The 25th Sigrid Jusélius International Symposium 2013
(Version April23, 2013)
Diagnosis and Therapy of Severe Liver Diseases
June 9 at 16.00 to June 12 at 12.00, 2013,
Scandic Marina Congress Center, Helsinki, Finland
Scientific Organisers:Krister Höckerstedt, professor emeritus in surgery, Department of Liver and Transplantation, University of
Helsinki
Martti Färkkilä, professor in gastroenterology,
Department of Gastroenterology, University of
Helsinki
Inquiries: The Symposium Secretariat, Sigrid Jusélius Foundation,
Eva Werner,
Program
The 25th Sigrid Jusélius Symposium 2013
Diagnosis and Therapy of Severe Liver Diseases
June 9 at 16.00 to June 12 at 12.00, Helsinki, Finland
Scientific Organisers:Krister Höckerstedt, professor emeritus in surgery,
Department of Liver and Transplantation, University of Helsinki
Martti Färkkilä, professor in gastroenterology,
Department of Gastroenterology, University of Helsinki
Program
Sunday June 9, 2013
Cancer I. Secondary liver tumours - colorectal metastases
Chairs: Professor Krister Höckerstedt , Helsinki, Finland
Professor Michael D’Angelica, New York, NY, USA
17.00 Signalling networks in human carcinogenesis – novel aspects and therapeutic options
Professor Peter Schirmacher, Institute of Pathology, University Hospital, Heidelberg, Germany
Discussion
17. 35 Predictors of colorectal liver metastases
Professor Ari Ristimäki, Department of Pathology, University of Helsinki, Helsinki, Finland
Discussion
18.10 Break-through of chemotherapy
Professor Petri Bono, Helsinki University Hospital, Helsinki, Finland
Discussion
18.45 Benefits and limits of surgical therapies
Professor Michael D’Angelica, Department of Surgery, Memorial Sloan-KetteringCancerCenter, New York, NY, USA
Discussion
19.30 End of session
19.45 Dinner
Monday June 10, 2013
Cancer II. Hepatocellular Carcinoma (HCC)
Chairs:Professor Petri Bono, Helsinki, Finland
Professor Jacques Belghiti, Paris, France
How to identify patients at risk for HCC
08.30 Risk Factors of HCC in patients with cirrhosis
Professor Michael Beaugrand, Service d’Hepato-Gastroenterologie, Hôpital Jean Verdier, Université Paris, Paris, France
Discussion
09.10 Diagnostic imaging methods – the good and the bad
Dr Jordi Rimola, Department of Radiology CDI, Hospital Clinic, University of Barcelona, Barcelona, Spain
Discussion
09.50-10.20 Coffee
Scientific basis for treatment of HCC
10.20 Signaling pathways and rationale for molecular therapies in HCC
Professor Augusto Villanueva, HCC translational Research Laboratory, Barcelona-Clinic Liver Cancer Group, Barcelona, Spainand Liver cancer program
Discussion
11.00 Loco-regional treatments
Dr Laura Crocetti, Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplant and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
Discussion
11.40 Surgical therapy. Liver resection and transplantation.
Professor Jacques Belghiti, Department of Hepato-Pancreato-Biliary Surgery and Transplantation, Assistance Publique Hôpitaux de Paris, Clichy, France
Discussion
12.30 -13.30 Lunch
Alcoholic Liver Disease (ALD)
Chairs: ProfessorHannu Alho, Helsinki, Finland
ProfessorPhilippe Mathurin, Lille, France
13.30 Biochemical markers of ALD. A critical reappraisal
Professor James Neuberger, Department of Hepatology, Queen Elizabeth University Hospital, Birmingham, UK
Discussion
14.05 Useful and useless treatments for alcoholism
Professor Michael Lucey, Division of Gastroenterology and Hepatology, Department of Medicine,
University of Wisconsin, Madison, WI, USA
Discussion
14.40 Treatment options for Acute Alcohol Hepatitis – liver transplantation or only medical therapy?
Professor Philippe Mathurin, Service d’Hepato-gastroénterologie, Hôpital Claude Huriez, Lille, France
Discussion
15.15-15.45 Coffee
Non-Alcoholic Fatty Liver Disease (NAFLD)
Chairs: ProfessorHannele Yki-Järvinen, Helsinki, Finland
Professor Henning Gronbaek, Aarhus, Denmark
15.45 Is there a biological rational for HCC in NASH-patients?
Professor Helen Reeves, Newcastle University Medical School, Newcastle, UK
Discussion
16.20 NAFLD – a sugar disease?
Professor Hannele Yki-Järvinen, Department of Internal Medicine, University of Helsinki, Helsinki, Finland
Discussion
16.55 Therapeutic options – only physical activity?
Professor Henning Gronbaek, Department of Hepatology Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
Discussion
17.30 End of the day
18.30 Cruising Dinner
Tuesday June 11
Acute Liver Failure (ALF) and Drug-Induced Severe Liver Injury (DILI)
Chairs:ProfessorHelena Isoniemi, Helsinki, Finland
ProfessorChris Day, Newcastle, UK
08.30Insights into genetic susceptibility of DILI
Professor Chris Day, Liver Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University, UK
Discussion
09.05 Mechanisms and treatment options of DILI
Professor Mikko Niemi, Department of Clinical Pharmacology, University of Helsinki, Helsinki, Finland
Discussion
09.40 DILI caused by dietary and herbal supplements
Professor Felix Stickel, Department of Visceral Surgery and Medicine, Institute of Clinical Pharmacology and Visceral Research, Inselspital, University of Berne, Berne, Switzerland
Discussion
10.20-10.40 Coffee
10.40Conservative Treatment of Acute Liver Failure
Professor Fin Stolze Larsen, Department of Hepatology, Rigshospitalet, Copenhagen, Denmark
Discussion
11.15Liver Transplantation in Acute Liver Failure
Professor Styrbjörn Friman, Department of Surgery and Transplantation, University of Gothenburg, Gothenburg, Sweden
Discussion
12.00-13.00 Lunch
Hepatitis C - Who benefits from treatment?
Chairs: ProfessorMartti Färkkilä, Helsinki, Finland
ProfessorStefan Zeuzem, Frankfurt, Germany
13.00 Genetics and Hepatitis C in clinical practice
Professor M. Heim, Division of Gastroenterology & Hepatology, University Hospital Basel, Basel, Switzerland
Discussion
13.35 Should all HCV patients be treated?
Professor Ole Weiland, Department of Hepatology and Dept. Infectious Diseases, Karolinska Institute and Huddinge Hospital, Stockholm, Sweden
Discussion
14.15 -14.45 Coffee
14.45 Interferon-free treatments
Professor Stefan Zeuzem, Germany University Hospital, J W Goethe University, Frankfurt, Germany
Discussion
15.25Management of HCV treatment failure
Professor Jean-Michael Pawlotsky, Department of Hepatology and Gastroenterology, INSERM U955, Hôpital Henri Mondor, Université Paris-Est ,Créteil, France
Discussion
16.05 Liver transplantation in HCV
Professor Sheung-Tat Fan, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Discussion
16.45 The Hong Kong management protocol of HCV after LT
Professor Sheung-Tat Fan
Discussion
17.00End of the day
18.30 Dinner
Wednesday June 12
Cholestatic liver disease. Primary Sclerosing Cholangitis (PSC)
Chairs: ProfessorTom Hemming-Karlsen, Oslo, Norway
ProfessorMartti Färkkilä, Helsinki, Finland
08.30 Pathogenesis of PSC – genes, inflammation or infection?
Professor Tom Hemming-Karlsen, Department of Gastroenterology, Oslo University Hospital, Oslo, Norway
Discussion
09.10 New strategies for screening and detection of biliary dysplasia
Professor Martti Färkkilä, Department of Gastroenterology, University of Helsinki, Helsinki, Finland
Discussion
9.50-10.20 Coffee
10.20 AreBiliary Dysplasia/Ca in situ indications for liver transplantationin PSC?
Professor Helena Isoniemi, Clinic of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland
Discussion
10.55 Surgical therapy of cholangiocancer
Professor Peter Neuhaus, Department of General, Visceral, and Transplantation Surgery, Charité Campus Virchow, Berlin, Germany
Discussion
11.35-12.30 Lunch
12.30 End of Symposium
______
Public lectures: Studia Generalia in the Scandic Grand Marina, Helsinki
Chairmen: Professor Krister Höckerstedt and Professor Martti Färkkilä
The presentations in English will be simultaneously interpreted into Finnish
Englanninkieliset esitykset tulkataan suomenkielelle
14.00 Suomessa on Euroopan korkein kuolleisuus maksasairauksiin.
Miksi ja mitä voimme tehdä?
Professor Martti Färkkilä, Department of Gastroenterology, University of Helsinki, Helsinki, Finland
Questions / Kysymyksiä
14.40 Alcohol Liver Disease - useful and useless treatments of alcoholism
Professor Michael Lucey, Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA
Questions / Kysymyksiä
15.20 Severe liver injury caused by dietary and herbal supplements
Professor Felix Stickel, Department of Visceral Surgery and Medicine, Inselspital, University of Bern, Bern, Switzerland
Questions / Kysymyksiä
16.00 End of Lectures
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