Table S3. Overview of KEGG modules that are overrepresented in the metagenomes of ileostomy effluent and feces, respectively. KEGG modules multiple testing corrected p-values and description of the modules are indicated.

Sample / KEGG / p-value / Description
ileostomy effluent / M10248 / 7.30E-303 / Biotin biosynthesis, pimeloyl-CoA => biotin
ileostomy effluent / M10211 / 5.39E-128 / Diphosphatidylglycerol biosynthesis, CDP-glycerol => cardiolipin
ileostomy effluent / M10191 / 2.66E-53 / C5 isoprenoid biosynthesis, mevalonate pathway
ileostomy effluent / M10052 / 1.44E-46 / Methionine biosynthesis, intermediates, homoserine => O-acetylhomoserine => cystathionine
ileostomy effluent / M10610 / 3.76E-40 / PTS-Fru-EII; PTS system, fructose-specific II component
ileostomy effluent / M10613 / 1.16E-33 / PTS-Man-EII; PTS system, mannose-specific II component
ileostomy effluent / M10616 / 1.18E-31 / PTS-Gat-EII; PTS system, galactitol-specific II component
ileostomy effluent / M10193 / 3.22E-31 / C10 isoprenoid biosynthesis
ileostomy effluent / M10284 / 8.73E-30 / Complex IV (Cytochrome c oxidase), cytochrome o ubiquinol oxidase/cytochrome c oxidase/quinol oxidase polypeptide
ileostomy effluent / M10006 / 6.72E-29 / Pentose phosphate pathway, oxidative phase
ileostomy effluent / M10053 / 1.54E-26 / Methionine biosynthesis, intermediates, homoserine => O-acetylhomoserine => L-homocysteine
ileostomy effluent / M10302 / 6.37E-25 / Reductive carboxylate cycle
ileostomy effluent / M10303 / 1.99E-24 / Methane oxidation, methylotroph, methane => CO2
ileostomy effluent / M10015 / 1.54E-21 / Malonate semialdehyde pathway
ileostomy effluent / M10091 / 1.93E-21 / Adenine nucleotide biosynthesis, IMP => ADP/dADP,ATP/dATP
ileostomy effluent / M10606 / 2.20E-21 / PTS-Scr-EII; PTS system, sucrose-specific II component
ileostomy effluent / M10090 / 1.27E-20 / Inosine monophosphate biosynthesis, PRPP + glutamine => IMP
ileostomy effluent / M10024 / 5.29E-20 / Methionine biosynthesis, apartate => homoserine => methionine
ileostomy effluent / M10050 / 2.17E-18 / Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
ileostomy effluent / M10602 / 5.12E-17 / PTS-Glc-EII; PTS system, glucose-specific II component
ileostomy effluent / M10104 / 2.98E-16 / CMP-N-Acetylneuraminate biosynthesis (mammals), ManNAc => Neu5Ac-9P => CMP-Neu5Ac
ileostomy effluent / M10059 / 1.09E-13 / Isoleucine degradation, isoleucine => propionyl-CoA
ileostomy effluent / M10101 / 2.96E-13 / UDP-N-Acetylgalactosamine and UDP-N-acetylmannosamine biosynthesis
ileostomy effluent / M10058 / 2.99E-13 / Leucine degradation, leucine => acetoacetate + acetyl-CoA
ileostomy effluent / M10299 / 3.14E-13 / C4-dicarboxylic acid cycle, phosphoenolpyruvate carboxykinase type
ileostomy effluent / M10078 / 3.54E-12 / Tyrosine degradation, tyrosine => homogentisate
ileostomy effluent / M10300 / 6.06E-12 / C4-dicarboxylic acid cycle, NAD+ -malic enzyme type
ileostomy effluent / M10120 / 9.25E-12 / ADP-L-glycero-D-manno-heptose biosynthesis
ileostomy effluent / M10153 / 2.57E-11 / Chondroitin sulfate degradation
ileostomy effluent / M10247 / 3.82E-11 / Cobalamin biosynthesis, cobinamide => cobalamin
ileostomy effluent / M10005 / 1.43E-09 / Pentose phosphate pathway and PRPP biosynthesis
ileostomy effluent / M10029 / 3.12E-09 / Isoleucine biosynthesis, pyruvate => isoleucine
ileostomy effluent / M10210 / 3.50E-09 / Phosphatidylglycerol biosynthesis, CDP-diacylglycerol => phosphatidylglycerol
ileostomy effluent / M10066 / 4.12E-09 / Tryptophan metabolism, tryptophan => serotonin => 5-hydroxyindoleacetate/melatonin
ileostomy effluent / M10152 / 5.25E-09 / Dermatan sulfate degradation
ileostomy effluent / M10604 / 1.38E-08 / PTS-Nag-EII; PTS system, N-acetylglucosamine-specific II component
ileostomy effluent / M10097 / 2.79E-08 / UDP-glucose and UDP-galactose biosynthesis
ileostomy effluent / M10092 / 6.47E-08 / Guanine nucleotide biosynthesis, IMP => GDP/dGDP,GTP/dGTP
ileostomy effluent / M10255 / 7.40E-08 / Ascorbate biosynthesis, animals
ileostomy effluent / M10603 / 2.97E-07 / PTS-Mal-EII; PTS system, maltose and glucose-specific II component
ileostomy effluent / M10118 / 7.65E-07 / Pentose interconversion, arabinose/ribulose/xylulose/xylose
ileostomy effluent / M10033 / 1.18E-06 / Chorismate biosynthesis, phosphoenolpyruvate + erythrose-4P => chorismate
ileostomy effluent / M10611 / 6.67E-06 / PTS-Mtl-EII; PTS system, mannitol-specific II component
ileostomy effluent / M10297 / 1.12E-05 / CAM, dark
ileostomy effluent / M10156 / 1.70E-05 / Lipopolysaccharide biosynthesis, inner core => outer core => O-antigen
ileostomy effluent / M10619 / 1.79E-05 / PTS-Dgl-EII; PTS system, D-glucosamine-specific II component
ileostomy effluent / M10011 / 1.90E-05 / Citrate cycle, module 2
ileostomy effluent / M10019 / 2.09E-05 / Glutamate biosynthesis, oxoglutarete => glutamate (glutamate synthase)
ileostomy effluent / M10027 / 1.89E-04 / Valine biosynthesis, pyruvate => valine
ileostomy effluent / M10028 / 5.11E-04 / Leucine biosynthesis, pyruvate => leucine
ileostomy effluent / M10261 / 5.78E-04 / Polyamine biosynthesis, ornithine => putrescine
ileostomy effluent / M10004 / 7.22E-04 / Pentose phosphate pathway
ileostomy effluent / M10177 / 9.27E-04 / Ketone body biosynthesis, acetyl-CoA => acetoacetate/3-hydroxybutyrate/acetone
ileostomy effluent / M10243 / 1.05E-03 / Glutathione biosynthesis, glutamate => glutathione
ileostomy effluent / M10618 / 6.23E-03 / PTS-Lac-EII; PTS system, lactose-specific II component
ileostomy effluent / M10016 / 2.28E-02 / Glucuronate pathway (uronate pathway)
ileostomy effluent / M10295 / 2.32E-02 / Reduced pentose phosphate cycle, Glycerate-3P => Glyceraldehyde-3P
ileostomy effluent / M10262 / 2.52E-02 / Ptrescine metabolism, N-acetylation, putrescine => 4-aminobutanoate
ileostomy effluent / M10008 / 4.39E-02 / Entner-Doudoroff pathway
ileostomy effluent / M10095 / 4.80E-02 / Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP
feces / M10288 / 2.08E-102 / V-type ATPase (Prokaryotes)
feces / M10114 / 3.00E-55 / Lipopolysaccharide biosynthesis, KDO2-lipid A
feces / M10155 / 1.28E-48 / Keratan sulfate degradation
feces / M10249 / 1.04E-45 / Pyridoxal biosynthesis, erythrose-4P => pyridoxal-5P
feces / M10273 / 6.73E-43 / Complex I (NADH dehydrogenase), NADH dehydrogenase I
feces / M10192 / 6.46E-40 / C5 isoprenoid biosynthesis, non-mevalonate pathway
feces / M10240 / 3.59E-39 / NAD biosynthesis, aspartate => NAD
feces / M10083 / 4.33E-30 / beta-Alanine biosynthesis, L-aspartate => beta-alanine
feces / M10298 / 9.68E-30 / CAM, light
feces / M10087 / 9.73E-26 / Taurine biosynthesis, cysteine => cysteate => taurine
feces / M10037 / 5.73E-23 / Histidine biosynthesis, PRPP => histidine
feces / M10079 / 1.52E-22 / Histidine degradation, histidine => N-formiminoglutamate => glutamate
feces / M10038 / 2.22E-21 / Glutamine degradation, glutamine => glutamate + NH3
feces / M10306 / 2.40E-21 / Sulfur reduction, sulfate => H2S
feces / M10160 / 2.22E-20 / Fatty acid biosynthesis, elongation
feces / M10204 / 9.23E-20 / CDP-diacylglycerol biosynthesis, PA => CDP-diacylglycerol
feces / M10099 / 9.04E-17 / GDP-Mannose biosynthesis, fructose-6P => GDP-Man
feces / M10013 / 1.40E-16 / Glyoxylate biosynthesis, glycolate => glyoxylate
feces / M10105 / 2.53E-16 / dTDP-Glucose, dTDP-galactose and dTDP-rhamnose biosynthesis
feces / M10046 / 4.26E-16 / Asparagine degradation, asparagine => aspartate +NH3
feces / M10030 / 2.17E-15 / Serine biosynthesis, glycerate-3P => serine
feces / M10051 / 1.74E-14 / Ectoine biosynthesis
feces / M10313 / 8.41E-13 / RNA polymerase, bacteria
feces / M10597 / 9.39E-12 / DNA polymerase III complex
feces / M10057 / 1.14E-11 / Threonine biosynthesis, glycine => threonine
feces / M10304 / 1.83E-11 / Methanogenesis
feces / M10017 / 3.15E-11 / Glutamate biosynthesis, oxoglutarate => glutamate (glutamate dehydrogenase)
feces / M10239 / 1.47E-09 / Ascorbate biosynthesis, plants
feces / M10023 / 2.66E-09 / Lysine biosynthesis, aspartate => lysine
feces / M10041 / 3.45E-09 / Ornithine biosynthesis, glutamate => ornithine
feces / M10314 / 4.08E-09 / RNA polymerase, archaea
feces / M10253 / 4.40E-08 / Phylloquinone biosynthesis, chorismate => phylloquinone
feces / M10102 / 5.35E-08 / UDP-Xylose biosynthesis, UDP-Glc => UDP-Xyl => Xyl
feces / M10025 / 7.97E-08 / Threonine biosynthesis, apartate => homoserine => threonine
feces / M10045 / 1.06E-07 / Aspartate degradation, aspartate => oxaloacetate
feces / M10020 / 1.25E-07 / Proline biosynthesis, glutamate => proline
feces / M10082 / 5.04E-07 / Selenocysteine metabolism
feces / M10250 / 2.73E-06 / Riboflavin biosynthesis, GTP => riboflavin/FMN/FAD
feces / M10305 / 3.39E-06 / Nitrogen fixation, N2 => ammonia
feces / M10001 / 5.14E-06 / Glycolysis
feces / M10241 / 7.43E-06 / Menaquinone biosynthesis, chorismate => menaquinone
feces / M10022 / 1.21E-05 / Asparagine biosynthesis, aspartate => asparagine
feces / M10042 / 2.35E-05 / Urea cycle
feces / M10055 / 7.43E-05 / Methionine degradation
feces / M10043 / 9.20E-05 / Arginine degradation, arginine => citrulline
feces / M10601 / 1.36E-04 / archaeal DNA polymerase II complex
feces / M10056 / 1.44E-04 / S-Adenosylmethionine biosynthesis, methionine => S-adenosylmethionine => methionine
feces / M10032 / 2.31E-04 / Cysteine biosynthesis, serine => cysteine
feces / M10215 / 2.47E-04 / Plasmenylethanolamine biosynthesis
feces / M10119 / 2.60E-04 / CMP-Kdo biosynthesis
feces / M10244 / 2.61E-04 / Pantothenate biosynthesis, valine => pantothenate
feces / M10012 / 4.58E-04 / Glyoxylate cycle
feces / M10188 / 5.15E-04 / Phosphatidylserine (PS) biosynthesis, CDP-diacylglycerol => PS
feces / M10117 / 5.58E-04 / Uronic acid metabolism
feces / M10010 / 1.46E-03 / Citrate cycle, module 1
feces / M10242 / 2.93E-03 / Ubiquinone biosynthesis, chorismate => ubiquinone, prokaryotes
feces / M10103 / 3.05E-03 / UDP-N-Acetylmuramate biosynthesis, UDP-GlcNAc => UDP-MurNAc
feces / M10270 / 7.34E-03 / C1-unit interconversion
feces / M10182 / 1.48E-02 / Phosphatidic acid (PA) biosynthesis
feces / M10061 / 1.57E-02 / Glycine biosynthesis, betaine => glycine
feces / M10054 / 2.19E-02 / Methionine salvage pathway
feces / M10007 / 2.36E-02 / Pentose phosphate pathway, non-oxidative phase
feces / M10181 / 2.55E-02 / Triacylglycerol biosynthesis
feces / M10278 / 4.28E-02 / Complex II (succinate dehydrogenase / fumarate reductase), succinate dehydrogenase