Table 1 Characteristics of XRCC1 gene R399Q polymorphism genotype distributions in studies included in this meta-analysis.
First author (reference) / Year / ethnicity / Number / Distribution of R399Q XRCC1 genotype / P for HWE(case/control) / RR RQ QQ / in controls
Cases Controls Cases Controls Cases Controls
Rahman et al.(1) / 2000 / African / 48/48 / 22 / 37 / 21 / 9 / 5 / 2 / 0.18
Krupa and Blasiak(2) / 2004 / Europe / 51/100 / 23 / 39 / 19 / 45 / 9 / 16 / 0.67
Yeh et al. (3) / 2005 / Asia / 718/729 / 407 / 384 / 260 / 291 / 51 / 54 / 1.00
Hong et al. (4) / 2005 / Asia / 209/209 / 112 / 136 / 88 / 64 / 9 / 9 / 0.66
Moreno et al. (5) / 2006 / Europe / 355/322 / 154 / 137 / 160 / 145 / 41 / 40 / 0.90
Skjelbred et al. (6) / 2006 / Europe / 157/399 / 63 / 148 / 70 / 187 / 24 / 64 / 0.75
Jin et al. (7) / 2007 / Asia / 202/616 / 109 / 337 / 72 / 222 / 21 / 57 / ＜0.05
Stern et al. (8) / 2007 / Asia / 294/1120 / 167 / 607 / 112 / 428 / 15 / 85 / 0.45
Sliwinski et al. (9) / 2008 / Europe / 100/100 / 47 / 39 / 37 / 45 / 16 / 16 / 0.67
Improta et al. (10) / 2008 / Europe / 109/121 / 46 / 53 / 54 / 61 / 9 / 7 / 0.06
Kasahara et al. (11) / 2008 / Asia / 68/121 / 42 / 62 / 23 / 48 / 3 / 11 / 0.66
Song et al. (12) / 2008 / Asia / 217/255 / 91 / 165 / 99 / 83 / 27 / 7 / 0.54
Wang et al. (13) / 2010 / Asia / 302/291 / 124 / 139 / 138 / 113 / 40 / 39 / ＜0.05
Huang et al. (14) / 2010 / Asia / 120/150 / 63 / 76 / 46 / 64 / 11 / 10 / 0.55
Ye et al. (15) / 2010 / Asia / 123/158 / 64 / 101 / 46 / 48 / 13 / 9 / 0.33
Engin et al. (16) / 2011 / Europe / 96/108 / 47 / 50 / 37 / 49 / 12 / 9 / 0.65
Canbay et al. (17) / 2011 / Europe / 79/247 / 63 / 202 / 16 / 43 / 0 / 2 / 1.00
Gsur et al. (18) / 2011 / Europe / 85/1663 / 35 / 667 / 31 / 763 / 19 / 233 / 0.53
Zhu et al. (19 / 2011 / Asia / 250/213 / 121 / 94 / 112 / 102 / 17 / 17 / 0.16
Zhao et al. (20) / 2012 / Asia / 486/970 / 239 / 556 / 188 / 354 / 59 / 60 / 0.73
Yin et al. (21) / 2012 / Asia / 685/776 / 356 / 436 / 275 / 299 / 54 / 41 / 0.29
Muñiz-Mendoza et al. (22) / 2012 / North America / 103/120 / 48 / 65 / 48 / 47 / 7 / 8 / 1.00
Table 2 Pooled measures on the relationship of XRCC1 gene R399Q polymorphism with Colorectal Cancer.
All included articles / After excluding for DHWEPopulation / Inherited / Pooled OR (95% CI) / I² / Pooled OR (95% CI) / I²
(number of studies) / model / FEM / REM / (%) / FEM / REM / (%)
Dominant / 1.104(1.024-1.191)** / 1.114(0.970-1.278) / 65.2 / 1.098(1.014-1.189) * / 1.109(0.951-1.292) / 67.8
All (22) / Recessive / 1.235(1.081-1.411) ** / 1.230(1.015-1.491) * / 43.6 / 1.269(1.099-1.465) ** / 1.259(1.013-1.565) * / 47.5
Codominant / 1.108(1.045-1.174) ** / 1.118(0.996-1.254) / 69.9 / 1.108(1.041-1.179) ** / 1.121(0.985-1.275) / 72.6
Homozygote / 1.251(1.089-1.437) ** / 1.248(0.995-1.565) / 55.3 / 1.269(1.093-1.474) ** / 1.265(0.977-1.639) / 59.4
DHWE: deviated from Hardy–Weinberg equilibrium in controls
** p﹤0.01; * p﹤0.05; FEM, fixed effect model; REM, random effect model
Dominant model: QQ+RQ vs. RR; Recessive model: QQ vs. RR+RQ; Codominant model: Q vs. R; Homozygote model: QQ vs. RR
Figure 1 Forest plots of relationship between XRCC1 gene R399Q polymorphism and CRC in dominant model (QQ + RQ vs. RR). White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CI.
Figure 2 Forest plots of relationship between XRCC1 gene R399Q polymorphism and CRC in recessive model (QQ vs. RR + RQ). White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CI.
Figure 3 Forest plots of relationship between XRCC1 gene R399Q polymorphism and CRC in codominant model (Q vs. R). White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CI.
Figure 4 Forest plots of relationship between XRCC1 gene R399Q polymorphism and CRC in homozygote model (QQ vs. RR). White diamond denotes the pooled OR. Black squares indicate the OR in each study, with square sizes inversely proportional to the standard error of the OR. Horizontal lines represent 95% CI.
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