Supplement

Table S1Descriptive Statistics for Individuals with Genetic Data

Measure / N / Mean / SD / Min / Max / Skewnessa / Kurtosisa / Reliability / Age
EF tasks / 386 / - / - / - / - / - / - / 16.5-24.7
Antisaccadeb / 378 / 1.06 / 0.20 / 0.47 / 1.57 / -0.14 / -0.08 / 0.90g / -
Stop-signal / 371 / 285.63 ms / 67.04 / 169 / 490 / 1.01 / 0.80 / 0.77g / -
Stroop / 366 / 214.60 ms / 93.98 / 46 / 488 / 0.71 / 0.30 / 0.92g / -
Keep-trackb / 376 / 0.94 / 0.18 / 0.38 / 1.50 / 0.49 / 0.81 / 0.65h / -
Letter-memoryb / 382 / 1.11 / 0.25 / 0.41 / 1.57 / 0.27 / -0.49 / 0.62h / -
Spatial 2-backb / 374 / 1.19 / 0.16 / 0.65 / 1.57 / -0.92 / 1.82 / 0.87h / -
Number-letter / 379 / 340.92 ms / 178.13 / -89.00 / 945 / 0.80 / 0.89 / 0.86g / -
Color-shape / 369 / 333.03ms / 189.16 / -196 / 916 / 0.83 / 1.09 / 0.83g / -
Category-switch / 374 / 340.05 ms / 181.33 / -23.00 / 1015 / 1.14 / 1.81 / 0.82g / -
CBCLc / 259 / 2.18 / 2.30 / 0.00 / 12.00 / 1.39 / 1.91 / 0.86i / 6.7-19.8
CES-Dd / 449 / 10.32 / 6.32 / 0.00 / 42.33 / 0.22 / 0.22 / 0.89j / 11.7-27.5
IQef / 387 / 105.04 / 11.86 / 54f / 139 / -0.25 / 0.91 / 0.87-0.96k / 16.0-24.7

Note. N represents the number that also had genetic data. EF = executive function; CBCL = Childhood Behavioral Checklist – attention subscale; CESD = Center for Epidemiologic Studies-Depression scale; IQ = intelligence quotient. This table presents raw scores for the CBCL, CES-D and IQ measures, however all analyses were done on transformed and regressed values.

aSkewness and kurtosis for all variables reflect the distributions after transformations.

bThese values were previously proportion correct and have undergone arcsine transformations.

cParent-rated CBCL scores averaged across each time point when available (ages 7-16 years).

dFor descriptive purposes we present sum score out of 20 questions, however an average across waves after regressing out age, sex, and age-by-sex at each wave was used as the final variable.

eScores from the Wechsler Adult Intelligence Scale and Wechsler Abbreviated Scale of Intelligence from the LTS and CTS samples, respectively, were combined to create a composite IQ measure.

fWe had one individual with a very low IQ score, however this individual was able to read and perform tasks.

gInternal reliability was calculatedby adjusting odd-even correlations with the Spearman–Brown prophecy formula.

hInternal reliability was calculated using Cronbach’s alpha.

iInternal reliability from (Achenbach & Rescorla, 2001).

jAveragedCronbach’s alpha from each CES-D wave, which ranged from .84 to .92.

kInternal reliability from (Wechsler, 1997; Wechlser, 1999).

Table S2Correlation between p-value bin thresholds for all PRS disorders

p-value Threshold Bin
5x10-6 / 5x10-5 / 0.0005 / 0.005 / 0.05 / 0.1 / 0.3 / 0.5
ADHD p< 1.0 bin / .05 / .01 / .15* / .29* / .55* / .68* / .85* / .91*
AUT p< 1.0 bin / .06 / .09 / .21* / .42* / .78* / .88* / .97* / .99*
BP p< 1.0 bin / -.03 / .07 / .21* / .42* / .74* / .83* / .96* / .99*
MDD p< 1.0 bin / -.00 / .02 / .11* / .37* / .72* / .81* / .92* / .99*
SCZ p< 1.0 bin / .31* / .36* / .52* / .70* / .90* / .95* / .99* / 1.00*

Note. Except for the most stringent p-value bins, the risk scores by bin within disorder are highly correlated with each other. For example, the bins for the Schizophrenia risk scores start correlating with a risk score including all SNPs (bin p<1.0) at r > 0.9 at the p<0.05 bin.

Table S3 Variances and N SNPs for each PRSp-value bin

p-value threshold bin / Variance (NSNPs)
ADHD / AUT / BP / MDD / SCZ
p5x10-6 / 1.07 (2) / 0.07 (7) / 0.15 (18) / 0.03(5) / 5.52(900)
p5x10-5 / 9.12 (20) / 0.32(42) / 0.72 (95) / 0.16(37) / 9.04 (2,080)
p <0.0005 / 69.18 (216) / 1.97 (310) / 3.30(584) / 0.91(264) / 15.13 (5,218)
p0.005 / 779.65(1,986) / 10.96(2,296) / 15.00(3,555) / 6.02(2,233) / 30.77(16,153)
p0.05 / 6725.57 (15,183) / 56.10(16,547) / 67.01(22,088) / 35.28(16,432) / 78.65(57,571)
p0.1 / 13601.68 (27,683) / 85.57(29,309) / 104.75(37,953) / 55.98(29,029) / 105.78(85,912)
p0.3 / 35775.04 (68,163) / 155.89(70,112) / 167.78(87,223) / 99.89(69,563) / 146.70(161,675)
p0.5 / 49047.05 (99,786) / 180.58(101,788) / 189.46(124,314) / 128.64(101,051) / 160.44(212,178)
p1.0 / 66302.10 (149,378) / 255.51 (149,300) / 194.53(179,878) / 136.50 (149,333) / 164.87 (280,946)

References

Achenbach TM, Rescorla LA (2001)Manual for the ASEBA School-Age Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families