10 20 30 40 50 60 70 80 90 100 110

HaeIII A2F A2R

alpha/beta-cons TACTGTCGCA AAAAGCGGCC TGTGC****G AAAAAAA*** *TTGAATATT TTCGAG*GTT TAACAAGCTA TAACC*GGAG TATTTTTCAT TCGACTTCTT TATGGCATAC

DgouAB/1(Hae) ...... C...... ****...... *** *.G...... *...... *...... A..

DgouAB/2(Hae) ...... C...... ****...... *** *...... A..*...... T.*AA...... A......

DgouAB/3(Hae) ...... C...... ****...... AAA A.G...... A..*...... *......

DgouAB/4(Hae) ...... C...... ****...... *** *...... A..*...... *A......

DgouAB/5(Hae) ...... C...... ****...... A** *...... *...... *......

DgouAB/6(Hae) ...... C...... ****...... A** *...... *...... *......

DgouAB/7(Hae) ...... C...... ****...... *** *...... A..*...... *A......

DgouAB/8(Hae) ...... A...... ****...... *** *...... *...... *......

DgouAB/9(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/10(PA2) ...... T...... C...... ****...... A** *...... C. ...A..*...... *......

DgouAB/11(PA2) ..A...... C...... ****...... *** *...... *.C...... *...... *....

DgouAB/12(PA2) ...... ****. .T.....*** *...... *...... *......

DgouAB/13(PA2) ...... ****...... A** *...... *...... *......

DgouAB/14(PA2) ...... ****...... AA* *...... *...... C......

DgouAB/15(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/16(PA2) ...... ****...... AA* *...... *...... *......

DgouAB/17(PA2) ...... C...... ****...... A** *...... *...... C...... *......

DgouAB/18(PA2) ...... T...... GC...... ****...... *** *.G...... *... ..G...... *......

DgouAB/19(PA2) ...... C...... ****...... T** *.*...... *...... *...... A A......

DgouAB/20(PA2) ...... C...... ****...... T** *.*...... *.C...... *......

DgouAB/21(PA2) ...... C...... ****...... A** *.G...... *...... *...... *......

DgouAB/22(PA2) ...... G .....****...... T** **...... *...... C...... *......

DgouAB/23(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/24(PA2) ...... C...... ****...... *** *...... A..*...... G...... *A......

DgouAB/25(PA2) ...... C....G .....****...... T** **...... A..*...... *A......

DgouAB/26(PA2) ...... C...... ****...... *** *.G...... *...... *...... G.

DgouAB/27(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/28(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/29(PA2) ...... C...... ****...... T** *...... *...... *...... C..

DgouAB/30(PA2) ...... C...... ****...... T** *G*...... *...... *......

DgouAB/31(PA2) ...... C...... ****...... A** *...... *...... *......

DgouAB/32(PA2) ...... C...... ****...... T** **...... A..*...... *......

DgouAB/33(PA2) ...... C...... ****...... *** *...... A..*...... *......

DgouAB/34(PA2) ...... C...... ****...... *** *.G...... *...... *......

DgouAB/35(PA2) ...... T...... C...... ****...... *** *.G...... *...... *......

DgouAB/36(PA2) ...... T...... C...... ****...... *** *.G...... *...... *......

DsmaAB/1(Hpa) ...... G...... T .....***** *...... A** A....C...... *A...... A*...... A.....

DsmaAB/2(Hpa) ...... T .....****...... *** A....C...... *A...... *......

DsmaAB/3(Hpa) ...... T .....GAAAA ...... A** A....C...... *A...... *......

DsmaAB/4(Hpa) ...... T .....****...... **** *.G..C...... *A...... *......

DsmaAB/5(Hpa) ...... T .....****. .*****.*** A....C...... *A...... *......

DsmaAB/10(Hpa) ...... T .....***** G...... A** A....C...... *A...... *......

DsmaAB/11(Hpa) ...... T .....***** *G.....A** AAA..C...... *A...... *......

DsmaAB/12(Hpa) ...... T .....****...... *** A....C...... *A...... *......

DsmaAB/13(Hpa) ...... T .....***** *G.....A** A...... *A...... *......

DsmaAB/14(Hpa) ...... T .....****...... *** A.G..C...... *A...... *......

DsmaAB/15(Hpa) ...... *** ****.....T .....***** *G.....A** A....C...... *A...... *...... T

DsmaAB/16(Hpa) ...... A.AT .....***** G..*...A** A.G..C...... *A...... *......

DsmaAB/17(Hpa) ...... A.T .....***** G...... A** *...GC...... *A...... T...... *......

DsmaAB/18(Hpa) ...... T .....***** G...... A** A....C...... *A...... *......

DsmaAB/19(Hpa) ...... T .....***** G...... A** A....C...... C..*A...... *......

DsmaAB/20(Hpa) ...... T .....****...... *** *.G..C...... *A...... *...... T.

DsmaAB/21(Hpa) ...... T .....****...... *** A.G..C...... *A...... *...... G ...... T.

DsmaAB/22(Hpa) ...... T .....****...... *** A.G..C...... *A...... *...A ...... T.

DsmaAB/23(Hpa) ...... T .....*AAAA ...... A** A....C...... *A...... *......

DsmaAB/24(Hpa) ...... T .....***** *G.....A** A....C...... *A...... *......

DsmaAB/25(Hpa) ...... T .....****...... *** A.G..C...... *A...... *......

DsmaAB/26(Hpa) ...... T .....****...... *** *.G..C...... *A...... *...... T.

DsmaAB/27(Hpa) ...... T...... T .....****...... **** A.G..C...... *A...... *......

DsmaAB/28(Hpa) ...... T .....****...... *.*** AAG..C...... *A...... *......

DsmaAB/29(Hpa) ...... T .....****...... A** A....C...... *A...... *......

DsmaAB/30(Hpa) ...... T .....***** G..G...A** A.G..C...... *A...... A...... *...... G......

DantAB/1(Dra) ...... ****. T...... *** *.G..C...... A*...... *......

DantAB/2(Dra) ...... ****...... *** *....C...... A*...... *......

DantAB/3(Dra) ...... ****...... **** *....C...... A*...... *......

DantAB/4(Dra) ...... *...... ****. T...... *** *.G..C...... A*...... *......

DantAB/5(Dra) ...... ****...... *** *....C...... A*...... *...... C...... G...

DantAB/6(Dra) ...... ****...... *** *....C...... AA...... G..*......

DantAB/7(Dra) ...... ****...... *** *....C...... A*...... *......

DsdoAB/1(Ssp) ...... A. ...C...... ***** G...... *** *....C...... *...... *...... T......

DsdoAB/2(Ssp) ...... ***** G...... *** *.A..C...... *T...... A...... *...... T......

DsdoAB/3(Ssp) ...... A...... ***** G...... A** *....C...... *...... A*...... T......

DsdoAB/4(Ssp) ...... A...... ***** G...... *** *....G...... *...... *...... T......

DsdoAB/5(Ssp) ...... A...... ***** G...... *** *....C...... *...... *...... T......

DsdoAB/6(Ssp) ...... A...... ***** G...... *** *....C...... *...... *...... T......

DkoeAB/B20/1(PA2) ...... C...... ****...... A** *...... A..*...... *A......

DkoeAB/B20/2(PA2) ...... C...... C...... ****...... T** *...... *...... *......

DkoeAB/B20/3(PA2) ...... C...... ****...... A** *...... *...... *......

DkoeAB/B20/4(PA2) ...... C...... ****...... *** *...... A..*...... G...... *A......

DkoeAB/B20/5(PA2) ...... T .....****...... A** *....C...... *A...... T...... *......

DkoeAB/B20/6(PA2) ...... ****...... *** *....C...... *A...... *......

DkoeAB/B20/7(PA2) ...... T...... T .....***** G...... A** A....C...... *A...... *......

DkoeAB/B20/9(PA2) ...... T ..C..****...... *** A....C...... *A...... T...... *......

DkoeAB/B20/1(PB1) ...... T...... T .....***** G...... A** A....C...... C..*A...... *......

DkoeAB/B20/2(PB1) ...... C...... ***** *G.....A** A...... *... C...... *......

DkoeAB/B20/3(PB1) ...... ****...... *** *...... C...... *...... *......

DkoeAB/B20/4(PB1) ...... C...... ****...... T** **...... A..*...... *...... *......

DkoeAB/B20/5(PB1) ...... C...... ****...... *** *.G...... *...... *......

DkoeAB/B20/6(PB1) ...... C...... ****...... A** *...... A..*.C...... *A......

DkoeAB/B26/1(PB1) ...... ****...... A** *....C...... A*...... *......

DkoeAB/B26/2(PB1) ...... ****...... T*** *...... *.C...... *......

DkoeAB/B26/3(PB1) ...... C...... ****...... A** *...... A..*...... *A......

DkoeAB/B26/4(PB1) ...... ****...... *** *...... *...... *......

DkoeAB/B26/5(PB1) ...... C..... G....****...... A** **...... *A...... *...... T......

DborAB/1(PB1) ...... ****...... *** *....C...... A*...... *......

DborAB/2(PB1) ...... ***** G...... A** *.G..C...... T...*...... G...... *......

DborAB/3(PB1) ...... ****...... *** *..C.C...... A*...... *......

DborAB/4(PB1) ********** ********** ********** ********** ********** ********** ********** *....*......

DborAB/5(PB1) ...... T .....***** G...... A** A....C...... *A...... *......

DborAB/6(PB1) ...... ****...... *** *....C...... A*...... *......

DborAB/7(PB1) ...... ****...... *** *....C...... *...... C..*......

DborAB/8(PB1) ...... C...... C...... ****...... A** *.G...... *...... *......

DborAB/9(PB1) ...... C...... ****...... A** *...... *...... *......

DborAB/10(PB1) ...... ****. .T.....*** *...... *...... *...... A...... G......

DborAB/11(PB1) ...... C...... ****...... T** **...... A..*...... *...... *......

DborAB/12(PB1) ...... ****...... A** *....C...... A*...... *...... G......

DborAB/13(PB1) ...... ****...... *** *....C...... A*...... *......

DbuzAB/D54/1(PB1) ...... C..A...... ****...... A** *.G...... *...... *...... G......

DbuzAB/J25/1(PB1) ...... G...... ****...... *** *....C...... A*...... *......

DbuzAB/J25/2(PB1) ...... ****...... *** *....C...... A*...... *...... C......

DbuzAB/J25/3(PB1) ...... ****...... *** *....C...... A*...... *......

DbuzAB/J25/4(PB1) ...... ****...... A** *....C...... A*...... *......

DbuzAB/CAT/1(PB1) ...... ****...... *** *.G..C...... A*...... *......

DbuzAB/CAT/2(PB1) ...... ****...... *** *....C...... A*...... *......

Supplemetary Figure S3

120 130 140 150 160 170 180 190 200 210 220

SspI B1F

alpha/beta-cons CATTTTAGAA GCGTCCTTTA TCGGAGAACT CAGATATATC TAAGGATCTG GCATGGTCTA AGAACTTTCC GAAATATTCA CATAATTCCA TAAAAATATG ACCAATTGAA

DgouAB/1(Hae) .....C......

DgouAB/2(Hae) .....C...... T G...... A......

DgouAB/3(Hae) .....C......

DgouAB/4(Hae) .....C......

DgouAB/5(Hae) .....C...... A......

DgouAB/6(Hae) .....C...... G......

DgouAB/7(Hae) .....C......

DgouAB/8(Hae) .....C...... *** ****.....T G...... A...... G......

DgouAB/9(PA2) .....C......

DgouAB/10(PA2) .....C...... A.T...... G......

DgouAB/11(PA2) .....C...... A....

DgouAB/12(PA2) .....C...... A...... T......

DgouAB/13(PA2) .....C......

DgouAB/14(PA2) .....C...... A...... TT......

DgouAB/15(PA2) .....C......

DgouAB/16(PA2) .....C...... A......

DgouAB/17(PA2) .....C...... T......

DgouAB/18(PA2) .....C......

DgouAB/19(PA2) .....C...... AT...... G......

DgouAB/20(PA2) .....C...... C......

DgouAB/21(PA2) .....CG......

DgouAB/22(PA2) .....C......

DgouAB/23(PA2) .....C......

DgouAB/24(PA2) .....C......

DgouAB/25(PA2) .....C......

DgouAB/26(PA2) .....C......

DgouAB/27(PA2) .....C...... T..G......

DgouAB/28(PA2) .....C......

DgouAB/29(PA2) .....C......

DgouAB/30(PA2) .....C...... G......

DgouAB/31(PA2) .....C......

DgouAB/32(PA2) .....C......

DgouAB/33(PA2) .....C......

DgouAB/34(PA2) .....C...... A......

DgouAB/35(PA2) .....C......

DgouAB/36(PA2) .....C......

DsmaAB/1(Hpa) ...... A...... ********* ********** ***...G.C......

DsmaAB/2(Hpa) ...... C.. ..A...... ********* ********** ***...G...... A....

DsmaAB/3(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/4(Hpa) ...... C.. ..A...... G...... ********* ********** ***...G...... A..

DsmaAB/5(Hpa) ...... C.. ..A...... ********* ********** ***...G...... A....

DsmaAB/10(Hpa) .....C...... C.. ..A...... A...... ********* ********** ***...G......

DsmaAB/11(Hpa) ...... A...... ********* ********** ***...G......

DsmaAB/12(Hpa) ...... C.. ..A...... T .********* ********** ***...G......

DsmaAB/13(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/14(Hpa) ...... C.. ..T...... ********* ********** ***...G......

DsmaAB/15(Hpa) ...... A...... ********* ********** ***...G......

DsmaAB/16(Hpa) ...... ***** ********** ********** *****...... ********* ********** ***...G..T ......

DsmaAB/17(Hpa) ...... G...... A...... A...... ********* ********** ***...G......

DsmaAB/18(Hpa) ...... C.. ..A...... ********* ********** ***...A......

DsmaAB/19(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/20(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/21(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/22(Hpa) ...... A...... C.. ..A....T...... ********* ********** ***...G......

DsmaAB/23(Hpa) ...... C.. ..A...... T...... ********* ********** ***...G......

DsmaAB/24(Hpa) ...... C.. ..A...... ********* ********** ***...G...... G

DsmaAB/25(Hpa) ...... A...... C.. ..A....T...... ********* ********** ***...G...... G...

DsmaAB/26(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/27(Hpa) ...... C.. ..A...... ********* ********** ***...G......

DsmaAB/28(Hpa) ...... C.. ..A...... ********* ********** ***...G...... A....

DsmaAB/29(Hpa) ...... T ...... C.. ..A...... G...... ********* ********** ***...G......

DsmaAB/30(Hpa) ...... ***** ********** ********** ******...... ********* ********** ***...G..T ......

DantAB/1(Dra) ...... A ......

DantAB/2(Dra) ......

DantAB/3(Dra) ...... C......

DantAB/4(Dra) ...... A.....A ...... A...... T......

DantAB/5(Dra) ...... A...

DantAB/6(Dra) ......

DantAB/7(Dra) ......

DsdoAB/1(Ssp) .....C...... A...... A...... A...... A......

DsdoAB/2(Ssp) .....C...... A...... A..T...... A...... TA......

DsdoAB/3(Ssp) .....C...... A...... A...... A...... A...... A. ..T......

DsdoAB/4(Ssp) .....C...... A...... A...... A A...... A......

DsdoAB/5(Ssp) .....C...... A...... A...... A...... A......

DsdoAB/6(Ssp) .....C...... A...... A...... A A...... A......

DkoeAB/B20/1(PA2) .....C......

DkoeAB/B20/2(PA2) .....C...... G......

DkoeAB/B20/3(PA2) .....C...... G......

DkoeAB/B20/4(PA2) .....C......

DkoeAB/B20/5(PA2) ...... C.. .TA...... C ....A...... A...... C....

DkoeAB/B20/6(PA2) .....C...... A......

DkoeAB/B20/7(PA2) ...... C.. ..A...... ********* ********** ***...G......

DkoeAB/B20/9(PA2) ...... C.. ..A...... ********* ********** ***...G......

DkoeAB/B20/1(PB1) ...... G.....C.. ..A...... ********* ********** ***...G......

DkoeAB/B20/2(PB1) .....C...... G......

DkoeAB/B20/3(PB1) .....C......

DkoeAB/B20/4(PB1) .....C......

DkoeAB/B20/5(PB1) .....C...... T G...... A...... G......

DkoeAB/B20/6(PB1) .....C...... T......

DkoeAB/B26/1(PB1) ......

DkoeAB/B26/2(PB1) .....C......

DkoeAB/B26/3(PB1) .....C...... A...... G......

DkoeAB/B26/4(PB1) .....C......

DkoeAB/B26/5(PB1) .....C.A...... T...... G......

DborAB/1(PB1) ......

DborAB/2(PB1) .....C...... A...... A...... A...... T...... A......

DborAB/3(PB1) ...... C......

DborAB/4(PB1) ...... A ......

DborAB/5(PB1) ...... C.. ..A...... ********* ********** ***...G... G......

DborAB/6(PB1) ......

DborAB/7(PB1) ...... A...... T...... T...... A. ..A......

DborAB/8(PB1) .....C......

DborAB/9(PB1) .....C......

DborAB/10(PB1) .....C.... .T...... A......

DborAB/11(PB1) .....C......

DborAB/12(PB1) ...... T...... A ...... TT ......

DborAB/13(PB1) ......

DbuzAB/D54/1(PB1) .....C......

DbuzAB/J25/1(PB1) ...... A......

DbuzAB/J25/2(PB1) ......

DbuzAB/J25/3(PB1) ...... A ......

DbuzAB/J25/4(PB1) ......

DbuzAB/CAT/1(PB1) ......

DbuzAB/CAT/2(PB1) ......

Supplemetary Figure S3 (cont.)

230 240 250 260 270 280 290 300 310 320 330

DraI B1R

alpha/beta-cons CTTTAAATGGC***TCTAGC TAGGTTATCC TTTGTCCGAT TTT*AAGCTC AACTA***** *TACTTTTTG AATCGACA*T AGACAGTTCT TTTGATATAA ACACAAACAT

DgouAB/1(Hae) ...... ***...... *C...... ***** *...... *. ...A..C......

DgouAB/2(Hae) ...... ***...... *C...... ***** *...... C...*......

DgouAB/3(Hae) ...... ***...... *C...... ***** *...... C...*......

DgouAB/4(Hae) ...... ***...... A...... *C...... ***** *...... C...*......

DgouAB/5(Hae) ...... ***...... *C...... ***** *...... C...*......

DgouAB/6(Hae) ...... ***...... *C...... ***** *...... C...*. ..G......

DgouAB/7(Hae) ...... ***...... *C...... ***** *...... *......

DgouAB/8(Hae) ...... ***...... TC...... ***** *...... C...*......

DgouAB/9(PA2) ...... ***...... *C...... ***** *...... C...*...... A......

DgouAB/10(PA2) ...... ***...... A.. ...*C...... ***** *...... C...*......

DgouAB/11(PA2) ...... ***...... *...... CATCT T...... *...... C......

DgouAB/12(PA2) ...... ***...... *C...... ***** *...... *...... C......

DgouAB/13(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/14(PA2) ...... ***...... *C..T...... ***** *...... C...*......

DgouAB/15(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/16(PA2) ...... ***...... *C...... ***** *...... *...... C......

DgouAB/17(PA2) ...... ***...... *...... CAACT T...... *...... C......

DgouAB/18(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/19(PA2) ...... ***...... C...... *C...... ***** *...... T..C...*......

DgouAB/20(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/21(PA2) ...... ***...... *C...... ***** *...... *...... C...... T......

DgouAB/22(PA2) ...... ***...... *C...... ***** *...... C...*...... A......

DgouAB/23(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/24(PA2) ...... ***...... A...... *C...*...... ***** *...... C...*......

DgouAB/25(PA2) ...... **C...... *C...... ***** *...... C...*......

DgouAB/26(PA2) ...... ***...... G...... T. ...*T...... ***** *...... C...*...... G......

DgouAB/27(PA2) ...... ***...... *C...... T***** *A...... C...*...... A ......

DgouAB/28(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/29(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/30(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/31(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/32(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/33(PA2) ...... ***...... *C...... ***** *...... *...... C......

DgouAB/34(PA2) ...... ***...... *C...... ***** *...... C...*...... C

DgouAB/35(PA2) ...... ***...... *C...... ***** *...... C...*......

DgouAB/36(PA2) ...... ***...... *C...... ***** *...... C...*......

DsmaAB/1(Hpa) ...... T***...... C...... *...... ***** *...... A ...... *......

DsmaAB/2(Hpa) ...... ***...... *...... ***** *...... A ...... *......

DsmaAB/3(Hpa) ...... ***.....A ....A...... *...... ***** *...... A ...... *...... C...... *......

DsmaAB/4(Hpa) ...... ***...... *...... ***** *...... A ...... *. ...G......

DsmaAB/5(Hpa) ...... ***...... *...... ***** *...... A ...... *......

DsmaAB/10(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/11(Hpa) ...... ***...... *...... ***** *...... A ...... *...... A. ...C......

DsmaAB/12(Hpa) ...... ***...... *...... ***** *...... A ...... *......

DsmaAB/13(Hpa) ...... ***...... *...... G....***** *...... A ...... *...... C......

DsmaAB/14(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/15(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/16(Hpa) ...... ***G...A...... *...... ***** *...... A ...... *......

DsmaAB/17(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/18(Hpa) ...... ***...... *...... ***** *...... A ...... T.*...... C......

DsmaAB/19(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/20(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/21(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/22(Hpa) ...... ***...... A...... *...... ***** *...... A ...... *...... C ......

DsmaAB/23(Hpa) ...... ***...... *...... T...***** *...... A ...... *...... C......

DsmaAB/24(Hpa) ...... ***...... *...... ***** *...... A ...... *...... C......

DsmaAB/25(Hpa) ...... ***...... *...... ***** *...... A ...... **** ***...... C......

DsmaAB/26(Hpa) ...... ***...... TA...... *...... ***** *...... A ...... *......

DsmaAB/27(Hpa) ...... ***...... *...... ***** *...... A ...... *......

DsmaAB/28(Hpa) ...... ***...... *...... A..***** *...... A ...T....*...... T ......

DsmaAB/29(Hpa) ...... ***...... *...... ***** *...... A ...... *. ...G...... C.....

DsmaAB/30(Hpa) ...... ***...... *...... ***** *...... A ...... *......

DantAB/1(Dra) ...... **C*...... *...... ***** *...... *...... C.A.A

DantAB/2(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DantAB/3(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DantAB/4(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DantAB/5(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DantAB/6(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DantAB/7(Dra) ...... **C*...... *...... ***** *...... *...... A.A

DsdoAB/1(Ssp) ...... T. .***...... *...... ***** *...... T...... *. ...AC......

DsdoAB/2(Ssp) ...A....T. .***...... *...... ***** *...... T...... *. ...AC...... A......

DsdoAB/3(Ssp) ...... ***...... *. ...*...... G***** *...... CA. ....A...*...... C......

DsdoAB/4(Ssp) ...... T. .***...... A...... *...... G***** *C.....CA. ....A...*...... C......

DsdoAB/5(Ssp) ...A....T. .***...... C...... *...... ***** *...... *...... C......

DsdoAB/6(Ssp) ...... ***...... *...... ***** *...... T...... *. ...AC......

DkoeAB/B20/1(PA2) ...... ***...... *C...... ***** *...... *...... C......

DkoeAB/B20/2(PA2) ...... ***...... *C...... ***** *...... C...*......

DkoeAB/B20/3(PA2) ...... ***...... *C...... ***** *...... C...*......

DkoeAB/B20/4(PA2) ...... ***...... A...... *C...... ***** *...... C...*......

DkoeAB/B20/5(PA2) ...... **C*...... A.....T ...... *...... ***** *...... A ...... *...... C......

DkoeAB/B20/6(PA2) ...... ***...... *...... ***** *...... *......

DkoeAB/B20/7(PA2) ...... ***...... *.G...... ***** *...... A ...... *...... C...... C......

DkoeAB/B20/9(PA2) ...... ***...... C...... *...... ***** *...... A ...... *...... G...

DkoeAB/B20/1(PB1) ...... ***...... C. ...*...... ***** *...... A ...... *...... C......

DkoeAB/B20/2(PB1) ...... ***...... *...... ***** *...... *......

DkoeAB/B20/3(PB1) ...... ***...... *C...... ***** *...... *...... C......

DkoeAB/B20/4(PB1) ...... ***...... *C...... ***** *...... C..G*......

DkoeAB/B20/5(PB1) ...... ***...... *C...... ***** *...... C...A......

DkoeAB/B20/6(PB1) ...... ***...... *C...... ***** *...A....* ...... *...... C...... T......

DkoeAB/B26/1(PB1) ...... **C*...... *...... ***** *...... *...... A.A

DkoeAB/B26/2(PB1) ...... ***...... *C...... ***** *...... *...... C......

DkoeAB/B26/3(PB1) ...... ***...... *C...... ***** *...... *...... C......

DkoeAB/B26/4(PB1) ...... ***.....A ...... *C...... ***** *...... *...... C......

DkoeAB/B26/5(PB1) ...... ***...... *C...... ***** *...... C...*......

DborAB/1(PB1) ...... **C*...... *...... ***** *...... *...... G...... A.A

DborAB/2(PB1) ...... ***...... C...... *...... ***** *...... *......

DborAB/3(PB1) ...... **C*...... *...... ***** *...... *...... A...... A.A

DborAB/4(PB1) ...... TCC*...... *...... ***** *...... T.*...... A.A

DborAB/5(PB1) ...... ***.....T ...... *C...... ***** *...... C...*......

DborAB/6(PB1) ...... **C*...... *...... ***** *...... *...... A.A

DborAB/7(PB1) ...... **C*...... G...... A*...... ***** *...... *. .T...... T....

DborAB/8(PB1) ...... ***...... *C...... ***** *...... C...*......

DborAB/9(PB1) ...... ***...... *C...... ***** *...... C...... C...*...... G......

DborAB/10(PB1) ...... ***...... *C...... ***** *...... C...*......

DborAB/11(PB1) ...... ***...... *C...... ***** *...... C...*......

DborAB/12(PB1) ...... **C*.....A ...... *...... ***** *....A...... *...... A.A

DborAB/13(PB1) ...... **C*...... *...... ***** *...... *. .A...... A.A

DbuzAB/D54/1(PB1) ...... ***...... T ...... *C...... ***** *...... C...*......

DbuzAB/J25/1(PB1) ...... **C*...... A.. ...*...... ***** *...... *...... T...... A

DbuzAB/J25/2(PB1) ...... **C*...... *...... ***** *...... *...... A.A

DbuzAB/J25/3(PB1) ...... **C*...... *...... ***** *...... *...... A.A

DbuzAB/J25/4(PB1) ...... **C*...... *...... ***** *...... G.....*...... A.A

DbuzAB/CAT/1(PB1) ...... **C*...... *...... ***** *...... *...... A.A

DbuzAB/CAT/2(PB1) ...... **C*...... GG ...*...... ***** *...... *...... C ...... A.A

Supplemetary Figure S3 (cont.)

340 350 360 370 380 390 395

HpaI

alpha/beta-cons TTTTTTC*** GAAAAAATTT TCATTTTT*G CCATTTTAAC CATCTTAGGT AACGTAAACC CTCTT

DgouAB/1(Hae) ...... ***C ...... A.*......

DgouAB/2(Hae) ...... ***C ...... *......

DgouAB/3(Hae) ...... T*** CG...... T..A..*...... T......

DgouAB/4(Hae) ...... TT*C ...... A..*...... T......

DgouAB/5(Hae) ...... *** ...... *......

DgouAB/6(Hae) ...... *** ...... *......

DgouAB/7(Hae) ...... TT** CG...... G.A..*...... T......

DgouAB/8(Hae) ...... ***C ...... *...... T......

DgouAB/9(PA2) ...... **** CG...... A..*...... T......

DgouAB/10(PA2) ...... T*** CG...... A..*...... T......

DgouAB/11(PA2) ...... ***C ...... A..*...... C......

DgouAB/12(PA2) ...... T**C ...... *......

DgouAB/13(PA2) ...... *** ...... A..*...... T......

DgouAB/14(PA2) ...... ***C ...... *...... C...... *

DgouAB/15(PA2) ...... *** ...... *......

DgouAB/16(PA2) ...... ***C ...... A..*...... T...... A...C ......

DgouAB/17(PA2) ...... ***C ...... A..*...... T.A ......

DgouAB/18(PA2) ...... *** ...... A...... *...... T ......

DgouAB/19(PA2) ...... *** ...... *. T......

DgouAB/20(PA2) ...... *** ...... *......

DgouAB/21(PA2) ...... T**C ...... *......

DgouAB/22(PA2) .....CG*** A...... A..*. ..T......

DgouAB/23(PA2) ...... *** ...... *......

DgouAB/24(PA2) ...... ***C ...... A..*...... T...... A.G......

DgouAB/25(PA2) ...... T**C ...... *...... G......

DgouAB/26(PA2) ...... *** ...... *......

DgouAB/27(PA2) ...... *** ...... A..*...... T......

DgouAB/28(PA2) ...... *** ...... *......

DgouAB/29(PA2) ...... *** ...... *......

DgouAB/30(PA2) ...... *** ....T...... *......

DgouAB/31(PA2) ...... *** ...... *T ......

DgouAB/32(PA2) ...... *** ...... *...... G...... C*......

DgouAB/33(PA2) ...... T**C ...... A..*...... T......

DgouAB/34(PA2) ...... *** ...... *...... T ......

DgouAB/35(PA2) ...... *** ...... A...... *...... T ......

DgouAB/36(PA2) ...... *** ...... A...... *...... T ......

DsmaAB/1(Hpa) ...... ***C ...... *. ....G......

DsmaAB/2(Hpa) ...... ***C ...... *. ....G......

DsmaAB/3(Hpa) ...... T**C ...... *. ....G......

DsmaAB/4(Hpa) ...... ***C ...... *. ....G......

DsmaAB/5(Hpa) ...... ***C ...... *. ....G......

DsmaAB/10(Hpa) ...... ***C ...... *. ....G......

DsmaAB/11(Hpa) ...... ***C ...... *. ....G......

DsmaAB/12(Hpa) ...... ***C ...... *. ....G......

DsmaAB/13(Hpa) ...... ***C ...... *. ....G......

DsmaAB/14(Hpa) ...... ***C ...... *. ....G......

DsmaAB/15(Hpa) ...... TTTC ...... G...... *. ....G......

DsmaAB/16(Hpa) ...... ***C ...... *. ....G......

DsmaAB/17(Hpa) ...... ***C ...... *. ....G......

DsmaAB/18(Hpa) ...... ***C ...... *. ....G......

DsmaAB/19(Hpa) ...... ***C ...... *. ....G......

DsmaAB/20(Hpa) ...... ***C ...... G...... *. ....G...... T......

DsmaAB/21(Hpa) ...... ***C ...... *. ....G......

DsmaAB/22(Hpa) ...... ***C ...... *. ....G......

DsmaAB/23(Hpa) ...... ***C ...... *. ....G......

DsmaAB/24(Hpa) ...... ***C ...... *. ....G......

DsmaAB/25(Hpa) ...... ***C ...... *. ....G......

DsmaAB/26(Hpa) ...... ***C ...... A...... *. ....G......

DsmaAB/27(Hpa) ...... ***C ...... *. ....G......

DsmaAB/28(Hpa) ...... ***C ...... *. ....G......

DsmaAB/29(Hpa) ...... ***C ...... *. ....G...... T..

DsmaAB/30(Hpa) ...... ***C ...... *. ....G......

DantAB/1(Dra) AA**..TTCG A.C....A...... *......

DantAB/2(Dra) ..**..GTCG A.*....A...... *...... T....

DantAB/3(Dra) .G**..TTCG A.*....A...... *...... GG.

DantAB/4(Dra) ..**..TTCG A.*....A...... *......

DantAB/5(Dra) ..**..TTCG A.*....A...... *. T......

DantAB/6(Dra) ...... TTCG A.*....A...... *...... GG.

DantAB/7(Dra) ..**..GTCG A.*....A...... *...... T....

DsdoAB/1(Ssp) .....CG**A A...... G.G ...... A*...... A... .T.....T......

DsdoAB/2(Ssp) ....C****G A.....TG.G ...... A*...... T.....T......

DsdoAB/3(Ssp) ..AA.CA**A C...... AA.*. T...... G.....T......

DsdoAB/4(Ssp) ..AA.CA**A C...... AA.*...... T......

DsdoAB/5(Ssp) ..AA.CA**A C...... AA.*...... G ...... T......

DsdoAB/6(Ssp) .....CG**A A...... G.G ...... A*...... A... .T.....T......

DkoeAB/B20/1(PA2) ...... TTTC ...... A..*...... T......

DkoeAB/B20/2(PA2) ...... *** ...... *......

DkoeAB/B20/3(PA2) ...... TT*C ...... *......

DkoeAB/B20/4(PA2) ...... ***C ...... A..*...... T......

DkoeAB/B20/5(PA2) ..**..T*CG A.*T...AA. *...... *...... A......

DkoeAB/B20/6(PA2) ...... TT*C ...... A...... *. T....A..G......

DkoeAB/B20/7(PA2) ...... ***C ...... *. ....G......

DkoeAB/B20/9(PA2) ...... ***C ...... *. ....G......

DkoeAB/B20/1(PB1) ...... ***C ...... T...... *. ....G......

DkoeAB/B20/2(PB1) .....C**** ...... G...... ?T......

DkoeAB/B20/3(PB1) ...... ***C ...... *...... T......

DkoeAB/B20/4(PB1) ...... *** ...... A..*......

DkoeAB/B20/5(PB1) ...... ***C ...... *......

DkoeAB/B20/6(PB1) ...... TT*C ...... A..*...... T...... **

DkoeAB/B26/1(PB1) ..**..TTCG A.*....A...... *......

DkoeAB/B26/2(PB1) ...... ***C ...... *...... T......

DkoeAB/B26/3(PB1) ...... ***C ...... C...... *...... T......

DkoeAB/B26/4(PB1) ...... T**C ...... *...... T......

DkoeAB/B26/5(PB1) ...... *** ...... AC..*A G...... T...... A...

DborAB/1(PB1) ..**..TTCG A.*....A...... *......

DborAB/2(PB1) .....CG**A A.....**...... A*...... C...... C.T......

DborAB/3(PB1) .***..TTCG A.*....A...... *...... C.. ..GG.

DborAB/4(PB1) AA**..TTCG A...... A...... *...... **** ********** *****

DborAB/5(PB1) ...... ***C ...... *. ....G...... G......

DborAB/6(PB1) ..**..TTCG A.*....A...... *......

DborAB/7(PB1) ..**..TTCG A.*...... G...G.*A ...... T...... G..G.

DborAB/8(PB1) ...... *** ...... *......

DborAB/9(PB1) ...... *** ...... *...... A .....

DborAB/10(PB1) ...... ***C ...... *......

DborAB/11(PB1) ...... *** ...... *...... T......

DborAB/12(PB1) ..**..TTCG ..*....A...... *......

DborAB/13(PB1) ..**..TTCG A.*....A...... *......

DbuzAB/D54/1(PB1) ...... *** ...... *...... G......

DbuzAB/J25/1(PB1) ..**..TTCG A.*....A...... *...... GG.

DbuzAB/J25/2(PB1) .G**..TTCG A.*....A...... *......

DbuzAB/J25/3(PB1) ..**..TTCG ..*....A...... *...... GG.

DbuzAB/J25/4(PB1) AA**..TTCG A.*....A...... *...... C...... GG.

DbuzAB/CAT/1(PB1) ..**..TTCG A.*....A...... *......

DbuzAB/CAT/2(PB1) ..**..TTCG A.*....A...... *......

Supplemetary Figure S3 (cont.)