Table 1 SIP Dimension Scores Stratified for EDSS at Baseline

Table 1 SIP dimension scores stratified for EDSS at baseline

SIP sub - scale1 / EDSS2 £ 3.5
mean / median
(range, ± sd) /

EDSS 4.0 - 5.5

mean / median
(range, ± sd) /

EDSS ³6.0

mean / median
(range, ± sd)

Ambulation

Placebo
Interferon / 17.6 / 16.4
(0 - 37, ±10.0)
17.6 / 17.8
(0 - 38, ± 17.6) / 27.5 / 28.0
(0 - 58, ±10.7)
26.7 / 28.3
(0 - 57, ±11.9) / 37.5 / 39.6
(8 - 70, ±13.5)
38.0 / 38.8
(9 - 78, ± 12.3)

Mobility

Placebo
Interferon / 7.4 / 7.8
(0 – 39, ±8.5)
4.3 / 0.0
(0 – 31, ±6.5) / 13.1 / 9.2
(0 - 49, ±13.0)
12.1 / 10.0
(0 - 51, ±12.0) / 19.5 / 15.7
(0 - 62, ±15.4)
21.5 / 17.7
(0 - 59, ±15.8)
Body care & movement
Placebo
Interferon / 5.7 / 3.2
(0 – 24, ±6.7)
6.5 / 4.9
(0 – 23, ±7.2) / 12.2 / 10.0
(0 - 45, ±9.9)
10.8 / 10.2
(0 - 33, ±8.0) / 19.7 / 17.8
(0 - 71, ±12.5)
22.2 / 20.0
(0 - 59, ±12.4)

Social interaction

Placebo
Interferon / 7.7 / 3.6
(0 – 46, ±9.4)
8.7 / 6.0
(0 – 41, ±9.4) / 12.2 / 8.4
(0 - 71, ± 11.9)
10.9 / 6.5
(0 - 56, ±11.7) / 12.8 / 9.0
(0 - 59, ±12.5)
14.5 / 11.0
(0 - 67, ±12.6)

Communication

Placebo
Interferon / 6.4 / 0.0
(0 – 30, ±8.5)
6.0 / 0.0
(0 – 53, ±10.3) / 8.9 / 0.0
(0 – 52, ±12.6)
8.3 / 0.0
(0 – 44, ±11.2) / 9.1 / 9.7
(0 - 61, ±11.3)
11.6 / 9.7
(0 - 89, ±16.7)

Alertness

Placebo

Interferon

/ 18.7 / 9.7
(0 - 92, ±25.2)
14.4 / 9.7
(0 - 77, ±18.1) / 20.8 / 10.0
(0 - 100, ±24.4)
15.4 / 9.7
(0 - 77, ±18.0) / 15.4 / 9.7
(0 - 100, ±18.6)
19.5 / 9.7
(0 - 92, ±21.8)

Emotional behaviour

Placebo
Interferon / 8.0 / 0.0
(0 - 59, ±13.1)
6.8 / 0.0
(0 - 81, ±12.9) / 8.8 / 0.0
(0 - 63, ±13.9)
10.1 / 7.7
(0 - 72, ±13.6) / 9.0 / 6.5
(0 - 52, ±12.1)
13.0 / 8.8
(0 - 100, ±17.4)

Sleep and rest

Placebo
Interferon / 10.5 / 9.8
(0 - 36, ± 10.0)
13.3 / 11.6
(0 - 83, ± 13.6) / 17.3 / 11.8
(0 - 79, ±15.6)
13.9 / 11.6
(0 - 59, ±13.0) / 16.8 / 12.2
(0 - 88, ±13.2)
16.4 / 9.8
(0 - 100, ±13.2)

Eating

Placebo
Interferon / 1.8 / 0.0
(0 – 21, ±4.4)
1.3 / 0.0
(0 – 14, ±3.1) / 2.1 / 0.0
(0 - 25, ±4.3)
2.3 / 0.0
(0 - 17, ±3.7) / 3.7 / 0.0
(0 - 32, ±6.1)
3.5 / 0.0
(0 - 25, ±5.2)

Work

Placebo
Interferon / 12.4 / 7.9
(0 - 46, ±15.2)
14.3 / 7.9
(0 - 46, ±15.6) / 20.5 / 11.4
(0 - 49, ±20.0)
20.9 / 12.8
(0 - 66, ±20.4) / 23.1 / 14.1
(0 - 54, ±23.1)
21.7 / 14.2
(0 - 60, ±20.1)

Home management

Placebo
Interferon / 17.9 / 14.7
(0 - 79, ±15.9)
16.9 / 13.2
(0 - 63, ±13.4) / 25.9 / 21.3
(0 - 79, ±17.5)
24.2 / 21.3
(0 - 87, ±17.4) / 31.4 / 30.5
(0 - 84, ±19.3)
32.8 / 30.5
(0 - 100, ±20.9)

Recreation / pastimes

Placebo
Interferon / 20.7 / 18.7
(0 - 62, ±14.1)
23.4 / 19.4
(0 - 58, ± 15.9) / 28.8 / 28.0
(0 - 91, ±19.4)
26.5 / 26.5
(0 - 72, ±19.2) / 30.8 / 30.2
(0 - 66, ±19.5)
30.8 / 29.9
(0 - 100, ±22.8)

Legend Table 1

1 higher SIP scores indicate poorer levels of self - reported HrQoL

2 higher EDSS scores indicate increased severity of disease