Table 1: List of Commercially Available Instrumented Single-Use Bioreactors (Liter-Scale)

Table 1: List of commercially available instrumented single-use bioreactors (liter-scale)

Reactor Category / Reactor Name / Working Volume [L] / Used successfully1 for cultivation of / Manufacturer
mechanical drive, wave action / AppliFlex / 0.5-25 / animal and plant cell cultures, algae2 / Applikon
CELL-tainer (20 L, 200 L) / 0.015-150 / microorganisms / Cell tainer Biotech
0.015-200 / animal cell cultures
CellTumbler (various Systems 50) / 0.5-10 / animal cell cultures / CerCell
SmartRocker Bioreactor / 0.5-25 / animal and plant cell cultures / Finesse
Wave Bioreactor System (System 20/50 and System 500/1000) / 0.2-500 / animal and plant cell cultures / GE Healthcare
ReadyToProcess WAVE25 / 0.2-25
Xuri Cellbag bioreactor (System W5 and W25) / 0.2-25 / human cells (e.g. cells and stem cells)
Allegro XRS 20 / 0.1-20 / animal cell cultures, microorganisms and T-cells / Pall Life Sciences
BIOSTAT RM bioreactor (System 20/50 and System 200) / 0.1-100 / animal and plant cell cultures, algae2 and microorganisms / Sartorius Stedim Biotech

n.a. not available, 1 application notes and/or papers exist, 2 version with LED illumination, 3 announced, 4 cubic plastic bag, 5 paddle stirrer, 6 Fibra-Cel carrier, 7 polyester microfibers, 8 working volume fixed bed

Table 1 continued

Reactor Category / Reactor Name / Working Volume [L] / Used successfully1 for cultivation of / Manufacturer
mechanical drive, stirred-tank, rigid tank / CellVessel 21 and 23 Series / 0.250-75 / animal cell cultures / CerCell
CellVessel 21 and 23 Series / 0.25-1 / microorganisms
BactoVessel 25 Series / 2-75
CelliGen BLU benchtop stirred-tank reactor (BioBLU 1c, 5c, 14c, 50c) / 0.25-40 / animal cell cultures and human cells (stem cells) / Eppendorf
CelliGen BLU benchtop stirred-tank reactor (BioBLU 1f) / 0.25-1.25 / microorganisms
DASGIP Parallel Bioreactor (BioBlock with BioBLU 1c) / 0.25-1.25 / animal cell cultures and human cells (stem cells)
DASGIP Parallel Bioreactor (BioBlock with BioBLU 1f) / microorganisms
Mobius CellReady 3 L bioreactor / 1-2.4 / animal cell cultures and human cells (stem cells) / Merck Millipore
UniVessel SU / 0.6-2 / animal and plant cell cultures, human cells (stem cells) and microorganisms / Sartorius Stedim Biotech
SmartVessel3 single-use bioreactor / 0.5-2.2 / animal and plant cell cultures / Finesse

n.a. not available, 1 application notes and/or papers exist, 2 version with LED illumination, 3 announced, 4 cubic plastic bag, 5 paddle, 6 Fibra-Cel carrier, 7 polyester microfibers, 8 working volume fixed bed

Table 1 continued

Reactor Category / Reactor Name / Working Volume [L] / Used successfully1 for cultivation of / Manufacturer
mechanical drive, stirred-tank, plastic bag / Xcellerex XDR (10 L, 50 L, 200 L, 500 L, 1000 L, 2000 L) / 4.5-2000 / animal cell cultures / GE Healthcare
Xcellerex XDR-50 MO Fermentor / 10-50 / microorganisms
Mobius CellReady (50 L, 200 L, 1000 L3, 2000 L3) / 10-20003 / animal cell cultures / Merck Millipore
Allegro STR (200 L, 1000 L3, 2000 L3) / 60-20003 / animal cell cultures / Pall Life Sciences
PadReactor (25 L, 50 L, 125 L, 250 L, 600 L, 1200 L)4, 5 / 8-960 / animal cell cultures
BIOSTAT STR (50 L, 200 L, 500 L, 1000 L, 2000 L3) / 12.5-20003 / animal cell cultures, human cells (stem cells) and microorganisms / Sartorius Stedim Biotech
HyPerforma S.U.B (50 L, 100 L, 250 L, 500 L, 1000 L, 2000 L) / 25-2000 / animal and plant cell cultures / ThermoScientific
HyPerforma S.U.F (30 L, 300 L) / 6-300 / microorganisms

Table 1 continued

Reactor Category / Reactor Name / Working Volume [L] / Used successfully1 for cultivation of / Manufacturer
mechanical drive, orbital shaken / OrbShake bioreactor (SB-10X, SB-50X, SB-200X, SB-2500X) / 1-2500 / animal and plant cell cultures, microorganisms / Adolf Kühner
Current Bioreactor (5 L, 50 L, 150 L, 300 L) / 0.5-300 / animal cell cultures / Hangzhou Amprotein Bioengineering
mechanical drive, rotating / Vertical Wheel bioreactor MagDrive (PBS3MAG, PBS15 MAG) / 1.8-15 / human cells (stem cells) / PBS Biotech
pneumatic drive / CEllMaker Felix3 / n.a. / animal cell cultures / Cellexus
CEllMaker Regular and CEllMaker Plus (8 L, 50 L) / 1-50 / microorganisms and algae
Vertical Wheel bioreactor AirDrive (PBS 3 Air, PBS 15 AIR, PBS 80 AIR, PBS 500 AIR) / 0.6-500 / animal cell cultures / PBS Biotech
hydraulic drive, hollow fiber bioreactor / Quantum Cell Expansion / absolute cell culture surface area: 2.1 m2 / adherent animal cell cultures and human cells (stem cells and T-cells) / Terumo BCT

Table 1 continued

Reactor Category / Reactor Name / Working Volume [L] / Used successfully1 for cultivation of / Manufacturer
hydraulic drive, parallel plate bioreactor / Xpansion Multiplate Bioreactor
(10 - 200 plates) / absolute cell culture surface area: -0.06-12.2 m2 / animal cell cultures and human cells (stem cells) / Pall Life Sciences
hydraulic drive, fixed bed bioreactor / Celligen BLU fixed bed bioreactor (5 L, BioBLU 5p)6 / 3.758 / adherent animal cell cultures and human cells (stem cells) / Eppendorf
iCELLis7
(nano, 500) / 0.04-258 / animal cell cultures and human cells (stem cells) / Pall Life Sciences