SupplementaryTable 4Antiviral, antibacterial, antifungal, cytotoxic and antiparasitic activities of the extracts of fungal species from cold-arid oligotrophic soil from continental Antarctica
Inhibition of the targets (%)Virus / Bacteria / Fungi / Tumor cells / Protozoa
Fungal species / UFMGCBa / Dengue virusg / E. coli / S. aureus / P. aeruginosa / C. albicans / C. krusei / C. sphaerosperum / MCF-7 / TK-10 / T. cruzi / L. amazonensis
Aspergillus sydowii / 9541 / 0 / 0 ± 23 / 95 ± 13 / 13 ± 5 / 0 ± 7 / 0 ± 5 / 73 ± 7 / 84 ± 10 / 40 ± 1 / 29 ± 4.5 / 0 ± 0
Penicillium allii-sativi / 9451 / >75 / 0 ± 6 / 97.4 ± 4 / 11 ± 20 / 0 ± 17 / 0 ± 1 / 30.4 ± 9 / 82 ± 10 / 52 ± 4 / 18 ± 1 / 24 ± 1
P. allii-sativi / 9458 / 0 / 0 ± 13 / 0 ± 21 / 1.5 ± 5 / 0 ± 1 / 0 ± 27 / 70 ± 11 / 11 ± 4 / 16 ± 10 / 6.5 ± 2 / 23 ± 3
P. allii-sativi / 9508 / 0 / 0 ± 6 / 92 ± 25 / 0 ± 5 / 0 ± 12 / 0 ± 4 / 39 ± 36 / 40 ± 22 / 1 ± 4 / 1.7 ± 1 / 0 ± 0
P. allii-sativi / 9509 / 0 / 0 ± 8 / 86 ± 5 / 9.5 ±9 / 0 ± 5 / 0 ± 1 / 46 ± 11 / 41 ± 15 / 0 ± 1 / 1.3 ± 1 / 0 ± 0
P. allii-sativi / 9524 / 0 / 0 ± 2 / 92.7 ± 5 / 17 ± 28 / 0 ± 4 / 0 ± 13 / 57 ± 37 / 46 ± 2 / 2 ± 0 / 28.3 ± 5 / 14 ± 2
Penicillium brevicompactum / 9446 / 50 / 0 ± 30 / 97 ± 25 / 15.9 ±4 / 10 ± 18 / 11.1 ± 4 / 56 ± 55 / 70 ± 8 / 16 ± 5 / 10 ± 2 / 36 ± 0
P. brevicompactum / 9448 / 0 / 0 ± 9 / 98 ± 20 / 0 ± 27 / 0 ± 2 / 28.2 ± 11 / 80.5 ± 7 / 22 ± 0 / 4 ± 1 / 18 ± 2 / 14 ± 0
P. brevicompactum / 9478 / >75 / 0 ± 7 / 0 ± 0 / 36 ± 2 / 0 ± 6 / 0 ± 6 / 76 ± 9 / 33 ± 66 / 47 ± 7 / 45 ± 1 / 13 ± 1
P. brevicompactum / 9480 / >75 / 0 ± 11 / 98 ± 20 / 0 ± 21 / 4.3 ± 46 / 0 ± 4 / 40 ±11 / 84 ± 1 / 58 ± 15 / 86 ± 1 / 19 ± 0
P. brevicompactum / 9538 / >75 / 0 ± 9 / 94 ± 3 / 0 ± 15 / 0 ± 2 / 0 ± 2 / 44.2 ± 8 / 94 ± 18 / 36 ± 9 / 11 ± 1 / 0 ± 0
Penicillium chrysogenum / 9466 / 0 / 0 ± 9 / 0 ± 3 / 0 ± 2 / 0 ± 3 / 0 ± 7 / 80 ± 6 / 19 ± 5 / 12 ± 0 / 24 ± 1 / 23 ± 0
P. chrysogenum / 9470 / 0 / 0 ± 9 / 0 ± 21 / 15 ± 1 / 0 ± 32 / 0 ± 4 / 65 ± 10 / 84 ± 1 / 20 ± 9 / 22 ± 9.5 / 20 ± 0
P. chrysogenum / 9445 / >75 / 0 ± 6 / 0 ± 8 / 0 ± 7 / 23 ± 34 / 30 ± 18 / 65 ± 7 / 72 ± 8 / 37 ± 8 / 18 ± 4.5 / 35 ± 0
P. chrysogenum / 9534 / 0 / 0 ± 17 / 87 ± 11 / 15 ± 4 / 0 ± 14 / 0 ± 3 / 31 ± 46 / 26 ± 7 / 0 ± 5 / 8.7 ± 2 / 0 ± 0
P. crhysogenum / 9438 / 0 / 0 ± 5 / 82 ± 10 / 1.5 ± 4 / 6 ± 5 / 12.6 ± 20 / 46 ± 26 / 0 ± 3 / 0 ± 10 / 7 ± 1 / 30 ± 7
Penicillium rubens / 9496 / 0 / 0 ± 11 / 0 ± 19 / 0 ± 4 / 14 ± 25 / 12 ± 10 / 76 ± 27 / 43 ± 19 / 0 ± 1 / 0 ± 0 / 0 ± 1
Control drugs / Chlob / 100± 5 / 98 ± 12 / 83 ± 6 / - / - / - / - / - / - / -
Amph Bc / - / - / - / 100 ± 23 / 100 ± 13 / - / - / - / - / 79 ± 2
Etod / - / - / - / - / - / - / 96 ± 5 / 80 ± 8 / - / -
Benze / - / - / - / - / - / - / - / - / 57 ± 7 / -
Benf / - / - / - / - / - / 94.5 ± 10 / - / - / - / -
aUFMGCB = Culture of Microorganisms and Cells of the Universidade Federal de Minas Gerais; bChlo = chloramphenicol;cAmph B = amphotericin B; dEto = etoposide; eBenz = benznidazole; fBenomyl; gDengue virus= % of Dengue virus 2 cytopathic effect inhibition in the presence of 25 ug mL-1 of extract; - = not assayed.E. coli = Escherichia coli; S. aureus = Staphylococcus aureus; P. aeruginosa = Pseudomonas aeruginosa; C. albicans = Candida albicans; C. krusei = Candida krusei; C. sphaerosperum = Cladosporium sphaerosperum; MCF-7 = breast tumor cell; TK-10 = renal tumor cell; T. cruzi = Trypanosoma cruzi and L. amazonensis = Leishmania amazonensis.For the antimicrobial activity, the extracts assayed at 250 µg mL-1. For the cytotoxic, leishmanicidal and trypanocidal activities, the extracts were assayed at20 μg mL-1 for use in the cytotoxic assays. In bold the extracts that displayed activities ≥ 70% or activities close those of the control drugs used for each assay.
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