Up-regulated / ACTN4, APBB3, NIPSNAP3B, UFM1, CLDN11, ERN1, KIF15, PHKB, ITFG2, ATP6AP1L, GREB1L, BRWD1, SYNE1, JARID2, EDNRA, ZNF704, GCNT1, TRIM69, ANGEL1, SLC25A36, TBRG1, ZC3HAV1, ACPL2, HEATR7A, IMPA2, KRAS, EHHADH, NR2C1, OXTR, CCDC6, MUM1, CETN3, ZMYM3, DCUN1D4, SLC6A16, DHTKD1, ZNF844, CYP3A5, ACYP1, OBFC2A, GATA6, APOBEC3B, PPARG, WHSC2, MAP3K1, SLC25A16, ZNF436, CCNT2, ADAM10, ZNF182, PTPN20A/B, MAPK1, SHC4, LIPH, DOPEY1, RUFY3, SAMD9L, MBNL2, RBM12, CSTF3, NDRG4, TMEM42, FBXL4, ATP5S, TMEM37, RASL11B, CD9, MRPS25, ATXN1, EPB41L4B, DTWD1, TIGD7, ADAT2, ZNF518B, ABLIM1, STAMBPL1, ZNF451, ENAH, TRPC4, HCRP1, CDA08, CEP68, CHPT1, TMCO6, ATXN3, WDSAM1, ZNF441, KHDRBS1, IRF2BP2, XPR1, ACPP, NCOA2, PDE4DIP, CRIPT, RBMS1, FMNL2, ANP32A, TMEM200C, TMX3, PIK3R1, CRISPLD2, CCNJ, GNB1, FMO5, CCDC41, FDFT1, PTPN12, STYK1, FRG1/B, AASS, SLC38A9, TFPI, ZNF471, USP13, ITPR1, CENPF, TNS1, TXNIP, TSC22D1, PHF17, MFSD6, ZBTB16, ZNF135, GTF2H2B, CAV1, A2BP1, VAMP1, KHNYN, NBPF11, FLT1, DBC1, PPP1R7, FAM48A, PALLD, ACOX3, MED17, HIST1H2AC, GART, ATP5C1, RAPGEF1, SCARNA15, CALD1, RGNEF, SAMD3, ZNF20/ZNF625, TCP11L1, RAB6A, WSB1, ATAD2, FGFR1OP2, BCL11A, ANKRD10, AP4B1, ERBB4, GPATCH2, BACH2, VCAM1, SNRPA1, NEK3, LOC374491, ZC3H6, PPP4R4, CHURC1, RFX3, SENP6, SDHA/SDHAP1, BTBD14A, RAPGEF2, DAZAP2, USP6NL, PCTK2, EDD, SKIL, PROCR, ZNF285, FECH, CNOT1, PARP11, FOXP1, NDUFB6, FAM82B, GK5, THYN1, IREB2, ZCCHC6, PLEKHH2, NBR1, PDK4, NPAS2, ANK3, USP25, NAIP, ACAS2, RIMKLB, ZNF533, XIST, YPEL2, LRP4, THSD7A, WHAMML1/2, EFCAB3, TRAF5, RPRD1A, ZNF818P, HPS3, SPAG16, CORO6, DUS4L, ZDHHC8P1, CROT, IPCEF1, ZNF578, FAM153B, TP53TG3, SMA3, SLC40A1, ZNF564, BBS12, MEF2C, CCDC85A, SCN3A, FBXW7, SLC39A10, CIRBP, LYPLAL1, TTC14, ALS2, WDR33, LRRFIP1, USP31, ARHGAP10, PLEKHA7, ZNF397, RBMS3, FLRT2, ATBF1, SPRY4, AKAP12, HBB, SH3GL3, PPL, DUSP5P, DKK3, IP6K2, DPY19L2, PRR16, TDRD12, SP100, ATP8B1, DLEU2, NR2F2, RUNX1, ZCCHC2, ARRDC3, XPO1, PGAP1, NLRP2, NUMA1, H1F0, OLFML2B, DLGAP1, GPCPD1, BCO2, ANKRD44, ANKRD22, PWRN1, FGG, SP192, PSPH, SSTR1, BCOR, KCNMA1, ZNF596, DOCK8, GM2A.
Down-regulated / CXCL2, CCL20, CXCL3, IL8, CXCL1, BEND4, CCL3, SPP1, IRF1, MXRA5, IL1B, TNFAIP2, EMR2, TNC, TNFAIP6, CD44, MLC1, CXCL6, ANKRD28, NFKBIZ, GNA11, BIRC3, NFKBIA, RASAL2, MNDA, NFKB1, GAL, LOC650794, TNFAIP3, MRO, DST, C7, RARRES1, PTTG1IP, CRH, CYCS, MMP16, NAV3, IFI6, PRND, INHBA, PTGER4, AHRR, IL7R, TIFA, AQP2, BGN, GCM1, RGS4, SIRPA, USP9X, CYP11A1, COL1A2, SOD2, ZDHHC11, HLA-DPA1, THOC6, LRP2BP, ETNK1, EGR4, RORB, DAF, HTRA3, PLK2, IGFBP4, DYRK2, ITGB2, PTGER2, LASS5, DIRAS3, RGS5, ST7L, PCDH10, SFRP1, HLA-DRA, SERPINF1, GPR56, NR2F1, NFIB, PAPPA, IL17RB, SNTB2, RNASE1, SNAP25, LSS, RALA, TMEM108, CHST11, CASQ1, PPP2R2D, CLASP1, MAFB, FSTL3, HSPA1A/B, PHLDA1, FAM100A, TMEM217, ARF3, GPR158, ZNF185, CYR61, FBLN5, TBC1D8, ATP2A3, TAGLN, STK10, THOC4, RBM39, DCAF4L1, ATRX, TNFSF13B, RASA4, INTS9, PDE2A, ABL2, WISP2, PITPNC1, FLNC, CDC42EP3, CYP27B1, SLC7A8, SRPK2, ARHGAP32, RYR2, EPHA2, INSIG1, PDE4D, PBEF1, PQBP1, SQSTM1, GALNT2, TRIB1, PLD1, LGALS12, NOTCH2NL,CD55, EHBP1, CORO1C, TSHZ2, POR, MUC20, NHS, LIF, FAM18A, SLCO3A1, CADM1, KCMF1, PTPRN, MTUS2, GK3P, SERTAD2, FAM118A, GRK5, MARK2, GUCY1A2, ZHX3, LRRC66, WTAP, FADS3, CENPN, PDLIM4, CTRB1/2, EREG, TEX264, CCL4, WDR91, PROK1, LOXL2, ZNF638, TNFRSF10D, PHACTR4, PID1, INO80D, SEC14L5, CILP, YBX1, ZNF331, CYB5D1, RND3, ARHGEF7, STK25, PDGFRL, ETS2, GAS1, THAP4, HEPH, PLOD2, KLRK1, SLC39A14, SLC7A2, LMO7, AFF3, WWC2, HEG1, LAMB2L, AMFR, ZBTB9, C4A/B, PFAAP5, CITED2, HGD, ISM1, ANKHD1/ANKHD1-EIF4EBP3, T3JAM, POLN, FMNL3, IRAK2, WDR27, CAMK1D, ERAP1, SRCAP, ADSSL1, TP53RK, MRTO4, ZNF688, IFITM1, AKAP2/PALM2-AKAP2, KRR1, MT1X, SLC27A4, CD59, RBM33, PPAP2C, POSTN, P4HB, CREM, FRMD5, SERPINA3, PHKG2, TIMM22, MFHAS1, LASS6, MALAT1, GALNTL4, PEX6, CHDH, CPEB1, ALDOA, SCUBE2, APOE, UNC84B, SPTBN5, ISYNA1, SDC4, ASB3/GPR75, AEN, RECQL4, MED16, ESAM, PSEN1, COL1A1, PMP22, ITPRIP, MLLT10, EIF1, CELSR3, CLN8, MGAT4B, SFXN3, RANGAP1, TIMP2, ASB6, TRAF3IP3, NSDHL, KCND1, FOXO3/B, OSTalpha, SUPT3H, DCLK1, TMEM49, HSD17B6, SNORA28, EEF1D, RAB2A, ARSA, ETS1, SH3RF1, ALPK3, APCDD1L, N4BP2L2, TOP3B, CYTH2, EGLN1, HOMER1, TTYH2, SYNPO2, GFPT2, SIK1, LATS2, FNDC4, TLCD2, KLF6, RAB7, SV2C, ATAD3B, ADAMTS6, RASAL1, CELA2A/B, CADPS, SYTL5, SLC19A2, NCAPG2, PVRL2, THBS1, SEC24A, CALU, CASP8, TCF21, MYO7A, KCNN2, FAM40B, RFWD3, TMEM163, REEP1, DIP2A, PGR, CLOCK, mar-03, PSMD11, ISG20.

Table S1. List of DEGs in CC of women with severe endometriosis #

# Fold change (M) ≥ 1.5 and P< 0.05