Table (E) T-1: Application of Recently Proposed Criteria for Diagnosis of Childhood Absence Epilepsy (7,14)) to Study Patients

1 Seizures with no clinical signs are in brackets. 2Single jerks of the head, body or arms occurring during seizures in sleep might be serendipitous physiological sleep myoclonus. For that reason, we used only jerks seen during seizures recorded not in sleep as an exclusion criterion. 3The proposed criteria do not define severe and mild loss of awareness or at which time in the seizure this is to be measured. Because, awareness is more severely affected at the beginning of the seizure (9, 12), we used partial awareness as an exclusion criterion only if it occurred in the first 5 seconds of the seizure. IPS – intermittent photic stimulation, s – seconds, Sz – seizure, W – awake state, D - Drowsy state, S - Sleep state, HV – hyperventilation, P – photic, T- response tested in at least one seizure and complete loss of awareness demonstrated, NT – no response testing performed, E- partial or complete awareness in early testing, L - partial or complete awareness in late testing, Fragment – inter-ictal fragment of generalized spike and wave,

Patient / Age < 4 years / IPS / Partially awareness in Seizure 3 / Myoclonia in Seizures 2 / States of Seizures with duration <4 s 1 / States with > 3 spikes / States of seizures with Disorganized discharges / Fulfil Loiseau and Panayiotopoulos criteria for CAE
1 / T / Yes
2 / L / (Single in sleep) / Yes
3 / L / Yes / D / No
4 / L / S in fragment / No
5 / L / Yes / HV / No
6 / E + L / (Single in sleep) / HV / D / No
7 / T / Yes / No
8 / 2.5 / L / D, S / S in fragment / D,S / No
9 / T / D, HV (S) / D / No
10 / 2.5 / NT / D / No
11 / T / Yes / W / No
12 / T / Yes
12 / E + L / (HV,S) / No
14 / E / HV / S, HV / No
15 / L / Yes / (S) / No
16 / L / D (S) / HV / No
17 / T / Yes / S, D / No
18 / E + L / (S) / S in fragment / HV / No
19 / T / S in fragment / No
20 / E / D / D, + S in frag / No
21 / T / HV (S), / D / No
22 / E + L / HV / No
23 / L / W,HV,S / No
24 / E + L / No
25 / L / Yes / D / No
26 / L / Yes
27 / 3 / L / No
28 / L / Yes / HV,D / No
29 / E + L / HV + S in frag / No
30 / 3.75 / T / No
31 / T / Yes / D / D / No
32 / L / (Single in sleep) / Yes
33 / E / HV, W / No
34 / L / Yes / No
35 / L / Yes / HV / No
36 / L / (Single in sleep) / S / No
37 / L / S in fragment / No
38 / Yes / E / W,D,HV,P / W / No
39 / NT / (Single in sleep) / HV, D / HV, P / No
40 / Yes / T / P (S) / HV,P / No
41 / E / (Single in sleep) / HV, D / S in fragment / HV / No
42 / Yes / E / P / P / P / No
43 / Yes / L / No
44 / Yes / E / P / P / P, / No
45 / Yes / E / HV, P (S) / P / HV,S,P / No
46 / E / Yes / D, HV / HV, S, D / No
47 / Yes / E + L / HV, P / No
Total / 4 / 7 / E =16, L=25 / Yes = 12
In sleep only= 6 / 21 / 13 / 25 / 5