To: ACRIN 6673 Protocol Investigators and Research Associates

From: ACRIN Data Management

CC: Gerald Dodd, III, MD, Shahla Masood, MD, Donna Hartfeil, Benjamin Herman, Fenghai Duan, PhD,

Mary Kelly-Truran, Chris Steward, Maria Oh, Tina Taylor

Date: February 12, 2009

Re: ACRIN 6673 Pathology Forms Submission Process

Please note the ACRIN 6673 protocol pathology submission process for participants whom undergo resection of their ablated hepatic tumors, liver transplant, or who expire and undergo autopsy:

Please submit the following:

Ø  1 PL* and 1 P4* Form for every ablated tumor

§  Refer to all TF* and RA* forms for the number of tumors ablated, the Tumor Number and couinaud liver segment of each tumor ablated.

Ø  1 PL and P4 Form for each new hepatic lesion discovered on the abdominal CT scan prior to liver resection, transplantation or autopsy

§  Refer to Q# 7 and Q# 7a on all IM* forms for evidence of remote intrahepatic tumor, and the total number of remote intrahepatic tumors.

§  Refer to Q# 5 on all NT* forms for the new Tumor Number and to Q# 6a couinaud liver segment of each new tumor.

Ø  1 PL and P4 Form for any new hepatic lesion(s) discovered at resection, transplantation, or autopsy

§  Refer to local pathology reports (P1*). Each new hepatic lesion discovered at transplant, resection or autopsy would be assigned a new tumor number on the P4 and PL forms. Tumor numbering must be a continuous process. Do not assign new tumors with tumor numbers already in use on IM and NT forms.

At the same time that the specimen and forms are being shipped to the central pathologist, copies of the P4 form, the PC* form and the pathology report (P1) should be faxed to ACRIN 6673 Data Management at 215-717-0936 or mailed to ACRIN 6673 Data Management. Please refer to the ACRIN 6673 protocol, Version Date: February 26, 2008, for pathology related guidelines- Sections: 9.5.6, 9.5.7, 10.2, 10.2.1, 10.2.2, 11.2.2 and 11.3.

If you have any questions, please do not hesitate to contact Tina Taylor at 434-296-3102 or . As always, thank you for your continued efforts to ensure quality data submission on the ACRIN 6673 study.

* PL: Local Pathology Interpretation Form, P4: Central Pathology Interpretation Form, TF: Primary RFA Treatment Form, RA: Additional RFA Treatment Form, IM: Imaging Follow-Up Form, NT: New Tumor Imaging Form, PC: Pathology Submission Form, P1: Pathology Report (from local medical records)