Supplementary Table S3. JX06 activity at 10 μM towards a panel of 323 kinases.
NO. / Kinase / Relative kinase activityof JX06 at 10 μM
1 / ALK2(h) / 106
2 / ALK4(h) / 113
3 / AMPKα1(h) / 101
4 / AMPKα2(h) / 99
5 / ASK1(h) / 125
6 / B-Raf(h) / 91
7 / B-Raf(V599E)(h) / 104
8 / CDK1/cyclinB(h) / 109
9 / CDK2/cyclinA(h) / 88
10 / CDK2/cyclinE(h) / 96
11 / CHK1(h) / 107
12 / CHK2(h) / 79
13 / CK2(h) / 103
14 / CK2α2(h) / 93
15 / CLK1(h) / 100
16 / CLK2(h) / 98
17 / c-RAF(h) / 103
18 / DAPK1(h) / 106
19 / DAPK2(h) / 104
20 / DMPK(h) / 104
21 / GRK1(h) / 103
22 / IRAK1(h) / 106
23 / IRAK4(h) / 97
24 / JNK1α1(h) / 103
25 / JNK2α2(h) / 105
26 / JNK3(h) / 100
27 / LIMK1(h) / 96
28 / LKB1(h) / 98
29 / LRRK2(h) / 94
30 / MAPK1(h) / 90
31 / MAPK2(h) / 88
32 / MEK1(h) / 102
33 / MARK1(h) / 94
34 / MINK(h) / 99
35 / MKK6(h) / 111
36 / MKK7β(h) / 99
37 / MLK1(h) / 93
38 / MRCKα(h) / 109
39 / MRCKβ(h) / 100
40 / MSK1(h) / 93
41 / MSK2(h) / 88
42 / MST1(h) / 102
43 / MST2(h) / 94
44 / p70S6K(h) / 100
45 / PAK1(h) / 98
46 / PASK(h) / 90
47 / PDK1(h) / 101
48 / PKA(h) / 109
49 / PKD2(h) / 106
50 / PRAK(h) / 129
51 / PRK2(h) / 91
52 / RIPK2(h) / 98
53 / Rsk1(h) / 98
54 / Rsk2(h) / 99
55 / TAK1(h) / 97
56 / TGFBR1(h) / 116
57 / Abl(h) / 103
58 / Abl(m) / 101
59 / Abl (H396P) (h) / 98
60 / Abl (M351T)(h) / 103
61 / Abl (Q252H) (h) / 96
62 / Abl(T315I)(h) / 86
63 / Abl(Y253F)(h) / 108
64 / ACK1(h) / 108
65 / ALK(h) / 105
66 / Arg(h) / 111
67 / Arg(m) / 87
68 / ARK5(h) / 99
69 / Aurora-A(h) / 102
70 / Aurora-B(h) / 96
71 / Aurora-C(h) / 83
72 / Axl(h) / 87
73 / Blk(h) / 115
74 / Blk(m) / 87
75 / Bmx(h) / 88
76 / BRK(h) / 108
77 / BrSK1(h) / 79
78 / BrSK2(h) / 90
79 / BTK(h) / 93
80 / BTK(R28H)(h) / 83
81 / CaMKI(h) / 97
82 / CaMKIIβ(h) / 101
83 / CaMKIIγ(h) / 102
84 / CaMKIδ(h) / 92
85 / CaMKIIδ(h) / 105
86 / CaMKIV(h) / 47
87 / CDK3/cyclinE(h) / 94
88 / CDK5/p25(h) / 97
89 / CDK5/p35(h) / 105
90 / CDK6/cyclinD3(h) / 95
91 / CDK7/cyclinH/MAT1(h) / 106
92 / CDK9/cyclin T1(h) / 110
93 / CHK2(I157T)(h) / 70
94 / CHK2(R145W)(h) / 76
95 / CK1γ1(h) / 87
96 / CK1γ2(h) / 73
97 / CK1γ3(h) / 66
98 / CK1δ(h) / 102
99 / CK1(y) / 91
100 / CLK3(h) / 94
101 / CLK4(h) / 90
102 / cKit(h) / 107
103 / cKit(D816V)(h) / 100
104 / cKit(D816H)(h) / 89
105 / cKit(V560G)(h) / 87
106 / cKit(V654A)(h) / 91
107 / CSK(h) / 106
108 / cSRC(h) / 101
109 / DCAMKL2(h) / 101
110 / DDR2(h) / 105
111 / DRAK1(h) / 88
112 / DYRK2(h) / 102
113 / eEF-2K(h) / 107
114 / EGFR(h) / 110
115 / EGFR(L858R)(h) / 100
116 / EGFR(L861Q)(h) / 99
117 / EGFR(T790M)(h) / 95
118 / EGFR(T790M,L858R)(h) / 108
119 / EphA1(h) / 102
120 / EphA2(h) / 95
121 / EphA3(h) / 95
122 / EphA4(h) / 92
123 / EphA5(h) / 91
124 / EphA7(h) / 99
125 / EphA8(h) / 98
126 / EphB2(h) / 102
127 / EphB1(h) / 88
128 / EphB3(h) / 90
129 / EphB4(h) / 84
130 / ErbB4(h) / 100
131 / FAK(h) / 14
132 / Fer(h) / 100
133 / Fes(h) / 81
134 / FGFR1(h) / 86
135 / FGFR1(V561M)(h) / 96
136 / FGFR2(h) / 103
137 / FGFR2(N549H)(h) / 92
138 / FGFR3(h) / 88
139 / FGFR4(h) / 68
140 / Fgr(h) / 103
141 / Flt1(h) / 59
142 / Flt3(D835Y)(h) / 103
143 / Flt3(h) / 100
144 / Flt4(h) / 58
145 / Fms(h) / 86
146 / Fms(Y969C)(h) / 94
147 / Fyn(h) / 114
148 / GCK(h) / 81
149 / GCN2(h) / 111
150 / GRK5(h) / 94
151 / GRK6(h) / 83
152 / GRK7(h) / 92
153 / GSK3α(h) / 67
154 / GSK3β(h) / 108
155 / Haspin(h) / 110
156 / Hck(h) / 98
157 / Hck(h) activated / 102
158 / HIPK1(h) / 88
159 / HIPK2(h) / 112
160 / HIPK3(h) / 87
161 / IGF-1R(h) / 89
162 / IGF-1R(h), activated / 77
163 / IKKα(h) / 104
164 / IKKβ(h) / 66
165 / IKKε(h) / 94
166 / IR(h) / 81
167 / IR(h), activated / 84
168 / IRE1(h) / 93
169 / IRR(h) / 119
170 / Itk(h) / 106
171 / JAK1(h) / 99
172 / JAK2(h) / 79
173 / JAK3(h) / 81
174 / KDR(h) / 89
175 / Lck(h) / 91
176 / Lck(h) activated / 57
177 / LOK(h) / 75
178 / Lyn(h) / 98
179 / Lyn(m) / 93
180 / MAPK2(m) / 76
181 / MAPKAP-K2(h) / 84
182 / MAPKAP-K3(h) / 97
183 / MELK(h) / 80
184 / Mer(h) / 92
185 / Met(h) / 101
186 / Met(D1246H)(h) / 104
187 / Met(D1246N)(h) / 92
188 / Met(M1268T)(h) / 93
189 / Met(Y1248C)(h) / 96
190 / Met(Y1248D)(h) / 96
191 / Met(Y1248H)(h) / 104
192 / MKK4(m) / 95
193 / MLCK(h) / 96
194 / Mnk2(h) / 96
195 / MSSK1(h) / 92
196 / MST3(h) / 62
197 / MST4(h) / 97
198 / mTOR(h) / 84
199 / mTOR/FKBP12(h) / 107
200 / MuSK(h) / 110
201 / NEK2(h) / 81
202 / NEK3(h) / 107
203 / NEK6(h) / 103
204 / NEK7(h) / 93
205 / NEK9(h) / 97
206 / NEK11(h) / 89
207 / NLK(h) / 93
208 / PAK2(h) / 95
209 / PAK4(h) / 78
210 / PAK5(h) / 108
211 / PAK6(h) / 91
212 / PAR-1Bα(h) / 107
213 / PEK(h) / 103
214 / PDGFRα(h) / 71
215 / PDGFRα(D842V)(h) / 116
216 / PDGFRα(V561D)(h) / 98
217 / PDGFRβ(h) / 121
218 / PhKγ2(h) / 79
219 / Pim-1(h) / 106
220 / Pim-2(h) / 54
221 / Pim-3(h) / 106
222 / PKBα(h) / 105
223 / PKBβ(h) / 83
224 / PKBγ(h) / 84
225 / PKCα(h) / 54
226 / PKCβI(h) / 65
227 / PKCβII(h) / 89
228 / PKCγ(h) / 46
229 / PKCδ(h) / 63
230 / PKCε(h) / 72
231 / PKCη(h) / 54
232 / PKCι(h) / 47
233 / PKCμ(h) / 94
234 / PKCθ(h) / 86
235 / PKCζ(h) / 95
236 / PKG1α(h) / 100
237 / PKG1β(h) / 101
238 / Plk1(h) / 97
239 / Plk3(h) / 97
240 / PrKX(h) / 103
241 / PTK5(h) / 108
242 / Pyk2(h) / 99
243 / Ret(h) / 101
244 / Ret (V804L)(h) / 94
245 / Ret(V804M)(h) / 88
246 / ROCK-I(h) / 80
247 / ROCK-II(h) / 90
248 / ROCK-II(r) / 97
249 / Ron(h) / 90
250 / Ros(h) / 88
251 / Rse(h) / 98
252 / Rsk1(r) / 75
253 / Rsk3(h) / 125
254 / Rsk4(h) / 84
255 / SAPK2a(h) / 105
256 / SAPK2a(T106M)(h) / 96
257 / SAPK2b(h) / 98
258 / SAPK3(h) / 105
259 / SAPK4(h) / 71
260 / SGK(h) / 77
261 / SGK2(h) / 47
262 / SGK3(h) / 104
263 / SIK(h) / 93
264 / Snk(h) / 97
265 / SNRK(h) / 37
266 / Src(1-530)(h) / 73
267 / Src(T341M)(h) / 89
268 / SRPK1(h) / 94
269 / SRPK2(h) / 110
270 / STK25(h) / 94
271 / STK33(h) / 101
272 / Syk(h) / 111
273 / TAO1(h) / 103
274 / TAO2(h) / 81
275 / TAO3(h) / 88
276 / TBK1(h) / 88
277 / Tec(h) activated / 117
278 / Tie2 (h) / 99
279 / Tie2(R849W)(h) / 97
280 / Tie2(Y897S)(h) / 95
281 / TLK1(h) / 94
282 / TLK2(h) / 102
283 / TrkA(h) / 95
284 / TrkB(h) / 110
285 / TrkC(h) / 96
286 / TSSK1(h) / 81
287 / TSSK2(h) / 91
288 / Txk(h) / 102
289 / TYK2(h) / 97
290 / ULK2(h) / 108
291 / ULK3(h) / 96
292 / Wee1(h) / 92
293 / WNK2(h) / 90
294 / WNK3(h) / 100
295 / VRK2(h) / 94
296 / Yes(h) / 86
297 / ZAP-70(h) / 112
298 / ZIPK(h) / 89
299 / PI3 Kinase (p110b/p85a)(h) / 101
300 / PI3 Kinase (p120g)(h) / 101
301 / PI3 Kinase (p110d/p85a)(h) / 99
302 / PI3 Kinase (p110a/p85a)(m) / 102
303 / PI3 Kinase (p110a/p65a)(m) / 97
304 / PI3 Kinase (p110a(E545K)/p85a)(m) / 92
305 / PI3 Kinase (p110a(H1047R)/p85a)(m) / 99
306 / PI3 Kinase (p110b/p85b)(m) / 101
307 / PI3 Kinase (p110b/p85a)(m) / 98
308 / PI3 Kinase (p110d/p85a)(m) / 92
309 / PI3 Kinase (p110a(E542K)/p85a)(m) / 97
310 / PI3 Kinase (p110a/p85a)(h) / 98
311 / PI3 Kinase (p110a(E542K)/p85a)(h) / 94
312 / PI3 Kinase (p110a(H1047R)/p85a)(h) / 99
313 / PI3 Kinase (p110a(E545K)/p85a)(h) / 95
314 / PI3 Kinase (p110a/p65a)(h) / 99
315 / PI3KC2a(h) / 90
316 / PI3KC2g(h) / 115
317 / PIP4K2a(h) / 98
318 / PIP5K1a(h) / 102
319 / PIP5K1g(h) / 95
320 / PDK1 / 5
321 / PDK2 / 20
322 / PDK3 / 13
323 / PDK4 / 57