Table 3. the Relationship Between MAP+ Regions and Pre-Surgical Evaluation Data for P1-P10
(Description of MRI Change) / Location of MAP+ Regions in relation to resection / Surgery / Localization from Preoperative Noninvasive Modalities / ICEEG Localization / Modalities Concordant with unresected MAP+ Regions
Scalp-EEG
Interictal Epileptiform / Scalp-EEG
ictal / PET / SPECT
(injection time) / MEG / Interictal / Ictal onset
P1 / L posterior basal temporal
(GW blurring on T1w) / 1 unresected
(Ipsilateral, same lobe as resection) / L temporal / L temporal / L temporo-parietal / Not done / Not done / Not done / L lateral temporal
L mesial temporal
L basal temporal / L lateral temporal / Scalp-EEG
ICEEG
P2 / L inferior mesial frontal
(GW blurring on T1w) / 1 unresected
(Ipsilateral, same lobe as resection ) / L parietal / R & L frontocentral
R & L frontal vertex / Nonlocalizable / Bilateral frontal / Pre-op:
L middle to anterior temporal
(150s)
Post-op:
L insula
L anterior dorsal lateral frontal
(18s) / L frontal / (widespread)
L frontal / (widespread)
L post-central
L precentral
L SMA / Scalp-EEG
PET
SPECT
MEG
P3 / L middle temporal
(GW blurring on T1w, T1 signal change) / 1 unresected
(Contralateral to resection) / R temporal / R frontal
L frontal
Bifrontal / # 1: Lateralized R hemisphere, max temporal
# 2:
L frontotemporal / R infero-lateral frontal / R frontal
R parietal
R frontal operculum
(# 1 seizure, 10s) / R temporal
L temporal / R mesial temporal
R occipital
R post cingulate / R mesial temporal / Scalp-EEG
MEG
P4 / R superior mesial frontal
R central
(For both: GW blurring on T1w, T1 signal change, FLAIR hyperintensity) / 1 resected, 1 unresected
(Ipsilateral, same lobe as resection) / (1st)
R mesial frontal / R fronto-central / R fronto-central / R frontal / Nonlocalizable
(16s) / Not done / R mesial frontal / R mesial frontal / Scalp-EEG
PET
ICEEG
(2nd)
R frontal including leg motor area / R frontal
& fronto-central / R fronto-central / Not done / Not done / Not done / R frontal / R posterior mesial frontal
P5 / R superior lateral frontal
(GW blurring on T1w, T1 signal change, T2/FLAIR hyperintensity)
R superior temporal
(GW blurring on T1w) / 1 resected, 1 unresected
(Ipsilateral, different lobe than resection) / (1st)
R frontal / R frontal / Lateralized R / R frontal
R temporal / Not done / Not done / R frontal / R frontal / Scalp-EEG
PET
ICEEG
(2nd)
R frontal premotor
R temporal / R frontotemporal R temporal
R parietal / R fronto-temporal / R frontal
R temporal / R orbitofrontal (13s) / Not done / Not done / Not done
P6 / L orbitofrontal
(GW blurring on T1w, T2/FLAIR hyperintensity)
L inferior lateral frontal
(T2 hyperintensity) / 1 resected, 1 unresected
(Ipsilateral, same lobe as resection) / L orbitofrontal / L frontal / L frontal
Nonlocalizable / L inferior frontal / L cingulate
L inferior lateral frontal
(9s) / Not done / L frontal
L orbitofrontal / L frontal
L orbitofrontal / Scalp-EEG
PET
SPECT
ICEEG
P7 / L inferior mesial occipital
L superior mesial occipital
(For both: GW blurring on T1w, FLAIR hyperintensity) / 1 resected, 1 unresected
(Ipsilateral, same lobe as resection) / R temporo-occipital / R occipito-parietal / Generalized max bifrontal / R occipital
R posterior temporal / R temporal occipital
(11s) / Not done / Not done / Not done / Scalp-EEG
PET
SPECT
P8 / R anterior insula
R inferior parietal
(For both: GW blurring on T1w) / 2 unresected
(Multiobar, ipsilateral to resection) / R temporo-parieto-occipital / R & L parieto-occipital / R parieto-occipital / R temporal / L temporal
R anterior frontal
R parietal
(21s) / Not done / R temporo-parieto-occipital / R parieto-occipital / Scalp-EEG
SPECT
ICEEG
P9 / R superior temporal
(GW blurring on T1w)
R inferior parietal
(GW blurring on T1w, T2/FLAIR hyperintensity) / 2 unresected
(Multiobar, ipsilateral to resection) / R temporal
R insula / R centro-parietal / R centro-parietal / Mid to anterior R temporal
R superior parietal / Not done / Not done / R lateral temporal
R peri-rolandic
R
mesial parietal / R lateral temporal / Scalp-EEG
PET
ICEEG
P10 / R superior temporal
(GW blurring on T1w)
L inferior temporal
(GW blurring on T1w)
R superior lateral frontal
(GW blurring on T1w, T1 signal change) / 2 unresected, 1 resected
(Multiobar, ipsilateral and contralateral to resection) / R temporal / Generalized
Multiregional L & R / Generalized / R temporal
R superior frontal / Not done / Not done / Not available / Not available / PET
Table 3. The relationship between MAP+ regions and pre-surgical evaluation data for P1-P10 whose MAP+ regions were only partially resected or had not been included in the resection. Included in the table are locations of the MAP+ regions, surgical resection, localization from pre-operative scalp EEG, PET, SPECT and MEG, as well as localization from invasive evaluation. Note that P4 and P5 had two surgeries; localization data are tabulated separately per surgery, and locations of MAP+ regions are reported in relation to the first surgery. In this Table and Table 4, description of the subtle MRI change after review under MAP guidance is reported along with location of MAP+ regions. Location of unresected MAP+ region vs resection (column 3) is categorized into: lobar (unresected MAP+ region in the same lobe as resection); multilobar (unresected MAP+ region in a different lobe than resection, but on the ipsilateral side); contralateral (unresected MAP+ region on the contralateral side of resection).