Table S-4: Sensitivity Analyses of Model Parameters in the Unmatched Patient Dataset (n=586)
Hemoglobin
Years Following First Infusion for Calculation of Cumulative Average Dose / Intercept / Emax / T50
t1 / p-value / t2 / p-value / t2d / p-value / t3 / p-value / t3d / p-value
1 Year / 0.2331 / 0.0013 / 2.2221 / <.0001 / 0.1912 / <.0001 / 1.6223 / <.0001 / 0.0233 / 0.7401
2 Years / 0.2447 / 0.0008 / 2.3230 / <.0001 / 0.2569 / <.0001 / 1.6835 / <.0001 / 0.1054 / 0.1826
3 Years / 0.2454 / 0.0007 / 2.3916 / <.0001 / 0.2931 / <.0001 / 1.8530 / <.0001 / 0.2306 / 0.0056
4 Years / 0.2483 / 0.0006 / 2.4098 / <.0001 / 0.2943 / <.0001 / 1.9338 / <.0001 / 0.2769 / 0.0010
5 Years / 0.2669 / 0.0002 / 2.4228 / <.0001 / 0.3051 / <.0001 / 1.9875 / <.0001 / 0.3027 / 0.0003
8 Years / 0.2567 / 0.0004 / 2.4349 / <.0001 / 0.2992 / <.0001 / 2.0667 / <.0001 / 0.3385 / <.0001
Platelet Count
Intercept / Emax / T50
t1 / p-value / t2 / p-value / t2d / p-value / t3 / p-value / t3d / p-value
1 Year / 4.4809 / <.0001 / 0.7701 / <.0001 / 0.01605 / 0.1357 / 1.5032 / <.0001 / -0.5312 / <.0001
2 Years / 4.4838 / <.0001 / 0.7630 / <.0001 / 0.01998 / 0.0809 / 1.4386 / <.0001 / -0.5166 / <.0001
3 Years / 4.4856 / <.0001 / 0.7649 / <.0001 / 0.02505 / 0.0316 / 1.5077 / <.0001 / -0.4470 / <.0001
4 Years / 4.4860 / <.0001 / 0.7675 / <.0001 / 0.02771 / 0.0191 / 1.5204 / <.0001 / -0.4193 / <.0001
5 Years / 4.4852 / <.0001 / 0.7644 / <.0001 / 0.02475 / 0.0344 / 1.5772 / <.0001 / -0.3626 / <.0001
8 Years / 4.4811 / <.0001 / 0.7764 / <.0001 / 0.03172 / 0.0054 / 1.7892 / <.0001 / -0.2240 / 0.0002
Spleen Volumes
Intercept / Emax / T50
t1 / p-value / t2 / p-value / t2d / p-value / t3 / p-value / t3d / p-value
1 Year / 2.3993 / <.0001 / -1.9556 / <.0001 / -0.1979 / 0.0021 / 4.0204 / <.0001 / 0.0721 / 0.4918
2 Years / 2.3716 / <.0001 / -2.4522 / <.0001 / -0.4189 / <.0001 / 4.5191 / <.0001 / 0.3033 / 0.0023
3 Years / 2.3681 / <.0001 / -2.7398 / <.0001 / -0.5397 / <.0001 / 4.7883 / <.0001 / 0.4338 / <.0001
4 Years / 2.3657 / <.0001 / -2.8831 / <.0001 / -0.5962 / <.0001 / 4.8778 / <.0001 / 0.4663 / <.0001
5 Years / 2.3665 / <.0001 / -2.8555 / <.0001 / -0.5766 / <.0001 / 4.8437 / <.0001 / 0.4457 / <.0001
8 Years / 2.3600 / <.0001 / -2.9532 / <.0001 / -0.5982 / <.0001 / 4.9859 / <.0001 / 0.4904 / <.0001
Liver Volume
Intercept / Emax / T50
t1 / p-value / t2 / p-value / t2d / p-value / t3 / p-value / t3d / p-value
1 Year / 0.3734 / <.0001 / -0.9900 / <.0001 / -0.1440 / 0.0011 / 4.2111 / <.0001 / 0.2359 / 0.0803
2 Years / 0.3783 / <.0001 / -0.9967 / <.0001 / -0.1414 / 0.0011 / 4.0326 / <.0001 / 0.1191 / 0.3705
3 Years / 0.3798 / <.0001 / -1.0582 / <.0001 / -0.1708 / <.0001 / 4.1339 / <.0001 / 0.1770 / 0.1498
4 Years / 0.3805 / <.0001 / -1.0908 / <.0001 / -0.1823 / <.0001 / 4.2151 / <.0001 / 0.2226 / 0.0587
5 Years / 0.3786 / <.0001 / -1.0956 / <.0001 / -0.1802 / <.0001 / 4.2344 / <.0001 / 0.2222 / 0.0661
8 Years / 0.3784 / <.0001 / -1.1365 / <.0001 / -0.1935 / <.0001 / 4.3726 / <.0001 / 0.2835 / 0.0141