Huff et al. (2010)(1) / NAc / 12 / OCD / 4 agitation and anxiety, 2 hypomania, 2 suicidal thoughts, 1 concentration problems / 1 dysesthesia in subclavicular region
Denys et al. (2010)(2) / NAc / 16 / OCD / 8 hypomania, 7 increased libido, 5 mild forgetfulness, 3 word finding problems, 3 headaches, 3 changes in menstruation, 2 cold shivers, 1 sexual intrusions, 4 stomach-aches, 1 dizziness, 3 taste reduction, 2 nausea, 3 difficulties to fall asleep, 2 micturition problems, 3 parasthesias in hands or feet. / 1 wound infection at incision, 4 tiredness, 7 feeling of numbness at incision site, 1 nausia, 2 headaches, 2 increase of depressive symptoms, 8 feeling of extension leads, 3 feeling of electrical current around neurostimulator, 3 feeling of neurostimulator in chest
Bewernick et al. (2010)(3) / NAc / 10 / MDD / 4 erythema, 3 anxiety increase, 3 sweating, 2 disequilibrium, 2 hypomania, 2 paresthesia, 2 agitation, 1headache, 1 lead dislodgement, 1 psychotic, 1 muscle cramp, 1 vision/oculomotor problems, 1 dysphagia / 3 dysphagia, 6 swollen eye, 3 pain
Malone et al. (2009) (4) / Vc/VS / 15 / MDD / 1 hypomania (in bipolar patient), / 1 pain associated with location of extension, 1 lead fracture
Greenberg et al. (2010) (5) / Vc/VS / 26 / OCD / 11 anxiety increase, 8 hypomania, 1 panic attack, 8 lowering mood, 1 flashback experience, 1 verbal perseveration / 2 small intracerebral hemorrhages, 1 tonic-clonic seizure after implantation, 1 superficial wound infection, 1 lead fracture
Table S1. Adverse events reported in DBS of ventral striatal area in OCD and MDD
No statistics have been published about adverse events in the nucleus accumbens region. For an overview of adverse events in the subthalamic nucleus see (6). Here we give an overview of all reported adverse events in DBS in MDD and OCD using the NAc region as target area. Only studies with 10 or more patients are reported (with exclusion of patients from Greenberg et al. 2006 (7)since the same patients are described in an subsequent article(5))Abbreviations: NAc: nucleus accumbens; Vc/VS: ventral capsule, ventral striatum; OCD: obsessive compulsive disorder; MDD: major depressive disorder;
Reference List
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(2) Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, et al. Deep Brain Stimulation of the Nucleus Accumbens for Treatment-Refractory Obsessive-Compulsive Disorder. Arch Gen Psychiatry 2010 Oct 1;67(10):1061-8.
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(7) Greenberg BD, Malone DA, Friehs GM, Rezai AR, Kubu CS, Malloy PF, et al. Three-Year Outcomes in Deep Brain Stimulation for Highly Resistant Obsessive-Compulsive Disorder. Neuropsychopharmacology 2006 Jul 19;31(11):2384-93.