Table 2List of differentially expressed genes in docetaxel resistant MCF-7 sublines and fold changes of expression.

Fold change
Proteins / Gene Name / Gene Symbol / Description / MCF-7/
30nMDOC / MCF-7/
120nMDOC
ABC Transporters / 209994_s_at / ABCB1;
ABCB4 / ATP-binding cassette, sub-family B (MDR/TAP), member 1 ; ATP-binding cassette, sub-family B (MDR/TAP), member 4 / 9.77 / 244.80
209993_at, 243951_at / ABCB1 / ATP-binding cassette, sub-family B (MDR/TAP), member 1 / 10.55 / 215.20
1570505_at / ABCB4 / ATP-binding cassette, sub-family B (MDR/TAP), member 4 / NS* / 17.03
223320_s_at / ABCB10 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / 3.86 / NS
205142_x_at / ABCD1 / ATP-binding cassette, sub-family D (ALD), member 1 / 3.54 / NS
202805_s_at / ABCC1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / -2.42 / NS
Glutathione Metabolism Related Proteins / 200736_s_at / GPX1 / glutathione peroxidase 1 / NS / 105.80
200824_at / GSTP1 / glutathione S-transferase pi / NS / 55.70
213170_at / GPX7 / glutathione peroxidase 7 / NS / 8.28
P450 Proteins / 208928_at / POR / P450 (cytochrome) oxidoreductase / NS / -5.10
219825_at / CYP26B1 / cytochrome P450, family 26, subfamily B, polypeptide 1 / NS / 10.66
206504_at / CYP24A1 / cytochrome P450, family 24, subfamily A, polypeptide 1 / 8.05 / NS
202436_s_at, 202435_s_at / CYP1B1 / cytochrome P450, family 1, subfamily B, polypeptide 1 / -3.06 / NS
TNF Receptors / 206467_x_at / TNFRSF6B ; RTEL1 / tumor necrosis factor receptor superfamily, member 6b, decoy ; regulator of telomere elongation helicase 1 (DcR3) / NS / 27.61
227345_at / TNFRSF10D / tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain (DcR2) / NS / 6.65
205153_s_at, 35150_at / CD40 / CD40 antigen (TNF receptor superfamily member 5) / NS / 16.80
TNF Ligands / 202688_at, 202687_s_at / TNFSF10 / tumor necrosis factor (ligand) superfamily, member 10 ; tumor necrosis factor (ligand) superfamily, member 10 (TRAIL) / 3.95 / -12.66
210314_x_at,209499_x_at / TNFSF13, TNFSF12 / tumor necrosis factor (ligand) superfamily, member 13 ; tumor necrosis factor (ligand) superfamily, member 12-member 13 (APRIL) / 3.57 / NS
Antiapoptotic Proteins / 212607_at / AKT3 / v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) / NS / 35.86
232210_at / BCL2 / B-cell CLL/lymphoma 2 / 5.78 / NS
222895_s_at / BCL11B / B-cell CLL/lymphoma 11B (zinc finger protein) / 2.75 / NS
229720_at / BAG1 / BCL2-associated athanogene / 2.40 / -2.63
209406_at, 230879_at / BAG2 / BCL2-associated athanogene 2 / NS / 7.66
217911_s_at / BAG3 / BCL2-associated athanogene 3 / 4.09 / -2.36
219624_at / BAG4 / BCL2-associated athanogene 4 / 2.57 / NS
202984_s_at,230427_s_at, 230427_s_at, 202985_s_at / BAG5 / BCL2-associated athanogene 5 / 2.56 / -3.04
Growth Factors and Cytokines / 201983_s_at, 224999_at, 201984_s_at / EGFR / epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / NS / 18.57
209101_at / CTGF / connective tissue growth factor / NS / 126.50
204858_s_at / ECGF1 / endothelial cell growth factor 1 (platelet-derived) / 3.30 / 5.60
206295_at / IL18 / interleukin 18 (interferon-gamma-inducing factor) / NS / 38.37
Microtubule Dynamics / 214023_x_at / TUBB2 / tubulin, beta polypeptide paralog (βII tubulin) / 2.73 / 16.39
209191_at / TUBB6
(βV tubulin) / tubulin, beta 6 (βV tubulin) / NS / 11.45
202154_x_at, 213476_x_at / TUBB3
(βIII tubulin) / tubulin, beta 3 (βIII tubulin) / 2.03 / 4.98
212233_at / MAP1B / Microtubule-associated protein 1B ; Homo sapiens, clone IMAGE:5535936, mRNA / 2.08 / 20.95
202890_at / MAP7 / microtubule-associated protein 7 / NS / -22.37
224896_s_at, 244078_at / TTL / tubulin tyrosine ligase / NS / 4.23
1557073_s_at / TTBK2 / Tau tubulin kinase 2 / NS / 3.95
203715_at / TBCE / tubulin-specific chaperone e / NS / 3.83
ECM Related Proteins [8] / 215177_s_at / ITGA6 / integrin, alpha 6 / NS / 24.66
201389_at / ITGA5 / integrin, alpha 5 (fibronectin receptor, alpha polypeptide) / NS / 4.914
211964_at, 211966_at / COL4A2 / collagen, type IV, alpha 2 / NS / 54.65
211981_at / COL4A1 / collagen, type IV, alpha 1 / NS / 11.99
213428_s_at, 212937_s_at / COL6A1 / collagen, type VI, alpha 1 / NS / 19.1
209156_s_at, 213290_at / COL6A2 / collagen, type VI, alpha 2 / NS / 6.193
227048_at / LAMA1 / laminin, alpha 1 / NS / 84.3
211651_s_at / LAMB1 / laminin, beta 1 ; laminin, beta 1 / NS / 16.72
209270_at / LAMB3 / laminin, beta 3 / NS / 7.755
219407_s_at / LAMC3 / laminin, gamma 3 / NS / 9.479
214701_s_at / FN1 / fibronectin 1 / NS / 33.94
222549_at / CLDN1 / claudin 1 / NS / 42.79
227059_at / GPC6 / glypican 6 / 13.90 / 78.43
212158_at / SDC2 / syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) / NS / 48.98
213905_x_at, 201261_x_at, 201262_s_at / BGN ; SDCCAG33 / biglycan ; serologically defined colon cancer antigen 33 / NS / 19.87
202766_s_at, 202765_s_at / FBN1 / fibrillin 1 (Marfan syndrome) / NS / 37.19
Matrix Metallopeptidases [8] / 202827_s_at / MMP14 / matrix metallopeptidase 14 (membrane-inserted) / NS / 3.493
207118_s_at / MMP23B; MMP23A / matrix metallopeptidase 23B ; matrix metallopeptidase 23ª / NS / 11.71
1555326_a_at
202381_at / ADAM9 / ADAM metallopeptidase domain 9 (meltrin gamma) / 2.55 / 5.751
217007_s_at / ADAM15 / ADAM metallopeptidase domain 15 (metargidin) / NS / -2.15
214913_at / ADAMTS3 / ADAM metallopeptidase with thrombospondin type 1 motif, 3 / NS / 13.64
201150_s_at / TIMP3 / TIMP metallopeptidase inhibitor 3 / NS / -97.09
EMT Related Proteins[65] / 213139_at / SNAI2 / snail homolog 2 (Drosophila) / NS / 23.45
205225_at / ER, ESR1 / estrogen receptor 1 / NS / -76.92
201131_s_at / CDH1 / cadherin 1, type 1, E-cadherin (epithelial) / NS / -319.49
203440_at
203441_s_at / CDH2 / cadherin 2, type 1, N-cadherin (neuronal) / NS / 6.09
201426_s_at / VIM / vimentin / NS / 110.90
209925_at / OCLN / occludin / 2.206 / -5.55
203953_s_at
203954_x_at / CLDN3 / claudin 3 / NS / -268.82
201428_at / CLDN4 / claudin 4 / NS / -21.98
202790_at / CLDN7 / claudin 7 / NS / -37.04
228335_at / CLDN11 / claudin 11 (oligodendrocyte transmembrane protein) / NS / 42.79
201983_s_at, 224999_at, 201984_s_at / EGFR / epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) / NS / 18.57
222164_at, 210973_s_at / FGFR1 / Fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) / NS / 7.70
205397_x_at,205398_s_at / SMAD3 / SMAD, mothers against DPP homolog 3 (Drosophila) / NS / 7.81
208944_at / TGFBR2 / transforming growth factor, beta receptor II (70/80kDa) / NS / 5.17

*Not significant