Table 3. Insertions in known proto-oncogenes, genes with an established role in hematopoiesis, and common insertion sites in the insertional dominance database (IDDb). See Kustikova et al., Blood 2007
Locus / Hits in IDDb / Hits in RTCGD / Gene ID (hyperlink) / Chromo-some / Name / (proposed ) function / Type of protein
FasL / 2 / 0 / 14103 / 1 H2.1 / Fas ligand (TNF superfamily, member 6) / growth factor
Vegfa / 1 / 0 / 22339 / 17B3 / vascular endothelial growth factor A
Tnfsf10 / 2 / 2 / 22035 / 3A3 / tumor necrosis factor (ligand) superfamily, member 10, apoptosis induction
Sema4b / 3 / 4 / 20352 / 7D1 / receptor activity / receptor
Axl / 1 / 0 / 26362 / 7A3-B1 / receptor activity, protein kinase activity, human proto-oncogene
Csf1r / 1 / 9 / 12978 / 18D / receptor of colony stimulating factor 1 (CSF-1)
Csfr3 / 1 / 0 / 12986 / 4D2+2 / G protein coupled receptor for granulocyte colony stimulating factor (G-CSF)
Gpr43 =Ffar2 / 2 / 0 / 233079 / 7A3 / G-protein coupled receptor, free fatty acid receptor
Igfbp4 / 2 / 0 / 16010 / 11 D-E1 / insulin-like growth factor binding protein 4
Ly78 / 2 / 0 / 17079 / 13D1 / lymphocyte antigen 78, receptor, signaling, CD180
Akt1 / 2 / 3 / 11651 / 12F1-F2 / intracellular signaling, kinase transforming protein / signal transducer
Bcl2l1 / 1 / 3 / 12048 / 2H1 / Bcl2-like1, anti-apoptosis
Ccnd3 / 1 / 13 / 12445 / 17B4 / cyclin D3, cell cycle
Mcl1 / 1 / 4 / 17210 / 3F2.1 / myeloid cell leukemia sequence 1, Bcl2-related antiapoptotic protein
Osbpl3 / 1 / 2 / 71720 / 6B3 / oxysterol binding protein-like 3, steroid metabolism
Pim2 / 2 / 5 / 18715 / X A1.1 / serine/threonine-protein kinase Pim-2, proviral integration site 2, anti-apoptosis
Plcg2 / 2 / 0 / 234779 / 8E1 / phospholipase C, gamma 2, survival signaling
Rab3gap2 / 2 / 0 / 381313 / 1H5 / similar to Rab3 GTPase activating protein, gene model 981
Rhof / 1 / 4 / 23912 / 5F / Ras homolog gene family member
Sesn2 = Hi95 / 3 / 0 / 230784 / 4D2.3 / Sestrin 2, induction in response to DNA damage
2610510B01Rik= Dopey2 / 1 / 4 / 70028 / 16 C4 / predicted leucine zipper transcription factor, dopey family / transcription factor
Bcl11a / 2 / 6 / 14025 / 11A3+2 / zinc finger, essential for lymphopoiesis
Cbfa2t3h / 1 / 7 / 12398 / 8E1 / Core-binding factor, runt domain, alpha subunit 2, translocated 2, 3 homolog
Cutl1 / 1 / 3 / 13047 / 5 G2 / cut-like 1 (Drosophila)=CCAAT displacement protein=Cux/CDP homeoprotein
Elk4 / 1 / 3 / 13714 / 1E3-G / ELK4, ETS family member
Evi1 / 13 / 20 / 14013 / 3A3 / associated with murine and human leukemia, SMAD interacting
Fli1 / 2 / 7 / 14247 / 9A4 / ETS family member
Fos
(LOC627366) / 2 / 5 / 14281 / 12 D2 / FBJ osteosarcoma oncogene
Fosb (Ercc1) / 1 / 0 / 14282 / 7A2 / FBJ osteosarcoma oncogene B
Foxo3a / 2 / 0 / 56484 / 10B2 / forkhead transcription factor, potentially pro-apoptotic
Gtf2i / 2 / 0 / 14886 / 5G2 / general transcription factor 2
Hhex / 1 / 26 / 15242 / 19C1 / hematopoietically expressed homeobox gene (T-cell oncogene)
Hic1 / 3 / 3 / 15248 / 11B5 / hypermethylated in cancer 1, transcription factor, Wnt antagonism
Hivep1 / 1 / 2 / 110521 / 13A4 / HIV enhancer binding protein 1
HoxA7 / 2 / 19 / 15404 / 6B3 / homeobox gene A7 and surrounding cluster
Hoxb4/Hoxb5 / 1 / 0 / 15412 / 11D / homeobox gene B4 and surrounding cluster
Lmo2 / 2 / 2 / 16909 / 2 E2 / LIM domain only 2, T-cell oncogene
Mef2d / 1 / 5 / 17261 / 3F1 / myocyte enhancer factor 2D
Mllt3 / 1 / 0 / 70122 / 4C4 / involved in leukemogenic translocations
Runx2 / 1 / 6 / 12393 / 17B3 / Runt related, essential for hematopoiesis
Runx3 / 1 / 5 / 12399 / 4D2.3 / Runt related, myeloid development
Sox4 / 1 / 64 / 20677 / 13A3-A5 / Sry box, lymphocyte activation
Tal1 / 1 / 0 / 21349 / 4D1 / Ebox family member, essential for hematopoiesis
Zfp3612 / 1 / 4 / 12193 / 17 E4 / zinc finger protein 36, C3H type-like
Dph5 / 2 / 0 / 69740 / 3F3 / DPH5 homolog (S. cerevisiae) transferase / metabolic
Lrrc6 / 2 / 0 / 54562 / 15D1 / leucin repeat containing 6 (testis) / unknown
Dym=
4933427L07Rik / 1 / 3 / 69190 / 18 E2 / dymeclin, function unknown
AB041803 / 2 / 8 / 232685 / 6A3.3 / hypothetical protein, function unknown
BC031781 / 1 / 2 / 208768 / 1H4 / hypothetical protein, function unknown
The classification as known proto-oncogenes follows the listing in the retrovirus-tagged cancer gene database (RTCGD July 2004-January 2006, http://rtcgd.ncifcrf.gov/) and additional literature. The gene ID is configured as a hyperlink to NCBI Entrez Gene (July 2004-October 2006, http://www.ncbi.nlm.nih.gov/entrez/).