Supplementary Table 5: Paternal alcohol consumption in the 12 months before pregnancy and risk of acute lymphoblastic leukemia and childhood brain tumors in children aged 0-2 years.

ALL case/ control n / ORa / 95% CI / CBT case/ control n / ORa / 95% CI
No Alcohol / 9/21 / 1.00 / Referent / 7/22 / 1 / Referent
Any Alcohol / 69/168 / 1.40 / 0.50, 3.94 / 51/179 / 0.98 / 0.35, 2.80
0 to <7 d/w / 40/77 / 1.00 / Referent / 21/84 / 1 / Referent
≥7 to <14 d/w / 18/49 / 0.85 / 0.42, 1.75 / 14/46 / 2.06 / 0.85, 5.02
≥14 to <21 d/w / 6/35 / 0.31 / 0.11, 0.85 / 5/39 / 0.81 / 0.26, 2.52
≥21 to <28 d/w / 4/9 / 0.76 / 0.20, 2.80 / 6/12 / 1.95 / 0.50, 7.57
≥28 d/w / 9/19 / 0.98 / 0.37, 2.64 / 12/20 / 2.83 / 1.02, 7.83
Linear term P-value / 0.44 / 0.08
Quadratic term P-value / 0.08 / 0.73
Beer
No beer / 16/48 / 1.00 / Referent / 14/50 / 1 / Referent
Any beer / 62/141 / 1.73 / 0.83, 3.62 / 44/151 / 0.94 / 0.43, 2.02
>0 to <7 beer/wk / 31/69 / 1.77 / 0.80, 3.95 / 20/74 / 0.82 / 0.35, 1.96
≥7 to <14 beer/wk / 15/35 / 1.81 / 0.70, 4.66 / 6/33 / 0.68 / 0.21, 2.23
≥14 to <21 beer/wk / 6/22 / 0.87 / 0.27, 2.81 / 10/25 / 1.59 / 0.54, 2.73
≥21 to <28 beer/wk / 3/4 / 2.80 / 0.51, 15.30 / 4/9 / 0.91 / 0.20, 4.26
≥28 beer/wk / 7/11 / 2.78 / 0.82, 9.45 / 4/10 / 1.26 / 0.27, 5.84
Linear trend / 0.25 / 0.48
Quadratic term P-value / 0.93 / 0.72
Wine
No wine / 62/117 / 1.00 / Referent / 43/132 / 1 / Referent
Any wine / 15/72 / 0.35 / 0.18, 0.71 / 15/69 / 0.96 / 0.45, 2.05
>0 to <7 wine/week / 13/47 / 0.45 / 0.22, 0.96 / 9/47 / 0.79 / 0.32, 1.95
≥7 wine/week / 2/25 / 0.14 / 0.03, 0.65 / 6/22 / 1.37 / 0.45, 4.14
Linear trend P-value / 0.002 / 0.82
Spirits/mixer
No spirits / 50/120 / 1.00 / Referent / 27/116 / 1 / Referent
Any spirits / 27/69 / 0.90 / 0.47, 1.70 / 31/85 / 1.57 / 0.80, 3.10
>0 to <7 spirits/week / 21/54 / 0.95 / 0.48, 1.88 / 21/73 / 1.22 / 0.59, 2.52
≥7 spirits/week / 6/15 / 0.73 / 0.23, 2.28 / 10/12 / 4.90 / 1.54, 15.56
Linear trend P-value / 0.63 / 0.03

a ORs adjusted for child’s age, sex, state of residence, year of birth group, ethnicity, paternal age group, paternal smoking, household income.

Article: Parental alcohol consumption and risk of childhood acute lymphoblastic leukemia and brain tumors

Journal Name: Cancer Causes & Control

Authors: Elizabeth Milne1, Kathryn R. Greenop1, Rodney J. Scott2, 3, Nicholas H. de Klerk1, Carol Bower1, Lesley J. Ashton4, John A. Heath5, 6, Bruce K. Armstrong7.

1Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia.

2 Hunter Medical Research Institute, School of Biomedical Sciences, Faculty of Health, University of Newcastle, New South Wales, Australia.

3 Hunter Area Pathology Service, HNEHealth, Newcastle, New South Wales, Australia.

4 Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW, Australia.

5 Children’s Cancer Centre, Royal Children’s Hospital, Melbourne, Victoria, Australia.

6Department of Paediatrics, University of Melbourne, Melbourne, Australia.

7 Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia

Author for correspondence:

Elizabeth Milne, Email: