering:

Over-crowding of the content in CLSC 3420, 3421 prevents adequate coverage of

all topics in this lecture-lab course set.

5. Course description exactly as it should appear in the next catalog:

6. If this is a course revision, briefly describe the requested change:

7. Undergraduate Catalog Page Number from current undergraduate catalog:

8. The Writing Across the Curriculum Committee must approve Writing Intensive

(WI) credit for all courses prior to their consideration by the UCC. If WI credit is

requested, has this course been approved for Writing Intensive (WI) credit?

Not applicable.

Yes No

If Yes, will all sections be Writing Intensive (yes/no)?

Yes No

9. Any course requesting Foundations Curriculum credit must be
reviewed by Academic Standards Committee prior to their consideration by
the UCC. If FC credit has been approved by the ASC, then check the
appropriate box (check at most one), otherwise leave all boxes blank.

10. Course Credit: Note: CLSC 3420 is lecture course; CLSC 3421 is lab course.

11. Anticipated yearly student enrollment:

12. Affected Degrees or Academic Programs:

13. Overlap or Duplication with Affected Units or Programs:

14. Approval by the Council for Teacher Education (required for courses affecting

teacher education programs):

15. Statements of Support:

16. Syllabus – please insert course syllabus below. You must include (a) the

name of the textbook chosen for the course, (b) the course objectives, (c) the

course content outline, and (d) the course assignments and grading plan.

CLSC 3420: HEMATOLOGY II LECTURE (3 sh)

Course meets for 3 lecture hours per week (1.5 hours twice per week).

Texts: Hematology: Clinical Principles and Applications, 2nd edition, by B. F. Rodak, 2002,

& Clinical Hematology Atlas, 2nd edition, by J. H. Carr and B. F. Rodak, 2004.

Objectives:

For each disorder, disease or abnormality related to leukocytes and erythrocytes covered in CLSC 3420, students will be able to demonstrate, on written tests, each of the following with at least 70% accuracy:

1.  Etiology (i.e., precise cause) of the disorder.

2.  Usual lab test results in the disorder for CBC parameters; leukocyte differential and morphology, erythrocyte morphology, and platelet morphology. (Note: Automated scatterplots for leukocytes for normal and disease/disorder states will be covered during hematology clinical rotation.)

3.  Usual and rare symptoms, epidemiology, and usual prognosis of the disorder.

4.  Usual diagnostic lab tests beyond CBC and peripheral blood smear review performed for the disorder and expected results.

5.  Applicable decision pathways for lab testing related to the disorder.

6.  Usual lab tests done to monitor progress of the disorder and expected results in improvement and worsening of patient status.

Topic Schedule:

Class # Topic Reading Assignment

from Rodak

Class 1 Introduction to anemias and abnormal RBC Chs. 16 & 40

morphology, cell counting and identification

automation

Class 2 & 3 Aplastic anemia, and NC/NC anemias associated Ch. 19

with other disorders

Class 4 & 5 Megaloblastic anemias/macrocytoses, Ch.18 & pp. 482-483

polycythemias & erythrocytoses

Class 6 & 7 Hypochromic and sideroblastic anemias Ch. 17

Class 8 Exam 1

Class 9, 10, 11 Quantitative hemoglobinopathies Ch. 25

Class 12, 13, 14 Qualitative hemoglobinopathies Ch. 24

Class 15, 16, 17 Hemolytic anemias Chs. 20, 21, 22, 23

Class 18 Exam 2

Class 19, 20, Leukocytes: non-malignant changes Chs. 26, 27

Class 21, 22, 23 Leukemias Chs. 32, 33, 34

Class 24 Exam 3

Class 25, 26 Myeloproliferative & myelodysplastic syndromes Chs. 35, 37

Class 27 Lymphoproliferative disorders Ch. 36

Class 28 Exam 4

Class 29 Final Exam

Evaluation of Learning and Course Grade:

4 unit tests and a comprehensive final examination will be given in CLSC 3420. Students will review three CD programs – Peripheral Blood Tutor, Hematography Plus, and Cases in Flow Cytometry. A worksheet to complete when reviewing each of the first two CD programs will be given. Worksheets submitted after the announced due date will receive a grade of zero

Evaluation Item Percent of Final Grade

Unit Test 1 15%

Unit Test 2 15%

Unit Test 3 15%

Unit Test 4 15%

Peripheral Blood Tutor Worksheet 1%

Hematography Plus CD Worksheet 9%

Professional Behavior & Class Preparedness 5%

Comprehensive Final Exam 25%

Scale for Course Grade: % accumulation of total possible points course grade

90 – 100% A

80 - 89 % B

70 - 79 % C

60 – 69% D

0 – 59% F

CLSC 3421: HEMATOLOGY II LAB (1 sh)

Lab meets for 3 hours once per week.

Texts: Hematology: Clinical Principles and Applications, 2nd edition by B. F. Rodak, 2002,

& Clinical Hematology Atlas, 2nd edition by J. H. Carr and B. F. Rodak, 2004.

(same ones used in CLSC 3410, 3411).

CLSC 3421 Lab Manual.

Course Organization:

The CLSC 3421 labs are oriented predominantly toward reviewing case study histories and associated PBS and, for some case studies, BM slides as well as performing a few selected procedures. Students are expected to organize their lab work/exercises and time for each set of labs. The lab exercises will be submitted in two sets: Erythrocyte labs and Leukocyte labs. Due dates are noted on the course Schedule. Lab exercise sets turned in late will have 10% of total points deducted for EACH day late.

In order to prepare students for working in health care teams, students will be assigned to a group (and a specific lab station) to work on the lab exercise questions. The group will develop a “group consensus answer” for all questions labeled Group. “Individual” questions are to be answered by each group member, though the members may discuss the questions in formulating their individual responses. Students will be assigned to lab stations so that they are adjacent to other members of their group. Group members, in addition to the instructor, may also help each other in reviewing case study slides. 10% to 15% of the points for each lab exercise set will be based on group effort, coordination, organization, cohesiveness, and overall effectiveness in working as a team.

Objectives:

Upon the completion of the labs in CLSC 3421, the student will demonstrate proficiency at the at least 70% level in the following as related to all erythrocyte and leukocyte disorders covered in the course:

1.  Describe typical laboratory test findings including those in hematology, coagulation and chemistry as applicable.

2.  Recognize typical cellular morphology on Wright’s-stained peripheral blood smears.

3.  Recognize typical cellular morphology and cell line distributions on Wright’s-stained bone marrow smears.

4.  Describe additional lab testing to differentiate disorders that have similar initial lab test results.

5.  Describe relevant epidemiology and treatment options.

6.  Describe genetic markers that can be used in diagnosis as applicable.

7.  Describe cytochemical stains and how each differentiates the various types of leukemias.

8.  Describe the principles for cell counting and differentiating types of leukocytes on

modern hematology instrumentation.

Evaluation of Learning and Grading Scale:

% of total points

Erythrocyte Lab Worksheets and Exercise Reports 20%

Leukocyte Lab Worksheets and Exercise Reports 10%

Professional Behavior & Class Preparedness 5%

Erythrocyte Lab Test 35%

Leukocyte Lab Test 30%

Grade Scale: (% of total points earned = grade)

90-100% = A 80-89% = B 70-79% = C 60-69% = D 0-59% = F

Schedule of Labs:

Week # Lab(s) in Manual Rodak Reading

Assignment (plus

indicated Lab(s)

section(s) in CLSC

3421 Lab Manual)

1 Labs #1 & #2: Review BM smears for normal Chs. 7, 15, & pp.

RBC development (all cell stages); review 164-166

PBSs for abnormal RBC morphology;

reticulocyte counts

2 & 3 Lab #3: PBSs on normocytic-normochromic Chs. 16, 18, 19, 20, 21, 22

anemias, Prussian Blue stain, PBSs on pp. 482-483, 693-694

megaloblastic and macrocytic anemias

4 & 5 Lab #4: PBSs and BMs on microcytic, hypo- Chs. 17, 25

chromic anemias, PBSs on quantitative

hemoglobinopathies

6 & 7 Lab #5: PBSs on qualitative hemoglobinopathies Chs. 23, 24

and hemolytic anemias, Hemoglobin F (acid pp. 353-354

elution test), sodium metabisulfite preparation,

Heinz body preparation with acetylphenylhydrazine

8 Lab #6: G6PD deficiency screen, Pyruvate Kinase pp. 276-282

deficiency screen

Though demonstration or hands-on experience with the following hematology tests/procedures is not possible, students are responsible for being able to demonstrate understanding on the Erythrocyte Lab Test (written) of the principles and general reactions, technical problems and cautions, interpretations, and diagnostic applications for the tests/procedures listed below:

Automated hematology instruments

(RBC, WBC and platelet parameters) Chapter 40

Osmotic fragility 268-269, 353

Ham’s acidified serum test 285

Sugar water (sucrose) test 285

Autohemolysis 269

Hemoglobin electrophoresis 327-328, 353

Sickle hemoglobin solubility test 327-328

Hemoglobin A2 column test 353

Hemoglobin C test/preparation Lab Manual p. 49

Hemoglobin H test/preparation 353, Lab Manual p. 48

Zinc protoporphyrin 216, 355

9 Erythrocyte Lab Test (written & practical).

Lab #7: Review normal BM smears for early Chs. 11, 26, 27

WBCs in all WBC cell lines; review PBSs on pp. 141-143, 189

abnormal WBC morphology and reactive changes

10, 11 & 12 Lab #8: PBSs and BMs on leukemias, Leukocyte Chs. 28, 32, 33, 34

Alkaline Phosphatase (LAP) stain, Sudan Black stain

13 Lab #9: PBSs and BMs on lymphomas, multiple Chs. 35, 36, 37

myeloma, and other myeloproliferative disorders;

PBSs on other abnormal PBS disorders and anomalies

Though demonstration or hands-on experience with the following hematology tests/procedures is not possible, students are responsible for being able to demonstrate understanding on the Leukocyte Lab Test (written) of the principles and general reactions, technical problems and cautions, interpretations, and diagnostic applications for the tests/procedures below:

Eosinophil count 158

Myeloperoxidase stain 386

Acid phosphatase / TRAP stain 391

Periodic Acid-Schiff (PAS) stain 387-388

14 Leukocyte Lab Test (written & practical)