Table 2 Presence or absence of haplotypes for which association with AD was observed in at least one sample in HCS and AD patients of all six samples.

HMGCS2rs1441008-rs651347-rs668156-rs532208

Centre / Diagnose / HT-G-G-G
absent / present
Switzerland / HCS / 122 / 48
71.8% / 28.2%
AD / 84 / 29
74.3% / 25.7%
P=0.63
Greece / HCS / 74 / 16
82.2% / 17.8%
AD / 171 / 55
75.7% / 24.3%
P=0.21
Germany / HCS / 43 / 13
76.8% / 23.2%
AD / 25 / 8
75.8% / 24.2%
P=0.91
Poland / HCS / 168 / 45
78.9% / 21.1%
AD / 150 / 30
83.3% / 16.7%
P=0.26
Sweden / HCS / 119 / 15
88.8% / 11.2%
AD / 118 / 32
78.7% / 21.3%
P=0.02
Belgium / HCS / 338 / 70
82.8% / 17.2%
AD / 486 / 140
77.6% / 22.4%
P=0.04
Centre / Diagnose / HT-G-A-T
absent / present
Switzerland / HCS / 113 / 57
66.5% / 33.5%
AD / 81 / 32
71.7% / 28.3%
P=0.35
Greece / HCS / 54 / 36
60.0% / 40.0%
AD / 163 / 63
72.1% / 27.9%
P=0.04
Germany / HCS / 42 / 14
75.0% / 25.0%
AD / 30 / 3
90.9% / 9.1%
P=0.06
Poland / HCS / 156 / 57
73.2% / 26.8%
AD / 129 / 51
71.7% / 28.3%
P=0.73
Sweden / HCS / 96 / 38
71.6% / 28.4%
AD / 118 / 32
78.7% / 21.3%
P=0.17
Belgium / HCS / 272 / 136
66.7% / 33.3%
AD / 418 / 208
66.8% / 33.2%
P=0.97

FDPSrs2297480-rs11264359-rs11264361

Centre / Diagnose / HA-T-A
absent / present
Switzerland / HCS / 16 / 189
7.8% / 92.2%
AD / 8 / 136
5.6% / 94.4%
P=0.41
Greece / HCS / 2 / 95
2.1% / 97.9%
AD / 19 / 250
7.1% / 92.9%
P=0.07
Germany / HCS / 2 / 70
2.8% / 97.2%
AD / 3 / 36
7.7% / 92.3%
P=0.23
Poland / HCS / 14 / 225
5.9% / 94.1%
AD / 12 / 208
5.5% / 94.5%
P=0.85
Sweden / HCS / 14 / 151
8.5% / 91.5%
AD / 4 / 183
2.1% / 97.9%
P=0.007
Belgium / HCS / 31 / 427
6.8% / 93.2%
AD / 37 / 681
5.2% / 94.8%
P=0.25
Centre / Diagnose / HA-G-A
absent / present
Switzerland / HCS / 197 / 8
96.1% / 3.9%
AD / 144 / 0
100.0% / .0%
P=0.02
Greece / HCS / 95 / 2
97.9% / 2.1%
AD / 258 / 11
95.9% / 4.1%
P=0.36
Germany / HCS / 70 / 2
97.2% / 2.8%
AD / 38 / 1
97.4% / 2.6%
P=0.95
Poland / HCS / 237 / 2
99.2% / .8%
AD / 216 / 4
98.2% / 1.8%
P=0.36
Sweden / HCS / 161 / 4
97.6% / 2.4%
AD / 182 / 5
97.3% / 2.7%
P=0.88
Belgium / HCS / 443 / 15
96.7% / 3.3%
AD / 695 / 23
96.8% / 3.2%
P=0.95

ACAD8rs570113-rs561945-rs514417

Centre / Diagnose / HA-T-A
absent / present
Switzerland / HCS / 18 / 185
8.9% / 91.1%
AD / 24 / 119
16.8% / 83.2%
P=0.03
Greece / HCS / 12 / 85
12.4% / 87.6%
AD / 28 / 241
10.4% / 89.6%
P=0.6
Germany / HCS / 8 / 66
10.8% / 89.2%
AD / 6 / 34
15.0% / 85.0%
P=0.52
Poland / HCS / 22 / 215
9.3% / 90.7%
AD / 22 / 197
10.0% / 90.0%
P=0.78
Sweden / HCS / 10 / 154
6.1% / 93.9%
AD / 12 / 173
6.5% / 93.5%
P=0.88
Belgium / HCS / 55 / 406
11.9% / 88.1%
AD / 82 / 636
11.4% / 88.6%
P=0.79

NPC2rs1468503-rs917394-rs1860108-rs1029699

Centre / Diagnose / HG-C-C-C
absent / present
Switzerland / HCS / 136 / 61
69.0% / 31.0%
AD / 94 / 44
68.1% / 31.9%
P=0.86
Greece / HCS / 60 / 35
63.2% / 36.8%
AD / 149 / 114
56.7% / 43.3%
P=0.27
Germany / HCS / 54 / 18
75.0% / 25.0%
AD / 19 / 20
48.7% / 51.3%
P=0.005
Poland / HCS / 169 / 67
71.6% / 28.4%
AD / 162 / 53
75.3% / 24.7%
P=0.37
Sweden / HCS / 118 / 39
75.2% / 24.8%
AD / 119 / 47
71.7% / 28.3%
P=0.48
Belgium / HCS / 320 / 133
70.6% / 29.4%
AD / 462 / 220
67.7% / 32.3%
P=0.3

ABCG1rs1378577-rs692383

Centre / Diagnose / HA-A
absent / present
Switzerland / HCS / 13 / 178
6.8% / 93.2%
AD / 19 / 115
14.2% / 85.8%
P=0.03
Greece / HCS / 12 / 84
12.5% / 87.5%
AD / 36 / 227
13.7% / 86.3%
P=0.77
Germany / HCS / 10 / 58
14.7% / 85.3%
AD / 3 / 36
7.7% / 92.3%
P=0.29
Poland / HCS / 32 / 198
13.9% / 86.1%
AD / 23 / 192
10.7% / 89.3%
P=0.3
Sweden / HCS / 15 / 141
9.6% / 90.4%
AD / 24 / 157
13.3% / 86.7%
P=0.3
Belgium / HCS / 45 / 405
10.0% / 90.0%
AD / 69 / 633
9.8% / 90.2%
P=0.92
Centre / Diagnose / HC-G
absent / present
Switzerland / HCS / 119 / 72
62.3% / 37.7%
AD / 67 / 67
50.0% / 50.0%
P=0.03
Greece / HCS / 56 / 40
58.3% / 41.7%
AD / 157 / 106
59.7% / 40.3%
P=0.82
Germany / HCS / 39 / 29
57.4% / 42.6%
AD / 21 / 18
53.8% / 46.2%
P=0.73
Poland / HCS / 112 / 118
48.7% / 51.3%
AD / 126 / 89
58.6% / 41.4%
P=0.04
Sweden / HCS / 90 / 66
57.7% / 42.3%
AD / 100 / 81
55.2% / 44.8%
P=0.65
Belgium / HCS / 293 / 157
65.1% / 34.9%
AD / 424 / 278
60.4% / 39.6%
P=0.11