Table S1a.Predictive Ability of Selected Biomarker Models and 90day Mortality at baseline.

Regression Models of 90 Day Mortality By Score Criterion
Number of Markers / ChiSq Score / Log Model Variables / Model ROC / Difference in AUROC / Pvalue1
2 / 53.85 / TNF, Lactate / 0.5976 / -8.58% / 0.001
2 / 53.12 / TAT, Lactate / 0.6738 / -0.96% / 0.24
2 / 51.97 / IL10, Lactate / 0.6703 / -1.31% / 0.14
3 / 58.74 / IL10, TNF, Lactate / 0.6803 / -0.30% / 0.53
3 / 54.97 / TNF, TAT, Lactate / 0.6762 / -0.72% / 0.32
3 / 54.41 / TNF, DDimer, Lactate / 0.6716 / -1.18% / 0.12
4 / 60.12 / IL10, TNF, TAT, Lactate / 0.6826 / -0.08% / 0.76
4 / 59.17 / IL10, TNF, Ddimer, Lactate / 0.6807 / -0.27% / 0.52
4 / 58.81 / IL6, IL10, TNF, Lactate / 0.6835 / 0.01% / 0.96
5 / 60.51 / IL10, TNF,TAT, Ddimer, Lactate / 0.6824 / -0.10% / 0.501
5 / 60.21 / IL6, IL10, TNF, TAT, Lactate / 0.6835 / 0.01% / 0.959
5 / 59.24 / IL6, IL10, TNF, Ddimer, Lactate / 0.6804 / -0.29% / 0.466
6 / 60.62 / IL6,IL10, TNF, TAT, Ddimer, Lactate / 0.6834 / ref / ref

Table S1b. Predictive Ability of Selected Biomarker Models and 90day Mortality at 24hrs.

Regression Models of 90 Day Mortality By Score Criterion
Number of Markers / ChiSq Score / Log Model Variables / Model ROC / Difference in AUROC / Pvalue1
2 / 50.48 / IL6 , Lactate / 0.6028 / -7.52% / 0.01
2 / 45.53 / TAT, Lactate / 0.6457 / -3.23% / 0.06
2 / 43.51 / IL6, TAT / 0.6362 / -4.18% / 0.04
3 / 55.35 / IL6, TAT, Lactate / 0.6367 / -4.13% / 0.04
3 / 53.23 / IL6, Ddimer, Lactate / 0.6464 / -3.16% / 0.07
3 / 51.03 / IL6, TNF, Lactate / 0.644 / -3.40% / 0.07
4 / 58.13 / IL6, TAT, Ddimer, Lactate / 0.6492 / -2.88% / 0.07
4 / 55.99 / IL6, TNF, TAT, Lactate / 0.6435 / -3.46% / 0.05
4 / 55.35 / IL6, IL10, TAT, Lactate / 0.6766 / -0.14% / 0.83
5 / 58.45 / Il6, TNF, TAT, Ddimer, Lactate / 0.6546 / -2.34% / 0.08
5 / 58.22 / IL6, IL10, TAT, Ddimer, Lactate / 0.6766 / -0.14% / 0.83
5 / 56.39 / IL6, IL10, TNF, TAT, Lactate / 0.6693 / -0.87% / 0.45
6 / 59.09 / IL6, IL10, TNF, TAT, Ddimer, Lactate / 0.6780 / ref / ref

P-value is test of equivalence between full and reduced model AUROC values.