UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
Arsenic Trifluoride
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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class
Purpose
Arsenic trifluoride is extremely toxic and corrosive. It is a powerful hemolytic agent. It can irritate severely the eyes, mucous membranes, and skin. Contact with skin, eyes, and other tissue can cause burns. Inhalation may cause digestive system disorders and liver toxicity. May be fatal if ingested. Certain arsenic compounds are recognized as cancer-causing agents. Arsenic trifluoride forms hydrofluoric acid on contact with moisture.
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 7784-35-2
Class: Very toxic, carcinogen
Molecular Formula: AsF3
Form (physical state): Liquid
Color: Colorless
Boiling point: 63 ˚C
Potential Hazards/Toxicity
Contact with skin and eyes causes severe irritation or burns. Burns are progressive while any unneutralized fluoride ions remain. Ingestion causes weakness and irritation of the mouth and stomach. Inhalation causes irritation of the nose and throat. Symptoms include irritation, redness, and pain. Arsenic poisoning may occur from excessive exposure. Chronic exposure to fluorides may cause fluorosis, a degenerative condition of bone tissue. May cause cancer. Inorganic arsenic-containing compounds have a permissible exposure limit (PEL) of 10 µg/m3.
Engineering Controls
Chemical fume hood. Adequate exhaust ventilation.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)
Hand Protection
Rubber protective gloves.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with arsenic trifluoride.
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
ANSI approved, tight-fitting safety glasses/goggles. Face shield recommended.
Skin and Body Protection
Flame resistant lab coat, long pants, and closed-toe shoes.
Hygiene Measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.
First Aid Procedures
If inhaled
Remove immediately to fresh air. If not breathing, give artificial respiration. If breathing is difficult, provide oxygen. Seek medical aid immediately.
In case of skin contact
Remove contaminated clothing as rapidly as possible. Flush affected skin with mild soap and plenty of water for at least 15 minutes. Seek immediate medical attention.
In case of eye contact
Persons with potential exposure to arsenic trifluoride should not wear contact lenses. Flush eyes with plenty of water for at least 30 minutes lifting lower and upper eyelids. Seek medical aid. Continue rinsing during transport to hospital.
If swallowed
Do not induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Seek medical aid immediately.
Special Handling and Storage Requirements
Precautions for safe handling: Avoid contact with skin, eyes, and clothing. Avoid inhalation and ingestion. Use only with adequate ventilation.
Conditions for safe storage: Store in cool, dry, well-ventilated area of non-combustible construction. Cylinders should be stored upright and firmly secured to prevent falling.
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html
Protocol/Procedure
Quantities covered by this SOP:
______(g , ml) to ______(g, ml)
Temperature range covered by this SOP:
__ °C – __ °C
General Overview and Purpose:
Enter the experimental purpose
Procedure:
Enter experimental procedure. You can copy procedure from your lab notebook or from literature.
NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
Arsenic Trifluoride 4 Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)