Supplementary Table S1. Clinical Characteristics of Women in TCGA Dataset

SUPPLEMENTARY TABLES

Supplementary Table S1. Clinical characteristics of women in TCGA dataset

Characteristics / Optimal debulking (n=332) / Suboptimal debulking (n=136) / P
Mean (SD) / Mean (SD)
Average age (years) / 58.6 (11.3) / 62.5 (12) / 0.001
N (%) / N (%)
Stage (n)
III / 282 (85%) / 112 (82%) / 0.48
IV / 50 (15%) / 24 (18%)
Grade (n)
Well differentiated / 3 (1%) / 1 (1%) / 0.9
Moderately differentiated / 33 (10%) / 16 (12%)
Poorly differentiated / 289 (87%) / 117 (86%)
Unknown / 7 (2%) / 2 (1%)

Supplementary Table S2. Clinical characteristics of women in the AOCS dataset

Characteristics / Optimal debulking
(n=112) / Suboptimal debulking
(n=78) / P
Mean (SD) / Mean (SD)
Average age (years) / 60.4 (+/- 9.2) / 59.3 (+/- 11.3) / 0.8
N (%) / N (%)
Primary
Ovary / 96 (86%) / 62 (79%) / 0.5
Peritoneum / 14 (12%) / 14 (18%)
Fallopian tube / 2 (2%) / 2 (3%)
Stage (n)
III / 107 (96%) / 67 (86%) / 0.02
IV / 5 (4%) / 11 (14%)
Grade (n)
Well differentiated / 2 (2%) / 2 (2%) / 0.7
Moderately differentiated / 44 (39%) / 27 (35%)
Poorly differentiated / 66 (59%) / 49 (63%)

Supplementary Table S3. List of genes differentially expressed at univariate significance level P<0.001 in the optimal cytoreduction group (no macroscopic residual disease) when compared to the suboptimal cytoreduction group in the AOCS set. These genes were included in the multivariate prediction analysis.

Symbol / P value / Fold-change (log-transformed) / Name
ADH1B / 3.92E-05 / 0.32 / alcohol dehydrogenase 1B (class I), beta polypeptide
LRCH1 / 4.86E-05 / 0.72 / leucine-rich repeats and calponin homology (CH) domain containing 1
ATMIN / 5.37E-05 / 0.76 / ATM interactor
BCHE / 5.59E-05 / 0.5 / butyrylcholinesterase
FAM126A / 7.05E-05 / 0.68 / family with sequence similarity 126, member A
PTGER3 / 8.21E-05 / 0.62 / prostaglandin E receptor 3 (subtype EP3)
COTL1 / 9.13E-05 / 0.63 / coactosin-like 1 (Dictyostelium)
KAL1 / 1.02E-04 / 0.53 / Kallmann syndrome 1 sequence
LY86 / 1.05E-04 / 0.67 / lymphocyte antigen 86
JDP2 / 1.23E-04 / 0.76 / Jun dimerization protein 2
GRINA / 1.32E-04 / 0.73 / glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
NFKBIA / 1.51E-04 / 0.73 / nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSMAF / 1.57E-04 / 0.79 / neutral sphingomyelinase (N-SMase) activation associated factor
PRKG1 / 1.58E-04 / 0.64 / protein kinase, cGMP-dependent, type I
ZFHX4 / 1.71E-04 / 0.63 / zinc finger homeobox 4
SCD / 2.02E-04 / 0.6 / stearoyl-CoA desaturase (delta-9-desaturase)
MSR1 / 2.03E-04 / 0.6 / macrophage scavenger receptor 1
FABP4 / 2.12E-04 / 0.27 / fatty acid binding protein 4, adipocyte
RAPH1 / 2.22E-04 / 0.72 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
IFFO1 / 2.28E-04 / 0.78 / intermediate filament family orphan 1
ODZ3 / 2.30E-04 / 0.63 / odz, odd Oz/ten-m homolog 3 (Drosophila)
RGS1 / 2.43E-04 / 0.53 / regulator of G-protein signaling 1
FAS / 3.00E-04 / 0.63 / Fas (TNF receptor superfamily, member 6)
XYLT1 / 3.16E-04 / 0.66 / xylosyltransferase I
N4BP2L2 / 3.39E-04 / 0.77 / NEDD4 binding protein 2-like 2
SIRPA / 3.91E-04 / 0.67 / signal-regulatory protein alpha
CELF2 / 3.92E-04 / 0.64 / CUGBP, Elav-like family member 2
CORO1A / 3.97E-04 / 0.65 / coronin, actin binding protein, 1A
DOCK11 / 3.97E-04 / 0.6 / dedicator of cytokinesis 11
STARD13 / 4.11E-04 / 0.75 / StAR-related lipid transfer (START) domain containing 13
PYGL / 4.22E-04 / 0.71 / phosphorylase, glycogen, liver
KIAA1659 / 4.23E-04 / 0.73 / KIAA1659 protein
PTPRD / 4.26E-04 / 0.58 / protein tyrosine phosphatase, receptor type, D
CRISPLD2 / 4.31E-04 / 0.5 / cysteine-rich secretory protein LCCL domain containing 2
CX3CR1 / 4.47E-04 / 0.52 / chemokine (C-X3-C motif) receptor 1
LOH3CR2A / 4.72E-04 / 0.68 / loss of heterozygosity, 3, chromosomal region 2, gene A
MGC45800 / 5.26E-04 / 0.85 / hypothetical LOC90768
LOC285812 / 5.38E-04 / 0.6 / hypothetical protein LOC285812
OSBPL3 / 5.42E-04 / 0.63 / oxysterol binding protein-like 3
SLC9A9 / 5.76E-04 / 0.8 / solute carrier family 9 (sodium/hydrogen exchanger), member 9
GADD45B / 5.76E-04 / 0.63 / growth arrest and DNA-damage-inducible, beta
TPM4 / 5.86E-04 / 0.73 / tropomyosin 4
C10orf54 / 5.86E-04 / 0.76 / chromosome 10 open reading frame 54
GFOD1 / 5.91E-04 / 0.67 / glucose-fructose oxidoreductase domain containing 1
FKBP14 / 6.32E-04 / 0.77 / FK506 binding protein 14, 22 kDa
FAM38A / 6.45E-04 / 0.67 / family with sequence similarity 38, member A
TNFSF13B / 6.61E-04 / 0.58 / tumor necrosis factor (ligand) superfamily, member 13b
GPR34 / 6.62E-04 / 0.59 / G protein-coupled receptor 34
STK17A / 6.62E-04 / 0.77 / serine/threonine kinase 17a
C21orf96 / 6.83E-04 / 0.66 / chromosome 21 open reading frame 96
VGLL3 / 6.88E-04 / 0.59 / vestigial like 3 (Drosophila)
ELMO1 / 6.93E-04 / 0.71 / engulfment and cell motility 1
ANKRD13C / 7.20E-04 / 0.83 / ankyrin repeat domain 13C
KDELR3 / 7.51E-04 / 0.66 / KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
MYCBP2 / 7.93E-04 / 0.8 / MYC binding protein 2
KLF6 / 7.99E-04 / 0.7 / Kruppel-like factor 6
HOXA3 / 8.82E-04 / 0.49 / homeobox A3
PTX3 / 8.98E-04 / 0.52 / pentraxin 3, long
TPM1 / 9.17E-04 / 0.71 / tropomyosin 1 (alpha)
GAL3ST4 / 9.58E-04 / 0.81 / galactose-3-O-sulfotransferase 4
CPSF1 / 9.58E-04 / 0.77 / cleavage and polyadenylation specific factor 1, 160kDa
AFAP1 / 9.59E-04 / 0.83 / actin filament associated protein 1
SAMSN1 / 9.59E-04 / 0.57 / SAM domain, SH3 domain and nuclear localization signals 1
ARF6 / 9.90E-04 / 0.81 / ADP-ribosylation factor 6
SNTB2 / 9.94E-04 / 0.78 / syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
FCGR1B / 9.95E-04 / 0.62 / Fc fragment of IgG, high affinity Ib, receptor (CD64)
ABCA17P / 9.73E-04 / 1.39 / ATP-binding cassette, sub-family A (ABC1), member 17, pseudogene
LOC641518 / 9.63E-04 / 1.2 / hypothetical LOC641518
DYX1C1 / 9.62E-04 / 1.29 / dyslexia susceptibility 1 candidate 1
PMF1 / 9.51E-04 / 1.2 / polyamine-modulated factor 1
BBS5 / 9.50E-04 / 1.23 / Bardet-Biedl syndrome 5
KCNN3 / 9.29E-04 / 1.49 / potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
CCDC65 / 9.14E-04 / 1.24 / coiled-coil domain containing 65
CYB5D1 / 8.84E-04 / 1.22 / cytochrome b5 domain containing 1
ATXN2 / 8.65E-04 / 1.17 / ataxin 2
TMEM42 / 8.47E-04 / 1.19 / transmembrane protein 42
TRIM58 / 8.39E-04 / 1.38 / tripartite motif containing 58
PRPF8 / 8.05E-04 / 1.2 / PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
TJAP1 / 7.90E-04 / 1.19 / tight junction associated protein 1 (peripheral)
RSPH1 / 7.84E-04 / 1.62 / radial spoke head 1 homolog (Chlamydomonas)
KIAA1377 / 7.80E-04 / 1.48 / KIAA1377
RANGRF / 7.67E-04 / 1.24 / RAN guanine nucleotide release factor
CCDC28A / 7.64E-04 / 1.24 / coiled-coil domain containing 28A
C2orf15 / 7.55E-04 / 1.14 / chromosome 2 open reading frame 15
EFHC1 / 7.48E-04 / 1.4 / EF-hand domain (C-terminal) containing 1
C1orf114 / 7.44E-04 / 1.54 / chromosome 1 open reading frame 114
WDR54 / 7.40E-04 / 1.37 / WD repeat domain 54
C11orf74 / 7.35E-04 / 1.26 / chromosome 11 open reading frame 74
MAD2L1BP / 7.34E-04 / 1.23 / MAD2L1 binding protein
PSMB7 / 7.28E-04 / 1.2 / proteasome (prosome, macropain) subunit, beta type, 7
LOC100130950 / 6.82E-04 / 1.13 / hypothetical LOC100130950
CUL9 / 6.77E-04 / 1.19 / cullin 9
PKDCC / 6.77E-04 / 1.48 / protein kinase domain containing, cytoplasmic homolog (mouse)
LRRC19 / 6.73E-04 / 1.16 / leucine rich repeat containing 19
EFHB / 6.73E-04 / 1.47 / EF-hand domain family, member B
HSP90AB1 / 6.70E-04 / 1.17 / heat shock protein 90kDa alpha (cytosolic), class B member 1
GLOD4 / 6.32E-04 / 1.2 / glyoxalase domain containing 4
C10orf126 / 6.23E-04 / 1.05 / chromosome 10 open reading frame 126
ZNF232 / 6.13E-04 / 1.34 / zinc finger protein 232
CUL7 / 6.02E-04 / 1.23 / cullin 7
C9orf93 / 5.99E-04 / 1.15 / chromosome 9 open reading frame 93
RNMTL1 / 5.89E-04 / 1.29 / RNA methyltransferase like 1
SMYD4 / 5.87E-04 / 1.19 / SET and MYND domain containing 4
MEA1 / 5.77E-04 / 1.24 / male-enhanced antigen 1
POP5 / 5.77E-04 / 1.23 / processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
DNAH7 / 5.70E-04 / 1.42 / dynein, axonemal, heavy chain 7
MED18 / 5.48E-04 / 1.16 / mediator complex subunit 18
LOC441204 / 5.44E-04 / 1.19 / hypothetical locus LOC441204
ZNF554 / 5.31E-04 / 1.13 / zinc finger protein 554
MIS12 / 5.16E-04 / 1.24 / MIS12, MIND kinetochore complex component, homolog (S. pombe)
LOC100129195 / 5.12E-04 / 1.15 / hypothetical LOC100129195
LOC730102 / 5.00E-04 / 1.16 / quinone oxidoreductase-like protein 2 pseudogene
HES2 / 4.99E-04 / 1.21 / hairy and enhancer of split 2 (Drosophila)
LOC338799 / 4.60E-04 / 1.19 / hypothetical LOC338799
FBXO36 / 4.48E-04 / 1.25 / F-box protein 36
FAM201A / 4.45E-04 / 1.33 / family with sequence similarity 201, member A
FSD1L / 4.43E-04 / 1.32 / fibronectin type III and SPRY domain containing 1-like
LRRC66 / 4.40E-04 / 1.09 / leucine rich repeat containing 66
FAM166B / 4.35E-04 / 1.25 / family with sequence similarity 166, member B
CARD18 / 4.29E-04 / 1.17 / caspase recruitment domain family, member 18
AKNAD1 / 4.25E-04 / 1.06 / AKNA domain containing 1
NDUFS2 / 4.17E-04 / 1.18 / NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NUCB2 / 4.08E-04 / 1.36 / nucleobindin 2
C3orf15 / 4.02E-04 / 1.54 / chromosome 3 open reading frame 15
C9orf66 / 3.89E-04 / 1.24 / chromosome 9 open reading frame 66
ZNF594 / 3.86E-04 / 1.28 / zinc finger protein 594
ZNF318 / 3.84E-04 / 1.32 / zinc finger protein 318
C6orf99 / 3.84E-04 / 1.13 / chromosome 6 open reading frame 99
C6orf165 / 3.64E-04 / 1.33 / chromosome 6 open reading frame 165
C15orf33 / 3.47E-04 / 1.13 / chromosome 15 open reading frame 33
ZNHIT3 / 3.44E-04 / 1.2 / zinc finger, HIT-type containing 3
IFT74 / 3.43E-04 / 1.4 / intraflagellar transport 74 homolog (Chlamydomonas)
NUDT17 / 3.41E-04 / 1.18 / nudix (nucleoside diphosphate linked moiety X)-type motif 17
BTBD9 / 3.34E-04 / 1.14 / BTB (POZ) domain containing 9
SPAG17 / 3.32E-04 / 1.54 / sperm associated antigen 17
LRRC34 / 3.24E-04 / 1.75 / leucine rich repeat containing 34
LRRIQ3 / 3.19E-04 / 1.11 / leucine-rich repeats and IQ motif containing 3
C3orf75 / 3.13E-04 / 1.17 / chromosome 3 open reading frame 75
ERP29 / 3.10E-04 / 1.21 / endoplasmic reticulum protein 29
LOC100505835 / 3.08E-04 / 1.18 / hypothetical LOC100505835
COQ7 / 2.99E-04 / 1.22 / coenzyme Q7 homolog, ubiquinone (yeast)
NUP88 / 2.97E-04 / 1.3 / nucleoporin 88kDa
VPS33A / 2.90E-04 / 1.12 / vacuolar protein sorting 33 homolog A (S. cerevisiae)
LOC100128640 / 2.84E-04 / 1.19 / hypothetical LOC100128640
PPFIA2 / 2.82E-04 / 1.12 / protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
MED11 / 2.81E-04 / 1.2 / mediator complex subunit 11
METTL16 / 2.78E-04 / 1.23 / methyltransferase like 16
POLH / 2.44E-04 / 1.27 / polymerase (DNA directed), eta
LOC100506668 / 2.32E-04 / 1.25 / hypothetical LOC100506668
TSNAXIP1 / 2.22E-04 / 1.21 / translin-associated factor X interacting protein 1
FLJ37453 / 2.22E-04 / 1.38 / hypothetical LOC729614
FLJ35776 / 2.10E-04 / 1.3 / hypothetical LOC649446
TXNDC17 / 2.05E-04 / 1.23 / thioredoxin domain containing 17
RAB36 / 2.04E-04 / 1.26 / RAB36, member RAS oncogene family
CETN2 / 2.02E-04 / 1.29 / centrin, EF-hand protein, 2
KIF9 / 1.97E-04 / 1.44 / kinesin family member 9
ADCYAP1R1 / 1.93E-04 / 1.71 / adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
SDHC / 1.93E-04 / 1.22 / succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
DBIL5P / 1.91E-04 / 1.18 / diazepam binding inhibitor-like 5, pseudogene
ZMYND10 / 1.84E-04 / 1.34 / zinc finger, MYND-type containing 10
AKD1 / 1.77E-04 / 1.32 / adenylate kinase domain containing 1
KLHDC9 / 1.77E-04 / 1.35 / kelch domain containing 9
ANKRD45 / 1.69E-04 / 1.61 / ankyrin repeat domain 45
KLC4 / 1.68E-04 / 1.21 / kinesin light chain 4
ALDH5A1 / 1.56E-04 / 1.43 / aldehyde dehydrogenase 5 family, member A1
AQP11 / 1.51E-04 / 1.35 / aquaporin 11
C6orf108 / 1.48E-04 / 1.28 / chromosome 6 open reading frame 108
SPEF1 / 1.46E-04 / 1.26 / sperm flagellar 1
C10orf25 / 1.43E-04 / 1.28 / chromosome 10 open reading frame 25
MGC11082 / 1.40E-04 / 1.32 / hypothetical LOC84777
MORN3 / 1.39E-04 / 1.22 / MORN repeat containing 3
ESM1 / 1.36E-04 / 1.46 / endothelial cell-specific molecule 1
CYB5D2 / 1.32E-04 / 1.3 / cytochrome b5 domain containing 2
GPS2 / 1.25E-04 / 1.21 / G protein pathway suppressor 2
LOC728543 / 1.16E-04 / 1.14 / hypothetical protein LOC728543
SOST / 1.08E-04 / 1.55 / sclerostin
NRTN / 1.03E-04 / 1.52 / neurturin
WDR49 / 8.93E-05 / 1.24 / WD repeat domain 49
C6orf130 / 8.90E-05 / 1.33 / chromosome 6 open reading frame 130
CDK20 / 8.53E-05 / 1.2 / cyclin-dependent kinase 20
CORT / 8.16E-05 / 1.13 / cortistatin
TMEM107 / 7.95E-05 / 1.33 / transmembrane protein 107
KIF27 / 7.35E-05 / 1.13 / kinesin family member 27
ZFP3 / 6.91E-05 / 1.36 / zinc finger protein 3 homolog (mouse)
SLC13A5 / 6.78E-05 / 1.47 / solute carrier family 13 (sodium-dependent citrate transporter), member 5
C1orf192 / 6.67E-05 / 2.35 / chromosome 1 open reading frame 192
TTC26 / 4.49E-05 / 1.3 / tetratricopeptide repeat domain 26
LOC284023 / 4.29E-05 / 1.27 / hypothetical LOC284023
HSPB9 / 4.16E-05 / 1.15 / heat shock protein, alpha-crystallin-related, B9
SENP3 / 3.77E-05 / 1.22 / SUMO1/sentrin/SMT3 specific peptidase 3
DALRD3 / 3.68E-05 / 1.28 / DALR anticodon binding domain containing 3
C1orf88 / 3.17E-05 / 1.88 / chromosome 1 open reading frame 88
UBXN10 / 2.97E-05 / 1.29 / UBX domain protein 10
C17orf49 / 2.97E-05 / 1.3 / chromosome 17 open reading frame 49
C9orf116 / 2.95E-05 / 1.48 / chromosome 9 open reading frame 116
TCTN2 / 2.18E-05 / 1.26 / tectonic family member 2
DNAJC28 / 1.93E-05 / 1.13 / DnaJ (Hsp40) homolog, subfamily C, member 28
TEC / 1.77E-05 / 1.28 / tec protein tyrosine kinase
DVL2 / 1.54E-05 / 1.25 / dishevelled, dsh homolog 2 (Drosophila)
OSCP1 / 1.52E-05 / 1.47 / organic solute carrier partner 1
METTL20 / 1.43E-05 / 1.28 / methyltransferase like 20
MRPS18A / 1.41E-05 / 1.29 / mitochondrial ribosomal protein S18A
WRAP53 / 1.23E-05 / 1.19 / WD repeat containing, antisense to TP53
PIH1D2 / 1.11E-05 / 1.35 / PIH1 domain containing 2
B9D1 / 9.40E-06 / 1.43 / B9 protein domain 1
TEKT2 / 6.30E-06 / 1.64 / tektin 2 (testicular)
LSMD1 / 6.20E-06 / 1.29 / LSM domain containing 1
DERL2 / 5.60E-06 / 1.29 / Der1-like domain family, member 2
POLR1C / 3.80E-06 / 1.31 / polymerase (RNA) I polypeptide C, 30kDa
MED31 / 3.20E-06 / 1.33 / mediator complex subunit 31
C6orf154 / 2.70E-06 / 1.34 / chromosome 6 open reading frame 154
C17orf97 / 1.50E-06 / 1.6 / chromosome 17 open reading frame 97
C17orf100 / 1.40E-06 / 1.36 / chromosome 17 open reading frame 100
LZTFL1 / 1.30E-06 / 1.46 / leucine zipper transcription factor-like 1
PSMB6 / 1.10E-06 / 1.25 / proteasome (prosome, macropain) subunit, beta type, 6
SPATA17 / 9.00E-07 / 2.05 / spermatogenesis associated 17
C1QBP / < 1e-07 / 1.43 / complement component 1, q subcomponent binding protein
KIAA0753 / < 1e-07 / 1.36 / KIAA0753
RPAIN / < 1e-07 / 1.38 / RPA interacting protein
EIF4A1 / < 1e-07 / 1.31 / eukaryotic translation initiation factor 4A1