Table S6.Components of intracellular signaling pathways involved in immune responses predicted from the P. strigosatranscriptome.

Signaling Pathway / Component / Predicted Domains (InterProScan)a / Transcript ID
Apoptosis / FasL / TNF / dist251225_c1_seq1
Fas / TNFR+DED / dist233052_c0_seq1
FADD-like / DED / dist97950_c0_seq1
Caspase 3-like / CASc / dist244920_c1_seq1
Caspase 8 / DED+DED+CASc / dist252854_c0_seq1
Caspase 9 / CARD+CASc / dist251986_c0_seq2
Bcl2-like / Bcl-2 / dist152189_c0_seq1
API5 / API5 / dist159764_c0_seq1
AIF2 / Pyr_Redox / dist253149_c0_seq1
TGF-beta / TGFB-like / TGF_beta,TGFb_propeptide / dist238328_c1_seq1
TGFBR1-like / TGFbeta_recp+TM+TGFbeta_GS+Pkinase / dist245909_c0_seq1
SARA-like / FYVE / dist304490_c0_seq1
SMAD2/3 / MH1+MH2 / dist250909_c2_seq1
SMAD4 / MH1(2) / dist246521_c4_seq1
TLR / MyD88 / Death+TIR / dist250879_c2_seq1
TRAF-like / Zf_TRAF(2)+MATH / dist246849_c5_seq1
TAB / PP2C / dist206647_c0_seq1
TAK1 / Pkinase / dist251115_c6_seq1
TRAM / TRAM1+TRAM_LAG1_CLN8 / dist242701_c1_seq1
TRAF3-like / RING+DM+zf-TRAF+End3+MATH / dist253127_c0_seq1
TBK1-like / PKc-like+UBL-TBK1 / dist249257_c5_seq1
IRF3 / IRF+IRF3 / dist97916_c0_seq1
IkBKinase / Pkinase / dist244412_c7_seq1
NFkB Inhibitor / Ank(3) / dist226100_c1_seq2
NFkB partial / RHD / dist243377_c6_seq1
Ank(5) / dist252982_c0_seq18
AnK(3)+Death / dist243377_c5_seq1
Wnt / Frizzled / 7tm / dist247246_c1_seq1
GSK-3B-like / Pkinase / dist237729_c0_seq1
Beta-catenin / ARM(5) / dist252284_c2_seq2
TCF-like / HMG-box / dist148750_c0_seq1
Notch / NOTCH-like / LNR+NOD+NODP+TM / dist222573_c1_seq1
EGF(2)+LNR(2) / dist222573_c4_seq1
EGF+LNR(3) / dist187720_c4_seq1
EGF(15) / dist249172_c0_seq1
Delta-like / DSL+EGF(20)+TM / dist250784_c1_seq1
TACE-like / Pep_M12B+Reprolysin+Disintegrin+Adam_CR / dist247195_c1_seq2
NUMB-like / PID / dist252640_c1_seq1
Deltex-like / Zf-RING+WWE / dist230122_c3_seq1
Suppressor of Hairless / Lag1_DNAbind+BTD+TIG / dist246926_c0_seq3
MAPK / FGF / FGF / dist251193_c0_seq3
FGFR-like / Ig+Pkinase_tyr / dist251021_c4_seq2
GRB2-like / SH2+SH3 / dist222508_c1_seq1
SOS-like / PH(2)+PDZ+RhoGEF+PH / dist252625_c0_seq9
Ras-like / RAS / dist234557_c1_seq1
MAPK-like / Pkinase / dist249945_c0_seq14
MNK-like / Pkinase / dist249376_c7_seq1
RSK-like / Pkinase(2) / dist252761_c2_seq3
CREB / pKID+bZIP_1 / dist252784_c1_seq12
MYC-like / HLH+Myc_N / dist217462_c1_seq1
Hedgehog / Hedgehog / HH_Signal+Hint / dist240860_c2_seq1
Patched / Patched / dist228738_c5_seq1
SMO-like / 7tm / dist221208_c0_seq1
Ci/Gli / zf-H2C2_2(2) / dist228856_c2_seq1
PI3K-Akt-mTOR / PI3K / PI3K_p85B+PI3K_rbd+PI3K_C2 / dist233999_c0_seq1
Akt/PKB / PH+Pkinase+Pkinase_C / dist249274_c0_seq1
Jak-Stat / Stat / STAT_alpha+STAT_bind+SH2 / dist241535_c1_seq1

aProtein domains predicted with InterProScan. SP, signal peptide; TM, transmembrane region; TNRF, tumor necrosis factor receptor; DED, death effector domain; CASc, caspase; CARD, caspase recruitment domain; Bcl-2; B-cell lymphoma-2; API5, apoptosis inhibitory protein 5; Pyr_Redox, Pyridine nucleotide-disulphide oxidoreductase; TGF, transforming growth factor; Pkinase, protein kinase; FYVE, Fab1/YOTB/Vac1/EEA1; MH, MAD homology; MATH, meprin and TRAF homology; TRAF, TNF receptor associated factor; PP2C, protein phosphatase 2C; TRAM, TRM2 and miaB; DM, Doublesex DNA-binding motif; IRF, interferon regulatory factor; ANK, ankyrin; RDH, Rel homology domain; 7tm, 7 transmembrane domains; ARM, Armadillo/beta-catenin-like repeats; HMG, high mobility group; LNR, Lin-12/Notch repeat; NOD, NOTCH domain; EGF, epidermal growth factor; DSL, Delta/Serrate ligand; PID, Phosphotyrosine interaction domain; WWE, Domain in Deltex and TRIP12 homologues; BTD, Beta trefoil DNA binding domain; TIG, Ig-like, plexins, transcription factors; FGF, fibroblast growth factor; Ig, immunoglobulin; SH, Src homology; PH, Pleckstrin homology; PDZ, PSD-95/Dlg/ZO; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; pKID, phosphorylatedkinase-inducible-domain; bZIP, basic-leucine zipper; HLH, helix loop helix; HH, hedgehog; Hint, Hedgehog/Intein; zf-H2C2, His(2)-Cys(2) zinc finger; PI3K_p85B, PI3-kinase family, p85-binding domain; PI3K_rbd, PI3-kinase family, Ras-binding domain; Pi3K_C2, Phosphoinositide 3-kinase with C2 domain; STAT, signal transducers and activators of transcription. Plus symbols (+) separate different domains within a protein. The number of repetitions of a given domainin parenthesis.