The Biology of the Laboratory Rabbit
Manning, P.J. , D. H. Ringler, and C.E. Newcomer, eds. 1994
2nd ed. 1994, Academic Press, San Diego, CA.
Chapter 9, "Viral Diseases" pages 171-204.

Questions:

  1. Which viral diseases of rabbits are of public health importance (i.e. zoonotic)?
  2. In which section of the US is Myxoma virus endemic; what is the natural reservoir?
  3. Myxoma virus and rabbit (Shope) fibroma virus are members of what genus? Family?
  4. What is the principal mode of transmission of myxomavirus?
  5. The Utrecht strain of rabbitpox is likely a laboratory variant of what human virus?
  6. Which of the following is NOT a common pathological finding in rabbits with rabbitpox virus?
  7. Subcutaneous edema and edema of the mouth
  8. Enlarged yellowish liver with gray nodules
  9. Vesicles and pustules similar to human variola infection
  10. Testicular necrosis
  11. Leporid herpesvirus 1 is a(n) ______herpes virus, while Leporid herpesvirus is a(n) ______herpesvirus
  12. Alpha, beta
  13. Gamma, unclassified
  14. Gamma, beta
  15. Beta, gamma
  1. Which of the following is false regarding cottontail rabbit papillomavirus?
  2. This disease was the first recognition of an oncogenic virus in mammals
  3. Embryonic rat skin is susceptible to virus, but regression generally occurs
  4. Neoplastic transformation only occurs in epidermis-bearing hair follicles
  5. Inoculation can be performed by skin scarification, intradermal or intramuscular injection
  6. The malignant tumors that arise from papillomas are ______.
  7. T/F: Rabbit oral papillomavirus infects only leporids.
  8. To what viral family does rotavirus belong?
  9. At what age do endemically infected rabbits begin to shed rotavirus?
  10. How is rotavirus shed?
  11. What are the common clinical signs seen in rotavirus outbreaks?
  12. Name three rule-outs for diarrhea in rabbits
  13. T/F: Antibodies to infectious cardiomyopathy vir! us (aka pleural effusion disease) cross-react with feline infectious peritonitis virus, canine caronavirus and procine transmissible gastroenteropathy virus.
  14. Which of the following is true regarding rabbit enteric coronavirus?
  15. Rabbits with diarrheal disease are usually geriatric adults
  16. The feeding of hay, delay in weaning and administration of coccidiostats have been shown to be effective in preventing mortality
  17. The virus has been demonstrated in t! he feces of healthy rabbits
  18. The agent is fairly easy to propagate in vitro
  19. What is the etiological agent (provisionally classified) of rabbit hemorrhagic disease?
  20. What is the morbidity and mortality rate of rabbit hemorrhagic disease virus?
  21. 0-25% morbidity; 0-25% mortality
  22. 25-50% morbidity; 50-70% mortality!
  23. 50-70% morbidity; 25-50% mortality
  24. 70-100% morbidity; 70-100% mortality
  25. What is the eventual cause of death with rabbit hemorrhagic disease?
  26. T/F: Persistent infection may develop on exposure to the tissue-derived virus for rabbit hemorrhagic disease
  27. Rabbits that survive rabbit hemorrhagic disease shed virus in their feces for at least ______month(s)?
  28. The European brown hare virus is similar to what other viral disease?
  29. Name two paramyxoviruses that have been isolated from rabbits.
  30. T/F: Sendai virus causes moderate severe respiratory infections in rabbits.
  31. T/F: Infection with the togaviruses eastern and western encephalitis viruses have been detected in snowshoe hares.
  32. Antibodies to St. Louis encephalitis virus, a membe! r of the ______virus family, have been detected in snowshoe hares.

Answers:

  1. None; there were no reports of spread between rabbits and humans
  2. western US; brush rabbit (Sylvilagus bachmani)
  3. genus = Leporipoxvirus; family = Poxviridae
  4. arthropods which feed on rabbits (mosquitoes, biting flies, gnats, lice)
  5. vaccinia virus
  6. c
  7. b
  8. d
  9. squamous cell carcinomas
  10. T
  11. Reoviridae
  12. 4 to 7 weeks of age
  13. In the feces
  14. diarrhea (severe, watery or mucous), anorexia, dehydration; 60-80% mortality
  15. Rotavirus, coccidiosis, salmonellosis, Tyzzer’s disease, clostridial enterotoxemia, colibacillosis
  16. T
  17. C
  18. Calicivirus
  19. d ( 70-8-% morbidity; almost 100% mortality)
  20. acute disseminated coagulopathy with deep vein thrombosis
  21. T
  22. One
  23. Rabbit hemorrhagic disease
  24. Rabbit syncytium virus; Sendai virus
  25. F
  26. T
  27. Flavivirus (Japanese encephalitis subgroup)