Table1.Univariate linear regression analyses before delivery. Dependent variable: WBC FGF21

factor / df / β / SE / t / P / β' / R2 / adj R2
Group / 1 / -3.13532 / 0.63515 / -4.94 / <0.0001 / -0.44443 / 0.1975 / 0.1894
age / 1 / -0.08145 / 0.12698 / -0.64 / 0.5227 / -0.06433 / 0.0041 / -0.0059
BMI / 1 / 0.13059 / 0.09794 / 1.33 / 0.1855 / 0.13281 / 0.0176 / 0.0077
OGTT0h / 1 / 1.11915 / 0.60063 / 1.86 / 0.0654 / 0.18407 / 0.0339 / 0.0241
WBC count / 1 / 1.03466 / 0.21072 / 4.91 / <0.0001 / 0.44254 / 0.1958 / 0.1877
CRP / 1 / 0.05060 / 0.07993 / 0.63 / 0.5281 / 0.06350 / 0.0040 / -0.0060
fast insulin / 1 / -0.00254 / 0.10196 / -0.02 / 0.9802 / -0.0025 / 0.0000 / -0.0101
HOMA-IR / 1 / 0.23293 / 0.45563 / 0.51 / 0.6103 / 0.05131 / 0.0026 / -0.0074
glucagon / 1 / 0.00283 / 0.00962 / 0.29 / 0.7693 / 0.02954 / 0.0009 / -0.0092
leptin / 1 / 0.03033 / 0.03329 / 0.91 / 0.3645 / 0.09118 / 0.0083 / -0.0017
Total Cholesterol / 1 / -0.08996 / 0.38662 / -0.23 / 0.8165 / -0.02338 / 0.0005 / -0.0095
Triglycerides / 1 / 0.79080 / 0.57456 / 1.38 / 0.1718 / 0.13703 / 0.0188 / 0.0089
HDL-cholesterol / 1 / 1.28770 / 0.54864 / 2.35 / 0.0209 / 0.22959 / 0.0527 / 0.0431
LDL-cholesterol / 1 / 0.30469 / 0.44550 / 0.68 / 0.4956 / 0.06858 / 0.0047 / -0.0054

Group:GDM=1,control=2.

Table2.Univariate linear regression analyses before delivery. Dependent variable: serumFGF21

factor / df / β / SE / t / P / β' / R2 / adj R2
group / 1 / -0.22811 / 0.07280 / -3.13 / 0.0023 / -0.30038 / 0.0902 / 0.0810
age / 1 / 0.0006118 / 0.01370 / 0.04 / 0.9645 / 0.00449 / 0.0000 / -0.0101
BMI / 1 / 0.02083 / 0.01043 / 2.00 / 0.0486 / 0.19677 / 0.0387 / 0.0290
OGTT0h / 1 / 0.13092 / 0.06445 / 2.03 / 0.0449 / 0.20004 / 0.0400 / 0.0303
WBCs count / 1 / 0.08030 / 0.02397 / 3.35 / 0.0011 / 0.31906 / 0.1018 / 0.0927
CRP / 1 / -0.01032 / 0.00856 / -1.21 / 0.2310 / -0.12026 / 0.0145 / 0.0045
fast insulin / 1 / 0.00569 / 0.01096 / 0.52 / 0.6047 / 0.05212 / 0.0027 / -0.0074
HOMA-IR / 1 / 0.04813 / 0.04887 / 0.98 / 0.3271 / 0.09850 / 0.0097 / -0.0003
glucagon / 1 / -0.00017939 / 0.00104 / -0.17 / 0.8629 / -0.01740 / 0.0003 / -0.0098
leptin / 1 / 0.00836 / 0.00350 / 2.39 / 0.0188 / 0.23351 / 0.0545 / 0.0450
Total Cholesterol / 1 / 0.01384 / 0.04161 / 0.33 / 0.7400 / 0.03343 / 0.0011 / -0.0090
Triglycerides / 1 / 0.17419 / 0.05993 / 2.91 / 0.0045 / 0.28040 / 0.0786 / 0.0693
HDL-cholesterol / 1 / 0.20678 / 0.05701 / 3.63 / 0.0005 / 0.34250 / 0.1173 / 0.1084
LDL-cholesterol / 1 / 0.04784 / 0.04783 / 1.00 / 0.3196 / 0.10003 / 0.0100 / 0.0000

Group:GDM=1, control=2. Serum FGF21 values are logarithmic transformation .

Table3. Univariate linear regression analyses . Dependent variable: D-values of WBC FGF21

factor / df / β / SE / t / P / β' / R2 / adj R2
group / 1 / -2.05732 / 0.73250 / -2.81 / 0.0060 / -0.27166 / 0.0738 / 0.0644
age / 1 / -0.01973 / 0.13658 / -0.14 / 0.8854 / -0.01452 / 0.0002 / -0.0099
BMI / 1 / 0.03300 / 0.16369 / 0.20 / 0.8406 / 0.02026 / 0.0004 / -0.0097
OGTT0h / 1 / 0.20908 / 0.69212 / 0.30 / 0.7632 / 0.03035 / 0.0009 / -0.0092
WBC count / 1 / 0.60765 / 0.25068 / 2.42 / 0.0172 / 0.23669 / 0.0560 / 0.0465
CRP / 1 / 0.03106 / 0.08171 / 0.38 / 0.7047 / 0.03817 / 0.0015 / -0.0086
fast insulin / 1 / 0.05315 / 0.10090 / 0.53 / 0.5995 / 0.05287 / 0.0028 / -0.0073
HOMA-IR / 1 / 0.43640 / 0.49752 / 0.88 / 0.3825 / 0.08782 / 0.0077 / -0.0023
glucagon / 1 / 0.00563 / 0.00819 / 0.69 / 0.4933 / 0.06895 / 0.0048 / -0.0053
leptin / 1 / 0.01595 / 0.03270 / 0.49 / 0.6268 / 0.04896 / 0.0024 / -0.0077
Total Cholesterol / 1 / -0.38590 / 0.33011 / -1.17 / 0.2452 / -0.11669 / 0.0136 / 0.0037
Triglycerides / 1 / 0.20717 / 0.57041 / 0.36 / 0.7172 / 0.03648 / 0.0013 / -0.0088
HDL-cholesterol / 1 / -0.28997 / 0.54629 / -0.53 / 0.5967 / -0.05327 / 0.0028 / -0.0072
LDL-cholesterol / 1 / 0.30725 / 0.51098 / 0.60 / 0.5490 / 0.06032 / 0.0036 / -0.0064

The factors are all used D-values except group,D=pregnancy-postpartum.group:GDM=1,control=2.

Table 4. Univariate linear regression analyses. Dependent variable: D-values of serum FGF21

factor / df / β / SE / t / P / β' / R2 / adj R2
group / 1 / -0.06490 / 0.05623 / -1.15 / 0.2512 / -0.11522 / 0.0133 / 0.0033
age / 1 / -0.01387 / 0.01006 / -1.38 / 0.1712 / -0.13721 / 0.0188 / 0.0089
BMI / 1 / -0.00308 / 0.01217 / -0.25 / 0.8005 / -0.02546 / 0.0006 / -0.0094
OGTT0h / 1 / 0.01005 / 0.05149 / 0.20 / 0.8456 / 0.01962 / 0.0004 / -0.0097
WBC count / 1 / 0.01465 / 0.01913 / 0.77 / 0.4458 / 0.07670 / 0.0059 / -0.0042
CRP / 1 / 0.00678 / 0.00604 / 1.12 / 0.2650 / 0.11196 / 0.0125 / 0.0026
fast insulin / 1 / 0.01104 / 0.00743 / 1.49 / 0.1406 / 0.14767 / 0.0218 / 0.0119
HOMA-IR / 1 / 0.05162 / 0.03678 / 1.40 / 0.1636 / 0.13967 / 0.0195 / 0.0096
glucagon / 1 / -0.00033031 / 0.00060949 / -0.54 / 0.5891 / -0.05439 / 0.0030 / -0.0071
leptin / 1 / 0.00192 / 0.00243 / 0.79 / 0.4313 / 0.07917 / 0.0063 / -0.0038
Total Cholestero / 1 / -0.01788 / 0.02466 / -0.73 / 0.4700 / -0.07270 / 0.0053 / -0.0048
Triglycerides / 1 / -0.00195 / 0.04245 / -0.05 / 0.9634 / -0.00462 / 0.0000 / -0.0101
HDL-cholesterol / 1 / 0.01140 / 0.04067 / 0.28 / 0.7798 / 0.02817 / 0.0008 / -0.0093
LDL-cholesterol / 1 / 0.06632 / 0.03749 / 1.77 / 0.0800 / 0.17505 / 0.0306 / 0.0209

The factors are all used D-values except group,D=pregnancy-postpartum. group:GDM=1,control=2. Serum FGF21 values are logarithmic transformation

Table 5. Univariate logistic regression analyses. Dependent variable: group

factor / df / β / SE / Wald2 / P value / β' / OR(95%CI) / R2
age / 1 / 0.1477 / 0.0751 / 3.8736 / 0.0491 / 0.2281 / 1.159 (1.001,1.343) / 0.0395
BMI / 1 / 0.2284 / 0.1176 / 3.7741 / 0.0521 / 0.2941 / 1.257(0.998,1.582) / 0.0487
WBC FGF21 / 1 / 0.1547 / 0.0588 / 6.9293 / 0.0085 / 0.3246 / 1.167(1.040,1.310) / 0.0737
Serum FGF21 / 1 / 0.00321 / 0.00126 / 6.4839 / 0.0109 / 0.3659 / 1.003(1.001,1.006) / 0.0797
OGTT0h / 1 / 1.7871 / 0.4695 / 14.4911 / 0.0001 / 0.5442 / 5.972(2.380,14.987) / 0.1682
WBC count / 1 / 0.4698 / 0.1559 / 9.0842 / 0.0026 / 0.3839 / 1.600(1.179,2.171) / 0.0984
CRP / 1 / 0.00655 / 0.0435 / 0.0227 / 0.8804 / 0.0166 / 1.007(0.924,1.096) / 0.0002
fast insulin / 1 / -0.00156 / 0.0528 / 0.0009 / 0.9764 / -0.00326 / 0.998(0.900,1.107) / 0.0000
HOMA-IR / 1 / 0.3407 / 0.2748 / 1.5368 / 0.2151 / 0.1438 / 1.406(0.820,2.409) / 0.0159
glucagon / 1 / -0.00162 / 0.00430 / 0.1419 / 0.7064 / -0.0416 / 0.998(0.990,1.007) / 0.0014
leptin / 1 / 0.00678 / 0.0172 / 0.1558 / 0.6930 / 0.0437 / 1.007(0.973,1.041) / 0.0016
Total Cholesterol / 1 / 0.1802 / 0.1764 / 1.0428 / 0.3072 / 0.1143 / 1.197(0.847,1.692) / 0.0104
Triglycerides / 1 / 0.2851 / 0.3030 / 0.8856 / 0.3467 / 0.1053 / 1.330(0.734,2.408) / 0.0089
HDL-cholesterol / 1 / 1.0059 / 0.3355 / 8.9889 / 0.0027 / 0.3877 / 2.734(1.417,5.277) / 0.0985
LDL-cholesterol / 1 / 0.5144 / 0.2913 / 3.1173 / 0.0775 / 0.2119 / 1.673(0.945,2.961) / 0.0330

The factors are all used D-values except group,D=(pregnancy–postpartum)