Supplementary Table S1. the Relationships Between the Levels of GREM1 Expression and The

Supplementary Table S1. The relationships between the levels of GREM1 expression and the clinicopathologic characteristics of PNETs

GREM1
(-)
(n=15) / GREM1
(+)
(n=17) / p-value
Age (yr), n (%)
40
<40 / 3
12 / 5
12 / 0.593
Sex, n (%)
Male
Female / 5
10 / 10
7 / 0.149
VHL disease
VHL +
VHL - / 0
15 / 3
14 / 0.087
Functional Syndrome
Present
Abscent / 6
9 / 11
6 / 0.341
Classification according to WHO 2000
Well-differentiated tumour
Well-differentiated carcinoma
Poorly differentiated carcinoma / 8
5
2 / 14
3
0 / 0.134
Classification according to WHO 2010
Neuroendocrine tumor Grade 1
Neuroendocrine tumor Grade 2
Neuroendocrine cancer Grade 3
Missing / 8
4
2
1 / 9
7
0
1 / 0.252
Size (cm)
<2
>2
Lymph node status
N0
N+
Liver metastasis
M0
M1
ENETSa staging
I+II
III+IV / 3
12
11
4
12
3
10
5 / 8
9
15
2
16
1
14
3 / 0.108
0.281
0.228
0.306

a European neureoendocrine tumor society staging system, *p <0.05

Supplementary Figure 1