Supplementary Table 1.UnivariateCompeting Risk Analysis of Out-of-Field Failures
VariableSHR (95% CI)P Value
Sex
Male1.44 (0.51-4.08)0.491
Female
Age
(continuous variable)0.95 (0.91-0.99)0.007
Ethnicity
Non-Caucasian2.18 (0.99-4.81)0.053
Caucasian
History of alcohol consumption
Frequenta2.01 (0.85-4.75)0.112
Occasional1.18 (0.39-3.58)0.771
None
Smoking status
Current1.21 (0.47-3.13)0.691
Everb0.80 (0.35-1.82)0.599
Never
Baseline body mass index
>301.37 (0.69-2.72)0.368
≤30
Tumor status
T3/T43.58 (0.89-14.4)0.072
T1/T2
Nodal status
N16.85 (2.15-21.9)0.001
N0
Metastatic status
M11.90 (0.96-3.76)0.067
M0
Tumor site
Middle7.41 (0.87-63.3)0.067
Lower5.28 (0.67-41.8)0.115
Cervical/upper
Table 2, continued
Tumor grade
G3 (poorly diff.)2.80 (1.37-5.76)0.005
G2 (moderately diff.)
Tumor histology
Squamous0.67 (0.30-1.51)0.338
Adenocarcinoma
Induction Chemotherapy
Yes1.82 (0.97-3.43)0.063
No
Radiation Dose
>50.4 Gy2.23 (1.06-4.69)0.035
≤50.4 Gy
Pre-treatment SUV
>101.97 (0.97-4.03)0.062
≤10
(continuous variable) 1.01 (0.98-1.14) 0.186
Post-treatment SUV
>3.52.17 (1.05-4.47)0.035
≤3.5
(continuous variable)1.17 (1.06-1.29)0.001
SUV Change
≥6.30.84 (0.42-1.67)0.615
<6.3
(continuous variable)1.01 (0.97-1.05)0.640
Tumor length
≥5 cm2.11 (1.08-4.12)0.029
<5 cm
In-field failures
Yes0.41 (0.16-1.09)0.074
No
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake value
aAlcohol status: frequent (≥1 drink/day), occasional (<7 drinks/week)
bSmoking status: ever (quit >1 year)
Supplementary Table 2. Multivariate Competing Risk Analysis for Out-of-Field Failures
In-Field Failures
Variable SHR (95% CI) P Value
Sex
Male2.48 (0.26-23.66)0.429
Female
Age
(continuous variable)0.95 (0.89-1.00)0.072
Ethnicity
Non-Caucasian1.67 (0.53-5.25)0.384
Caucasian
Tumor status
T3/T43.16 (0.75-13.40)0.119
T1/T2
Nodal status
N15.89 (1.30-26.66)0.021
N0
Metastatic status
M10.80 (0.27-2.40)0.694
M0
Tumor grade
G3 (poorly diff.)2.38 (0.77-7.30)0.130
G2 (moderately diff.)
Tumor histology
Squamous0.17 (0.03-1.05)0.056
Adenocarcinoma
Induction Chemotherapy
Yes1.62 (0.52-5.03)0.407
No
Radiation Dose
>50.4 Gy4.01 (0.60-26.89)0.152
≤50.4 Gy
Pre-treatment SUV
>101.51 (0.54-4.22)0.436
≤10
Post-treatment SUV
>3.51.32 (0.52-3.36)0.565
≤3.5
Tumor length
≥5 cm1.08 (0.36-3.24)0.892
<5 cm
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake value
Supplementary Table 3.Univariate Competing Risk analysis for All Failures
VariableSHR (95% CI)P Value
Sex
Male1.67 (0.73-3.83)0.227
Female
Age
(continuous variable)0.96 (0.94-0.99)0.003
Ethnicity
Non-caucasion2.53 (1.62-3.93)<0.001
Caucasian
History of alcohol consumption
Frequenta2.82 (1.35-5.91)0.006
Occasional1.62 (0.64-4.10)0.308
None
Smoking status
Current0.95 (0.48-1.90)0.890
Ever0.77 (0.45-1.33)0.353
Never
Baseline body mass index
>300.64 (0.37-1.13)0.123
≤30
Tumor status
T3/T44.37 (1.71-11.16)0.002
T1/T2
Nodal status
N12.11 (1.27-3.50)0.004
N0
Metastatic status
M11.53 (0.94-2.47)0.085
M0
Tumor site
Middle1.43 (0.60-3.44)0.420
Lower1.22 (0.55-2.70)0.632
Cervical/upper
Table 2, continued
Tumor grade
G3 (poorly diff.)1.95 (1.23-3.09)0.005
G2 (moderately diff.)
Tumor histology
Squamous0.76 (0.43-1.32)0.326
Adenocarcinoma
Induction Chemotherapy
Yes1.52 (0.98-2.36)0.062
No
Radiation Dose
>50.4 Gy1.59 (0.91-2.79)0.105
≤50.4 Gy
Pre-treatment SUV
>101.87 (1.16-3.01)0.011
≤10
(continuous variable)1.02 (0.99-1.04) 0.140
Post-treatment SUV
>3.51.95 (1.22-3.12)0.006
≤3.5
(continuous variable)1.11 (1.05-1.18)0.001
SUV Change
≥6.30.70 (0.43-1.11)0.131
<6.3
(continuous variable)1.00 (0.97-1.02)0.694
Tumor length
≥5 cm1.85 (1.17-2.92)0.009
<5 cm
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake value
aAlcohol status: frequent (≥1 drink/day), occasional (<7 drinks/week)
Supplementary Table 4. Multivariate Competing Risk Analysis for All Failures
All Failures
Variable SHR (95% CI) P Value
Sex
Male1.39 (0.48-4.02)0.538
Female
Age
(continuous variable)0.96 (0.93-0.99)0.008
Ethnicity
Non-Caucasian2.55 (1.50-4.32)0.001
Caucasian
Tumor status
T3/T43.56 (1.34-9.47)0.011
T1/T2
Nodal status
N12.05 (1.06-3.99)0.034
N0
Metastatic status
M10.78 (0.38-1.59)0.494
M0
Tumor grade
G3 (poorly diff.)1.32 (0.71-2.44)0.381
G2 (moderately diff.)
Tumor histology
Squamous0.42 (0.19-0.94)0.035
Adenocarcinoma
Induction Chemotherapy
Yes0.96 (0.48-1.88)0.895
No
Radiation Dose
>50.4 Gy2.10 (0.92-4.81)0.078
≤50.4 Gy
Pre-treatment SUV
>101.21 (0.67-2.18)0.519
≤10
Post-treatment SUV
>3.51.41 (0.85-2.34)0.189
≤3.5
Tumor length
≥5 cm1.00 (0.54-1.87)0.995
<5 cm
Abbreviations: CI, confidence interval, diff., differentiated; SUV, standardized uptake value