Supplementary Table S1. Mutation Spectrum in 451 Primary Localized GIST

Supplementary table S1. Mutation spectrum in 451 primary localized GIST

# GENE EXON MUTATION PROTEIN CHANGE

1 KIT 11 c.1735_1738delinsT p.Asp579_His580delinsTyr

2 PDGFRA 18 c.2544C>A p.Asn848Lys

3 KIT 11 c.1722_1739dup p.Gln575_His580dup

4 KIT 11 c.1650_1662delinsG p.Pro551_Glu554del

5 KIT 11 c.1729_1767dup p.Pro577_Leu589dup

6 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

7 KIT 11 c.1669T>C p.Trp557Arg

8 KIT 11 c.1652_1669del p.Pro551_Trp557delinsArg

9 KIT 11 c.1674_1681delinsAC p.Val559_Glu561delinsGln

10 PDGFRA 14 c.1977C>G p.Asn659Lys

11 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

12 KIT 11 c.1701_1726delinsGGAAG p.Asn567_Leu576delinsLysGluVal

13 KIT 11 c.1669_1674del p.Trp557_Lys558del

14 KIT 11 c.1673_1674insTCC p.Lys558delinsAsnPro

15 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

16 KIT 11 c.1678_1728del p.Val560_Leu576del

17 KIT 11 c.1678_1728del p.Val560_Leu576del

18 KIT 11 c.1679T>A p.Val560Asp

19 KIT 11 c.1669_1674del p.Trp557_Lys558del

20 PDGFRA 14 c.1975A>T p.Asn659Tyr

21 KIT 11 c.1669T>C p.Trp557Arg

22 WT

23 PDGFRA 18 c.2525A>T p.Asp842Val

24 KIT 13 c.1924A>G p.Lys642Gln

25 KIT 11 c.1722_1730del p.Gln575_Pro577del

26 PDGFRA 18 c.2525A>T p.Asp842Val

27 WT

28 KIT 11 c.1723_1731dup p.Gln575_Pro577dup

29 KIT 11 c.1739_1740ins30 p.Asp579_His580insGlnGluAsnProThrGlnLeuProTyrAsp

30 KIT 11 c.1673_1693del p.Lys558_Gly565delinsArg

31 PDGFRA 12 c.1682T>A p.Val561Asp

32 KIT 11 c.[1673A>T(;)1676T>A] p.[Lys558Met(;)Val559Asp]

33 KIT 11 c.1652_1658delinsT p.Pro551_Tyr553delinsLeu

34 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

35 KIT 11 c.1655_1657del p.Met552_Tyr553delinsAsn

36 WT

37 PDGFRA 12 c.1676_1696del p.Trp559_Ser566delinsCys

38 PDGFRA 18 c.2524_2537delinsTG p.Asp842_Asp846delinsCys

39 PDGFRA 18 c.2525A>T p.Asp842Val

40 PDGFRA 18 c.2525A>T p.Asp842Val

41 WT

42 WT

43 KIT 11 c.1655_1676delinsC p.Met552_Val559delinsThr

44 KIT 11 c.1676T>G p.Val559Gly

45 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

46 KIT 11 c.1705_1728del p.Val569_Leu576del

47 KIT 11 c.1648-9_1672del p.?

48 KIT 11 c.1669T>G p.Trp557Gly

49 KIT 11 c.1668_1679del p.Gln556_Val560delinsHis

50 KIT 11 c.1648_1663delinsGTAC p.Lys550_Val555delinsValLeu

51 WT

52 WT

53 WT

54 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

55 KIT 11 c.1669_1674del p.Trp557_Lys558del

56 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

57 KIT 11 c.1662_1667del p.Val555_Gln556del

58 KIT 11 c.1676T>C p.Val559Ala

59 WT

60 KIT 11 c.1669_1674del p.Trp557_Lys558del

61 PDGFRA 18 c.2526_2538delinsG p.Asp842_Asp846delinsGlu

62 KIT 11 c.1727_1729del p.Leu576del

63 PDGFRA 18 c.2525A>T p.Asp842Val

64 KIT 11 c.1676T>A p.Val559Asp

65 KIT 13 c.1924A>G p.Lys642Glu

66 KIT 11 c.1703_1727delinsG p.Tyr568_Leu576delinsCys

67 KIT 11 c.1652_1669del p.Pro551_Trp557delinsArg

68 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

69 PDGFRA 18 c.2525A>T p.Asp842Val

70 PDGFRA 18 c.2525A>T p.Asp842Val

71 PDGFRA 18 c.2524G>T p.Asp842Tyr

72 WT

73 KIT 11 c.1653_1664del p.Met552_Val555del

74 KIT 11 c.1666_1674del p.Gln556_Lys558del

75 PDGFRA 18 c.2525A>T p.Asp842Val

76 KIT 11 c.1669_1683del p.Trp557_Glu561del

77 KIT 11 c.1672_1681delinsC p.Lys558_Glu561delinsGln

78 KIT 11 c.1648-9_1672del p.?

79 KIT 11 c.1676T>A p.Val559Asp

80 KIT 11 c.1676T>G p.Val559Gly

81 KIT 11 c.1665_1679del p.Gln556_Val560del

82 KIT 11 c.1673_1674insTCC p.Lys558delinsAsnPro

83 PDGFRA 18 c.2525A>T p.Asp842Val

84 KIT 11 c.1727T>C p.Leu576Pro

85 WT

86 KIT 11 c.1730C>T p.Pro577Leu

87 WT

88 KIT 11 c.1723_1773dup p.Gln575_Phe591dup

89 PDGFRA 18 c.2525A>T p.Asp842Val

90 KIT 11 c.1675_1678delinsA p.Val559_Val560delinsIle

91 PDGFRA 18 c.2525A>T p.Asp842Val

92 PDGFRA 18 c.2525A>T p.Asp842Val

93 PDGFRA 18 c.2525A>T p.Asp842Val

94 KIT 11 c.1676T>A p.Val559Asp

95 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

96 KIT 11 c.1676T>C p.Val559Ala

97 KIT 11 c.1650_1667del p.Pro551_Gln556del

98 KIT 11 c.1653_1664del p.Met552_Val555del

99 KIT 11 c.1669_1674del p.Trp557_Lys558del

100 KIT 11 c.1679_1681del p.Val560del

101 KIT 11 c.1669_1674del p.Trp557_Lys558del

102 KIT 11 c.1715_1750dup p.Glu583_Phe584insTyrProThrGlnLeuProTyrAspHisLysTrpGluPhe

103 PDGFRA 18 c.2525A>T p.Asp842Val

104 KIT 11 c.1669_1674del p.Trp557_Lys558del

105 KIT 11 c.1648_1674del p.Lys550_Lys558del

106 KIT 11 c.1679T>A p.Val560Asp

107 KIT 11 c.1670_1714del p.Trp557_Asp572delinsTyr

108 KIT 11 c.1669_1674del p.Trp557_Lys558del

109 KIT 11 c.1672_1716del p.Lys558_Asp572del

110 PDGFRA 12 c.1741C>T p.Pro581Ser

111 KIT 11 c.1679T>A p.Val560Asp

112 PDGFRA 12 c.1682T>A p.Val561Asp

113 PDGFRA 18 c.2526_2537del p.Ile843_Asp846del

114 KIT 11 c.1671_1679del p.Trp557_Val560delinsCys

115 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

116 KIT 11 c.1705_1728del p.Val569_Leu576del

117 KIT 11 c.1763G>A p.Arg558Lys

118 KIT 11 c.1679_1681del p.Val560del

119 PDGFRA 18 c.2525A>T p.Asp842Val

120 KIT 11 c.1655_1669del p.Met552_Trp557delinsArg

121 KIT 11 c.1714_1719dup p.Asp572_Pro573dup

122 KIT 11 c.1679_1681del p.Val560del

123 KIT 11 c.1723_1725del p.Gln575del

124 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

125 KIT 11 c.1676T>G p.Val559Gly

126 KIT 13 c.1924A>G p.Lys642Glu

127 KIT 11 c.1679T>A p.Val560Asp

128 PDGFRA 18 c.2525A>T p.Asp842Val

129 KIT 11 c.1672_1677del p.Lys558_Val559del

130 KIT 11 c.1669_1674del p.Trp557_Lys558del

131 KIT 11 c.[1650_1670del];[1650_1670del] p.[Pro551_Trp557del];[Pro551_Trp557del]

132 KIT 11 c.1688_1717del p.Ile563_Pro573delinsThr

133 KIT 11 c.1674_1676del p.Lys558_Val559delinsAsn

134 PDGFRA 18 c.2525A>T p.Asp842Val

135 PDGFRA 12 c.1682T>A p.Val561Asp

136 KIT 11 c.1655_1672del p.Met552_Trp557del

137 KIT 11 c.1670_1675del p.Trp557_Val559delinsPhe

138 WT

139 KIT 11 c.[1690_1734del];[1690_1734del] p.[Asn564_Tyr578del;[Asn564_Tyr578del]

140 KIT 11 c.1676T>A p.Val559Asp

141 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

142 KIT 11 c.1648_1764del p.Lys550_Lys558del

143 WT

144 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

145 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

146 PDGFRA 18 c.2525A>T p.Asp842Val

147 KIT 11 c.1657_1674del p.Tyr553_Lys558del

148 KIT 11 c.1665_1679del p.Gln556_Val560del

149 KIT 11 c.1672_1683del p.Lys558_Glu561del

150 PDGFRA 12 c.1741C>T p.Pro581Ser

151 PDGFRA 18 c.2525A>T p.Asp842Val

152 PDGFRA 18 c.2524G>T p.Asp842Tyr

153 KIT 11 c.1769G>A p.Ser590Asn

154 WT

155 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

156 PDGFRA 18 c.2525A>T p.Asp842Val

157 BRAF 15 c.1799T>A p.Val600Glu

158 KIT 11 c.1678_1680del p.Val560del

159 KIT 11 c.1669_1674del p.Trp557_Lys558del

160 PDGFRA 18 c.2525A>T p.Asp842Val

161 PDGFRA 18 c.2525A>T p.Asp842Val

162 PDGFRA 12 c.1771G>A p.Asp591Asn

163 KIT 11 c.1664_1714del p.Val555_Ile571del

164 KIT 11 c.1732_1773dup p.Tyr578_Phe591dup

165 WT

166 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

167 KIT 11 c.1669T>G p.Trp557Gly

168 KIT 11 c.1654_1716delinsTCA p.Met552_Asp572delinsSer

169 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

170 KIT 11 c.1671_1715del p.Trp557_Asp572delinsCys

171 KIT 11 c.1669T>A p.Trp557Arg

172 PDGFRA 18 c.2525A>T p.Asp842Val

173 KIT 11 c.1671_1676del p.Trp557_Val559del

174 KIT 11 c.1653_1673del p.Met552_Lys558del

175 KIT 11 c.1669_1674del p.Trp557_Lys558del

176 PDGFRA 18 c.2525A>T p.Asp842Val

177 KIT 11 c.1727T>C p.Leu576Pro

178 KIT 11 c.1676T>C p.Val559Ala

179 KIT 11 c.1669_1683del p.Trp557_Glu561del

180 KIT 11 c.1672_1722del p.Lys558_Thr574del

181 PDGFRA 18 c.2525A>T p.Asp842Val

182 KIT 11 c.1676T>A p.Val559Asp

183 KIT 11 c.1669_1683del p.Trp557_Glu561del

184 KIT 11 c.1669T>C p.Trp557Arg

185 KIT 11 c.1727_1729del p.Leu576del

186 KIT 11 c.1671_1676del p.Trp557_Val559delinsCys

187 KIT 11 c.1676T>C p.Val559Ala

188 KIT 11 c.1676T>C p.Val559Ala

189 KIT 11 c.1676T>A p.Val559Asp

190 WT

191 KIT 11 c.1674_1676del p.Lys558_Val559delinsAsn

192 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

193 KIT 11 c.1679T>A p.Val560Asp

194 KIT 11 c.1669_1674del p.Trp557_Lys558del

195 WT

196 KIT 11 c.1676T>A p.Val559Asp

197 KIT 11 c.1671_1674delinsC p.Trp557_Lys558delinsCys

198 KIT 11 c.[1676T>A];[1676T>A] p.[Val559Ala];[Val559Ala]

199 KIT 11 c.1669T>C p.Trp557Arg

200 WT

201 KIT 11 c.1676T>A p.Val559Asp

202 KIT 11 c.1727T>C p.Leu576Pro

203 KIT 11 c.1684G>A p.Glu562Lys

204 KIT 11 c.1648-6_1672del p.?

205 KIT 11 c.1729_1731del p.Pro577del

206 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

207 KIT 11 c.1676T>G p.Val559Gly

208 KIT 11 c.1676T>C p.Val559Ala

209 PDGFRA 18 c.2525A>T p.Asp842Val

210 WT

211 KIT 11 c.1725_1760dup p.Asn587delinsLeuProTyrAspHisLysTrpGluPheProArgLys

212 PDGFRA 14 c.1977C>G p.Asn659Lys

213 KIT 11 c.1676T>A p.Val559Asp

214 PDGFRA 18 c.2525A>T p.Asp842Val

215 PDGFRA 18 c.2525A>T p.Asp842Val

216 PDGFRA 18 c.2525A>T p.Asp842Val

217 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

218 KIT 11 c.1676T>A p.Val559Asp

219 WT

220 WT

221 PDGFRA 18 c.2525A>T p.Asp842Val

222 KIT 11 c.1669_1674del p.Trp557_Lys558del

223 PDGFRA 18 c.2525A>T p.Asp842Val

224 PDGFRA 18 c.2525A>T p.Asp842Val

225 KIT 11 c.1671_1674delinsC p.Trp557_Lys558delinsCys

226 WT

227 PDGFRA 18 c.2525A>T p.Asp842Val

228 KIT 11 c.1727T>C p.Leu576Pro

229 KIT 11 c.1676T>A p.Val559Asp

230 PDGFRA 18 c.2525A>T p.Asp842Val

231 WT

232 KIT 11 c.1651_1665del p.Pro551_Val555del

233 WT

234 PDGFRA 18 c.2525A>T p.Asp842Val

235 KIT 11 c.1669_1683del p.Trp557_Glu561del

236 KIT 11 c.1705_1728del p.Val569_Leu576del

237 KIT 11 c.1674_1718del p.Val559_Pro573del

238 KIT 11 c.1676T>C p.Val559Ala

239 KIT 11 c.1679T>A p.Val560Asp

240 KIT 11 c.1703_1727delinsGTTG p.Tyr568_Leu576delinsCysCys

241 KIT 11 c.1674_1718del p.Val559_Pro573del

242 PDGFRA 18 c.2525A>T p.Asp842Val

243 KIT 11 c.1735_1737del p.Asp579del

244 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

245 KIT 11 c.1676T>A p.Val559Asp

246 KIT 11 c.1676T>A p.Val559Asp

247 KIT 11 c.1669_1674del p.Trp557_Lys558del

248 PDGFRA 18 c.2525A>T p.Asp842Val

249 PDGFRA 18 c.2526_2537del p.Ile843_Asp846del

250 WT

251 KIT 11 c.1679T>A p.Val560Asp

252 PDGFRA 18 c.2546A>G p.Tyr849Cys

253 KIT 11 c.1673_1687del p.Lys558_Glu562del

254 PDGFRA 18 c.2528_2539del p.Ile843_Ser847delinsThr

255 KIT 11 c.1676T>A p.Val559Asp

256 PDGFRA 18 c.2524_2542delinsCGATCGA p.Asp842_Ser847delinsArgSer

257 KIT 11 c.1655_1657del p.Met552_Tyr553delinsAsn

258 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

259 PDGFRA 18 c.2528_2539del p.Ile843_Ser847delinsThr

260 WT

261 KIT 11 c.1651_1653del p.Pro551del

262 KIT 11 c.1679_1681del p.Val560del

263 KIT 11 c.1671_1676del p.Trp557_Val559delinsCys

264 KIT 11 c.1669T>C p.Trp557Arg

265 KIT 11 c.1730_1771dup p.Phe591delinsSerTyrAspHisLysTrpGluPheProArgAsnArgLeuSer

266 WT

267 KIT 11 c.1662_1682del p.Val555_Glu561del

268 KIT 11 c.1651_1662del p.Pro551_Glu554del

269 KIT 11 c.1657_1662del p.Tyr553_Glu554del

270 WT

271 KIT 11 c.1673_1687del p.Lys558_Glu562del

272 KIT 11 c.1679T>A p.Val560Asp

273 PDGFRA 18 c.2525A>T p.Asp842Val

274 KIT 11 c.1648-6_1670del p.?

275 PDGFRA 14 c.1977C>G p.Asn659Lys

276 KIT 11 c.1673_1674insTCC p.Lys558delinsAsnPro

277 KIT 11 c.1671_1676del p.Trp557_Val559delinsCys

278 KIT 11 c.1669_1672delinsG p.Trp557_Lys558delinsGlu

279 KIT 11 c.1679T>A p.Val560Asp

280 KIT 11 c.1669T>A p.Trp557Arg

281 KIT 13 c.1924A>G p.Lys642Glu

282 KIT 11 c.[1705_1728del];[1705_1728del] p.[Val569_Leu576del];[Val569_Leu576del]

283 PDGFRA 18 c.2525A>T p.Asp842Val

284 KIT 11 c.1735_1737del p.Asp579del

285 BRAF 15 c.1799T>A p.Val600Glu

286 WT

287 KIT 11 c.[1658_1669del];[1658_1669del] p.[Tyr553_Glu556del];[Tyr553_Glu556del]

288 KIT 11 c.1670G>C p.Trp557Ser

289 KIT 11 c.1669T>A p.Trp557Arg

290 KIT 11 c.1656_1676del p.Met552_Val559delinsIle

291 KIT 11 c.1674_1679del p.Lys558_Val560delinsAsn

292 PDGFRA 18 c.2525_2534delinsT p.Asp842_His845delinsVal

293 KIT 11 c.1714_1755dup p.Asp572_Pro585dup

294 PDGFRA 18 c.2525A>T p.Asp842Val

295 KIT 11 c.1668_1676del p.Gln556_Val559delinsHis

296 WT

297 WT

298 KIT 11 c.1679T>G p.Val560Gly

299 KIT 11 c.1669_1674del p.Trp557_Lys558del

300 WT

301 KIT 11 c.1676T>G p.Val559Gly

302 KIT 11 c.1652_1669del p.Pro551_Trp557del

303 KIT 11 c.1676T>G p.Val559Gly

304 WT

305 KIT 11 c.1652_1660del p.Pro551_Glu554delinsGln

306 WT

307 WT

308 KIT 11 c.1676T>A p.Val559Asp

309 KIT 11 c.1676T>A p.Val559Asp

310 WT

311 KIT 11 c.1670_1671insTTC p.Trp557delinsCysSer

312 KIT 11 c.1664_1714del p.Val555_Ile571del

313 KIT 11 c.1676T>C p.Val559Ala

314 KIT 11 c.1679T>A p.Val560Asp

315 KIT 11 c.1669_1674del p.Trp557_Lys558del

316 WT

317 KIT 11 c.1669_1674delinsTCTTCG p.Trp557_Lys558delinsSerSer

318 KIT 11 c.1656G>A p.Met552Ile

319 KIT 9 c.1367C>T p.Pro456Leu

320 PDGFRA 18 c.2464C>T p.Arg822Cys

321 WT

322 KIT 11 c.1652_1666del p.Pro551_Val555del

323 PDGFRA 12 c.1682T>C p.Val561Ala

324 WT

325 WT

326 WT

327 KIT 11 c.1671_1679del p.Trp557_Val560delinsCys

328 KIT 11 c.1676_1684del p.Val559_Glu561del

329 KIT 11 c.1679T>A p.Val560Asp

330 KIT 11 c.1669T>G p.Trp557Gly

331 PDGFRA 18 c.2525A>T p.Asp842Val

332 KIT 11 c.1669_1674del p.Trp557_Lys558del

333 KIT 11 c.1729_1773dup p.Pro577_Phe591dup

334 WT

335 KIT 11 [c.1674G>A (;) c. 1676T>A] p.Val559Asp

336 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

337 WT

338 KIT 11 c.1690_1722delinsTCTCCT p.Asn564_Thr574delinsSerPro

339 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

340 BRAF 15 c.1799T>A p.Val600Glu

341 WT

342 KIT 11 c.1670_1671insTTC p.Trp557delinsCysSer

343 KIT 9 c.1427G>A p.Ser476Asn

344 PDGFRA 18 c.2531T>G p.Met844Arg

345 KIT 11 c.1669T>C p.Trp557Arg

346 PDGFRA 18 c.2525A>T p.Asp842Val

347 KIT 11 c.1655_1666del p.Met552_Gln556delinsLys

348 KIT 11 c.1673_1674insTCC p.Lys558delinsAsnPro

349 KIT 11 c.1676T>A p.Val559Asp

350 KIT 11 c.1669T>G p.Trp557Gly

351 KIT 11 c.1648-4_1663del p.?

352 KIT 11 c.1679T>A p.Val560Asp

353 PDGFRA 18 c.2525A>T p.Asp842Val

354 PDGFRA 18 c.2525A>T p.Asp842Val

355 WT

356 WT

357 WT

358 KIT 17 c.2466T>G p.Asn822Lys

359 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

360 KIT 11 c.1661_1675del p.Glu554_Lys558del

361 KIT 11 [c.1735_1737del]+ [c.1749G>A] p.Asp579del

362 KIT 11 c.1668_1689del p.Trp557_Ile563del

363 KIT 11 c.1670_1671insTTC p.Trp557delinsCysSer

364 KIT 11 c.1648-7_1672del p.?

365 PDGFRA 18 c.2525_2537delinsC p.Asp842_Asp846delinsAla

366 KIT 11 c.1679_1680delinsAG p.Val560Glu

367 KIT 11 c.1676_1723del p.Val559_Gln575delinsGlu

368 KIT 11 c.1649_1663del p.Lys550_Val555delinsIle

369 PDGFRA 18 c.2525A>T p.Asp842Val

370 BRAF 15 c.1799T>A p.Val600Glu

371 KIT 11 c.1676T>A p.Val559Asp

372 WT

373 KIT 11 c.1648_1668del p.Lys550_Gln556del

374 KIT 11 c.1722_1730del p.Gln575_Pro577del

375 PDGFRA 18 c.2525A>T p.Asp842Val

376 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

377 WT

378 PDGFRA 18 c.2525A>T p.Asp842Val

379 WT

380 KIT 11 c.1670_1675del p.Trp557_Val559delinsPhe

381 PDGFRA 18 c.2526_2541delinsATCC p.Asp842_Ser847delinsGluSer

382 WT

383 KIT 11 c.1669_1683del p.Trp557_Glu561del

384 KIT 17 c.2466T>G p.Asn822Lys

385 PDGFRA 18 c.2525A>T p.Asp842Val

386 WT

387 WT

388 KIT 11 c.1678_1728del p.Val560_Leu576del

389 KIT 11 c.1662_1676del p.Glu554_Val559delinsAsp

390 KIT 11 c.1676T>C p.Val559Ala

391 BRAF 15 c.1799T>A p.Val600Glu

392 PDGFRA 14 c.1977C>G p.Asn659Lys

393 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

394 KIT 11 c.1669_1677del p.Trp557_Val559del

395 KIT 11 c.1727_1729del p.Leu576del

396 PDGFRA 18 c.2525A>T p.Asp842Val

397 PDGFRA 18 c.2525A>T p.Asp842Val

398 PDGFRA 12 c.1741C>T p.Pro581Ser

399 KIT 17 c.2466T>G p.Asn822Lys

400 KIT 11 c.1727_1729del p.Leu576del

401 PDGFRA 18 c.2525A>T p.Asp842Val

402 PDGFRA 14 c.1977C>G p.Asn659Lys

403 PDGFRA 18 c.2525A>T p.Asp842Val

404 KIT 11 c.1653_1670del p.Met552_Trp557del

405 KIT 11 c.1721_1756dup p.Thr574_Pro585dup

406 KIT 11 c.1665_1679del p.Gln556_Val560del

407 KIT 11 c.1669_1674del p.Trp557_Lys558del

408 KIT 11 c.1667T>A p.Trp557Arg

409 KIT 11 c.1676T>A p.Val559Asp

410 KIT 11 c.1676T>A p.Val559Asp

411 KIT 11 c.1648-2_1672delinsT p.?

412 KIT 11 c.1756_1761del p.Trp557_Lys558del

413 WT

414 KIT 11 [c.1648-3_1673del (;) c.1680T>G] p.?

415 WT

416 PDGFRA 18 c.2525A>T p.Asp842Val

417 WT

418 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

419 WT

420 KIT 11 c.1711_1737dup p.Ile571_Asp579dup

421 PDGFRA 18 c.2525A>T p.Asp842Val

422 KIT 11 c.1667_1673delinsC p.Gln556_Lys558delinsPro

423 PDGFRA 18 c.2525A>T p.Asp842Val

424 KIT 11 c.1669_1683del p.Trp557_Glu561del

425 KIT 11 c.1668_1679del p.Gln556_Val560delinsHis

426 KIT 11 c.1678_1680del p.Val560del

427 KIT 11 c.1676T>G p.Val559Gly

428 PDGFRA 12 c.1674_1712del p.Trp559_Glu571del

429 PDGFRA 18 c.2525A>T p.Asp842Val

430 KIT 11 c.1669T>G p.Trp557Gly

431 PDGFRA 18 c.2524_2525delinsAT p.Asp842Ile

432 PDGFRA 18 c.2524_2525delinsTT p.Asp842Phe

433 PDGFRA 18 c.2525A>T p.Asp842Val

434 PDGFRA 14 c.1954G>A p.Gly652Arg

435 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

436 KIT 9 c.1504_1509dup p.Ala502_Tyr503dup

437 KIT 11 c.1673insTCC p.Lys558delinsAsnPro

438 WT

439 KIT 11 c.1672_1680del p.Lys558_Val560del

440 KIT 11 c.1676T>A p.Val559Asp

441 KIT 11 c.1717_1718delinsTT p.Pro573Leu

442 KIT 11 c.1654_1659del p.Met552_Tyr553del

443 KIT 11 c.1669_1674del p.Trp557_Lys558del

444 KIT 11 [c.1648-4_1671del(;)c.1680T>G] p.?

445 PDGFRA 18 c.2525A>T p.Asp842Val

446 KIT 11 c.1648-5_1672del p.?

447 KIT 11 c.1676T>C p.Val559Ala

448 KIT 11 c.1669_1683del p.Trp557_Glu561del

449 PDGFRA 18 c.2525A>T p.Asp842Val

450 KIT 11 c.1669_1674del p.Trp557_Lys558del

451 PDGFRA 18 c.2525A>T p.Asp842Val

6