Supplementary Table 6. Tissue-specific genes in the trisomy 21 amniotic fluid transcriptome

Supplemental Table 6. Tissue specific genes in the trisomy 21 amniotic fluid transcriptome
Novel neurodevelopmental information revealed in amniotic fluid supernatant from fetuses with trisomies 18 and 21. Human Genetics. Lisa Hui, Donna K. Slonim, Heather C. Wick, Kirby L. Johnson, Keiko Koide, and Diana W. Bianchi. Corresponding author: Lisa Hui, Mother Infant Research Institute at Tufts Medical Center,
Probe Set ID / Gene Symbol / Gene Title / Tissue with highest expression
203566_s_at / AGL / amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase / Pineal_day Pineal_night
202760_s_at / AKAP2 /// PALM2-AKAP2 / A kinase (PRKA) anchor protein 2 /// PALM2-AKAP2 readthrough / CD19+_BCells(neg._sel.) 721_B_lymphoblasts
212609_s_at / AKT3 / V-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) / Fetalbrain
206385_s_at / ANK3 / ankyrin 3, node of Ranvier (ankyrin G) / PrefrontalCortex Amygdala Hypothalamus Fetalbrain MedullaOblongata CingulateCortex Thalamus OccipitalLobe ParietalLobe
214933_at / CACNA1A / calcium channel, voltage-dependent, P/Q type, alpha 1A subunit / Cerebellum PrefrontalCortex CerebellumPeduncles
218309_at / CAMK2N1 / calcium/calmodulin-dependent protein kinase II inhibitor 1 / PrefrontalCortex Amygdala Wholebrain OccipitalLobe ParietalLobe CingulateCortex TemporalLobe MedullaOblongata Hypothalamus SubthalamicNucleus Pons Thalamus
201853_s_at / CDC25B / cell division cycle 25 homolog B (S. pombe) / CD4+_Tcells CD8+_Tcells CD56+_NKCells
217878_s_at / CDC27 / cell division cycle 27 homolog (S. cerevisiae) / CD71+_EarlyErythroid
213183_s_at / CDKN1C / Cyclin-dependent kinase inhibitor 1C (p57, Kip2) / Placenta
204971_at / CSTA / cystatin A (stefin A) / Tongue
207608_x_at / CYP1A2 / cytochrome P450, family 1, subfamily A, polypeptide 2 / Liver
207407_x_at / CYP4A11 / cytochrome P450, family 4, subfamily A, polypeptide 11 / Liver
209570_s_at / D4S234E / DNA segment on chromosome 4 (unique) 234 expressed sequence / Fetalbrain Pituitary Hypothalamus Cerebellum
201278_at / DAB2 / disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) / Placenta
203139_at / DAPK1 / death-associated protein kinase 1 / Placenta
201681_s_at / DLG5 / discs, large homolog 5 (Drosophila) / Placenta
214395_x_at / EEF1D / eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) / FetalThyroid
91826_at / EPS8L1 / EPS8-like 1 / Placenta
207300_s_at / F7 / coagulation factor VII (serum prothrombin conversion accelerator) / Liver Fetalliver
211734_s_at / FCER1A / Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide / BDCA4+_DentriticCells CD34+ CD33+_Myeloid
213940_s_at / FNBP1 / formin binding protein 1 / 721_B_lymphoblasts CD19+_BCells(neg._sel.) CD4+_Tcells CD8+_Tcells CD56+_NKCells
215017_s_at / FNBP1L / formin binding protein 1-like / Fetalbrain
202748_at / GBP2 / guanylate binding protein 2, interferon-inducible / WholeBlood CD56+_NKCells CD8+_Tcells CD4+_Tcells CD14+_Monocytes
201921_at / GNG10 / guanine nucleotide binding protein (G protein), gamma 10 / WholeBlood
214864_s_at / GRHPR / glyoxylate reductase/hydroxypyruvate reductase / Liver
204550_x_at / GSTM1 / glutathione S-transferase mu 1 / Liver
204418_x_at / GSTM2 / glutathione S-transferase mu 2 (muscle) / Liver
206074_s_at / HMGA1 / high mobility group AT-hook 1 / 721_B_lymphoblasts CD105+_Endothelial
209291_at / ID4 / inhibitor of DNA binding 4, dominant negative helix-loop-helix protein / Thyroid
215712_s_at / IGFALS / insulin-like growth factor binding protein, acid labile subunit / Liver
211532_x_at / KIR2DS2 / killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 / CD56+_NKCells
221841_s_at / KLF4 / Kruppel-like factor 4 (gut) / CD33+_Myeloid
213287_s_at / KRT10 / keratin 10 / Skin
207935_s_at / KRT13 / keratin 13 / Tongue
213240_s_at / KRT4 / keratin 4 / Tongue
209125_at / KRT6A / keratin 6A / Tongue BronchialEpithelialCells
214580_x_at / KRT6A /// KRT6B /// KRT6C / keratin 6A /// keratin 6B /// keratin 6C / Tongue BronchialEpithelialCells
222036_s_at / MCM4 / minichromosome maintenance complex component 4 / 721_B_lymphoblasts CD105+_Endothelial
217187_at / MUC5AC / mucin 5AC, oligomeric mucus/gel-forming / Trachea
209124_at / MYD88 / myeloid differentiation primary response gene (88) / CD33+_Myeloid WholeBlood CD14+_Monocytes CD56+_NKCells BDCA4+_DentriticCells
203216_s_at / MYO6 / myosin VI / Pineal_night Pineal_day
221923_s_at / NPM1 / nucleophosmin (nucleolar phosphoprotein B23, numatrin) / 721_B_lymphoblasts CD34+ CD105+_Endothelial
201928_at / PKP4 / plakophilin 4 / Spinalcord PrefrontalCortex Hypothalamus
219014_at / PLAC8 / placenta-specific 8 / BDCA4+_DentriticCells CD56+_NKCells 721_B_lymphoblasts CD34+ CD19+_BCells(neg._sel.)
222253_s_at / POM121L9P / POM121 membrane glycoprotein-like 9, pseudogene / TestisIntersitial TestisGermCell Testis TestisLeydigCell TestisSeminiferousTubule
203407_at / PPL / periplakin / Tongue
203401_at / PRPS2 / phosphoribosyl pyrophosphate synthetase 2 / Ovary
206687_s_at / PTPN6 / protein tyrosine phosphatase, non-receptor type 6 / CD19+_BCells(neg._sel.) CD14+_Monocytes WholeBlood CD56+_NKCells CD33+_Myeloid CD4+_Tcells CD8+_Tcells BDCA4+_DentriticCells 721_B_lymphoblasts
204547_at / RAB40B / RAB40B, member RAS oncogene family / Amygdala Wholebrain PrefrontalCortex Caudatenucleus Hypothalamus ParietalLobe OccipitalLobe MedullaOblongata
203186_s_at / S100A4 / S100 calcium binding protein A4 / WholeBlood CD14+_Monocytes CD33+_Myeloid CD105+_Endothelial CD56+_NKCells
206884_s_at / SCEL / sciellin / Tongue Tonsil Skin
33323_r_at, 33322_i_at / SFN / stratifin / BronchialEpithelialCells Tongue
214354_x_at / SFTPB / surfactant protein B / Lung Fetallung
213139_at / SNAI2 / snail homolog 2 (Drosophila) / BronchialEpithelialCells
214549_x_at / SPRR1A / small proline-rich protein 1A / Tongue
205064_at / SPRR1B / small proline-rich protein 1B / Tongue
218990_s_at / SPRR3 / small proline-rich protein 3 / Tongue Tonsil
202125_s_at / TRAK2 / trafficking protein, kinesin binding 2 / CD71+_EarlyErythroid
204141_at / TUBB2A / tubulin, beta 2A / Amygdala Fetalbrain Wholebrain Hypothalamus PrefrontalCortex Cerebellum
217823_s_at / UBE2J1 / ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) / BDCA4+_DentriticCells
212774_at / ZNF238 / zinc finger protein 238 / CerebellumPeduncles Fetalbrain Cerebellum PrefrontalCortex Pineal_day Amygdala

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