Table S1. Snps Evaluated and Allele Frequency

Table S1. SNPs evaluated and Allele Frequency

Gene / SNP (rs number) / Function / Allele / Chromosome / Chromosome Position / Strand / Reported MAF / Observed MAF / P value for HWE / Genotyping method
CYP11B1 / rs5303 / 3’UTR / T>C / 8 / 143952097 / - / 0.128 / 0.152 / 0.103 / PCR and sequencing
rs1134095 / 3’UTR / C>T / 8 / 143951292 / - / 0.122 / 0.159 / 0.088 / Mass array
rs4736312 / 3’UTR / A>C / 8 / 143950939 / + / 0.220 / 0.146 / 0.121 / Mass array
rs7003319 / 3’UTR / T>C / 8 / 143951749 / + / 0.220 / 0.159 / 0.088 / Mass array
CYP17A1 / rs6162 / H46H / G>A / 10 / 104586971 / + / 0.456 / 0.463 / 0.862 / Mass array
rs6163 / S65S / C>A / 10 / 104586914 / + / 0.452 / 0.482 / 0.990 / Mass array
rs743572 / 5’UTR / A>G / 10 / 104587142 / + / 0.453 / 0.488 / 0.821 / Mass array
CYP19A1 / rs1062033 / Intron / G>C / 15 / 49335230 / - / 0.488 / 0.421 / 0.492 / Mass array
rs10046 / 3’UTR / C>T / 15 / 49290278 / - / 0.407 / 0.463 / 0.246 / Mass array
rs700518 / V80V / A>G / 15 / 49316404 / - / 0.465 / 0.445 / 0.147 / Mass array
rs700519 / R264C / C>T / 15 / 49295260 / - / 0.116 / 0.140 / 0.140 / PCR and sequencing
rs727479 / Intron / G>T / 15 / 49321839 / + / 0.256 / 0.293 / 0.585 / Mass array
rs4646 / 3’UTR / A>C / 15 / 49290136 / + / 0.279 / 0.329 / 0.656 / Mass array
CYP1A1 / rs4646422 / G45D / G>A / 15 / 72802358 / - / 0.140 / 0.146 / 0.121 / Mass array
rs1048943 / I462V / A>G / 15 / 72800038 / - / 0.256 / 0.213 / 0.629 / PCR and sequencing
CYP1A2 / rs2470890 / N516N / C>T / 15 / 72834479 / + / 0.128 / 0.134 / 0.161 / Mass array
rs762551 / Intron / C>A / 15 / 72828970 / + / 0.337 / 0.372 / 0.525 / PCR and sequencing
rs2069514 / Intron / G>A / 15 / 72825273 / + / 0.242 / 0.274 / 0.0006 / PCR and sequencing
CYP1B1 / rs1056836 / L432V / C>G / 2 / 38151707 / - / 0.128 / 0.134 / 0.651 / Mass array
rs1056837 / D449D / T>C / 2 / 38151654 / - / 0.140 / 0.134 / 0.161 / Mass array
CYP20A1 / rs1048013 / L346F / C>T / 2 / 203862797 / + / 0.314 / 0.238 / 0.406 / Mass array
CYP24A1 / rs4809957 / 3’UTR / A>G / 20 / 52204578 / + / 0.425 / 0.439 / 0.209 / Mass array
rs2296241 / A184A / A>G / 20 / 52219626 / + / 0.433 / 0.427 / 0.632 / Mass array
rs6068816 / T248T / C>T / 20 / 52214498 / + / 0.356 / 0.293 / 0.585 / Mass array
CYP26A1 / rs4418728 / Intron / G>T / 10 / 94829714 / + / 0.221 / 0.152 / 0.936 / Mass array
rs10882140 / Intron / G>T / 10 / 94832203 / + / 0.186 / 0.140 / 0.575 / PCR and sequencing
CYP2A13 / rs1709082 / Intron / T>G / 19 / 46293449 / + / 0.100 / 0.073 / 0.475 / Mass array
CYP2A6 / rs8192720 / L8L / C>T / 19 / 46048150 / - / 0.131 / 0.207 / 0.749 / Mass array
rs28399433 / 5’near gene / T>G / 19 / 46048219 / - / 0.235 / 0.213 / 0.136 / Mass array
CYP2A7 / rs3869579 / R311C / G>A / 19 / 46075639 / + / 0.415 / 0.238 / 0.150 / PCR and sequencing
CYP2B6 / rs3745274 / Q172H / G>T / 19 / 46204681 / + / 0.195 / 0.152 / 0.936 / Mass array
rs8192719 / Intron / C>T / 19 / 46210613 / + / 0.156 / 0.171 / 0.761 / Mass array
rs4803419 / Intron / C>T / 19 / 46204632 / + / 0.448 / 0.396 / 0.956 / PCR and sequencing
rs2279343 / K262R / A>G / 19 / 46207103 / + / 0.188 / 0.128 / 0.184 / PCR and sequencing
rs2279344 / Intron / G>A / 19 / 46207323 / + / 0.341 / 0.348 / 0.594 / Mass array
CYP2C18 / rs2281891 / T385M / CT / 10 / 96493058 / - / 0.465 / 0.280 / 0.397 / Mass array
rs2860840 / 3’UTR / C>T / 10 / 96485222 / + / 0.233 / 0.165 / 0.532 / Mass array
rs1326830 / 3’UTR / G>T / 10 / 96485783 / - / 0.174 / 0.195 / 0.932 / Mass array
CYP2C19 / rs4244285 / P227P / G>A / 10 / 96531606 / + / 0.256 / 0.280 / 0.163 / Mass array
CYP2D6 / rs16947 / C296R / T>C / 22 / 40853887 / + / 0.169 / 0.171 / 0.634 / PCR and sequencing
rs1065852 / P34S / C>T / 22 / 40856638 / - / 0.283 / 0.238 / 0.005 / Mass array
rs1058164 / V136V / G>C / 22 / 40855076 / - / 0.438 / 0.470 / 0.633 / PCR and sequencing
CYP2E1 / rs2515641 / F421F / C>T / 10 / 135201352 / + / 0.155 / 0.122 / 0.821 / Mass array
rs2031920 / 5’near gene / C>T / 10 / 135189835 / + / 0.237 / 0.238 / 0.319 / Mass array
rs3813867 / 5’near gene / G>C / 10 / 135189595 / + / 0.289 / 0.213 / 0.629 / Mass array
rs2070673 / 5’near gene / A>T / 10 / 135190557 / + / 0.467 / 0.445 / 0.912 / Mass array
rs2070672 / 5’near gene / A>G / 10 / 135190538 / + / 0.244 / 0.189 / 0.441 / Mass array
CYP2F1 / rs305968 / P32P / G>A / 19 / 46314029 / + / 0.267 / 0.299 / 0.376 / Mass array
CYP2S1 / rs338599 / P74P / G>C / 19 / 46392333 / - / 0.122 / 0.189 / 0.960 / Mass array
CYP39A1 / rs2277119 / R103H / G>A / 6 / 46717864 / - / 0.211 / 0.226 / 0.913 / Mass array
rs9381468 / Intron / A>G / 6 / 46733233 / + / 0.354 / 0.433 / 0.102 / Mass array
rs953062 / Intron / A>G / 6 / 46734312 / + / 0.233 / 0.280 / 0.163 / Mass array
rs7761731 / N324K / T>A / 6 / 46671776 / + / 0.214 / 0.244 / 0.599 / Mass array
CYP3A4 / rs2242480 / Intron / T>C / 7 / 94095711 / + / 0.280 / 0.268 / 0.285 / Mass array
CYP3A43 / rs533486 / Intron / G>A / 7 / 99278630 / - / 0.291 / 0.287 / 0.886 / Mass array
CYP3A5 / rs776746 / Splicing stie / A>G / 7 / 99108475 / - / 0.262 / 0.238 / 0.318 / Mass array
CYP3A7 / rs2257401 / R409T / C>G / 7 / 99144621 / + / 0.344 / 0.268 / 0.103 / Mass array
rs2740565 / Intron / T>A / 7 / 99131411 / - / 0.349 / 0.250 / 0.508 / Mass array
CYP4A11 / rs11211402 / Intron / C>T / 1 / 47164641 / + / 0.183 / 0.262 / 0.038 / Mass array
CYP4B1 / rs4646487 / R173W / C>T / 1 / 47051762 / + / 0.110 / 0.159 / 0.380 / Mass array
rs2297810 / M331I / C>T / 1 / 47053446 / - / 0.300 / 0.287 / 0.494 / Mass array
rs4646491 / R340C / C>T / 1 / 47053471 / + / 0.289 / 0.256 / 0.347 / Mass array
rs2297809 / R375C / G>A / 1 / 47055359 / - / 0.289 / 0.256 / 0.718 / Mass array
CYP4F11 / rs1060463 / D446N / G>A / 19 / 15886176 / - / 0.465 / 0.372 / 0.871 / Mass array
rs3765070 / I106I / T>C / 19 / 15901292 / - / 0.453 / 0.384 / 0.607 / Mass array
CYP4F2 / rs2108622 / V433M / C>T / 19 / 15851431 / + / 0.207 / 0.250 / 0.941 / Mass array
rs2074900 / H343H / G>A / 19 / 15857820 / + / 0.202 / 0.220 / 0.499 / PCR and sequencing
rs3093106 / P55P / T>C / 19 / 15869257 / - / 0.100 / 0.110 / 0.264 / PCR and sequencing
CYP4F8 / rs2056822 / P447P / A>C / 19 / 15600597 / + / 0.302 / 0.280 / 0.397 / Mass array
rs4239614 / 3’UTR / C>T / 19 / 15601220 / + / 0.302 / 0.287 / 0.349 / Mass array
rs4646523 / L20L / G>T / 19 / 15587487 / + / 0.400 / 0.421 / 0.254 / Mass array
CYP51A1 / rs7797834 / H453H / A>G / 7 / 91581086 / + / 0.198 / 0.183 / 0.583 / Mass array
CYP7A1 / rs13251066 / Intron / A>G / 8 / 59580307 / + / 0.360 / 0.354 / 0.116 / Mass array
rs12542233 / 5’near gene / C>T / 8 / 59576955 / + / 0.430 / 0.409 / 0.220 / Mass array
rs3808607 / 5’near gene / G>T / 8 / 59575478 / + / 0.419 / 0.439 / 0.418 / Mass array
rs8192879 / 3’UTR / A>G / 8 / 59566130 / - / 0.256 / 0.280 / 0.427 / Mass array
CYP7B1 / rs6987861 / Intron / G>A / 8 / 65872021 / + / 0.140 / 0.238 / 0.825 / Mass array
CYP8B1 / rs6771233 / Intron / G>T / 3 / 42897701 / + / 0.337 / 0.341 / 0.829 / Mass array
rs6774801 / Intron / G>T / 3 / 42898780 / + / 0.322 / 0.311 / 0.320 / Mass array

MAF minor allele frequency,HWE Hardy-Weinberg equilibrium