Research output
Listing of Research output
The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability
Grey, W., Ivey, A., Milne, T. A., Haferlach, T., Grimwade, D., Uhlmann, F., Voisset, E. & Yu, V. Jan 2018 In : Biochimica et Biophysica Acta. 1865, 1, p. 105-116 12 p.
Research output: Contribution to journal › Article
Pml nuclear body disruption cooperates in APL pathogenesis and impairs DNA damage repair pathways in mice
Voisset, E., Moravcsik, E., Stratford, E. W., Jaye, A., Palgrave, C. J., Hills, R. K., Salomoni, P., Kogan, S. C., Solomon, E. & Grimwade, D. 30 Nov 2017 In : Blood.
Research output: Contribution to journal › Article
Comparative genomic analysis of PML and RARA breakpoints in paired diagnosis/relapse samples of patients with acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
Iaccarino, L., Ottone, T., Hasan, S. K., Divona, M., Cicconi, L., Lavorgna, S., Alfonso, V., Basso, G., Barragán, E., Bocchia, M., Rego, E. M., Grimwade, D., Voso, M. T. & Lo-Coco, F. 24 Aug 2017 In : Leukemia and Lymphoma. p. 1-3 3 p.
Research output: Contribution to journal › Article
A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS
Amodeo, V. , A, D. , Betts, J. , Bartesaghi, S. , Zhang, Y. , Richard-Londt, A. , Ellis, M. , Roshani, R. , Vouri, M. , Galavotti, S. , Oberndorfer, S. , Leite, A. P. , Mackay, A. , Lampada, A. , Wessel Stratford, E. , Li, N. , Dinsdale, D. , Grimwade, D. , Jones, C. , Nicotera, P. & 3 others Michod, D., Brandner, S. & Salomoni, P. 11 Jul 2017 In : Cell reports. 20, 2, p. 411-426 16 p.
Research output: Contribution to journal › Article
Clinical relevance of failed and missing cytogenetic analysis in acute myeloid leukaemia
Chilton, L., Harrison, C. J., Ashworth, I., Murdy, D., Burnett, A. K., Grimwade, D., Moorman, A. V. & Hills, R. K. 1 May 2017 In : Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 31, 5, p. 1234-1237 4 p.
Research output: Contribution to journal › Letter
Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
Döhner, H. , Estey, E. , Grimwade, D. , Amadori, S. , Appelbaum, F. R. , Büchner, T. , Dombret, H. , Ebert, B. L. , Fenaux, P. , Larson, R. A. , Levine, R. L. , Lo-Coco, F. , Naoe, T. , Niederwieser, D. , Ossenkoppele, G. J. , Sanz, M. , Sierra, J. , Tallman, M. S. , Tien, H. F. , Wei, A. H. & 2 others Löwenberg, B. & Bloomfield, C. D. 26 Jan 2017 In : Blood. 129, 4, p. 424-447 24 p.
Research output: Contribution to journal › Article
The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia
Jovanovic, J. V., Chillón, M. C., Vincent-Fabert, C., Dillon, R., Voisset, E., Gutiérrez, N. C., Sanz, R. G., Lopez, A. A. M., Morgan, Y. G., Lok, J., Solomon, E., Duprez, E., Díaz, M. G. & Grimwade, D. 16 Dec 2016 In : Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K.
Research output: Contribution to journal › Letter
CORRESPONDENCE: Assessment of minimal residual disease in standard-risk AML: Assessment of minimal residual disease in standard-risk AML
Hills, R. K., Ivey, A. & Grimwade, D. 11 Aug 2016 In : New England Journal of Medicine. 375, 6, p. e9.3-e9.4
Research output: Contribution to journal › Letter
Just 1 test to diagnose AML?!!
Dillon, R. & Grimwade, D. 7 Jul 2016 In : Blood. 128, 1, p. 7-8 2 p.
Research output: Contribution to journal › Comment/debate
Genetically distinct leukemic stem cells in human CD34-acute myeloid leukemia are arrested at a hemopoietic precursor-like stage
Quek, L. , Otto, G. W. , Garnett, C. , Lhermitte, L. , Karamitros, D. , Stoilova, B. , Lau, I. J. , Doondeea, J. , Doondeea, B. , Kennedy, A. , Metzner, M. , Goardon, N. , Ivey, A. , Allen, C. , Gale, R. , Davies, B. , Sternberg, A. , Killick, S. , Hunter, H. , Cahalin, P. & 13 others Price, A., Carr, A., Griffiths, M., Virgo, P., Mackinnon, S., Grimwade, D., Freeman, S., Russell, N., Craddock, C., Mead, A., Peniket, A., Porcher, C. & Vyas, P. 1 Jul 2016 In : The Journal of experimental medicine. 213, 8, p. 1513-1535 23 p.
Research output: Contribution to journal › Article
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance
Grimwade, D., Ivey, A. & Huntly, B. J. P. 7 Jan 2016 In : Blood. 127, 1, p. 29-41 13 p.
Research output: Contribution to journal › Article
Acute myeloid leukemia
Grimwade, D., Knapper, S. & Mrózek, K. 1 Jan 2016 Molecular Pathology in Clinical Practice:Second Edition. Springer International Publishing Switzerland, p. 527-559 33 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
The experience of the International Consortium on Acute Promyelocytic Leukemia in monitoring minimal residual disease in acute promyelocytic leukaemia
Lange, A. P., Lima, A. S., Lucena-Araujo, A. R., Jácomo, R. H., Melo, R. A., Bittencourt, R. I., Pasquini, R., Pagnano, K., Fagundes, E. M., Chauffaille, M. L., Chiattone, C. S., Sanz, M. A., Lo-Coco, F., Grimwade, D. & Rego, E. M. 2016 In : British Journal of Haematology.
Research output: Contribution to journal › Article
High Δnp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia
Lucena-Araujo, A. R. , Kim, H. T. , Thomé, C. , Jacomo, R. H. , Melo, R. A. , Bittencourt, R. , Pasquini, R. , Pagnano, K. , Glória, A. B. F. , De Lourdes Chauffaille, M. , Athayde, M. , Chiattone, C. S. , Mito, I. , Bendlin, R. , Souza, C. , Bortolheiro, C. , Coelho-Silva, J. L. , Schrier, S. L. , Tallman, M. S. , Grimwade, D. & 7 others Ganser, A., Berliner, N., Ribeiro, R. C., Lo-Coco, F., Löwenberg, B., Sanz, M. A. & Rego, E. M. 12 Nov 2015 In : Blood. 126, 20, p. 2302-2306 5 p.
Research output: Contribution to journal › Article
Acute Myeloid Leukaemia
Burnett, A. K. & Grimwade, D. 6 Nov 2015 Postgraduate Haematology: Seventh Edition. WILEY-BLACKWELL, p. 352-370 19 p.
Research output: Chapter in Book/Report/Conference proceeding › Chapter
Leukemia diagnosis: Today and tomorrow
Béné, M. C., Grimwade, D., Haferlach, C., Haferlach, T. & Zini, G. 1 Oct 2015 In : European Journal of Haematology. 95, 4, p. 365-373 9 p.
Research output: Contribution to journal › Article
Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): Results of a randomised, controlled, phase 3 trial
Burnett, A. K., Russell, N. H., Hills, R. K., Bowen, D., Kell, J., Knapper, S., Morgan, Y. G., Lok, J., Grech, A., Jones, G., Khwaja, A., Friis, L., McMullin, M. F., Hunter, A., Clark, R. E. & Grimwade, D. Oct 2015 In : The Lancet Oncology. 16, 13, p. 1295-1305 11 p.
Research output: Contribution to journal › Article
Arsenic trioxide-based therapy of relapsed acute promyelocytic leukemia: registry results from the European LeukemiaNet
Lengfelder, E. , Lo-Coco, F. , Ades, L. , Montesinos, P. , Grimwade, D. , Kishore, B. , Ramadan, S. M. , Pagoni, M. , Breccia, M. , Huerta, A. J. G. , Nloga, A. M. , González-Sanmiguel, J. D. , Schmidt, A. , Lambert, J. F. , Lehmann, S. , Di Bona, E. , Cassinat, B. , Hofmann, W. K. , Görlich, D. , Sauerland, M. C. & 2 others Fenaux, P. & Sanz, M. 11 May 2015 In : Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 29, 5, p. 1084-1091 8 p.
Research output: Contribution to journal › Article
PcG methylation of the HIST1 cluster defines an epigenetic marker of acute myeloid leukemia
Tiberi, G., Pekowska, A., Oudin, C., Ivey, A., Autret, A., Prebet, T., Koubi, M., Lembo, F., Mozziconacci, M. J., Bidaut, G., Chabannon, C., Grimwade, D., Vey, N., Spicuglia, S., Calmels, B. & Duprez, E. 11 May 2015 In : Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 29, 5, p. 1202-1206 5 p.
Research output: Contribution to journal › Letter
Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia
Kühnl, A. , Valk, P. J. M. , Sanders, M. A. , Ivey, A. , Hills, R. K. , Mills, K. I. , Gale, R. E. , Kaiser, M. F. , Dillon, R. , Joannides, M. , Gilkes, A. , Haferlach, T. , Schnittger, S. , Duprez, E. , Linch, D. C. , Delwel, R. , Löwenberg, B. , Baldus, C. D. , Solomon, E. , Burnett, A. K. & 1 others Grimwade, D. 7 May 2015 In : Blood. 125, 19, p. 2985-2994 10 p.
Research output: Contribution to journal › Article
Minimal residual disease-directed therapy in acute myeloid leukemia
Kayser, S., Schlenk, R. F., Grimwade, D., Yosuico, V. E. D. & Walter, R. B. 9 Apr 2015 In : Blood. 125, 15, p. 2331-2335 5 p.
Research output: Contribution to journal › Article
Defining minimal residual disease in acute myeloid leukemia: Which platforms are ready for "prime time"?
Grimwade, D. & Freeman, S. D. 5 Dec 2014 In : Hematology-American society hematology education program. 2014, 1, p. 222-233 12 p.
Research output: Contribution to journal › Article
Defining minimal residual disease in acute myeloid leukemia: Which platforms are ready for "prime time"?
Grimwade, D. & Freeman, S. D. 27 Nov 2014 In : Blood. 124, 23, p. 3345-3355 11 p.
Research output: Contribution to journal › Article
Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study
Lucena-Araujo, A. R. , Kim, H. T. , Jacomo, R. H. , Melo, R. A. , Bittencourt, R. , Pasquini, R. , Pagnano, K. , Fagundes, E. M. , Chauffaille, M. D. L. , Chiattone, C. S. , Lima, A. S. , Kwaan, H. C. , Gallagher, R. , Niemeyer, C. M. , Schrier, S. L. , Tallman, M. S. , Grimwade, D. , Ganser, A. , Berliner, N. , Ribeiro, R. C. & 4 others Lo-Coco, F., Lowenberg, B., Sanz, M. A. & Rego, E. M. Aug 2014 In : British Journal of Haematology. 166, 4, p. 540-549 10 p.
Research output: Contribution to journal › Article
Loss of imprinting at the 14q32 domain is associated with microRNA overexpression in acute promyelocytic leukemia
Manodoro, F., Marzec, J., Chaplin, T., Miraki-Moud, F., Moravcsik, E., Jovanovic, J. V., Wang, J., Iqbal, S., Taussig, D., Grimwade, D., Gribben, J. G., Young, B. D. & Debernardi, S. 27 Mar 2014 In : Blood. 123, 13, p. 2066-2074 9 p.
Research output: Contribution to journal › Article
Hyperdiploidy with 49-65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome
Chilton, L., Hills, R. K., Harrison, C. J., Burnett, A. K., Grimwade, D. & Moorman, A. V. Feb 2014 In : Leukemia. 28, 2, p. 321-328 8 p.
Research output: Contribution to journal › Article
Wilms' Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses
Uttenthal, B., Martinez-Davila, I., Ivey, A., Craddock, C., Chen, F., Virchis, A., Kottaridis, P., Grimwade, D., Khwaja, A., Stauss, H. & Morris, E. C. Feb 2014 In : British Journal of Haematology. 164, 3, p. 366-375 10 p.
Research output: Contribution to journal › Article
Prognostic value of monitoring a candidate immunophenotypic leukaemic stem/progenitor cell population in patients allografted for acute myeloid leukaemia
Bradbury, C., Houlton, A. E., Akiki, S., Gregg, R., Rindl, M., Khan, J., Ward, J., Khan, N., Griffiths, M., Nagra, S., Hills, R., Burnett, A., Russell, N., Vyas, P., Grimwade, D., Craddock, C. & Freeman, S. D. 2014 In : Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 4 p.
Research output: Contribution to journal › Article
Topoisomerase II and leukemia
Pendleton, M., Lindsey, R. H., Felix, C. A., Grimwade, D. & Osheroff, N. 2014 In : Annals of the New York Academy of Sciences. 1310, 1, p. 98-110 13 p.
Research output: Contribution to journal › Article
Prognostic relevance of treatment response measured by flow cytometric residual disease detection in older patients with acute myeloid leukemia
Freeman, S. D., Virgo, P., Couzens, S., Grimwade, D., Russell, N., Hills, R. K. & Burnett, A. K. 10 Nov 2013 In : Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 31, 32, p. 4123-4131 9 p., N/A
Research output: Contribution to journal › Article
NUP98-NSD1 Fusion in Association with FLT3-ITD Mutation Identifies a Prognostically Relevant Subgroup of Pediatric Acute Myeloid Leukemia Patients Suitable for Monitoring by Real Time Quantitative PCR
Akiki, S., Dyer, S. A., Grimwade, D., Ivey, A., Abou-Zeid, N., Borrow, J., Jeffries, S., Caddick, J., Newell, H., Begum, S., Tawana, K., Mason, J., Velangi, M. & Griffiths, M. Nov 2013 In : Genes Chromosomes and Cancer. 52, 11, p. 1053-1064 12 p., N/A
Research output: Contribution to journal › Article
Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study