Table E-1. Baseline Characteristics of 53 Subjects. Median Values and Range

Table E-1. Baseline characteristics of 53 subjects. Median values and range.

Age
years / Gender
m=male
f=female / CSF NFL
ng/L / CSF
HIV RNA
log cop/mL / Plasma
HIV RNA
log cop/mL / CSF Neopterin nmol/L / CD4 cell count cells/µL / CSF WBC count
cells/µL
All subjects
(n=53) / 38
(17-64) / 36 m
17 f / <250
(<250-15087) / 4.05
(1.81-6.26) / 4.95
(2.58-5.97) / 24.8
(8-121) / 138
(0-440) / B4
(0-60)
Normal NFL
(n=32) / 37
(17-64) / 20 m
12 f / <250 / 4.07
(2.41-5.67) / 4.92
(3.83-5.88) / 19.4
(8-92) / 165
(0-440) / 7
(0-60)
Elevated NFL
(n=21) / 41
(26-60) / 16 m
5 f / 780
(340-15087) / 3.90
(1.81-6.26) / 4.95
(2.58-5.97) / 38.3
(15.2-121) / 44
(0-392) / 2
(0-47)
Non-ADC
(n=12) / 48
(29-60) / 8 m
4 f / 518
(340-1960) / 2.90
(1.90-5.56) / 5.19
(4.31-5.97) / 34.4
(15.2-52.6) / 33
(0-180) / 1
(0-29)
ADC
(n=9) / 38
(26-57) / 8 m
1 f / 8000
(470-15087) / 5.25
(1.81-6.26) / 4.94
(2.58-5.67) / 65.6
(18.6-121) / 138
(20-392) / 12
(0-47)

Table E-2. Results in patients with elevated CSF NFL at baseline (n=21), three months (n=21) and at one year (n=16). Median values and IQR.

Baseline / 3 months / Significance / One year / Significance*
CSF NFL
ng/L / 780
(480-7300) / 340
(<250-4070) / p<0.001 / <249
(<249-287) / p<0.001
CSF HIV RNA
log cop/mL / 3.90
(2.31-5.25) / <1.69
(<1.69-2.37) / p<0.001 / <1.69
(<1.69-<1.69) / p<0.001
Plasma HIV RNA
log cop/mL / 4.95
(4.46-5.43) / 1.91
(1.70-2.37) / p<0.001 / <1.69
(<1.69-<1.69) / p<0.001
CSF Neopterin
nmol/L / 38.3
(23.6-52.5) / 12
(5.8-19.6) / p<0.01 / 11.1
(6.3-12.6) / p<0.01
CSF WBC count
cells/µL / 2
(1-12) / 1
(1-4) / p<0.05 / 1
(0-2) / p<0.05
CD4 cell count
cells/µL / 44
(27-138) / 169
(108-277) / p<0.001 / 275
(216-390) / p<0.001

*Baseline to one year