Supplementary Table 9. Tissue-specific genes differentially regulated in trisomy 21 amniotic fluid compared with euploid controls

Supplemental Table 9. Tissue-specific genes differentially regulated in trisomy 21 amniotic fluid compared with euploid controls
Novel neurodevelopmental information revealed in amniotic fluid supernatant from fetuses with trisomies 18 and 21. Human Genetics. Lisa Hui, Donna K. Slonim, Heather C. Wick, Kirby L. Johnson, Keiko Koide, and Diana W. Bianchi. Corresponding author: Lisa Hui, Mother Infant Research Institute at Tufts Medical Center,
Probe Set ID / Gene Symbol / Gene Title / direction of differential regulation in trisomy 21 vs controls / GNF tissue with highest expression
220129_at / SOHLH2 / spermatogenesis and oogenesis specific basic helix-loop-helix 2 / down / 721_B_lymphoblasts
221920_s_at / SLC25A37 / solute carrier family 25, member 37 / down / CD71+_EarlyErythroid Bonemarrow
204913_s_at / SOX11 / SRY (sex determining region Y)-box 11 / down / Fetalbrain
221766_s_at / FAM46A / family with sequence similarity 46, member A / down / Placenta
212793_at / DAAM2 / dishevelled associated activator of morphogenesis 2 / down / Spinalcord Hypothalamus PrefrontalCortex Retina Thalamus Caudatenucleus
206765_at / KCNJ2 / potassium inwardly-rectifying channel, subfamily J, member 2 / down / WholeBlood
200956_s_at / SSRP1 / structure specific recognition protein 1 / up / 721_B_lymphoblasts
206074_s_at / HMGA1 / high mobility group AT-hook 1 / up / 721_B_lymphoblasts CD105+_Endothelial
204118_at / CD48 / CD48 molecule / up / 721_B_lymphoblasts CD19+_BCells(neg._sel.) CD14+_Monocytes CD4+_Tcells CD56+_NKCells CD8+_Tcells CD33+_Myeloid BDCA4+_DentriticCells WholeBlood
201819_at / SCARB1 / scavenger receptor class B, member 1 / up / AdrenalCortex Adrenalgland
210644_s_at / LAIR1 / leukocyte-associated immunoglobulin-like receptor 1 / up / BDCA4+_DentriticCells Thymus CD56+_NKCells
211571_s_at / VCAN / versican / up / CD33+_Myeloid CD14+_Monocytes
202510_s_at / TNFAIP2 / tumor necrosis factor, alpha-induced protein 2 / up / CD33+_Myeloid CD14+_Monocytes WholeBlood
203799_at / CD302 / CD302 molecule / up / CD33+_Myeloid CD14+_Monocytes WholeBlood
207968_s_at / MEF2C / myocyte enhancer factor 2C / up / Fetalbrain
205075_at / SERPINF2 / serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 / up / Liver
205774_at / F12 / coagulation factor XII (Hageman factor) / up / Liver
206153_at / CYP4F11 / cytochrome P450, family 4, subfamily F, polypeptide 11 / up / Liver
203167_at / TIMP2 / TIMP metallopeptidase inhibitor 2 / up / Placenta
205388_at / TNNC2 / troponin C type 2 (fast) / up / SkeletalMuscle
205900_at / KRT1 / keratin 1 / up / Skin
204029_at / CELSR2 / cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) / up / Wholebrain PrefrontalCortex Amygdala MedullaOblongata CingulateCortex ParietalLobe

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