UCSF Lab Standard Operating Procedure
Chemical Process, Name or Hazard Class:
Acrylic Acid
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Type of SOP: ☐ Process ☒Hazardous Chemical ☐ Hazardous Class
Purpose
Acrylic acid is a flammable liquid that is also an irritant, and corrosive, and should be treated with care by researchers. Acrylic acid is a hazard due to peroxide initiation of polymerization. It is generally used as a monomer for radical polymerizations. This compound should be inspected prior to use for peroxide crystals that may have collected around the cap, on the inside, or on the outside of the bottle by a starch iodide test paper. Styrene should be in a secondary container labeled with “peroxide forming chemical,” and should be stored in a cabinet with the same labell
Physical & Chemical Properties/Definition of Chemical Group
CAS#: 79-10-7
Class: Combustible Liquid, Target Organ Effect, Harmful by ingestion., Corrosive, Peroxide Former
Molecular Formula: C3H4O2
Form (physical state): Liquid
Color: Colorless
Boiling point: 139 °C
Potential Hazards/Toxicity
Acute toxicity
Oral LD50
LD50 Oral - mouse - 830 mg/kg
Inhalation LC50
LC50 Inhalation - rat - 4 h - > 5,100 mg/m3
Dermal LD50
LD50 Dermal - rabbit - > 2,000 mg/kg
Skin corrosion/irritation
Skin - rabbit - Severe skin irritation - 24 h
Serious eye damage/eye irritation
Eyes - rabbit - Severe eye irritation
Respiratory or skin sensitization
guinea pig - Did not cause sensitization on laboratory animals.
Germ cell mutagenicity
Laboratory experiments have shown mutagenic effects.
Specific target organ toxicity - single exposure (Globally Harmonized System)
Inhalation - May cause respiratory irritation. - Respiratory system
Specific target organ toxicity - repeated exposure (Globally Harmonized System)
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Material is extremely destructive to the tissue of the mucous
membranes and upper respiratory tract.
Ingestion Harmful if swallowed.
Skin Harmful if absorbed through skin. Causes skin burns.
Eyes Causes eye burns. Causes severe eye burns.
Signs and Symptoms of Exposure
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx,
spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to
tissue of the mucous membranes and upper respiratory tract, eyes, and skin.
Engineering Controls
Work with acrylic acid should be conducted in a fume hood. Sash height should be kept low to avoid escaping fumes. Use explosion proof equipment like a blast shield to protect from explosions in the case of peroxide detonation.
Personal Protective Equipment (PPE)
Respirator Protection
If lab personnel would like to use respirator on a voluntary basis, they must be trained and fit-tested by EH&S. This is a regulatory requirement. (http://or.ucsf.edu/ehs/8193-DSY/version/default/part/4/data/)
Hand Protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Immersion protection Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: > 480 min
Material tested:Butoject® (Aldrich Z677647, Size M)
Splash protection
Material: Nitrile rubber
Minimum layer thickness: 0.2 mm
Break through time: > 30 min
Material tested:Dermatril® P (Aldrich Z677388, Size M)
data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 873000, e-mail , test method: EN374
If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an Industrial Hygienist familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.
NOTE: Consult with your preferred glove manufacturer to ensure that the gloves you plan on using are compatible with Acrylic Acid.
Refer to glove selection chart from the links below:
http://www.ansellpro.com/download/Ansell_8thEditionChemicalResistanceGuide.pdf
OR
http://www.allsafetyproducts.biz/page/74172
OR
http://www.showabestglove.com/site/default.aspx
OR
http://www.mapaglove.com/
Eye Protection
Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and Body Protection
Complete suit protecting against chemicals, Flame retardant antistatic protective clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
First Aid Procedures
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Consult a physician
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Continue rinsing eyes during transport to hospital
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Special Handling and Storage Requirements
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.
Conditions for safe storage Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Hygroscopic.
Spill and Accident Procedure
Chemical Spill Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only)
Spill – Assess the extent of danger. Assist contaminated or injured persons. Evacuate the spill area. Avoid breathing vapors. If possible, confine the spill to a small area using a spill kit or absorbent material. Keep others from entering contaminated area (e.g., use caution tape, barriers, etc.).
Small (<1 L) – If you have training, you may assist in the clean-up effort. Use appropriate personal protective equipment and clean-up material for chemical spilled. Double bag spill waste in clear plastic bags, label and take to the next chemical waste pick-up.
Large (>1 L) – Dial 9-911 from campus phone or 415-476-1414 from cell phone or 415-206-8522 (SFGH only) for assistance.
Chemical Spill on Body or Clothes – Remove clothing and rinse body thoroughly in emergency shower for at least 15 minutes. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Chemical Splash Into Eyes – Immediately rinse eyeball and inner surface of eyelid with water for 15 minutes by forcibly holding the eye open. If discomfort persists, proceed to the Emergency Department. If no further discomfort is experienced, have the SDS ready and contact Poison Control Hotline at 1-800-222-1222 for further exposure information. Notify your direct supervisor and EH&S at 415-476-1300 during work hours, or 9-911 during non-working hours and weekends.
Medical Emergency Dial 9-911 (campus phone) or 476-6911 (cell phone)
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Non-Life Threatening Emergency– Go to Occupational Health Programs (OHP) Clinic, 415-885-7580, 2330 Post Street, Suite 460 Hours of Operation for Appointments: Monday - Friday 7:30 a.m. - 4:00 p.m. (except Holidays).
Note: All serious injuries must be reported to EH&S at 415-476-1300 within 8 hours.
Needle stick/puncture exposure (as applicable to chemical handling procedure) – Wash the affected area with antiseptic soap and warm water for 15 minutes. For mucous membrane exposure, flush the affected area for 15 minutes using an eyewash station. Page the needle stick nurse by dialing 415-353-7842 (STIC).
Decontamination/Waste Disposal Procedure
Clean contaminated surfaces with soap and water and paper towels. Dispose of the paper towels as hazardous waste.
Safety Data Sheet (SDS) Location
Online SDS can be accessed at http://or.ucsf.edu/ehs/7241-DSY/msds.html
Protocol/Procedure
Quantities covered by this SOP:
______(g , ml) to ______(g, ml)
Temperature range covered by this SOP:
__ °C – __ °C
General Overview and Purpose:
Enter the experimental purpose
Procedure:
Enter experimental procedure. You can copy procedure from your lab notebook or from literature.
NOTE
Any deviation from this SOP requires approval from the Principal Investigator.
Acrylic Acid 5 Date: Click here to enter a date.
Modified from SOP templates developed by UCLA EH&S (http://www.sop.ehs.ucla.edu/)