Supplementary Table 2. Whole-genome array-CGH results: the first and the last deleted/duplicated oligomeres are reported (the position of oligomeres are referred to hg18 assembly and they must be understood in Mb).
Case / Gender / Age / ALL Type / Onset/relapse / Sample
origin / array-CGH results
Gain / Heterozygosus loss / Homozygosus loss
1. / 463-06 / M / 3y 8m / B# / o / BM / none / none / none
2. / 1330-07 / M / 11y 8m / B# / o / BM / none / none / none
3. / 1326-07 / M / 4y 1m / B# / o / BM / none / none / none
4. / 544-07 / F / 8y 1m / B# / o / BM / none / 3pter-q21.2[tel-125.945],3q25.2-qter[155.500-tel],5q22.3-23.1[115.084-120.477],5q23.2-q23.3[126.169-128.473],7p14.3-q21.3[34.903-98.093],9,14q32.33[105.442-105.481] / none
544-07 / F / 12y 5m / B# / r / BM / 1,4,5,8 / 3pter-q21.2[tel-125.945],3q25.2-qter[155.500-tel],5q22.3-23.1[115.084-120.477],5q23.2-q23.3[126.169-128.473],7p14.3-q21.3[34.903-98.093],9,14q32.33[105.442-105.481],15 / none
5. / 762-07 / M / 8y 6m / B# / r / BM / 6q23.3-qter[135.750-tel] / 1q41-qter[218.990-tel],3p14.3*[57.978-58.073],6q16.1-q21[97.090-111.049],7p,14q32.33[105.354-106.072],16q / none
6. / 884-07 / M / 4y 3m / B# / r / BM / 5,8,14,17,X / 2pter[tel-2.756],2p25.2[3.039-3.480],2p21-p16.3[46.156-48.454],9p22.1-p13.1[18.629-39.146],13q33.4[110.309-110.527],14q32.33[105.442-105.481] / 9p21.3[20.810-22.690]
7. / 920-07 / F / 4m / B§ / o / BM / none / 11q23.3[117.865-120.565] / none
8. / 795-07 / F / 5y 2m / B° / o / PB / 1q21.3-q42.12 [152.406-224.650],21,X / none / none
9. / 797-07 / M / 17y 2m / B° / o / BM / 4pter-p16.2[tel-5.191],5q13.3-qter[73.959-tel],21 / 2pter-p25.2[tel-5.191],4p15.33-p15.31[11.990-20.493],7pter-p12.2[tel-49.993],12p13.1-p11.22[14.463-28.794],12q24.23-q24.32[117.782-125.802],13q32.1-q33.21[94.968-103.076],13q33.2-q33.3[104.449-106.357],20p12.1-p11.21[15.386-25.680] / 12q12.12[23.278-24.174]
10. / 796-07 / M / 3y 9m / B° / o / BM / 21 / 6p22[26.276-26.354],14q32.33[105.442-105.481] / none
11. / 1063-07 / F / 3y / B / o / PB / 12pter-p13.2[tel-11.897],21q11.2-q22.12[13.549-35.181],Xq21.2-qter[85.575-tel] / 6q16.3-qter[102.879-tel],12p13.2-p13.1[11.935-13.259], 14q32.33[105.442-106.072] / 9p21.3[20.607-22.136]
12. / 148-07 / M / 3y 2m / B / o / BM / none / none / none
13. / 603-07 / M / 13y 7m / B / o / BM / 8pter-p23.1[tel-6.782],9p,13q12.2[26.897-27.542],20pter-q11.22[tel-33.357],20q12[37.587-40.947],X / 1p31.1-p13.3[82.181-110.542],3,7,14q32.33[105.442-105.947],15,16pter-p13.3[tel-4.519],17,19 / none
603-07 / M / 17y 4m / B / r / BM / 9p,13q12.2[26.897-27.542],20pter-q11.22 [tel-33.357],20q12[37.587-40.947],X / 1p31.1 -p13.3[82.181-110.542],3,7,8pter-p23.1[tel-6.782],14q32.33[105.442-105.947],15,16pter-p13.3[tel-4.519],17,19 / none
14. / 416-06 / F / 4y 1m / B / o / BM / 4p,10pter-q23.33[tel-97.572],14,17,18,21,21,X / 13q14.2[48.765-49.645],14q32.33[105.442-105.481] / none
15. / 636-06 / F / 5y 8m / B / o / PB / 3q26.1-qter[163.019-tel],4,5pter-p13.1[tel-39.161],6,7q,10,11,14,17q22-q25.3[49.544-78.586],18,21,X / 7p,12q24.31-q24.33[123.362-132.277],16pter-p13.13[tel-11.048],17p,19pter[tel-2.277] / none
16. / 314-07 / M / 4y 5m / B / o / BM / 4,8,21,X / none / 9p21.3[20,607-22,316]
17. / 296-06 / F / 1y 7m / B / o / BM / 21 / 14q32.33[105.442-105.481] / none
18. / 751-07 / F / 9y 3m / B / o / BM / 17q,21 / 16q,17p,Xq / none
751-07 / F / 13y 1m / B / r / BM / none / 6p22.2[26.265-26.354] / none
19. / 794-07 / F / 5y 1m / B / o / BM / 8,14,17q,18,21,X / 20q13.13-q13.2[48.152-52.7] / none
794-07 / F / 7y 3m / B / r / BM / 8,14,17q11.1-q12[22.651-33.047], 17q12-qter[33.121-tel],21,X / 1q42.13-qter[226.891-tel],17pter-p11.2[tel-15.961], 20q13.13-q13.2 [48.152-52.7] / none
20. / 918-07 / F / 4y 3m / B / o / BM / none / 9p21.3-q13[20.446-70.111] / none
21. / 1062-07 / F / 1y / B / o / BM / 6,14,17,18,21,21,X / none / none
22. / 1322-07 / M / 7y 2m / B / o / BM / 1q21.1-q25.2[143.638-177.068],11q24.3-q25*[130.209-130.772] / 1p36.12-p36.11[23.229-24.658],2q34-q35[212.567-216.777],14q32.33[105.354-105.946] / none
23. / 402-06 / M / 5y 3m / B / o / BM / 4,6,14,21,21,X / none / 9p22.1-p21.3[19.804-22.316]
402-06 / M / 7y 10m / B / r / BM / 6,14,21,X / 9p22.1-p21.3[19.804-21.362],9p21.3[22.690-22.992] / 9p21.3[21.374 -22.316]
24. / 1207-06 / M / 8y 1m / B / o / BM / none / 14q32.33[105.946-106.072] / none
25. / 46-07 / F / 3y 8m / B / o / BM / 8 / 9p,14q32.33[105.946-106.072],20q / 9p21.3[21.845-21.980]
26. / 543-07 / F / 3y 3m / B / o / BM / 21,X / 10q23.31[89.688-90.955] / none
27. / 750-07 / F / 1y 10m / B / o / BM / none / 1p34.3[36.539-38.261],1p34.1-p32.3[45.014-54.003],1q42.13-qter[225.899-tel],4q34.3-qter[177.873-tel],7q21.11-q22.1[77.067- 102.263],14q32.33[105.442-105.481] / none
28. / 761-07 / F / 4y 10m / B / o / BM / 4,6,14,17,18,21 / 14q32.33[105.442-105.481] / none
761-07 / F / 8y 2m / B / 1°r. / BM / 4,6,8,14,17,18,21,21,X / 14q32.33[105.442-105.481] / none
761-07 / F / 9y 0m / B / 2°r. / BM / 21 / none / none
29. / 883-07 / F / 7y 7m / B / o / BM / 14,21,X,Y / 6p22[26.276-26.354],14q32.33[105.442-105.481] / none
30. / 885-07 / M / 6y 5m / B / o / BM / 6,10,17,18,21,X / none / none
31. / 886-07 / M / 5y / B / o / PB / 21 / 6q14.1-q22.33[78.983-130.804],9p21.3[21.294- 22.889],14q32.33[105.442-106.311],18pter-p11.21[tel-11.878],18q11.2-q12.3[19.358-37.434],18q21.31-qter[54.518-tel] / none
32. / 801-07 / F / 5y 10m / B / o / BM / none / 1p36.11-p34.3[26.282-38.363],1p32.3-p31.1[50.729-70.285],6q16.1-q22.31[98.326-123.196],11q22.3-q23.3[104.320-116.165],12p13.2[11.678-11.965],19q13.11[37.540-40.241] / none
33. / 916-07 / F / 13y 3m / B / o / BM / none / none / none
34. / 887-07 / M / 2y 10m / B / o / BM / 4,6,14q11.2-q23.3[19.365-64.565],17,18,21,21,X / none / none
35. / 917-07 / M / 5y 4m / B / o / PB / none / 12p13.31-p12.3[9.639-14.844],14q32.33[105.354-105.467],22q12.1-q12.2[25.231-28.922] / none
36. / 1064-07 / M / 8y 11m / B / o / BM / 14,21,X / 1,2,4q21.22-q21.23[83.492-84.802],7,9q22.2-q34.3[89.162-136.778],12pter-p12.1[tel-24.918],12p11.22-p11.21[29.423-33.082],12q23.1-q23.2 [99.050-101.258],13,14q32.22[105.442-105.481],15,19,20,22 / none
37. / 1068-07 / F / 1y 9m / B / o / BM / 4,6,8,14,17,18,21,22,X / 14q32.33[105.442-106.072] / none
38. / 1066-07 / M / 7y 4m / B / o / BM / none / 7p21.1*[20.208-20.788],9p22.1-p21.3[19.804-22.992],12p13.1*[14.463-14.542],14q32.33[105.442-106.072],15q15.1[39.183-39.787],19p13.3-p13.2[1.766-7.870] / none
39. / 1067-07 / F / 3y 6m / B / o / BM / Xq25-q28[122.901-154.405] / 11q14.1-qter[77.648-tel],14q32.33[105.442-106.072] / none
40. / 1323-07 / F / 2y 3m / B / o / BM / 4,6,14,17q,21,21,X / 5p14.3-p14.2[22.727-24.224],17p / none
41. / 800-07 / F / 4y 4m / B / o / BM / 4,6,14,17q21.33-qter[45.624-tel],21,21,X / 14q32.33[105.442-105.481] / none
42. / 1324-07 / F / 1y 9m / B / o / BM / 4,6,10,14,17,18,21,21,X,X / none / none
43. / 919-07 / M / 3y 7m / B / o / BM / 4,6,9,10,18,21,X / none / none
44. / 888-06 / M / 12y 3m / B / r / BM / 7q11.23-q22.1[72.969-101.002] / 2p25.1-24.1[7.312-22.903],3q11.2-q21.2[95.112-127.983],3q24[144.894-146.012],6q12-q22.32[65.145-127.704],9p21.3[21.957-21.998],11p15.1-p12[20.040-39.686],12p13.2-p12.3[11.312-16.406],15q25.1-q26.3[77.167-100.168],17pter-p13.1 [tel-9.537] / none
45. / 1206-06 / F / 17y 4m / B / r / BM / none / 2q22.1-q24.2[141.702-160.331],8p,14q32.33[105.481-106.329],X / none
46. / 1065-07 / M / 1y 6m / B / r / BM / none / 3p21.31[47.257-49.396],14q32.33[105.442-106.072] / 2p21-16.3[47.508-47.712],13q12.12[19.254-19.329]
47. / 1327-07 / M / 8y 4m / B / r / BM / 13q12.11-q12.3 x3[18.601-28.330] / 9p21.3-p13.1[21.845-39.146],13q12.3-qter[28.535-tel],14q32.33[105.442-106.072] / 9p21.3[21.957-21.998]
48. / 1623-06 / M / 4y 6m / B / r / PBL / 17,X,Y / 9p21.3[21.095-21.998] / none
49. / 149-07 / F / 2y / B / r / BM / 16p,17q,21,21 / None / none
50. / 538-07 / F / 3y 10m / B / r / BM / 6,14,16,17,21,21,X / 14q32.33[105.442-105.481] / none
51. / 1329-07 / M / 14y 6m / B / r / BM / none / 9p21.3[21.968-21.998],14q32.33[105.442-105.947] / Xp21.1[31.949-33.918]
52. / 1331-07 / M / 2y 1m / B / r / BM / 6q12-q13*[70.186-70.500] / 6q14.1-q15[76.687-88.141],6q16.2-q22.31[99.250-122.673],6q22.33-q23.1[128.760-130.650],10p14-p13[12.202-15.929],12p13.31-p11.23[7.544-27.349],12q21.1-q21.31[74.175- 81.079],15q15.1[39.599-40.507] / 12p13.2[11.965-12.510]
53. / 1792-06 / M / 11y / B / r / BM / none / none / none
54. / 1208-06 / M / 14y 10m / T / o / BM / none / none / none
55. / 1562-06 / M / 6y 11m / T / o / PBL / none / none / 9p21.3[21.957-21.998]
56. / 147-07 / M / 13y 4m / T / o / BM / 3pter-p24.2[tel-18,094] / 1q42.2*[231.459-231.873],4q35.1*[184.187-184.310],5q35.1-qter[170.813-tel],7q22.1-q22.3[102.042-105.997],7q36.1-q36.2[148.968-152.459],9p21.3[21.337-21.795],10q26.3*[131.156 -131.972],14q32.33[105.354-105.481],22q12.1-q12.2[26.572-28.275] / 9p21.3[21.845-22.136]
57. / 217-07 / M / 7y 3m / T / o / PBL / none / none / 9p21.3[21.845-21.980]
58. / 219-07 / M / 7y / T / o / PBL / none / 9p21.3[21.067-21.733],9p21.3[22.889-22.992],12p13.2-p13.1[12.373-13.606],12p13.1-p12.3*[14.463-15.041],13q14.2[47.832-48.036] / 9p21.3[21.795-22.690],13q14.2[47.883-47.953]
59. / 546-07 / M / 4y 10m / T / o / BM / 14q13.1-q13.3[33.317-36.847],14q21.1-q21.3[38.415-46.882],14q31.1[79.742-82.072] / 6q13-q16.3[73.577-101.425],11p14.2-p12[22.316-43.385],12p13.31-p12.3[8.912-19.318],14q11.2-q12[19.365-32.371],14q21.1[36.908-37.951],14q21.3-q23.1[49.093-58.432],14q23.1-q23.2[58.605-63.567],14q24.2-q24.3[69.996-76.431],14q31.3-q32.2[87.763-97.436] / none
60. / 604-07 / F / 13y 5m / T / o / BM / 4,6pter-p22.3[tel-19.463],X / 13q14.11-q34[40.404-114.077] / none
61. / 547-07 / M / 18y 2m / T / o / BM / 13q12.11-q14.2[18.601-47.772],13q31.3-qter[90.124-tel],19 / 9p21.3[21.845-21.980],13q14.2-q31.3[47.832-89.705] / none
62. / 1460-07 / M / 14y 4m / T / o / BM / 12 / 9p21.3[20.943-21.537],9p21.3[22.136-22.316],14q32.2*[98.389-99.675],19p13.2[10.738-12.335] / 9p21.3[21.733-21.998]
63. / 1321-07 / M / 10y 10m / T / r / BM / 8,12p13.2[11.358-11.897],15,19 / 1q42.3-q43*[234.246-234.697],9p21.3[21.271-24.873],9p21.1[30.542-32.020],15q26.1*[88.752-89.430] / 9p21.3[21.795-23.779],Xq26.2[132.268-133.253]
64. / 218-07 / M / 16y 3m / T / r / BM / none / 6q12-q22.31[69.621-123.715],9p21.3[21.537-22.316] / none
65. / 749-07 / F / 7y 4m / T / o / BM / 1q31.3-qter[197.183-tel],14q31.2-q32.33[83.821-106.329],22q13.1-13.33[35.960-49.468] / 5q21.3-qter[109.952-tel],12pter-p12.1[tel- 22.729] / none
749-07 / F / 9y 6m / T / r / BM / 1q31.3-qter[197.183-tel],14q31.2-q32.33[83.821-106.329],22q13.1-13.33[35.960-49.468] / 5q21.3-qter[109.952-tel],12pter-p12.1[tel-22.729] / none
M: Male; F: Female; #: t(9;22)(q34;q11); §: t(4;11)(q21; q23); °: Down syndrome; BM: bone marrow; PBL: peripheral blood lymphocytes; o: onset; r: relapse; *uncertain copy number alteration (constitutional or acquired?) because saliva was not available. In red the cases selected for the present study on 9p21 deletions. The presence of translocations t(9;22) and t(4;11) was screened by Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR).