Online Resource 1: PrV, BoHV-1 and BoHV-5 proteins analysed in this work
Size(aa) / Function
Protein / PrV / BoHV-1 / BoHV-5
gB / 854 / 870 / 884 / cell entry, cell-to-cell spread, binds cell surface heparan sulphate, possible membrane fusogen
gC / 479 / 482 / 460 / cell attachment, binds cell surface heparan sulphate, binds complement C3b to block neutralization
gD / 383 / 399 / 398 / cell attachment, binds cell surface receptors
gE / 549 / 575 / 573 / cell-to-cell spread, complexed with envelope glycoprotein I to form an Fc-receptor
gG / 478 / 418 / 418 / cell-to-cell spread
gH / 656 / 822 / 827 / cell entry, cell-to-cell spread, possible membrane fusogen, complexed with envelope glycoprotein L
gI / 335 / 327 / 371 / cell-to-cell spread, complexed with envelope glycoprotein E to form an Fc-receptor
gK / 292 / 300 / 302 / virion morphogenesis, membrane fusion
gL / 140 / 133 / 133 / virion morphogenesis, membrane fusion
gM / 354 / 401 / 383 / virion morphogenesis, membrane fusion, complexed with envelope glycoprotein N
gN / 74 / 79 / 78 / virion morphogenesis, membrane fusion, complexed with envelope glycoprotein M
us9 / 98 / 144 / 134 / tegument-associated,axonal transport, localizes envelope proteins
Tegument
vp22 / 249 / 258 / 267 / virion morphogenesis, possibly RNA transport to uninfected cells
vp16 / 413 / 482 / 482 / virion morphogenesis, gene regulation, transactivates immediate early genes
vp13/14 / 750 / 739 / 741 / possibly gene regulation, RNA-binding protein, modulates transactivating tegument protein VP16
vp11/12 / 693 / 748 / 734 / possibly gene regulation, modulates transactivating tegument protein VP16
Large Tegument Protein / 3084 / 3203 / 3204 / capsid transport, ubiquitin-specific protease (N-terminal region), complexed with tegument protein UL37
ul37 / 919 / 1024 / 1054 / virion morphogenesis, complexed with large tegument protein
host shut off / 365 / 459 / 454 / cellular mRNA degradation, mRNA-specific RNase
ul25 / 534 / 598 / 603 / DNA encapsidation, possibly stabilizes the capsid and retains the genome, located on capsid near vertices
ul21 / 525 / 574 / 603 / virion morphogenesis, interacts with microtubules
ul17 / 597 / 701 / 707 / DNA packaging, DNA encapsidation, dna cleavage
ul16 / 328 / 339 / 343 / possibly virion morphogenesis
ul7 / 266 / 299 / 301 / virion morphogenesis, virion egress
ul14 / 159 / 222 / 224 / virion morphogenesis, vp16 localization, blocks apoptosis
Tegument Serine/Threonine Protein Kinase / 398 / 492 / 495 / virion morphogenesis